JP2013518055A5 - - Google Patents
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- Publication number
- JP2013518055A5 JP2013518055A5 JP2012550170A JP2012550170A JP2013518055A5 JP 2013518055 A5 JP2013518055 A5 JP 2013518055A5 JP 2012550170 A JP2012550170 A JP 2012550170A JP 2012550170 A JP2012550170 A JP 2012550170A JP 2013518055 A5 JP2013518055 A5 JP 2013518055A5
- Authority
- JP
- Japan
- Prior art keywords
- val92ala
- axl
- asp87gly
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33647810P | 2010-01-22 | 2010-01-22 | |
| US61/336,478 | 2010-01-22 | ||
| PCT/US2011/022125 WO2011091305A2 (en) | 2010-01-22 | 2011-01-21 | Inhibition of axl signaling in anti-metastatic therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518055A JP2013518055A (ja) | 2013-05-20 |
| JP2013518055A5 true JP2013518055A5 (https=) | 2014-02-27 |
| JP5965322B2 JP5965322B2 (ja) | 2016-08-03 |
Family
ID=44307615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550170A Expired - Fee Related JP5965322B2 (ja) | 2010-01-22 | 2011-01-21 | 抗転移療法におけるａｘｌシグナル伝達の阻害 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8618254B2 (https=) |
| EP (2) | EP2525824B1 (https=) |
| JP (1) | JP5965322B2 (https=) |
| KR (3) | KR20200100866A (https=) |
| CN (2) | CN103154020B (https=) |
| AU (2) | AU2011207381B2 (https=) |
| BR (1) | BR112012018022A2 (https=) |
| CA (2) | CA2786149C (https=) |
| DK (2) | DK3241840T3 (https=) |
| ES (2) | ES2632345T3 (https=) |
| PT (2) | PT2525824T (https=) |
| RU (1) | RU2556822C2 (https=) |
| WO (1) | WO2011091305A2 (https=) |
| ZA (2) | ZA201204866B (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2786149C (en) | 2010-01-22 | 2019-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| US9074192B2 (en) | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| EP2638173B1 (en) | 2010-11-08 | 2019-06-19 | The Board of Trustees of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| US10197501B2 (en) | 2011-12-12 | 2019-02-05 | Kla-Tencor Corporation | Electron-bombarded charge-coupled device and inspection systems using EBCCD detectors |
| WO2013090776A1 (en) * | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| US9188544B2 (en) | 2012-04-04 | 2015-11-17 | Kla-Tencor Corporation | Protective fluorine-doped silicon oxide film for optical components |
| US9496425B2 (en) | 2012-04-10 | 2016-11-15 | Kla-Tencor Corporation | Back-illuminated sensor with boron layer |
| US9601299B2 (en) | 2012-08-03 | 2017-03-21 | Kla-Tencor Corporation | Photocathode including silicon substrate with boron layer |
| WO2014035828A2 (en) * | 2012-08-27 | 2014-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| EA201690863A1 (ru) * | 2012-10-24 | 2016-09-30 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" | Нуклеиново-кислотная регуляция специфического белка блокировки роста 6 (gas6) |
| US9151940B2 (en) | 2012-12-05 | 2015-10-06 | Kla-Tencor Corporation | Semiconductor inspection and metrology system using laser pulse multiplier |
| US9426400B2 (en) | 2012-12-10 | 2016-08-23 | Kla-Tencor Corporation | Method and apparatus for high speed acquisition of moving images using pulsed illumination |
| PT3326622T (pt) | 2012-12-14 | 2021-04-07 | Univ Leland Stanford Junior | Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática |
| US20150315552A1 (en) * | 2012-12-14 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL Signaling in Primary Tumor Therapy |
