JP2013519379A5 - - Google Patents

Download PDF

Info

Publication number
JP2013519379A5
JP2013519379A5 JP2012553038A JP2012553038A JP2013519379A5 JP 2013519379 A5 JP2013519379 A5 JP 2013519379A5 JP 2012553038 A JP2012553038 A JP 2012553038A JP 2012553038 A JP2012553038 A JP 2012553038A JP 2013519379 A5 JP2013519379 A5 JP 2013519379A5
Authority
JP
Japan
Prior art keywords
polypeptide
cell
seq
immunoglobulin
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012553038A
Other languages
English (en)
Japanese (ja)
Other versions
JP6034696B2 (ja
JP2013519379A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/024554 external-priority patent/WO2011100566A2/en
Publication of JP2013519379A publication Critical patent/JP2013519379A/ja
Publication of JP2013519379A5 publication Critical patent/JP2013519379A5/ja
Application granted granted Critical
Publication of JP6034696B2 publication Critical patent/JP6034696B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012553038A 2010-02-12 2011-02-11 ポリペプチド発現細胞の同定及び単離の方法 Expired - Fee Related JP6034696B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30425110P 2010-02-12 2010-02-12
US61/304,251 2010-02-12
US201161437889P 2011-01-31 2011-01-31
US61/437,889 2011-01-31
PCT/US2011/024554 WO2011100566A2 (en) 2010-02-12 2011-02-11 Methods for identifying and isolating cells expressing a polypeptide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016139165A Division JP2017014220A (ja) 2010-02-12 2016-07-14 ポリペプチド発現細胞の同定及び単離の方法

Publications (3)

Publication Number Publication Date
JP2013519379A JP2013519379A (ja) 2013-05-30
JP2013519379A5 true JP2013519379A5 (https=) 2014-04-03
JP6034696B2 JP6034696B2 (ja) 2016-11-30

Family

ID=44368462

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012553038A Expired - Fee Related JP6034696B2 (ja) 2010-02-12 2011-02-11 ポリペプチド発現細胞の同定及び単離の方法
JP2016139165A Withdrawn JP2017014220A (ja) 2010-02-12 2016-07-14 ポリペプチド発現細胞の同定及び単離の方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016139165A Withdrawn JP2017014220A (ja) 2010-02-12 2016-07-14 ポリペプチド発現細胞の同定及び単離の方法

Country Status (12)

