JP2013523652A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013523652A5 JP2013523652A5 JP2013501501A JP2013501501A JP2013523652A5 JP 2013523652 A5 JP2013523652 A5 JP 2013523652A5 JP 2013501501 A JP2013501501 A JP 2013501501A JP 2013501501 A JP2013501501 A JP 2013501501A JP 2013523652 A5 JP2013523652 A5 JP 2013523652A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- alkyl
- group
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000005842 heteroatom Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 150000002431 hydrogen Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31722310P | 2010-03-24 | 2010-03-24 | |
| US61/317,223 | 2010-03-24 | ||
| PCT/US2011/029879 WO2011119894A2 (en) | 2010-03-24 | 2011-03-24 | Heterocyclic compounds useful for kinase inhibition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016236174A Division JP6391126B2 (ja) | 2010-03-24 | 2016-12-05 | キナーゼ阻害に役立つ複素環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523652A JP2013523652A (ja) | 2013-06-17 |
| JP2013523652A5 true JP2013523652A5 (OSRAM) | 2014-05-15 |
| JP6065183B2 JP6065183B2 (ja) | 2017-01-25 |
Family
ID=44673873
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501501A Expired - Fee Related JP6065183B2 (ja) | 2010-03-24 | 2011-03-24 | キナーゼ阻害に役立つ複素環式化合物 |
| JP2016236174A Expired - Fee Related JP6391126B2 (ja) | 2010-03-24 | 2016-12-05 | キナーゼ阻害に役立つ複素環式化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016236174A Expired - Fee Related JP6391126B2 (ja) | 2010-03-24 | 2016-12-05 | キナーゼ阻害に役立つ複素環式化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8957216B2 (OSRAM) |
| EP (1) | EP2550266B1 (OSRAM) |
| JP (2) | JP6065183B2 (OSRAM) |
| KR (2) | KR101844088B1 (OSRAM) |
| CN (1) | CN102884060B (OSRAM) |
| AU (2) | AU2011232372B2 (OSRAM) |
| CA (1) | CA2794086A1 (OSRAM) |
| ES (1) | ES2677356T3 (OSRAM) |
| IL (1) | IL222068B (OSRAM) |
| MX (2) | MX345552B (OSRAM) |
| RU (2) | RU2640862C2 (OSRAM) |
| WO (1) | WO2011119894A2 (OSRAM) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2534145A4 (en) * | 2010-02-08 | 2013-09-11 | Kinagen Inc | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING THE INHIBITION OF ALLOSTERIC KINASE |
| EP2550266B1 (en) | 2010-03-24 | 2018-05-09 | Amitech Therapeutics Solutions, Inc. | Heterocyclic compounds useful for kinase inhibition |
| BR112012033715A2 (pt) | 2010-07-02 | 2016-11-22 | Gilead Sciences Inc | inibidores de quinase de regulação de sinal de apoptose. |
| US9045485B2 (en) | 2010-12-16 | 2015-06-02 | Convergence Pharmaceuticals Limited | ASK 1 inhibiting pyrrolopyrimidine derivatives |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| PE20190736A1 (es) | 2012-06-13 | 2019-05-23 | Incyte Holdings Corp | Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr) |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| KR102269032B1 (ko) | 2013-04-19 | 2021-06-24 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| KR20160142402A (ko) | 2014-04-25 | 2016-12-12 | 화이자 인코포레이티드 | 도파민 d1 리간드로서 헤테로방향족 화합물 및 이의 용도 |
| WO2015162518A1 (en) * | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| MX2017003933A (es) | 2014-09-24 | 2017-06-30 | Gilead Sciences Inc | Metodos de tratamiento de la enfermedad hepatica. |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| PT3237404T (pt) | 2014-12-23 | 2021-01-19 | Gilead Sciences Inc | Processos de preparação de inibidores ask1 |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| ES2895769T3 (es) | 2015-02-20 | 2022-02-22 | Incyte Corp | Heterociclos bicíclicos como inhibidores de FGFR |
| US10654808B2 (en) * | 2015-04-07 | 2020-05-19 | Guangdong Raynovent Biotech Co., Ltd. | Tyrosine kinase inhibitor and pharmaceutical composition comprising same |
| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US11471538B2 (en) | 2017-02-10 | 2022-10-18 | INSERM (Institut National de la Santéet de la Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP3732285A1 (en) | 2017-12-28 | 2020-11-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| CN108191781B (zh) * | 2018-01-08 | 2020-01-21 | 浙江大学 | 取代三氮唑类衍生物及其在制备抗肿瘤转移药物中的应用 |
| GB201801226D0 (en) * | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
| SG11202010882XA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Salts of an fgfr inhibitor |
