JP2013518055A5 - - Google Patents
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- Publication number
- JP2013518055A5 JP2013518055A5 JP2012550170A JP2012550170A JP2013518055A5 JP 2013518055 A5 JP2013518055 A5 JP 2013518055A5 JP 2012550170 A JP2012550170 A JP 2012550170A JP 2012550170 A JP2012550170 A JP 2012550170A JP 2013518055 A5 JP2013518055 A5 JP 2013518055A5
- Authority
- JP
- Japan
- Prior art keywords
- val92ala
- axl
- asp87gly
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33647810P | 2010-01-22 | 2010-01-22 | |
| US61/336,478 | 2010-01-22 | ||
| PCT/US2011/022125 WO2011091305A2 (en) | 2010-01-22 | 2011-01-21 | Inhibition of axl signaling in anti-metastatic therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518055A JP2013518055A (ja) | 2013-05-20 |
| JP2013518055A5 true JP2013518055A5 (https=) | 2014-02-27 |
| JP5965322B2 JP5965322B2 (ja) | 2016-08-03 |
Family
ID=44307615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550170A Expired - Fee Related JP5965322B2 (ja) | 2010-01-22 | 2011-01-21 | 抗転移療法におけるａｘｌシグナル伝達の阻害 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8618254B2 (https=) |
| EP (2) | EP2525824B1 (https=) |
| JP (1) | JP5965322B2 (https=) |
| KR (3) | KR101951410B1 (https=) |
| CN (2) | CN107082805A (https=) |
| AU (2) | AU2011207381B2 (https=) |
| BR (1) | BR112012018022A2 (https=) |
| CA (2) | CA3056999A1 (https=) |
| DK (2) | DK3241840T3 (https=) |
| ES (2) | ES2928111T3 (https=) |
| PT (2) | PT2525824T (https=) |
| RU (1) | RU2556822C2 (https=) |
| WO (1) | WO2011091305A2 (https=) |
| ZA (2) | ZA201204866B (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2525824T (pt) | 2010-01-22 | 2017-07-13 | Univ Leland Stanford Junior | Inibição da sinalização de axl em terapêutica antimetastática |
| US9074192B2 (en) * | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| US10844106B2 (en) | 2010-11-08 | 2020-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| US10197501B2 (en) | 2011-12-12 | 2019-02-05 | Kla-Tencor Corporation | Electron-bombarded charge-coupled device and inspection systems using EBCCD detectors |
| US9879061B2 (en) | 2011-12-15 | 2018-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis |
| WO2013152031A1 (en) | 2012-04-04 | 2013-10-10 | Kla-Tencor Corporation | Protective fluorine-doped silicon oxide film for optical components |
| US9496425B2 (en) | 2012-04-10 | 2016-11-15 | Kla-Tencor Corporation | Back-illuminated sensor with boron layer |
| US9601299B2 (en) | 2012-08-03 | 2017-03-21 | Kla-Tencor Corporation | Photocathode including silicon substrate with boron layer |
| WO2014035828A2 (en) * | 2012-08-27 | 2014-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| EA201690863A1 (ru) * | 2012-10-24 | 2016-09-30 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" | Нуклеиново-кислотная регуляция специфического белка блокировки роста 6 (gas6) |
| US9151940B2 (en) | 2012-12-05 | 2015-10-06 | Kla-Tencor Corporation | Semiconductor inspection and metrology system using laser pulse multiplier |
| US9426400B2 (en) | 2012-12-10 | 2016-08-23 | Kla-Tencor Corporation | Method and apparatus for high speed acquisition of moving images using pulsed illumination |
| WO2014093707A1 (en) * | 2012-12-14 | 2014-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in primary tumor therapy |
| CA2894539C (en) * | 2012-12-14 | 2021-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy |
| US9478402B2 (en) | 2013-04-01 | 2016-10-25 | Kla-Tencor Corporation | Photomultiplier tube, image sensor, and an inspection system using a PMT or image sensor |
| US20160266136A1 (en) * | 2013-08-30 | 2016-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | High-affinity binding to gas6 |
| US9347890B2 (en) | 2013-12-19 | 2016-05-24 | Kla-Tencor Corporation | Low-noise sensor and an inspection system using a low-noise sensor |
| US9748294B2 (en) | 2014-01-10 | 2017-08-29 | Hamamatsu Photonics K.K. | Anti-reflection layer for back-illuminated sensor |
| US9410901B2 (en) | 2014-03-17 | 2016-08-09 | Kla-Tencor Corporation | Image sensor, an inspection system and a method of inspecting an article |
| EP2921857B1 (en) * | 2014-03-18 | 2017-05-03 | Medizinische Universität Wien | Soluble axl receptor tyrosine kinase in the diagnosis of cancer |
| WO2015156674A2 (en) | 2014-04-10 | 2015-10-15 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
| US9525265B2 (en) | 2014-06-20 | 2016-12-20 | Kla-Tencor Corporation | Laser repetition rate multiplier and flat-top beam profile generators using mirrors and/or prisms |
| US9767986B2 (en) | 2014-08-29 | 2017-09-19 | Kla-Tencor Corporation | Scanning electron microscope and methods of inspecting and reviewing samples |
| US10137173B2 (en) | 2014-10-20 | 2018-11-27 | Aravive Biologics, Inc. | Antiviral activity of Gas6 inhibitor |
| SG10201903424RA (en) * | 2014-10-21 | 2019-05-30 | Kyowa Hakko Kirin Co Ltd | ANTI HUMAN Gas6 MONOCLONAL ANTIBODY |
| US10876176B2 (en) | 2014-12-18 | 2020-12-29 | Aravive Biologics, Inc. | Antifibrotic activity of GAS6 inhibitor |
| US9860466B2 (en) | 2015-05-14 | 2018-01-02 | Kla-Tencor Corporation | Sensor with electrically controllable aperture for inspection and metrology systems |
| US10748730B2 (en) | 2015-05-21 | 2020-08-18 | Kla-Tencor Corporation | Photocathode including field emitter array on a silicon substrate with boron layer |
| US10462391B2 (en) | 2015-08-14 | 2019-10-29 | Kla-Tencor Corporation | Dark-field inspection using a low-noise sensor |
| US9865447B2 (en) | 2016-03-28 | 2018-01-09 | Kla-Tencor Corporation | High brightness laser-sustained plasma broadband source |
| US10313622B2 (en) | 2016-04-06 | 2019-06-04 | Kla-Tencor Corporation | Dual-column-parallel CCD sensor and inspection systems using a sensor |
| US10778925B2 (en) | 2016-04-06 | 2020-09-15 | Kla-Tencor Corporation | Multiple column per channel CCD sensor architecture for inspection and metrology |
| US11662646B2 (en) | 2017-02-05 | 2023-05-30 | Kla Corporation | Inspection and metrology using broadband infrared radiation |
| KR102076777B1 (ko) * | 2017-06-23 | 2020-02-12 | 이화여자대학교 산학협력단 | Gas6 단백질 또는 이의 수용체 활성화제를 포함하는 섬유증의 예방 또는 치료용 조성물 |
| US10806016B2 (en) | 2017-07-25 | 2020-10-13 | Kla Corporation | High power broadband illumination source |
| US10690589B2 (en) * | 2017-07-28 | 2020-06-23 | Kla-Tencor Corporation | Laser sustained plasma light source with forced flow through natural convection |
| EP3703731A4 (en) | 2017-11-04 | 2021-07-21 | Aravive Biologics, Inc. | METHOD OF TREATMENT OF METASTATIC CANCER USING AXL DECOY RECEPTORS |
| US11067389B2 (en) | 2018-03-13 | 2021-07-20 | Kla Corporation | Overlay metrology system and method |
| US10714327B2 (en) | 2018-03-19 | 2020-07-14 | Kla-Tencor Corporation | System and method for pumping laser sustained plasma and enhancing selected wavelengths of output illumination |