Country Link
US (5) US8551715B2 (https=)
EP (1) EP2534257B1 (https=)
JP (2) JP6034696B2 (https=)
KR (1) KR20120117931A (https=)
CN (1) CN102844442B (https=)
AU (1) AU2011215685B2 (https=)
CA (1) CA2789446A1 (https=)
IL (1) IL221349A0 (https=)
MX (1) MX2012009175A (https=)
NZ (1) NZ601743A (https=)
SG (2) SG183196A1 (https=)
WO (1) WO2011100566A2 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
EA018260B1 (ru) 2006-09-29 2013-06-28 Онкомед Фармасьютикалз, Инк. Антитела к дельта-подобному лиганду 4 человека и их применение
EP2125887A4 (en) 2007-01-24 2010-11-10 Oncomed Pharm Inc COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
US8859229B2 (en) * 2007-02-02 2014-10-14 Yale University Transient transfection with RNA
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
CN104402998A (zh) 2008-07-08 2015-03-11 昂考梅德药品有限公司 分离的抗体
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
ES2700450T3 (es) 2009-10-16 2019-02-15 Oncomed Pharm Inc Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensores
US8551715B2 (en) 2010-02-12 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for identifying and isolating cells expressing a polypeptide
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
US10106598B2 (en) 2010-12-01 2018-10-23 Merck Sharp & Dohme Corp. Surface, anchored Fc-bait antibody display system
CN107459577A (zh) 2010-12-01 2017-12-12 默沙东公司 表面锚定的fc‑诱饵抗体展示系统
BR112014000765A2 (pt) 2011-07-15 2017-06-13 Oncomed Pharm Inc agentes de ligação a rspo e seus usos
LT3485903T (lt) 2011-09-23 2023-02-27 Mereo Biopharma 5, Inc. Vegf/ dll4 surišantys agentai ir jų panaudojimas
MX2014014951A (es) 2012-06-06 2015-03-13 Oncomed Pharm Inc Agentes aglutinantes que modulan la trayectoria hippo y sus usos.
IN2015KN00350A (https=) 2012-07-13 2015-07-10 Oncomed Pharm Inc
PL3489261T3 (pl) 2012-08-24 2021-08-16 The Regents Of The University Of California Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
EP2906295A4 (en) * 2012-10-15 2016-06-01 Oncomed Pharm Inc METHOD FOR THE TREATMENT OF EYE DISEASES
US8921055B2 (en) * 2012-10-30 2014-12-30 Berkeley Lights, Inc. Detecting cells secreting a protein of interest
US9599620B2 (en) 2012-10-31 2017-03-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
CA3249218A1 (en) * 2013-03-11 2026-03-02 Regeneron Pharmaceuticals, Inc. Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
GB201405845D0 (en) 2014-04-01 2014-05-14 Ucl Business Plc Signalling system
GB201407852D0 (en) 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
GB201415347D0 (en) * 2014-08-29 2014-10-15 Ucl Business Plc Signalling system
WO2016070051A2 (en) 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Combination therapy for treatment of disease
CN107207597A (zh) * 2014-11-06 2017-09-26 儿研所儿童医学中心 用于癌症和自身免疫疾病的免疫疗法
BR112017011893A2 (pt) 2014-12-05 2018-07-24 City Of Hope células t modificadas no receptor de antígeno quimérico direcionado para cs1
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Ｔｉｇｉｔ結合劑和彼之用途
EP3353204B1 (en) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Ｃａｒ ｔ細胞療法のための方法および組成物
IL299099B2 (en) 2016-06-27 2025-07-01 Univ California Cancer treatment combinations
CN110662552A (zh) 2016-11-30 2020-01-07 昂科梅德制药有限公司 包含tigit结合剂的癌症治疗方法
CN110612119B (zh) 2017-02-07 2024-10-29 西雅图儿童医院（Dba西雅图儿童研究所） 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞療法のための組成物および方法
SG11201908384XA (en) 2017-03-24 2019-10-30 Lankenau Inst Medical Res Methods and compositions for inducible extracellular membrane capture of monoclonal immunoglobulins secreted by hybridomas
JP7549303B2 (ja) 2018-01-22 2024-09-11 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞の使用方法
SG11202007426XA (en) 2018-02-06 2020-09-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
CN112105382A (zh) 2018-02-23 2020-12-18 恩多塞特公司 用于car t细胞疗法的顺序方法
WO2020037178A1 (en) 2018-08-16 2020-02-20 Memorial Sloan-Kettering Cancer Center Leucine zipper-based compositions and methods of use
EP3837287A4 (en) * 2018-08-16 2022-05-11 Memorial Sloan Kettering Cancer Center CELL SORTING SYSTEMS AND APPLICATION METHODS
WO2020114479A1 (zh) * 2018-12-07 2020-06-11 江苏恒瑞医药股份有限公司 多特异性蛋白分子
CN109738506B (zh) * 2019-01-10 2021-02-26 青岛大学附属医院 一种成熟脂肪细胞中自噬相关蛋白乙酰化位点研究方法
WO2020210816A1 (en) * 2019-04-12 2020-10-15 Methodist Hospital Research Institute Therapeutic particles that enable antigen presenting cells to attack cancer cells
AU2021217003A1 (en) 2020-02-04 2022-09-15 Seattle Children's Hospital (dba Seattle Children's Research Institute) Anti-dinitrophenol chimeric antigen receptors
US20250129362A1 (en) 2021-08-25 2025-04-24 Iontas Limited Preparation of libraries of protein variants expressed in eukaryotic cells
JP2025521114A (ja) * 2022-05-16 2025-07-08 シティ・オブ・ホープ 抗ｃｄ８４抗体及びその使用
AU2024214841A1 (en) * 2023-02-01 2025-08-28 Allen Institute Intein-mediated reconstitution of voltage-gated sodium channel function
WO2024251820A1 (en) 2023-06-06 2024-12-12 Iontas Limited Preparation of libraries of bispecific binders expressed in eukaryotic cells
WO2025151797A1 (en) * 2024-01-12 2025-07-17 Sonoma Biotherapeutics, Inc. Chimeric antigen receptors with atypical transmembrane and/or hinge domains

