JP2013522326A - がん幹細胞を標的とするための新規の方法 - Google Patents

がん幹細胞を標的とするための新規の方法 Download PDF

Info

Publication number
JP2013522326A
JP2013522326A JP2013500247A JP2013500247A JP2013522326A JP 2013522326 A JP2013522326 A JP 2013522326A JP 2013500247 A JP2013500247 A JP 2013500247A JP 2013500247 A JP2013500247 A JP 2013500247A JP 2013522326 A JP2013522326 A JP 2013522326A
Authority
JP
Japan
Prior art keywords
compound
polymorph
cancer
peak
furan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013500247A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013522326A5 (OSRAM
Inventor
ジャン ジャ リ,
デイビッド レゲット,
ヤウジー リ,
ウェイ リ,
Original Assignee
ボストン バイオメディカル, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ボストン バイオメディカル, インコーポレイテッド filed Critical ボストン バイオメディカル, インコーポレイテッド
Publication of JP2013522326A publication Critical patent/JP2013522326A/ja
Publication of JP2013522326A5 publication Critical patent/JP2013522326A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2013500247A 2010-03-19 2011-03-21 がん幹細胞を標的とするための新規の方法 Pending JP2013522326A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31588610P 2010-03-19 2010-03-19
US31589010P 2010-03-19 2010-03-19
US61/315,890 2010-03-19
US61/315,886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029283 WO2011116399A1 (en) 2010-03-19 2011-03-21 Novel methods for targeting cancer stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015179115A Division JP6246169B2 (ja) 2010-03-19 2015-09-11 がん幹細胞を標的とするための新規の方法

Publications (2)

Publication Number Publication Date
JP2013522326A true JP2013522326A (ja) 2013-06-13
JP2013522326A5 JP2013522326A5 (OSRAM) 2014-04-17

Family

ID=47678420

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013500247A Pending JP2013522326A (ja) 2010-03-19 2011-03-21 がん幹細胞を標的とするための新規の方法

Country Status (18)

Country Link
US (2) US9730909B2 (OSRAM)
EP (1) EP2547205B1 (OSRAM)
JP (1) JP2013522326A (OSRAM)
CN (1) CN103025159A (OSRAM)
AU (1) AU2011227023B2 (OSRAM)
BR (1) BR112012023660B8 (OSRAM)
CA (2) CA2946890A1 (OSRAM)
DK (1) DK2547205T3 (OSRAM)
ES (1) ES2987670T3 (OSRAM)
FI (1) FI2547205T3 (OSRAM)
HR (1) HRP20240658T1 (OSRAM)
LT (1) LT2547205T (OSRAM)
PL (1) PL2547205T3 (OSRAM)
RS (1) RS65536B1 (OSRAM)
RU (1) RU2591823C2 (OSRAM)
SI (1) SI2547205T1 (OSRAM)
SM (1) SMT202400193T1 (OSRAM)
WO (1) WO2011116399A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014098049A (ja) * 2010-03-19 2014-05-29 Boston Biomedical Inc がん幹細胞を標的とするための新規の化合物および組成物
WO2015190489A1 (ja) * 2014-06-09 2015-12-17 京都薬品工業株式会社 新規抗癌剤

