JP2013518846A5 - - Google Patents

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Publication number
JP2013518846A5
JP2013518846A5 JP2012551587A JP2012551587A JP2013518846A5 JP 2013518846 A5 JP2013518846 A5 JP 2013518846A5 JP 2012551587 A JP2012551587 A JP 2012551587A JP 2012551587 A JP2012551587 A JP 2012551587A JP 2013518846 A5 JP2013518846 A5 JP 2013518846A5
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JP
Japan
Prior art keywords
chloro
methyl
phenyl
carboxylic acid
propylamino
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Granted
Application number
JP2012551587A
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English (en)
Japanese (ja)
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JP5876419B2 (ja
JP2013518846A (ja
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Application filed filed Critical
Priority claimed from PCT/EP2011/051296 external-priority patent/WO2011095452A1/en
Publication of JP2013518846A publication Critical patent/JP2013518846A/ja
Publication of JP2013518846A5 publication Critical patent/JP2013518846A5/ja
Application granted granted Critical
Publication of JP5876419B2 publication Critical patent/JP5876419B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012551587A 2010-02-02 2011-01-31 アリールベンジルアミン化合物 Expired - Fee Related JP5876419B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30060710P 2010-02-02 2010-02-02
US61/300,607 2010-02-02
PCT/EP2011/051296 WO2011095452A1 (en) 2010-02-02 2011-01-31 Aryl benzylamine compounds

Publications (3)

Publication Number Publication Date
JP2013518846A JP2013518846A (ja) 2013-05-23
JP2013518846A5 true JP2013518846A5 (cg-RX-API-DMAC10.html) 2014-03-06
JP5876419B2 JP5876419B2 (ja) 2016-03-02

Family

ID=43734141

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012551587A Expired - Fee Related JP5876419B2 (ja) 2010-02-02 2011-01-31 アリールベンジルアミン化合物

Country Status (9)

