JP2013519379A5 - - Google Patents
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- Publication number
- JP2013519379A5 JP2013519379A5 JP2012553038A JP2012553038A JP2013519379A5 JP 2013519379 A5 JP2013519379 A5 JP 2013519379A5 JP 2012553038 A JP2012553038 A JP 2012553038A JP 2012553038 A JP2012553038 A JP 2012553038A JP 2013519379 A5 JP2013519379 A5 JP 2013519379A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cell
- seq
- immunoglobulin
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30425110P | 2010-02-12 | 2010-02-12 | |
| US61/304,251 | 2010-02-12 | ||
| US201161437889P | 2011-01-31 | 2011-01-31 | |
| US61/437,889 | 2011-01-31 | ||
| PCT/US2011/024554 WO2011100566A2 (en) | 2010-02-12 | 2011-02-11 | Methods for identifying and isolating cells expressing a polypeptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016139165A Division JP2017014220A (ja) | 2010-02-12 | 2016-07-14 | ポリペプチド発現細胞の同定及び単離の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519379A JP2013519379A (ja) | 2013-05-30 |
| JP2013519379A5 true JP2013519379A5 (https=) | 2014-04-03 |
| JP6034696B2 JP6034696B2 (ja) | 2016-11-30 |
Family
ID=44368462
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553038A Expired - Fee Related JP6034696B2 (ja) | 2010-02-12 | 2011-02-11 | ポリペプチド発現細胞の同定及び単離の方法 |
| JP2016139165A Withdrawn JP2017014220A (ja) | 2010-02-12 | 2016-07-14 | ポリペプチド発現細胞の同定及び単離の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016139165A Withdrawn JP2017014220A (ja) | 2010-02-12 | 2016-07-14 | ポリペプチド発現細胞の同定及び単離の方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US8551715B2 (https=) |
| EP (1) | EP2534257B1 (https=) |
| JP (2) | JP6034696B2 (https=) |
| KR (1) | KR20120117931A (https=) |
| CN (1) | CN102844442B (https=) |
| AU (1) | AU2011215685B2 (https=) |
| CA (1) | CA2789446A1 (https=) |
| IL (1) | IL221349A0 (https=) |
| MX (1) | MX2012009175A (https=) |
| NZ (1) | NZ601743A (https=) |
| SG (2) | SG183196A1 (https=) |
| WO (1) | WO2011100566A2 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2413087T3 (es) | 2006-06-13 | 2013-07-15 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para el diagnóstico y tratamiento del cáncer |
| DK2066694T3 (en) | 2006-09-29 | 2016-02-08 | Oncomed Pharm Inc | Compositions and Methods for Diagnosing and Treating Cancer |
| WO2008091641A2 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| WO2008097926A2 (en) * | 2007-02-02 | 2008-08-14 | Yale University | Transient transfection with rna |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| US10155038B2 (en) | 2007-02-02 | 2018-12-18 | Yale University | Cells prepared by transient transfection and methods of use thereof |
| CN102112490B (zh) | 2008-07-08 | 2014-10-22 | 昂考梅德药品有限公司 | Notch1受体结合剂和其使用方法 |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| HUE029661T2 (en) | 2009-10-16 | 2017-03-28 | Oncomed Pharm Inc | A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents |
| CA2789446A1 (en) | 2010-02-12 | 2011-08-18 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| US10106598B2 (en) | 2010-12-01 | 2018-10-23 | Merck Sharp & Dohme Corp. | Surface, anchored Fc-bait antibody display system |
| US9365846B2 (en) | 2010-12-01 | 2016-06-14 | Merck Sharp & Dohme Corp. | Surface, anchored Fc-bait antibody display system |
| JP6185463B2 (ja) | 2011-07-15 | 2017-08-23 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Rspo結合剤およびその使用法 |
| LT3485903T (lt) | 2011-09-23 | 2023-02-27 | Mereo Biopharma 5, Inc. | Vegf/ dll4 surišantys agentai ir jų panaudojimas |
| EP3202419A1 (en) | 2012-06-06 | 2017-08-09 | OncoMed Pharmaceuticals, Inc. | Pvrig binding agents that modulate the hippo pathway and uses thereof |
| US9181333B2 (en) | 2012-07-13 | 2015-11-10 | Oncomed Pharmaceuticals, Inc. | RSPO3 binding agents and uses thereof |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| EP2906295A4 (en) * | 2012-10-15 | 2016-06-01 | Oncomed Pharm Inc | METHOD FOR THE TREATMENT OF EYE DISEASES |
| US8921055B2 (en) * | 2012-10-30 | 2014-12-30 | Berkeley Lights, Inc. | Detecting cells secreting a protein of interest |
| US9599620B2 (en) | 2012-10-31 | 2017-03-21 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