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE027443T2 (en) 2007-09-10 2016-10-28 Boston Biomedical Inc A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors
JP6433085B2 (ja) * 2013-04-09 2018-12-05 ボストン バイオメディカル, インコーポレイテッド がんの処置に使用するための2−アセチルナフト[2,3−b]フラン−4,9−ジオン
WO2015120304A1 (en) 2014-02-07 2015-08-13 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-b]furane derivative or pharmaceutically acceptable salt thereof
HK1250942A1 (zh) 2015-04-17 2019-01-18 Boston Biomedical, Inc. 用於治疗癌症的方法
SG11201708504XA (en) 2015-04-17 2017-11-29 Boston Biomedical Inc Methods for treating cancer
EA201792623A1 (ru) 2015-06-03 2018-04-30 Бостон Биомедикал, Инк. Композиции, содержащие ингибитор стволовости рака и иммунотерапевтический агент, для применения в лечении рака
WO2016205334A1 (en) 2015-06-16 2016-12-22 Vascular Strategies Llc Drug delivery and imaging chemical conjugate, formulations and methods of use thereof
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
JP2019506392A (ja) 2016-01-20 2019-03-07 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
WO2018005444A2 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
WO2018213424A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer
EP3762391A4 (en) * 2018-03-08 2022-08-03 ExxonMobil Technology and Engineering Company SPIROCENTRIC COMPOUNDS AND POLYMERS THEREOF
EP3865130A4 (en) 2018-10-12 2022-07-20 1Globe Biomedical Co., Ltd. NEW COMBINATION SOLUTION FOR THE TREATMENT OF CHEMOTHERAPY-REFRACTORY CANCER
CN111825644B (zh) * 2019-04-18 2023-07-28 中国医学科学院药物研究所 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途
CN117350965A (zh) * 2023-10-07 2024-01-05 中国原子能科学研究院 对象内放射性微球的指标预估装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402192A1 (fr) 1989-05-31 1990-12-12 BODET, Jean Augustin Article en carton ou matière analogue et procédé de fabrication
JPH04139177A (ja) 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc フラルベンゾキノン誘導体及びその製造方法並びに制癌剤
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
US6174913B1 (en) 1998-06-05 2001-01-16 The University Of North Carolina At Chapel Hill Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
EP1146869A2 (en) 1999-01-27 2001-10-24 University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
CA2386793C (en) 1999-08-02 2006-03-28 F. Hoffmann-La Roche Ag New selective retinoid agonists
JP2001097860A (ja) 1999-09-29 2001-04-10 Japan Science & Technology Corp 抗薬剤耐性菌剤と抗クラミジア剤
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
US7998947B2 (en) 2001-03-28 2011-08-16 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
WO2003045357A1 (en) 2001-11-27 2003-06-05 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
US20030139466A1 (en) * 2001-11-29 2003-07-24 Peritt David L. Methods for pretreating a subject with extracorporeal photopheresis
JP2005526084A (ja) 2002-03-15 2005-09-02 ナットイムネ・アクティーゼルスカブ マンノース結合レクチンを含む医薬組成物
US20060142271A1 (en) 2002-09-17 2006-06-29 Klaus Muller Novel lapacho compounds and methods of use thereof
AR042052A1 (es) * 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
IS6633A (is) 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
KR20060031809A (ko) 2003-06-09 2006-04-13 더 리젠츠 오브 더 유니버시티 오브 미시간 암 치료 및 진단용 조성물 및 방법
US20050049207A1 (en) 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
WO2005033048A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists
PT1701941E (pt) 2003-12-11 2012-08-03 Univ Texas Compostos para o tratamento de doenças proliferativas celulares
CA2563305A1 (en) 2004-04-09 2005-11-24 University Of South Florida Combination therapies for cancer and proliferative angiopathies
JP2004224802A (ja) 2004-04-21 2004-08-12 Japan Science & Technology Agency 抗菌剤
KR20070085433A (ko) 2004-11-24 2007-08-27 노파르티스 아게 Jak 저해제들과 bcr-abl, flt-3, fak 또는raf 키나제 저해제들 중 하나 이상의 조합물
CN101511179A (zh) 2005-02-25 2009-08-19 密执安州立大学董事会 Stat3的小分子抑制剂及其用途
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
JP2006290871A (ja) 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
CN101142202A (zh) * 2005-03-16 2008-03-12 太日保日本株式会社 抗癌化合物及其中间体和生产方法
US20060252073A1 (en) 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
US20070243192A1 (en) 2006-02-21 2007-10-18 Regents Of The University Of Michigan Growth hormone receptor antagonist cancer treatment
BRPI0709916B8 (pt) 2006-03-31 2021-05-25 Univ Texas drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas
US20070238770A1 (en) 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
US8828451B2 (en) 2006-10-04 2014-09-09 University Of South Florida Akt sensitization of cancer cells
JP4077863B1 (ja) 2007-05-31 2008-04-23 タヒボジャパン株式会社 抗癌活性を有する光学活性2−(1−ヒドロキシエチル)−5−ヒドロキシナフト[2,3−b]フラン−4,9−ジオンの製法
WO2009060282A2 (en) 2007-11-06 2009-05-14 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
SG10201704745UA (en) * 2010-03-19 2017-07-28 Boston Biomedical Inc Novel compounds and compositions for targeting cancer stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
JP2010539098A (ja) * 2007-09-10 2010-12-16 ボストン バイオメディカル, インコーポレイテッド 癌治療のための新規の組成物および方法
JP2010539095A (ja) * 2007-09-10 2010-12-16 ボストン バイオメディカル, インコーポレイテッド 新規のStat3経路阻害剤及び癌幹細胞阻害剤