| US9478402B2 (en) | 2013-04-01 | 2016-10-25 | Kla-Tencor Corporation | Photomultiplier tube, image sensor, and an inspection system using a PMT or image sensor |
| WO2015030849A1 (en) * | 2013-08-30 | 2015-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | High-affinity binding to gas6 |
| US9347890B2 (en) | 2013-12-19 | 2016-05-24 | Kla-Tencor Corporation | Low-noise sensor and an inspection system using a low-noise sensor |
| US9748294B2 (en) | 2014-01-10 | 2017-08-29 | Hamamatsu Photonics K.K. | Anti-reflection layer for back-illuminated sensor |
| US9410901B2 (en) | 2014-03-17 | 2016-08-09 | Kla-Tencor Corporation | Image sensor, an inspection system and a method of inspecting an article |
| EP2921857B1 (en) * | 2014-03-18 | 2017-05-03 | Medizinische Universität Wien | Soluble axl receptor tyrosine kinase in the diagnosis of cancer |
| US20170027940A1 (en) | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
| US9525265B2 (en) | 2014-06-20 | 2016-12-20 | Kla-Tencor Corporation | Laser repetition rate multiplier and flat-top beam profile generators using mirrors and/or prisms |
| US9767986B2 (en) | 2014-08-29 | 2017-09-19 | Kla-Tencor Corporation | Scanning electron microscope and methods of inspecting and reviewing samples |
| US10137173B2 (en) | 2014-10-20 | 2018-11-27 | Aravive Biologics, Inc. | Antiviral activity of Gas6 inhibitor |
| SG11201703292VA (en) * | 2014-10-21 | 2017-06-29 | Kyowa Hakko Kirin Co Ltd | ANTI HUMAN Gas6 MONOCLONAL ANTIBODY |
| ES2834618T3 (es) * | 2014-12-18 | 2021-06-18 | Aravive Biologics Inc | Actividad antifibrótica del inhibidor de GAS6 |
| US9860466B2 (en) | 2015-05-14 | 2018-01-02 | Kla-Tencor Corporation | Sensor with electrically controllable aperture for inspection and metrology systems |
| US10748730B2 (en) | 2015-05-21 | 2020-08-18 | Kla-Tencor Corporation | Photocathode including field emitter array on a silicon substrate with boron layer |
| US10462391B2 (en) | 2015-08-14 | 2019-10-29 | Kla-Tencor Corporation | Dark-field inspection using a low-noise sensor |
| US9865447B2 (en) | 2016-03-28 | 2018-01-09 | Kla-Tencor Corporation | High brightness laser-sustained plasma broadband source |
| US10313622B2 (en) | 2016-04-06 | 2019-06-04 | Kla-Tencor Corporation | Dual-column-parallel CCD sensor and inspection systems using a sensor |
| US10778925B2 (en) | 2016-04-06 | 2020-09-15 | Kla-Tencor Corporation | Multiple column per channel CCD sensor architecture for inspection and metrology |
| US11662646B2 (en) | 2017-02-05 | 2023-05-30 | Kla Corporation | Inspection and metrology using broadband infrared radiation |
| WO2018236194A1 (ko) * | 2017-06-23 | 2018-12-27 | 이화여자대학교 산학협력단 | Gas6 단백질 또는 이의 수용체 활성화제를 포함하는 섬유증의 예방 또는 치료용 조성물 |
| US10806016B2 (en) | 2017-07-25 | 2020-10-13 | Kla Corporation | High power broadband illumination source |
| US10690589B2 (en) * | 2017-07-28 | 2020-06-23 | Kla-Tencor Corporation | Laser sustained plasma light source with forced flow through natural convection |
| US20200289613A1 (en) * | 2017-11-04 | 2020-09-17 | Aravive Biologics, Inc. | Methods of treating metastatic cancers using axl decoy receptors |
| US11067389B2 (en) | 2018-03-13 | 2021-07-20 | Kla Corporation | Overlay metrology system and method |
| US10714327B2 (en) | 2018-03-19 | 2020-07-14 | Kla-Tencor Corporation | System and method for pumping laser sustained plasma and enhancing selected wavelengths of output illumination |