| US10568195B2 (en) | 2018-05-30 | 2020-02-18 | Kla-Tencor Corporation | System and method for pumping laser sustained plasma with a frequency converted illumination source |
| US11114489B2 (en) | 2018-06-18 | 2021-09-07 | Kla-Tencor Corporation | Back-illuminated sensor and a method of manufacturing a sensor |
| US10823943B2 (en) | 2018-07-31 | 2020-11-03 | Kla Corporation | Plasma source with lamp house correction |
| US10943760B2 (en) | 2018-10-12 | 2021-03-09 | Kla Corporation | Electron gun and electron microscope |
| US11262591B2 (en) | 2018-11-09 | 2022-03-01 | Kla Corporation | System and method for pumping laser sustained plasma with an illumination source having modified pupil power distribution |
| US11114491B2 (en) | 2018-12-12 | 2021-09-07 | Kla Corporation | Back-illuminated sensor and a method of manufacturing a sensor |
| US10811158B1 (en) | 2019-07-19 | 2020-10-20 | Kla Corporation | Multi-mirror laser sustained plasma light source |
| US11844172B2 (en) | 2019-10-16 | 2023-12-12 | Kla Corporation | System and method for vacuum ultraviolet lamp assisted ignition of oxygen-containing laser sustained plasma sources |
| CN110982791A (zh) * | 2019-12-26 | 2020-04-10 | 百泰生物药业有限公司 | 一种分泌axl抗体的杂交瘤细胞的制备筛选方法 |
| US11761969B2 (en) | 2020-01-21 | 2023-09-19 | Kla Corporation | System and method for analyzing a sample with a dynamic recipe based on iterative experimentation and feedback |
| US11848350B2 (en) | 2020-04-08 | 2023-12-19 | Kla Corporation | Back-illuminated sensor and a method of manufacturing a sensor using a silicon on insulator wafer |
| MX2023000810A (es) * | 2020-07-19 | 2023-05-19 | Aravive Inc | Metodos de diagnostico para el cancer utilizando receptores señuelo axl. |
| WO2025264067A1 (ko) * | 2024-06-21 | 2025-12-26 | 기초과학연구원 | Axl의 세포내 도메인 또는 이의 유래 단편 및 이를 이용한 오토파지 조절 용도 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
| US5468634A (en) * | 1991-06-24 | 1995-11-21 | The University Of North Carolina At Chapel Hill | Axl oncogene |
| CA2175893C (en) * | 1993-11-23 | 2010-06-22 | Paul J. Godowski | Protein tyrosine kinases named rse |
| US5538861A (en) | 1994-07-29 | 1996-07-23 | Amgen Inc. | DNA encoding a stimulating factor for the axl receptor |
| US20030022293A1 (en) * | 1997-09-18 | 2003-01-30 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| IL163547A0 (en) | 2002-02-12 | 2005-12-18 | Quark Biotech Inc | Use of the axl receptor for diagnosis and treatment of renal disease |
| EP1382969A1 (en) * | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| WO2004108748A2 (en) * | 2002-09-24 | 2004-12-16 | Dow, Kenneth, Centocor, Inc. | Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses |
| WO2004092735A2 (en) * | 2003-04-18 | 2004-10-28 | Novartis Ag | Methods and compositions targeting tyrosine kinases for the diagnosis and treatment of osteoarthritis |
| WO2005001053A2 (en) * | 2003-06-09 | 2005-01-06 | Samuel Waksal | Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist |
| JP2005278631A (ja) * | 2004-03-04 | 2005-10-13 | National Institute Of Advanced Industrial & Technology | Ａｘｌリガンド結合領域蛋白質、その製造方法及びそれを用いたスクリーニング方法 |
| JP2008522162A (ja) * | 2004-11-24 | 2008-06-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド | Ｍｅｒの診断用および治療用の作用薬 |
| CA2607133A1 (en) * | 2005-05-02 | 2006-11-09 | Toray Industries, Inc. | Composition and method for diagnosing esophageal cancer and metastasis of esophageal cancer |
| WO2008045978A1 (en) * | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