| EP4282419A1 (en) | 2012-12-20 | 2023-11-29 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| JP6456350B2 (ja) * | 2013-03-11 | 2019-01-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | キメラ主要組織適合複合体(mhc)クラスii分子を発現する遺伝子導入マウス |
| GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
| GB201407852D0 (en) | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
| ES2808153T3 (es) | 2014-10-31 | 2021-02-25 | Mereo Biopharma 5 Inc | Terapia de combinación para tratamiento de enfermedad |
| US20190119353A1 (en) * | 2014-11-06 | 2019-04-25 | Children's Research Institute, Children's National Medical Center | Immunotherapeutics for cancer and autoimmune diseases |
| KR102558502B1 (ko) | 2014-12-05 | 2023-07-20 | 시티 오브 호프 | Cs1 표적화된 키메라 항원 수용체-변형된 t 세포 |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit結合劑和彼之用途 |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| EP3439675A4 (en) | 2016-04-08 | 2019-12-18 | Purdue Research Foundation | METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY |
| TWI767915B (zh) | 2016-06-27 | 2022-06-21 | 加州大學董事會 | Ror-1與btk拮抗劑的組合 |
| MX2019006072A (es) | 2016-11-30 | 2019-08-14 | Oncomed Pharm Inc | Metodos para tratamiento de cancer que comprenden agentes de enlace al inmunoreceptor de celulas t con dominios ige itim (tigit). |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| IL312457A (en) | 2017-03-24 | 2024-06-01 | Lankenau Inst Medical Res | Methods and compositions for inducible extracellular membrane trapping of monoclonal immunoglobulins secreted by hybridomas |
| US11311576B2 (en) | 2018-01-22 | 2022-04-26 | Seattle Children's Hospital | Methods of use for CAR T cells |
| US12312416B2 (en) | 2018-02-06 | 2025-05-27 | Seattle Children's Hospital | Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors |
| AU2019225174B2 (en) | 2018-02-23 | 2025-11-20 | Endocyte, Inc. | Sequencing method for CAR T cell therapy |
| CN112996819B (zh) * | 2018-08-16 | 2025-11-04 | 纪念斯隆-凯特琳癌症中心 | 细胞分选系统及使用方法 |
| EP3836944A4 (en) | 2018-08-16 | 2022-05-11 | Memorial Sloan Kettering Cancer Center | LEUCINE ZIPPER BASED COMPOSITIONS AND METHODS OF USE |
| TW202033218A (zh) * | 2018-12-07 | 2020-09-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 多特異性蛋白分子 |
| CN109738506B (zh) * | 2019-01-10 | 2021-02-26 | 青岛大学附属医院 | 一种成熟脂肪细胞中自噬相关蛋白乙酰化位点研究方法 |
| US20220177912A1 (en) * | 2019-04-12 | 2022-06-09 | The Methodist Hospital | Therapeutic particles that enable antigen presenting cells to attack cancer cells |
| CN115210252A (zh) | 2020-02-04 | 2022-10-18 | 西雅图儿童医院(Dba西雅图儿童研究所) | 抗二硝基苯酚的嵌合抗原受体 |
| EP4392571A1 (en) | 2021-08-25 | 2024-07-03 | Iontas Limited | Preparation of libraries of protein variants expressed in eukaryotic cells |
| EP4526351A2 (en) * | 2022-05-16 | 2025-03-26 | City of Hope | Anti-cd84 antibodies and uses thereof |
| JP2026504390A (ja) * | 2023-02-01 | 2026-02-05 | アレン インスティテュート | インテインを介した電位依存性ナトリウムチャネルの機能の再構築 |
| WO2024251820A1 (en) | 2023-06-06 | 2024-12-12 | Iontas Limited | Preparation of libraries of bispecific binders expressed in eukaryotic cells |
| WO2025151797A1 (en) * | 2024-01-12 | 2025-07-17 | Sonoma Biotherapeutics, Inc. | Chimeric antigen receptors with atypical transmembrane and/or hinge domains |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US7166423B1 (en) | 1992-10-21 | 2007-01-23 | Miltenyi Biotec Gmbh | Direct selection of cells by secretion product |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| US7264963B1 (en) | 1995-08-18 | 2007-09-04 | Morphosys Ag | Protein(poly)peptide libraries |
| EP0937095A4 (en) * | 1996-10-25 | 1999-12-22 | Cell Genesys Inc | TARGETED CYTOLYSIS OF CANCER CELLS |
| AU6537798A (en) * | 1997-03-14 | 1998-10-12 | Denise Casentini-Borocz | Targeted cytolysis of cancer cells |
| US6423316B1 (en) * | 1997-03-26 | 2002-07-23 | Imperial College Innovative Limited | Anticoagulant fusion protein anchored to cell membrane |
| US5837994C1 (en) | 1997-04-02 | 2001-10-16 | Gentex Corp | Control system to automatically dim vehicle head lamps |