| US10568195B2 (en) | 2018-05-30 | 2020-02-18 | Kla-Tencor Corporation | System and method for pumping laser sustained plasma with a frequency converted illumination source |
| US11114489B2 (en) | 2018-06-18 | 2021-09-07 | Kla-Tencor Corporation | Back-illuminated sensor and a method of manufacturing a sensor |
| US10823943B2 (en) | 2018-07-31 | 2020-11-03 | Kla Corporation | Plasma source with lamp house correction |
| US10943760B2 (en) | 2018-10-12 | 2021-03-09 | Kla Corporation | Electron gun and electron microscope |
| US11262591B2 (en) | 2018-11-09 | 2022-03-01 | Kla Corporation | System and method for pumping laser sustained plasma with an illumination source having modified pupil power distribution |
| US11114491B2 (en) | 2018-12-12 | 2021-09-07 | Kla Corporation | Back-illuminated sensor and a method of manufacturing a sensor |
| US10811158B1 (en) | 2019-07-19 | 2020-10-20 | Kla Corporation | Multi-mirror laser sustained plasma light source |
| US11844172B2 (en) | 2019-10-16 | 2023-12-12 | Kla Corporation | System and method for vacuum ultraviolet lamp assisted ignition of oxygen-containing laser sustained plasma sources |
| CN110982791A (zh) * | 2019-12-26 | 2020-04-10 | 百泰生物药业有限公司 | 一种分泌axl抗体的杂交瘤细胞的制备筛选方法 |
| US11761969B2 (en) | 2020-01-21 | 2023-09-19 | Kla Corporation | System and method for analyzing a sample with a dynamic recipe based on iterative experimentation and feedback |
| US11848350B2 (en) | 2020-04-08 | 2023-12-19 | Kla Corporation | Back-illuminated sensor and a method of manufacturing a sensor using a silicon on insulator wafer |
| KR20230050349A (ko) * | 2020-07-19 | 2023-04-14 | 아라바이브 인크. | Axl 유인 수용체를 이용한 암의 진단 방법 |
| WO2025264067A1 (ko) * | 2024-06-21 | 2025-12-26 | 기초과학연구원 | Axl의 세포내 도메인 또는 이의 유래 단편 및 이를 이용한 오토파지 조절 용도 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| EP0394827A1 (en) | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
| US5468634A (en) * | 1991-06-24 | 1995-11-21 | The University Of North Carolina At Chapel Hill | Axl oncogene |
| AU697142B2 (en) * | 1993-11-23 | 1998-10-01 | Genentech Inc. | Protein tyrosine kinases named Rse |
| US5538861A (en) | 1994-07-29 | 1996-07-23 | Amgen Inc. | DNA encoding a stimulating factor for the axl receptor |
| US20030032102A1 (en) * | 1997-09-18 | 2003-02-13 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| AU2003223172A1 (en) | 2002-02-12 | 2003-09-04 | Quark Biotech, Inc. | Use of the axl receptor for diagnosis and treatment of renal disease |
| EP1382969A1 (en) | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| WO2004108748A2 (en) * | 2002-09-24 | 2004-12-16 | Dow, Kenneth, Centocor, Inc. | Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses |
| CA2522984A1 (en) * | 2003-04-18 | 2004-10-28 | Novartis Ag | Methods and compositions targeting tyrosine kinases for the diagnosis and treatment of osteoarthritis |
| CN1972712A (zh) * | 2003-06-09 | 2007-05-30 | 塞缪尔·瓦克萨尔 | 用胞外拮抗物和胞内拮抗物抑制受体酪氨酸激酶的方法 |
| JP2005278631A (ja) * | 2004-03-04 | 2005-10-13 | National Institute Of Advanced Industrial & Technology | Ａｘｌリガンド結合領域蛋白質、その製造方法及びそれを用いたスクリーニング方法 |
| JP2008522162A (ja) * | 2004-11-24 | 2008-06-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド | Ｍｅｒの診断用および治療用の作用薬 |
| EP2177614B1 (en) * | 2005-05-02 | 2014-12-31 | Toray Industries, Inc. | Composition and method for diagnosing esophageal cancer and metastasis of esophageal cancer |
