JP2013522311A5 - - Google Patents
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- Publication number
- JP2013522311A5 JP2013522311A5 JP2013500162A JP2013500162A JP2013522311A5 JP 2013522311 A5 JP2013522311 A5 JP 2013522311A5 JP 2013500162 A JP2013500162 A JP 2013500162A JP 2013500162 A JP2013500162 A JP 2013500162A JP 2013522311 A5 JP2013522311 A5 JP 2013522311A5
- Authority
- JP
- Japan
- Prior art keywords
- phe
- lys
- arg
- aromatic
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31394510P | 2010-03-15 | 2010-03-15 | |
| US61/313,945 | 2010-03-15 | ||
| US37681310P | 2010-08-25 | 2010-08-25 | |
| US61/376,813 | 2010-08-25 | ||
| PCT/US2011/028543 WO2011116007A1 (en) | 2010-03-15 | 2011-03-15 | Combination therapies using cyclosporine and aromatic cationic peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013522311A JP2013522311A (ja) | 2013-06-13 |
| JP2013522311A5 true JP2013522311A5 (OSRAM) | 2014-05-01 |
Family
ID=44649559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500162A Pending JP2013522311A (ja) | 2010-03-15 | 2011-03-15 | シクロスポリンおよび芳香族カチオン性ペプチドを用いた併用療法 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US8697657B2 (OSRAM) |
| EP (6) | EP3375449A1 (OSRAM) |
| JP (1) | JP2013522311A (OSRAM) |
| WO (1) | WO2011116007A1 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013516426A (ja) * | 2009-12-31 | 2013-05-13 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 冠状動脈バイパス移植術を行うための方法 |
| JP2013516425A (ja) * | 2009-12-31 | 2013-05-13 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 血管閉塞傷害の予防または治療方法 |
| EP3375449A1 (en) * | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| CN106620645A (zh) * | 2010-07-09 | 2017-05-10 | 康德生物医疗技术公司 | 预防或治疗缺血/再灌注损伤之后无复流的方法 |
| WO2013049697A1 (en) | 2011-09-29 | 2013-04-04 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
| EP3466439A1 (en) | 2011-12-09 | 2019-04-10 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| WO2013149172A1 (en) * | 2012-03-30 | 2013-10-03 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment neuropathy |
| JP2014196281A (ja) * | 2012-08-01 | 2014-10-16 | 健輔 江頭 | 医薬組成物 |
| EP3485897A1 (en) | 2012-08-02 | 2019-05-22 | Stealth Peptides International, Inc. | D-arg-2'6'-dmt-lys-phe-nh2 for decreasing statin side effects |
| MX2015005102A (es) * | 2012-10-22 | 2016-02-09 | Stealth Peptides Int Inc | Metodos para la reduccion de los riesgos asociados con el insuficiencia cardiaca y factores asociado con el mismo. |
| US20130303436A1 (en) * | 2012-12-06 | 2013-11-14 | Stealth Peptides Internatioanl, Inc. | Peptide therapeutics and methods for using same |
| HUE046924T2 (hu) | 2013-03-01 | 2020-03-30 | Stealth Biotherapeutics Corp | Módszerek és készítmények Barth szindróma megelõzésében vagy kezelésében történõ alkalmazásra |
| CA2916884C (en) | 2013-03-01 | 2021-02-09 | Stealth Biotherapeutics Corp | Methods for the treatment of mitochondrial disease |
| WO2014165607A2 (en) * | 2013-04-02 | 2014-10-09 | Stealth Peptides International, Inc. | Aromatic-cationic peptide formulations, compositions and methods of use |
| EP2996707B1 (en) * | 2013-05-14 | 2019-09-11 | Stealth Biotherapeutics Corp | Methods for the prevention or treatment of left ventricle remodeling |
| US20140363391A1 (en) * | 2013-06-06 | 2014-12-11 | Demetris Yannopoulos | System and method for administering poloxamers and anesthetics while performing cpr and minimizing reperfusion injury |
| US10047395B2 (en) | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| CA2916497C (en) | 2013-06-26 | 2022-07-12 | Stealth Biotherapeutics Corp | Methods for the regulation of matrix metalloproteinase expression |
| CA2916492A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Biotherapeutics Corp | Peptide therapeutics and methods for using same |
| WO2015023680A1 (en) * | 2013-08-12 | 2015-02-19 | Stealth Peptides International, Inc. | Combination therapy for the treatment of ischemia-reperfusion injury |
| WO2015100376A1 (en) * | 2013-12-27 | 2015-07-02 | Stealth Peptides International, Inc. | Pharmaceutically relevant aromatic-cationic peptides |
| JP2017512762A (ja) * | 2014-03-03 | 2017-05-25 | ステルス バイオセラピューティックス コープ | 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法 |
| WO2015183988A1 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including therapeutic small molecules and uses thereof |
| WO2015183995A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
| WO2015183984A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including tocopherol and uses thereof |
