DE602008004351D1 - Flüssige proteinformulierungen mit gdf-5 zur verwendung bei erhöhten temperaturen - Google Patents

Flüssige proteinformulierungen mit gdf-5 zur verwendung bei erhöhten temperaturen

Info

Publication number
DE602008004351D1
DE602008004351D1 DE602008004351T DE602008004351T DE602008004351D1 DE 602008004351 D1 DE602008004351 D1 DE 602008004351D1 DE 602008004351 T DE602008004351 T DE 602008004351T DE 602008004351 T DE602008004351 T DE 602008004351T DE 602008004351 D1 DE602008004351 D1 DE 602008004351D1
Authority
DE
Germany
Prior art keywords
gdf
protein formulations
increased temperatures
liquid protein
temperatures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008004351T
Other languages
English (en)
Inventor
Venkata Garigapati
Dongling Su
Julius Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Orthopaedics Inc
Original Assignee
Advanced Technologies and Regenerative Medicine LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Technologies and Regenerative Medicine LLC filed Critical Advanced Technologies and Regenerative Medicine LLC
Publication of DE602008004351D1 publication Critical patent/DE602008004351D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE602008004351T 2007-06-29 2008-06-24 Flüssige proteinformulierungen mit gdf-5 zur verwendung bei erhöhten temperaturen Active DE602008004351D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94709207P 2007-06-29 2007-06-29
PCT/US2008/068007 WO2009006097A1 (en) 2007-06-29 2008-06-24 Liquid protein formulations comprising gdf-5 for use at elevated temperatures

Publications (1)

Publication Number Publication Date
DE602008004351D1 true DE602008004351D1 (de) 2011-02-17

Family

ID=39760356

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008004351T Active DE602008004351D1 (de) 2007-06-29 2008-06-24 Flüssige proteinformulierungen mit gdf-5 zur verwendung bei erhöhten temperaturen

Country Status (7)

Country Link
EP (1) EP2170368B1 (de)
JP (1) JP5362715B2 (de)
CN (1) CN101801404A (de)
AT (1) ATE494001T1 (de)
CA (1) CA2692231A1 (de)
DE (1) DE602008004351D1 (de)
WO (1) WO2009006097A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
EP2276458A1 (de) * 2008-04-14 2011-01-26 Advanced Technologies and Regenerative Medicine, LLC Flüssige gepufferte gdf-5-formulierungen
JP5960120B2 (ja) 2010-03-31 2016-08-02 スタビリテック リミテッド ウイルス粒子の安定化
AU2011234264B2 (en) 2010-03-31 2016-02-04 Stabilitech Ltd Excipients for stabilising viral particles, polypeptides or biological material
EP2598177B1 (de) * 2010-07-30 2015-06-17 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Wirkstofffreisetzungsvorrichtungen und wachstumsfaktorformulierungen für beschleunigte wundheilung
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
US20150150983A1 (en) * 2013-12-02 2015-06-04 Depuy Mitek, Llc Intra-articular Formulations and Methods for Treatment of Osteoarthritis
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
CN106636051A (zh) * 2016-04-11 2017-05-10 南京工业大学 一种提高海藻糖合成酶热稳定的方法
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
WO2019059302A1 (ja) * 2017-09-22 2019-03-28 旭化成ファーマ株式会社 安定性に優れるテリパラチド含有液状医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0978285B1 (de) * 1998-08-07 2005-11-23 F. Hoffmann-La Roche Ag Stabilisierte pharmazeutische Zusammensetzungen von Hedgehog-Proteinen und deren Verwendung
US20060286171A1 (en) * 2005-06-17 2006-12-21 Tianhong Zhou Bone morphogenetic protein formulations
AU2006295340B2 (en) * 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
AU2007234612B2 (en) * 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations

Also Published As

Publication number Publication date
CA2692231A1 (en) 2009-01-08
ATE494001T1 (de) 2011-01-15
JP5362715B2 (ja) 2013-12-11
WO2009006097A1 (en) 2009-01-08
CN101801404A (zh) 2010-08-11
EP2170368A1 (de) 2010-04-07
EP2170368B1 (de) 2011-01-05
JP2010532368A (ja) 2010-10-07

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