| SI3788047T1 (sl) | 2018-05-04 | 2024-11-29 | Incyte Corporation | Trdne oblike inhibitorja fgfr in postopki priprave le-teh |
| CN108864060A (zh) * | 2018-06-03 | 2018-11-23 | 刘思良 | 一种重氮类衍生物及其在癌症治疗中的应用 |
| CN108610336A (zh) * | 2018-06-03 | 2018-10-02 | 刘思良 | 一种重氮类衍生物及其在癌症治疗中的应用 |
| CN108586439A (zh) * | 2018-06-03 | 2018-09-28 | 刘思良 | 一种Raf激酶抑制剂及其在癌症治疗中的应用 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11607416B2 (en) | 2019-10-14 | 2023-03-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021113462A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| AU2021212770A1 (en) | 2020-01-30 | 2022-08-18 | Shangpharma Innovation Inc. | Strad-binding agents and uses thereof |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2023222849A1 (en) * | 2022-05-19 | 2023-11-23 | Astrazeneca Ab | Amino heteroaromatic compounds useful in the treatment of liver diseases |
| CN119173506A (zh) | 2022-05-19 | 2024-12-20 | 阿斯利康(瑞典)有限公司 | 用于治疗肝病的酰胺杂芳香族化合物 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3993073A (en) | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US4069307A (en) | 1970-10-01 | 1978-01-17 | Alza Corporation | Drug-delivery device comprising certain polymeric materials for controlled release of drug |
| US3731683A (en) | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
| US3996934A (en) | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3742951A (en) | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| US3921636A (en) | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
| US3993072A (en) | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device |
| US3972995A (en) | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
| US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4031894A (en) | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| US4031893A (en) | 1976-05-14 | 1977-06-28 | Survival Technology, Inc. | Hypodermic injection device having means for varying the medicament capacity thereof |
| US4060084A (en) | 1976-09-07 | 1977-11-29 | Alza Corporation | Method and therapeutic system for providing chemotherapy transdermally |
| US4201211A (en) | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| JPS5562012A (en) | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
| US4230105A (en) | 1978-11-13 | 1980-10-28 | Merck & Co., Inc. | Transdermal delivery of drugs |
| US4291015A (en) | 1979-08-14 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing a vasodilator |
| US5116817A (en) | 1982-12-10 | 1992-05-26 | Syntex (U.S.A.) Inc. | LHRH preparations for intranasal administration |
| US4476116A (en) | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| US5633009A (en) | 1990-11-28 | 1997-05-27 | Sano Corporation | Transdermal administration of azapirones |
| US5540664A (en) | 1993-05-27 | 1996-07-30 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
| WO1995031235A1 (en) | 1994-05-16 | 1995-11-23 | Washington Biotech Corporation | Modular automatic or manual emergency medicine injection system |
| US5358489A (en) | 1993-05-27 | 1994-10-25 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
| US5962685A (en) | 1994-08-02 | 1999-10-05 | Nippon Soda Co., Ltd. | Oxazole derivatives, process for producing the same, and herbicide |
| US5665378A (en) | 1994-09-30 | 1997-09-09 | Davis; Roosevelt | Transdermal therapeutic formulation |
| US6929801B2 (en) | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
| US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
| US5869090A (en) | 1998-01-20 | 1999-02-09 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| US6946144B1 (en) | 1998-07-08 | 2005-09-20 | Oryxe | Transdermal delivery system |
| US7544189B2 (en) | 2000-10-10 | 2009-06-09 | Meridian Medical Technologies, Inc. | Needle and hub assembly for automatic injector |
| WO2003032916A2 (en) * | 2001-10-16 | 2003-04-24 | Structural Bioinformatics Inc. | Organosulfur inhibitors of tyrosine phosphatases |
| US7189712B2 (en) * | 2002-10-10 | 2007-03-13 | Smithkline Beecham Corporation | 1,3-Oxazole compounds for the treatment of cancer |
| AR042052A1 (es) * | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| WO2005004818A2 (en) | 2003-07-09 | 2005-01-20 | Imclone Systems Incorporated | Heterocyclic compounds and their use as anticancer agents |