| US7176179B1 (en) * | 1997-05-30 | 2007-02-13 | The Regents Of The University Of California | Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| US6180343B1 (en) | 1998-10-08 | 2001-01-30 | Rigel Pharmaceuticals, Inc. | Green fluorescent protein fusions with random peptides |
| US6197294B1 (en) * | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
| DE19900635A1 (de) * | 1999-01-11 | 2000-07-13 | Deutsches Krebsforsch | Selektion von monoklonalen Antikörpern |
| WO2001002588A2 (en) | 1999-07-02 | 2001-01-11 | Morphosys Ag | Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests |
| US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| US7094571B2 (en) | 2000-10-27 | 2006-08-22 | The Board Of Regents Of The University Of Texas System | Combinatorial protein library screening by periplasmic expression |
| AU2001297872B2 (en) | 2000-11-17 | 2006-11-09 | University Of Rochester | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
| US6919183B2 (en) | 2001-01-16 | 2005-07-19 | Regeneron Pharmaceuticals, Inc. | Isolating cells expressing secreted proteins |
| WO2002088334A1 (en) * | 2001-04-30 | 2002-11-07 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| DE60319259T2 (de) | 2002-06-14 | 2009-03-05 | Dyax Corp., Cambridge | Rekombination von nukleinsäurebibliotheksmitgliedern |
| JP4748984B2 (ja) * | 2002-06-16 | 2011-08-17 | ダイアックス、コープ | 核酸ライブラリーメンバーの組換え |
| AU2003304195B8 (en) * | 2002-07-15 | 2008-08-28 | Board Of Regents, The University Of Texas System | Combinatorial protein library screening by periplasmic expression |
| FR2849039B1 (fr) | 2002-12-24 | 2010-10-01 | Centre Nat Rech Scient | Nouvelle proteine associee aux centrosomes et ses applications |
| US20070048740A1 (en) | 2003-02-14 | 2007-03-01 | Research Association For Biotechnology | Full-length cDNA |
| EP1447413A3 (en) * | 2003-02-14 | 2006-01-04 | Research Association for Biotechnology | Full-length human cDNA |
| US7479538B2 (en) * | 2004-11-12 | 2009-01-20 | The Zhabilov Trust | Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing, and treating HIV |
| KR20080073293A (ko) | 2005-10-14 | 2008-08-08 | 메디뮨 엘엘씨 | 항체 라이브러리의 세포 디스플레이 |
| WO2007115230A2 (en) * | 2006-03-30 | 2007-10-11 | University Of Medicine And Dentistry Of New Jersey | A strategy for homo- or hetero-dimerization of various proteins in solutions and in cells |
| JP2010517577A (ja) * | 2007-02-09 | 2010-05-27 | メディミューン,エルエルシー | 酵母細胞原形質膜による抗体ライブラリー提示 |
| US8067339B2 (en) | 2008-07-09 | 2011-11-29 | Merck Sharp & Dohme Corp. | Surface display of whole antibodies in eukaryotes |
| CA2789446A1 (en) | 2010-02-12 | 2011-08-18 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
| US9365846B2 (en) * | 2010-12-01 | 2016-06-14 | Merck Sharp & Dohme Corp. | Surface, anchored Fc-bait antibody display system |
-
2011
- 2011-02-11 CA CA2789446A patent/CA2789446A1/en not_active Abandoned
- 2011-02-11 MX MX2012009175A patent/MX2012009175A/es active IP Right Grant
- 2011-02-11 CN CN201180009377.8A patent/CN102844442B/zh not_active Expired - Fee Related
- 2011-02-11 AU AU2011215685A patent/AU2011215685B2/en not_active Ceased
- 2011-02-11 EP EP11742877.1A patent/EP2534257B1/en active Active
- 2011-02-11 JP JP2012553038A patent/JP6034696B2/ja not_active Expired - Fee Related
- 2011-02-11 SG SG2012058194A patent/SG183196A1/en unknown
- 2011-02-11 SG SG10201503736XA patent/SG10201503736XA/en unknown
- 2011-02-11 NZ NZ601743A patent/NZ601743A/en not_active IP Right Cessation
- 2011-02-11 US US13/025,733 patent/US8551715B2/en not_active Expired - Fee Related
- 2011-02-11 KR KR1020127023732A patent/KR20120117931A/ko not_active Ceased
- 2011-02-11 WO PCT/US2011/024554 patent/WO2011100566A2/en not_active Ceased
-
2012
- 2012-08-08 IL IL221349A patent/IL221349A0/en unknown
-
2013
- 2013-09-06 US US14/020,030 patent/US8945878B2/en not_active Expired - Fee Related
- 2013-09-06 US US14/020,012 patent/US9023621B2/en not_active Expired - Fee Related
-
2015
- 2015-04-03 US US14/678,592 patent/US9422546B2/en not_active Expired - Fee Related
-
2016
- 2016-07-14 JP JP2016139165A patent/JP2017014220A/ja not_active Withdrawn
- 2016-07-14 US US15/210,250 patent/US9873726B2/en not_active Expired - Fee Related
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