Country Link
US (1) US8791100B2 (cg-RX-API-DMAC10.html)
EP (1) EP2531487B1 (cg-RX-API-DMAC10.html)
JP (1) JP5876419B2 (cg-RX-API-DMAC10.html)
CN (1) CN102741227B (cg-RX-API-DMAC10.html)
AR (1) AR080102A1 (cg-RX-API-DMAC10.html)
ES (1) ES2504090T3 (cg-RX-API-DMAC10.html)
TW (1) TW201130811A (cg-RX-API-DMAC10.html)
UY (1) UY33214A (cg-RX-API-DMAC10.html)
WO (1) WO2011095452A1 (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2015129859A1 (ja) * 2014-02-28 2017-03-30 キッセイ薬品工業株式会社 新規なアニリン誘導体、それを含有する医薬組成物およびそれらの用途
CN111548257B (zh) * 2020-05-28 2022-11-15 安道麦马克西姆有限公司 一种（4-异丙氧基-2-甲基）苯基异丙基酮的制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
WO1991015583A1 (en) 1990-04-05 1991-10-17 The American National Red Cross A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
US6060272A (en) 1997-05-07 2000-05-09 Human Genome Sciences, Inc. Human G-protein coupled receptors
US6310078B1 (en) * 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
JP2002531057A (ja) 1998-08-19 2002-09-24 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Ｅｄｇ受容体ファミリーに関連したｇタンパク質結合受容体である１４２７４受容体
DE19846979A1 (de) 1998-09-11 2000-03-23 Max Delbrueck Centrum G-Protein gekoppelter Rezeptor EDG6 und seine Verwendung
NZ510712A (en) 1998-10-13 2004-11-26 Arena Pharm Inc Non-endogenous, constitutively activated human G protein-coupled receptors
ATE301673T1 (de) 1998-11-20 2005-08-15 Arena Pharm Inc Menschliche, an ein g-protein gekoppelter rezeptor rup3 ohne bekannten ligand
US6323333B1 (en) 1999-04-05 2001-11-27 Smithkline Beecham Corporation Mouse EDG1
WO2001004139A2 (en) 1999-07-13 2001-01-18 Smithkline Beecham Corporation Human axor29 receptor
GB9923890D0 (en) 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
WO2001066742A2 (en) 2000-03-03 2001-09-13 Incyte Genomics, Inc. G-protein coupled receptors
AU4251301A (en) 2000-03-24 2001-10-03 Bayer Aktiengesellschaft Regulation of human nerve growth factor-elated g protein-coupled receptor
AU2001242800A1 (en) 2000-03-28 2001-10-08 Takeda Chemical Industries Ltd. Novel g protein-coupled receptor protein and dna thereof
DE60128906T2 (de) 2000-04-26 2008-02-07 Sanofi-Aventis Deutschland Gmbh Edg8-rezeptor, dessen herstellung und verwendung
DE10028901A1 (de) 2000-06-10 2001-12-20 Michael Brues Arminosäuresequenz
WO2002006446A2 (en) 2000-07-17 2002-01-24 Genaissance Pharmaceuticals, Inc. Haplotypes of the edg6 gene
AU2001288563A1 (en) 2000-08-31 2002-03-13 University Of Connecticut Regulation of angiogenesis via modulation of edg receptor mediated signal transduction comprising sphingosine-1-phosphate administration
CN1253449C (zh) 2000-11-07 2006-04-26 诺瓦提斯公司 作为蛋白激酶c抑制剂的吲哚基马来酰亚胺衍生物
US7521192B2 (en) * 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
CN1592625A (zh) 2001-08-10 2005-03-09 惠氏公司 G蛋白偶联受体测定
DE60329073D1 (de) 2002-01-18 2009-10-15 Merck & Co Inc Edg-rezeptoragonisten
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
AR039209A1 (es) 2002-04-03 2005-02-09 Novartis Ag Derivados de indolilmaleimida
US20030225288A1 (en) 2002-04-12 2003-12-04 Millennium Pharmaceuticals, Inc. Imidazolidine compounds
EP1523556A1 (en) 2002-07-18 2005-04-20 Sri International Methods of treating conditions associated with an edg-1 receptor
MXPA05003054A (es) 2002-09-20 2005-05-27 Pfizer Prod Inc Ligandos de amida y sulfonamida para el receptor de estrogenos.
AU2003279915A1 (en) 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
KR20050084224A (ko) 2002-12-09 2005-08-26 더 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 야누스 티로신 키나제 3을 선택적으로 저해하는 방법
EP1628967B1 (en) 2003-05-19 2014-04-09 Irm Llc Immunosuppressant compounds and compositions
WO2005014532A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
AU2004268455B2 (en) * 2003-08-29 2009-12-17 Ono Pharmaceutical Co., Ltd. Compound capable of binding S1P receptor and pharmaceutical use thereof
US7825109B2 (en) * 2003-08-29 2010-11-02 Ono Pharmaceutical Co., Ltd. Compound capable of binding S1P receptor and pharmaceutical use thereof
JPWO2005028667A1 (ja) 2003-09-19 2006-11-30 独立行政法人理化学研究所 ヒト肥満細胞で発現するｇ蛋白質共役型受容体を標的とした薬剤およびそのスクリーニング方法
EP1524265A1 (en) 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors
CN1902171A (zh) * 2003-11-10 2007-01-24 舍林股份公司 用作ccr－5拮抗剂的苄醚胺化合物
ES2389203T3 (es) 2004-01-12 2012-10-24 Ym Biosciences Australia Pty Ltd Inhibidores de quinasa selectivos
US20060057559A1 (en) * 2004-06-23 2006-03-16 Rigel Pharmaceuticals, Inc. High-throughput cell migration screening assay
WO2006014802A2 (en) 2004-07-27 2006-02-09 Merck & Co., Inc. Canis sphingosine 1-phosphate receptor isoform 1
EP2384749A1 (en) 2004-11-29 2011-11-09 Novartis AG Dosage regimen of an S1P receptor agonist
CN101119714A (zh) * 2005-02-14 2008-02-06 弗吉尼亚大学专利基金会 含有由氨基和苯基取代的环烷基和5元杂环的1-磷酸鞘氨醇激动剂
US20090176776A1 (en) 2005-10-21 2009-07-09 University Of Alabama At Birmingham Small molecule inhibitors of hiv-1 capsid assembly
WO2007139946A2 (en) 2006-05-25 2007-12-06 University Of Tennessee Research Foundation Gpcr ligands identified by computational modeling
US7655396B1 (en) * 2006-09-29 2010-02-02 Allergan, Inc. Methods for detecting receptor modulator activity
US20080108077A1 (en) * 2006-11-07 2008-05-08 Stephanie Chissoe Genes associated with rheumatoid arthritis
JP2009007341A (ja) * 2007-06-01 2009-01-15 Mitsubishi Tanabe Pharma Corp 医薬組成物
ATE505454T1 (de) * 2007-09-20 2011-04-15 Amgen Inc 1-(4-(4-benzylbenzamid)-benzyl)-azetidin-3- carboxylsäurederivate und entsprechende verbindungen als s1p-rezeptor-modulatoren zur behandlung von immunerkrankungen
WO2009053481A1 (en) 2007-10-25 2009-04-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions and methods for modulating nk and t cell trafficking
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
UY31631A1 (es) 2008-02-06 2009-09-30 Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones
WO2009103778A1 (en) 2008-02-19 2009-08-27 Novasaid Ab Compounds and methods
WO2009137081A2 (en) 2008-05-07 2009-11-12 Massachusetts Institute Of Technology Small molecule inhibitors of plasmodium falciparum dihydroorotate dehydrogenase
UY32349A (es) 2008-12-23 2010-07-30 Novartis Ag Derivados de biaril-bencil-amina

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