| ES2870481T3 (es) | 2014-08-21 | 2021-10-27 | Stealth Biotherapeutics Corp | Péptido D-Arg-2,6-Dmt-Lys-Phe-NH2 para el tratamiento del síndrome de Alport |
| US10683534B2 (en) * | 2015-01-27 | 2020-06-16 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
| US20180042983A1 (en) * | 2015-02-13 | 2018-02-15 | Stealth Peptides International, Inc. | Therapeutic compositions including mitochondrial fission inhibitor peptides, variants thereof, and methods of using the same |
| CA2978905A1 (en) * | 2015-03-06 | 2016-09-15 | Stealth Biotherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| WO2017093897A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| CA3017359A1 (en) * | 2016-03-11 | 2017-09-14 | Scott M. Duncan | Crystalline salt forms |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| WO2018223032A1 (en) * | 2017-06-02 | 2018-12-06 | Stealth Biotherapeutics Corp. | Crystalline salt forms of sbt-20 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| WO2020131283A1 (en) | 2018-12-18 | 2020-06-25 | Stealth Biotherapeutics Corp. | Analogs that target mitochondrial diseases |
| CN113544138B (zh) * | 2018-12-18 | 2024-10-29 | 隐形生物治疗公司 | 线粒体靶向肽 |
| CN111449050A (zh) * | 2019-01-20 | 2020-07-28 | 睿诺医疗科技(上海)有限公司 | 环孢菌素类似物及其用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5786332A (en) * | 1995-03-06 | 1998-07-28 | Trega Biosciences, Inc. | Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels |
| SE520730C2 (sv) * | 1995-01-20 | 2003-08-19 | Eskil Elmer | Behandling av hjärnischemi och hjärnskador med ett neuroprotektivt läkemedel |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| WO2000051625A1 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| SE9900961D0 (sv) * | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
| JP2003507438A (ja) * | 1999-08-24 | 2003-02-25 | セルゲイト, インコーポレイテッド | オリゴアルギニン部分を使用する上皮組織を横切るおよび上皮組織内への薬物送達の増強 |
| PT1599216E (pt) | 2003-02-04 | 2013-12-17 | Cornell Res Foundation Inc | Métodos de prevenção da transição de permeabilidade mitocondrial |
| NZ549393A (en) | 2004-01-23 | 2009-07-31 | Cornell Res Foundation Inc | Methods for reducing oxidative damage |
| JP2007532507A (ja) * | 2004-04-08 | 2007-11-15 | ノバルティス アクチエンゲゼルシャフト | 脳虚血ならびに脳および脊髄傷害の処置のためのサイクロスポリンの使用 |
| EP2023948A1 (en) * | 2006-05-04 | 2009-02-18 | Michel Ovize | Use of cyclosporin a or melle4-cyclosporin for the treatment of acute myocardial infarction |
| WO2008094275A1 (en) * | 2007-01-30 | 2008-08-07 | New York University | Peptides for treatment of conditions associated with nitric oxide |
| WO2009108695A2 (en) * | 2008-02-26 | 2009-09-03 | Cornell University | Methods for prevention and treatment of acute renal injury |
| US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| JP5780969B2 (ja) * | 2008-12-31 | 2015-09-16 | サイネクシス,インコーポレーテッド | シクロスポリンaの誘導体 |
| EP4302829B1 (en) * | 2009-08-24 | 2025-05-21 | Stealth BioTherapeutics Inc. | Peptide for use in preventing or treating macular degeneration |
| JP2013516426A (ja) | 2009-12-31 | 2013-05-13 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 冠状動脈バイパス移植術を行うための方法 |
| JP2013516425A (ja) * | 2009-12-31 | 2013-05-13 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 血管閉塞傷害の予防または治療方法 |
| EP2528934A4 (en) | 2010-01-25 | 2013-08-21 | Univ Cornell | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
| US20130040901A1 (en) * | 2010-02-26 | 2013-02-14 | University Of Florida Research Foundation Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3375449A1 (en) * | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
-
2011
- 2011-03-15 EP EP18158672.8A patent/EP3375449A1/en not_active Withdrawn
- 2011-03-15 EP EP11756870.9A patent/EP2547352A4/en not_active Withdrawn
- 2011-03-15 EP EP19162382.6A patent/EP3560508A1/en not_active Withdrawn
- 2011-03-15 EP EP14163505.2A patent/EP2808029A3/en not_active Withdrawn
- 2011-03-15 WO PCT/US2011/028543 patent/WO2011116007A1/en not_active Ceased
- 2011-03-15 JP JP2013500162A patent/JP2013522311A/ja active Pending
- 2011-03-15 US US13/634,192 patent/US8697657B2/en active Active
- 2011-03-15 EP EP17150292.5A patent/EP3210615A1/en not_active Withdrawn
- 2011-03-15 EP EP15187915.2A patent/EP3040080A1/en not_active Withdrawn
-
2014
- 2014-02-20 US US14/185,471 patent/US9561258B2/en active Active
-
2017
- 2017-01-03 US US15/397,030 patent/US10702577B2/en active Active
-
2020
- 2020-01-14 US US16/742,806 patent/US20200376074A1/en not_active Abandoned
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