| EP2078010B1 (en) | 2006-12-29 | 2014-01-29 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| WO2008098139A2 (en) * | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
| US7633055B2 (en) * | 2007-03-08 | 2009-12-15 | Lumination Llc | Sealed light emitting diode assemblies including annular gaskets and methods of making same |
| EP2139869A2 (en) | 2007-04-13 | 2010-01-06 | SuperGen, Inc. | Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders |
| CA2692320A1 (en) * | 2007-07-02 | 2009-01-08 | Wyeth | Methods of treating bone disorders with modulators of axl |
| EP2219671A4 (en) | 2007-11-09 | 2011-02-09 | Salk Inst For Biological Studi | USE OF TAM RECEPTOR INHIBITORS AS IMMU ENHANCERS AND TAM ACTIVATORS AS IMMUNOSUPPRESSORS |
| JP5769969B2 (ja) * | 2007-11-12 | 2015-08-26 | ユー３・ファーマ・ゲーエムベーハー | Ａｘｌ抗体 |
| TW201106972A (en) | 2009-07-27 | 2011-03-01 | Genentech Inc | Combination treatments |
| US9074192B2 (en) * | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| PT2525824T (pt) | 2010-01-22 | 2017-07-13 | Univ Leland Stanford Junior | Inibição da sinalização de axl em terapêutica antimetastática |
| RU2577986C2 (ru) | 2010-06-18 | 2016-03-20 | Дженентек, Инк. | Антитела против axl и способы их применения |
| US9879061B2 (en) | 2011-12-15 | 2018-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis |
| CA2894539C (en) * | 2012-12-14 | 2021-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy |
| WO2014093707A1 (en) * | 2012-12-14 | 2014-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in primary tumor therapy |
-
2011
- 2011-01-21 PT PT117352641T patent/PT2525824T/pt unknown
- 2011-01-21 PT PT171593346T patent/PT3241840T/pt unknown
- 2011-01-21 DK DK17159334.6T patent/DK3241840T3/da active
- 2011-01-21 EP EP11735264.1A patent/EP2525824B1/en active Active
- 2011-01-21 KR KR1020127021717A patent/KR101951410B1/ko not_active Expired - Fee Related
- 2011-01-21 CA CA 3056999 patent/CA3056999A1/en not_active Abandoned
- 2011-01-21 WO PCT/US2011/022125 patent/WO2011091305A2/en not_active Ceased
- 2011-01-21 CN CN201610819620.7A patent/CN107082805A/zh active Pending
- 2011-01-21 RU RU2012136113/10A patent/RU2556822C2/ru active
- 2011-01-21 AU AU2011207381A patent/AU2011207381B2/en not_active Ceased
- 2011-01-21 JP JP2012550170A patent/JP5965322B2/ja not_active Expired - Fee Related
- 2011-01-21 DK DK11735264.1T patent/DK2525824T3/en active
- 2011-01-21 ES ES17159334T patent/ES2928111T3/es active Active
- 2011-01-21 CN CN201180014940.0A patent/CN103154020B/zh not_active Expired - Fee Related
- 2011-01-21 BR BR112012018022A patent/BR112012018022A2/pt not_active Application Discontinuation
- 2011-01-21 KR KR1020207023736A patent/KR20200100866A/ko not_active Ceased
- 2011-01-21 CA CA2786149A patent/CA2786149C/en active Active
- 2011-01-21 ES ES11735264.1T patent/ES2632345T3/es active Active
- 2011-01-21 KR KR1020197004772A patent/KR20190019220A/ko not_active Ceased
- 2011-01-21 EP EP17159334.6A patent/EP3241840B1/en active Active
-
2012
- 2012-06-29 ZA ZA2012/04866A patent/ZA201204866B/en unknown
- 2012-07-20 US US13/554,954 patent/US8618254B2/en not_active Expired - Fee Related
-
2013
- 2013-07-24 US US13/950,111 patent/US9266947B2/en active Active
- 2013-10-15 ZA ZA2013/07676A patent/ZA201307676B/en unknown
-
2016
- 2016-08-08 AU AU2016213693A patent/AU2016213693A1/en not_active Abandoned
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