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
US7166423B1 (en) 1992-10-21 2007-01-23 Miltenyi Biotec Gmbh Direct selection of cells by secretion product
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US6696248B1 (en) 1995-08-18 2004-02-24 Morphosys Ag Protein/(poly)peptide libraries
AU725609C (en) 1995-08-18 2002-01-03 Morphosys Ag Protein/(poly)peptide libraries
EP0937095A4 (en) * 1996-10-25 1999-12-22 Cell Genesys Inc TARGETED CYTOLYSIS OF CANCER CELLS
AU6537798A (en) * 1997-03-14 1998-10-12 Denise Casentini-Borocz Targeted cytolysis of cancer cells
DE69833545T2 (de) 1997-03-26 2006-12-14 Imperial College Innovations Ltd. In der zellmembran verankertes antikoagulant-fusionsprotein
US5837994C1 (en) 1997-04-02 2001-10-16 Gentex Corp Control system to automatically dim vehicle head lamps
US7176179B1 (en) * 1997-05-30 2007-02-13 The Regents Of The University Of California Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide
EP1958962A3 (en) 1997-06-12 2013-05-01 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
US6180343B1 (en) 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
US6197294B1 (en) * 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation
DE19900635A1 (de) * 1999-01-11 2000-07-13 Deutsches Krebsforsch Selektion von monoklonalen Antikörpern
ATE482275T1 (de) 1999-07-02 2010-10-15 Morphosys Ag Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden
US7498304B2 (en) * 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
US7094571B2 (en) 2000-10-27 2006-08-22 The Board Of Regents Of The University Of Texas System Combinatorial protein library screening by periplasmic expression
EP1340088B1 (en) * 2000-11-17 2007-01-17 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
WO2002057423A2 (en) * 2001-01-16 2002-07-25 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US20030171546A1 (en) * 2001-04-30 2003-09-11 City Of Hope Chimeric immunoreceptor useful in treating human cancers
DE60319259T2 (de) 2002-06-14 2009-03-05 Dyax Corp., Cambridge Rekombination von nukleinsäurebibliotheksmitgliedern
JP4748984B2 (ja) * 2002-06-16 2011-08-17 ダイアックス、コープ 核酸ライブラリーメンバーの組換え
US6916474B2 (en) * 2002-07-15 2005-07-12 Board Of Regents, The University Of Texas System Antibodies with increased affinities for anthrax antigens
FR2849039B1 (fr) * 2002-12-24 2010-10-01 Centre Nat Rech Scient Nouvelle proteine associee aux centrosomes et ses applications
US20070048740A1 (en) 2003-02-14 2007-03-01 Research Association For Biotechnology Full-length cDNA
EP1447413A3 (en) * 2003-02-14 2006-01-04 Research Association for Biotechnology Full-length human cDNA
US7479538B2 (en) * 2004-11-12 2009-01-20 The Zhabilov Trust Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing, and treating HIV
KR20080073293A (ko) 2005-10-14 2008-08-08 메디뮨 엘엘씨 항체 라이브러리의 세포 디스플레이
US20110038854A1 (en) * 2006-03-30 2011-02-17 University Of Medicine And Dentistry Of New Jersey Strategy for homo- or hetero-dimerization of various proteins in solution and in cell
US20110076752A1 (en) * 2007-02-09 2011-03-31 Medimmune, Llc Antibody library display by yeast cell plasma membrane
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
US8551715B2 (en) 2010-02-12 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for identifying and isolating cells expressing a polypeptide
CN107459577A (zh) * 2010-12-01 2017-12-12 默沙东公司 表面锚定的fc‑诱饵抗体展示系统

Similar Documents

Publication Publication Date Title
JP2013519379A5 (https=)
JP7150880B2 (ja) 抗－ｂ７－ｈ３抗体およびその用途
JP7287963B2 (ja) 抗ｔｉｇｉｔ抗体並びに治療剤及び診断剤としてのその使用
CN110088133B (zh) 抗独特型抗体及相关方法
US11505605B2 (en) T cell-redirected antigen-binding molecule for cells having immunosuppression function
KR101455447B1 (ko) Ｍｕｃ１＊ 항체
CN107880128B (zh) 一种抗cd19的全人源抗体或抗体片段及其方法和应用
US20190077872A1 (en) Method for enhancing humoral immune response
WO2022135536A1 (zh) Cd3人源化抗体及其应用
TW202332697A (zh) 細胞傷害誘導治療劑
EP3999550A1 (en) Anti-dll3 chimeric antigen receptors and uses thereof
JP2017536412A (ja) Ｔ細胞再標的化ヘテロ二量体免疫グロブリン
CN109661235B (zh) 抗原结合分子及其使用的方法
CA3117756A1 (en) Novel agonistic antibody molecules
CN104829727B (zh) 一种双特异性抗体cd19×cd3的构建及应用
TW202221042A (zh) Pd-1/vegf四價雙特異性抗體、其製備方法和用途
CN113912731A (zh) 一种抗fgl1抗体及其应用
JP2025503573A (ja) 抗ｇｐｒｃ５ｄ抗体及びその応用
CA3117864A1 (en) Novel antagonistic anti tnfr2 antibody molecules
US20250000976A1 (en) Anti-bcma single domain antibodies and therapeutic constructs
JP2025504795A (ja) 抗体及びその用途
CN112794907A (zh) 一株全人源抗人huOX40单克隆抗体
CN113423720A (zh) CAR文库和scFv的制造方法
CN119894930A (zh) 一种双特异性抗体及其应用
TW202321311A (zh) 與scFv等之連接子結合的抗體