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014098049A (ja) * 2010-03-19 2014-05-29 Boston Biomedical Inc がん幹細胞を標的とするための新規の化合物および組成物
WO2015190489A1 (ja) * 2014-06-09 2015-12-17 京都薬品工業株式会社 新規抗癌剤
JPWO2015190489A1 (ja) * 2014-06-09 2017-05-25 京都薬品工業株式会社 新規抗癌剤
US10005752B2 (en) 2014-06-09 2018-06-26 Kyoto Pharmaceutical Industries, Ltd. Anticancer agent
US10377730B2 (en) 2014-06-09 2019-08-13 Kyoto Pharmaceutical Industries, Ltd. Anticancer agent
JP2019206529A (ja) * 2014-06-09 2019-12-05 京都薬品工業株式会社 新規抗癌剤
US10689355B2 (en) 2014-06-09 2020-06-23 Kyoto Pharmaceuticals Industries, Ltd. Anticancer agent
US11267797B2 (en) 2014-06-09 2022-03-08 Kyoto Pharmaceutical Industries, Ltd. Anticancer agent

Also Published As

Publication number Publication date
SMT202400193T1 (it) 2024-07-09
US20130028944A1 (en) 2013-01-31
EP2547205A4 (en) 2013-08-14
SI2547205T1 (sl) 2024-08-30
HRP20240658T1 (hr) 2024-08-16
BR112012023660B8 (pt) 2021-05-25
CN103025159A (zh) 2013-04-03
CA2793527A1 (en) 2011-09-22
US9730909B2 (en) 2017-08-15
BR112012023660A2 (pt) 2015-09-15
ES2987670T3 (es) 2024-11-15
EP2547205B1 (en) 2024-03-20
RS65536B1 (sr) 2024-06-28
CA2946890A1 (en) 2011-09-22
FI2547205T3 (fi) 2024-05-27
US20170319537A1 (en) 2017-11-09
BR112012023660B1 (pt) 2021-05-18
AU2011227023B2 (en) 2015-05-28
EP2547205A1 (en) 2013-01-23
RU2012144420A (ru) 2014-04-27
LT2547205T (lt) 2024-06-10
AU2011227023A1 (en) 2012-09-27
WO2011116399A1 (en) 2011-09-22
RU2591823C2 (ru) 2016-07-20
DK2547205T3 (da) 2024-05-27
PL2547205T3 (pl) 2024-07-08

Similar Documents

Publication Publication Date Title
JP5602935B2 (ja) がん幹細胞を標的とするための新規の化合物および組成物
JP6246169B2 (ja) がん幹細胞を標的とするための新規の方法
JP2013522326A (ja) がん幹細胞を標的とするための新規の方法
JP6433085B2 (ja) がんの処置に使用するための2−アセチルナフト[2,3−b]フラン−4,9−ジオン
AU2015218436B2 (en) Novel Methods For Targeting Cancer Stem Cells
HK1239527A1 (en) Novel compounds and compositions for targeting cancer stem cells
HK1229744A1 (en) 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140303

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140319

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150312

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150522

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20151109