| WO2008045978A1 (en) * | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
| EP2078010B1 (en) | 2006-12-29 | 2014-01-29 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| WO2008098139A2 (en) * | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
| US7633055B2 (en) * | 2007-03-08 | 2009-12-15 | Lumination Llc | Sealed light emitting diode assemblies including annular gaskets and methods of making same |
| EP2139869A2 (en) | 2007-04-13 | 2010-01-06 | SuperGen, Inc. | Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders |
| WO2009005813A1 (en) * | 2007-07-02 | 2009-01-08 | Wyeth | Modulators of axl for use in treating bone disorders |
| EP2217716A4 (en) | 2007-11-09 | 2011-02-09 | Salk Inst For Biological Studi | USE OF TAM RECEPTOR INHIBITORS AS ANTIMICROBIAL AGENTS |
| AU2008323206B2 (en) * | 2007-11-12 | 2014-08-14 | U3 Pharma Gmbh | AXL antibodies |
| WO2011014457A1 (en) | 2009-07-27 | 2011-02-03 | Genentech, Inc. | Combination treatments |
| US9074192B2 (en) * | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| CA2786149C (en) | 2010-01-22 | 2019-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| BR112012027995A2 (pt) | 2010-06-18 | 2017-01-10 | Genentech Inc | anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl |
| WO2013090776A1 (en) | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| PT3326622T (pt) * | 2012-12-14 | 2021-04-07 | Univ Leland Stanford Junior | Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática |
| US20150315552A1 (en) * | 2012-12-14 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL Signaling in Primary Tumor Therapy |
-
2011
- 2011-01-21 CA CA2786149A patent/CA2786149C/en active Active
- 2011-01-21 BR BR112012018022A patent/BR112012018022A2/pt not_active Application Discontinuation
- 2011-01-21 PT PT117352641T patent/PT2525824T/pt unknown
- 2011-01-21 KR KR1020207023736A patent/KR20200100866A/ko not_active Ceased
- 2011-01-21 CN CN201180014940.0A patent/CN103154020B/zh not_active Expired - Fee Related
- 2011-01-21 CN CN201610819620.7A patent/CN107082805A/zh active Pending
- 2011-01-21 RU RU2012136113/10A patent/RU2556822C2/ru active
- 2011-01-21 EP EP11735264.1A patent/EP2525824B1/en active Active
- 2011-01-21 DK DK17159334.6T patent/DK3241840T3/da active
- 2011-01-21 CA CA 3056999 patent/CA3056999A1/en not_active Abandoned
- 2011-01-21 KR KR1020197004772A patent/KR20190019220A/ko not_active Ceased
- 2011-01-21 KR KR1020127021717A patent/KR101951410B1/ko not_active Expired - Fee Related
- 2011-01-21 DK DK11735264.1T patent/DK2525824T3/en active
- 2011-01-21 JP JP2012550170A patent/JP5965322B2/ja not_active Expired - Fee Related
- 2011-01-21 ES ES11735264.1T patent/ES2632345T3/es active Active
- 2011-01-21 WO PCT/US2011/022125 patent/WO2011091305A2/en not_active Ceased
- 2011-01-21 AU AU2011207381A patent/AU2011207381B2/en not_active Ceased
- 2011-01-21 PT PT171593346T patent/PT3241840T/pt unknown
- 2011-01-21 ES ES17159334T patent/ES2928111T3/es active Active
- 2011-01-21 EP EP17159334.6A patent/EP3241840B1/en active Active
-
2012
- 2012-06-29 ZA ZA2012/04866A patent/ZA201204866B/en unknown
- 2012-07-20 US US13/554,954 patent/US8618254B2/en not_active Expired - Fee Related
-
2013
- 2013-07-24 US US13/950,111 patent/US9266947B2/en active Active
- 2013-10-15 ZA ZA2013/07676A patent/ZA201307676B/en unknown
-
2016
- 2016-08-08 AU AU2016213693A patent/AU2016213693A1/en not_active Abandoned
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