| CA2577782A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as pai-1 inhibitors |
| KR20070055563A (ko) * | 2004-08-23 | 2007-05-30 | 와이어쓰 | 혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(ｐａｉ-1)의 조절제로서의옥사졸로-나프틸 산 |
| CN101044125A (zh) * | 2004-08-25 | 2007-09-26 | 塔尔基公司 | 杂环化合物和应用方法 |
| JP5275628B2 (ja) * | 2004-08-25 | 2013-08-28 | ターゲジェン インコーポレーティッド | 複素環式化合物および使用方法 |
| MX2007009313A (es) * | 2005-02-01 | 2007-09-12 | Wyeth Corp | Amino-piridinas como inhibidores de ????-secretasa. |
| JP5201817B2 (ja) * | 2005-10-28 | 2013-06-05 | 大塚製薬株式会社 | 医薬組成物 |
| US7868177B2 (en) * | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
| US7932390B2 (en) * | 2006-06-29 | 2011-04-26 | Hoffman-La Roche Inc. | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives |
| WO2008093677A1 (ja) | 2007-01-29 | 2008-08-07 | Santen Pharmaceutical Co., Ltd. | 血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体 |
| JP5540227B2 (ja) | 2009-02-04 | 2014-07-02 | 株式会社大塚製薬工場 | フェニルイミダゾール化合物 |
| EP2534145A4 (en) * | 2010-02-08 | 2013-09-11 | Kinagen Inc | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING THE INHIBITION OF ALLOSTERIC KINASE |
| EP2550266B1 (en) | 2010-03-24 | 2018-05-09 | Amitech Therapeutics Solutions, Inc. | Heterocyclic compounds useful for kinase inhibition |
-
2011
- 2011-03-24 EP EP11760266.4A patent/EP2550266B1/en not_active Not-in-force
- 2011-03-24 RU RU2012144751A patent/RU2640862C2/ru active
- 2011-03-24 JP JP2013501501A patent/JP6065183B2/ja not_active Expired - Fee Related
- 2011-03-24 MX MX2016006136A patent/MX345552B/es unknown
- 2011-03-24 ES ES11760266.4T patent/ES2677356T3/es active Active
- 2011-03-24 KR KR1020127027421A patent/KR101844088B1/ko not_active Expired - Fee Related
- 2011-03-24 MX MX2012010980A patent/MX339192B/es active IP Right Grant
- 2011-03-24 CN CN201180023503.5A patent/CN102884060B/zh not_active Expired - Fee Related
- 2011-03-24 AU AU2011232372A patent/AU2011232372B2/en not_active Ceased
- 2011-03-24 WO PCT/US2011/029879 patent/WO2011119894A2/en not_active Ceased
- 2011-03-24 RU RU2018100142A patent/RU2018100142A/ru unknown
- 2011-03-24 US US13/636,298 patent/US8957216B2/en active Active
- 2011-03-24 KR KR1020187008081A patent/KR20180032686A/ko not_active Ceased
- 2011-03-24 CA CA2794086A patent/CA2794086A1/en not_active Abandoned
-
2012
- 2012-09-23 IL IL222068A patent/IL222068B/en not_active IP Right Cessation
-
2015
- 2015-02-12 US US14/620,527 patent/US9212151B2/en not_active Expired - Fee Related
- 2015-12-10 US US14/965,334 patent/US10214513B2/en active Active
-
2016
- 2016-09-23 AU AU2016231623A patent/AU2016231623B2/en not_active Ceased
- 2016-12-05 JP JP2016236174A patent/JP6391126B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013523652A5 (OSRAM) | ||
| RU2012144751A (ru) | Гетероциклические соединения, эффективные для ингибирования киназы | |
| RU2477723C2 (ru) | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе | |
| JP2017537940A5 (OSRAM) | ||
| JP2016503797A5 (OSRAM) | ||
| RU2016119519A (ru) | Соединения гетероарила в качестве ингибиторов btk и их применение | |
| JP2017528498A5 (OSRAM) | ||
| JP2014511892A5 (OSRAM) | ||
| HRP20171957T1 (hr) | Derivati 2-(2,4,5-supstituiranog-anilino) pirimidina kao modulatori egfr koji su korisni za liječenje raka | |
| JP2016530283A5 (OSRAM) | ||
| JP2018511631A5 (OSRAM) | ||
| CY1118102T1 (el) | Αλατα διαμινιου φαινοθειαζινης και η χρηση αυτων | |
| JP2018522866A5 (OSRAM) | ||
| CY1117719T1 (el) | Παραγωγα αμινοπυριμιδινης ως διαμορφωτες της lrrk2 | |
| JP2014508804A5 (OSRAM) | ||
| JP2012522729A5 (OSRAM) | ||
| JP2016506387A5 (OSRAM) | ||
| JP2017507122A5 (OSRAM) | ||
| RU2017111200A (ru) | Циклогексилэтилзамещенные диаза- и триаза-трициклические соединения в качестве антагонистов индоламин-2,3-диоксигеназы для лечения рака | |
| RU2008102968A (ru) | Производные изохинолина в качестве ингибиторов rho-киназы | |
| JP2014511891A5 (OSRAM) | ||
| RU2012116526A (ru) | Способы получения производных пиримидина, применимых в качестве ингибиторов протеинкиназы | |
| RU2012138579A (ru) | Производные пиримидина и их применение в лечении респираторных заболеваний, таких как copd | |
| JP2014512364A5 (OSRAM) | ||
| JP2014500265A5 (OSRAM) |