PT2525824T - Inibição da sinalização de axl em terapêutica antimetastática - Google Patents
Inibição da sinalização de axl em terapêutica antimetastática Download PDFInfo
- Publication number
- PT2525824T PT2525824T PT117352641T PT11735264T PT2525824T PT 2525824 T PT2525824 T PT 2525824T PT 117352641 T PT117352641 T PT 117352641T PT 11735264 T PT11735264 T PT 11735264T PT 2525824 T PT2525824 T PT 2525824T
- Authority
- PT
- Portugal
- Prior art keywords
- axl
- tumor
- cells
- gas6
- leu
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33647810P | 2010-01-22 | 2010-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2525824T true PT2525824T (pt) | 2017-07-13 |
Family
ID=44307615
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117352641T PT2525824T (pt) | 2010-01-22 | 2011-01-21 | Inibição da sinalização de axl em terapêutica antimetastática |
| PT171593346T PT3241840T (pt) | 2010-01-22 | 2011-01-21 | Inibição da sinalização de axl em terapêutica anti-metastática |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT171593346T PT3241840T (pt) | 2010-01-22 | 2011-01-21 | Inibição da sinalização de axl em terapêutica anti-metastática |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8618254B2 (https=) |
| EP (2) | EP2525824B1 (https=) |
| JP (1) | JP5965322B2 (https=) |
| KR (3) | KR20200100866A (https=) |
| CN (2) | CN103154020B (https=) |
| AU (2) | AU2011207381B2 (https=) |
| BR (1) | BR112012018022A2 (https=) |
| CA (2) | CA2786149C (https=) |
| DK (2) | DK3241840T3 (https=) |
| ES (2) | ES2632345T3 (https=) |
| PT (2) | PT2525824T (https=) |
| RU (1) | RU2556822C2 (https=) |
| WO (1) | WO2011091305A2 (https=) |
| ZA (2) | ZA201204866B (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2786149C (en) | 2010-01-22 | 2019-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| US9074192B2 (en) | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| EP2638173B1 (en) | 2010-11-08 | 2019-06-19 | The Board of Trustees of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| US10197501B2 (en) | 2011-12-12 | 2019-02-05 | Kla-Tencor Corporation | Electron-bombarded charge-coupled device and inspection systems using EBCCD detectors |
| WO2013090776A1 (en) * | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| US9188544B2 (en) | 2012-04-04 | 2015-11-17 | Kla-Tencor Corporation | Protective fluorine-doped silicon oxide film for optical components |
| US9496425B2 (en) | 2012-04-10 | 2016-11-15 | Kla-Tencor Corporation | Back-illuminated sensor with boron layer |
| US9601299B2 (en) | 2012-08-03 | 2017-03-21 | Kla-Tencor Corporation | Photocathode including silicon substrate with boron layer |
| WO2014035828A2 (en) * | 2012-08-27 | 2014-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| EA201690863A1 (ru) * | 2012-10-24 | 2016-09-30 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" | Нуклеиново-кислотная регуляция специфического белка блокировки роста 6 (gas6) |
| US9151940B2 (en) | 2012-12-05 | 2015-10-06 | Kla-Tencor Corporation | Semiconductor inspection and metrology system using laser pulse multiplier |
| US9426400B2 (en) | 2012-12-10 | 2016-08-23 | Kla-Tencor Corporation | Method and apparatus for high speed acquisition of moving images using pulsed illumination |
| PT3326622T (pt) | 2012-12-14 | 2021-04-07 | Univ Leland Stanford Junior | Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática |
| US20150315552A1 (en) * | 2012-12-14 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL Signaling in Primary Tumor Therapy |
| US9478402B2 (en) | 2013-04-01 | 2016-10-25 | Kla-Tencor Corporation | Photomultiplier tube, image sensor, and an inspection system using a PMT or image sensor |
| WO2015030849A1 (en) * | 2013-08-30 | 2015-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | High-affinity binding to gas6 |
| US9347890B2 (en) | 2013-12-19 | 2016-05-24 | Kla-Tencor Corporation | Low-noise sensor and an inspection system using a low-noise sensor |
| US9748294B2 (en) | 2014-01-10 | 2017-08-29 | Hamamatsu Photonics K.K. | Anti-reflection layer for back-illuminated sensor |
| US9410901B2 (en) | 2014-03-17 | 2016-08-09 | Kla-Tencor Corporation | Image sensor, an inspection system and a method of inspecting an article |
| EP2921857B1 (en) * | 2014-03-18 | 2017-05-03 | Medizinische Universität Wien | Soluble axl receptor tyrosine kinase in the diagnosis of cancer |
| US20170027940A1 (en) | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
| US9525265B2 (en) | 2014-06-20 | 2016-12-20 | Kla-Tencor Corporation | Laser repetition rate multiplier and flat-top beam profile generators using mirrors and/or prisms |
| US9767986B2 (en) | 2014-08-29 | 2017-09-19 | Kla-Tencor Corporation | Scanning electron microscope and methods of inspecting and reviewing samples |
| US10137173B2 (en) | 2014-10-20 | 2018-11-27 | Aravive Biologics, Inc. | Antiviral activity of Gas6 inhibitor |
| SG11201703292VA (en) * | 2014-10-21 | 2017-06-29 | Kyowa Hakko Kirin Co Ltd | ANTI HUMAN Gas6 MONOCLONAL ANTIBODY |
| ES2834618T3 (es) * | 2014-12-18 | 2021-06-18 | Aravive Biologics Inc | Actividad antifibrótica del inhibidor de GAS6 |
| US9860466B2 (en) | 2015-05-14 | 2018-01-02 | Kla-Tencor Corporation | Sensor with electrically controllable aperture for inspection and metrology systems |
| US10748730B2 (en) | 2015-05-21 | 2020-08-18 | Kla-Tencor Corporation | Photocathode including field emitter array on a silicon substrate with boron layer |
| US10462391B2 (en) | 2015-08-14 | 2019-10-29 | Kla-Tencor Corporation | Dark-field inspection using a low-noise sensor |
| US9865447B2 (en) | 2016-03-28 | 2018-01-09 | Kla-Tencor Corporation | High brightness laser-sustained plasma broadband source |
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| US10778925B2 (en) | 2016-04-06 | 2020-09-15 | Kla-Tencor Corporation | Multiple column per channel CCD sensor architecture for inspection and metrology |
| US11662646B2 (en) | 2017-02-05 | 2023-05-30 | Kla Corporation | Inspection and metrology using broadband infrared radiation |
| WO2018236194A1 (ko) * | 2017-06-23 | 2018-12-27 | 이화여자대학교 산학협력단 | Gas6 단백질 또는 이의 수용체 활성화제를 포함하는 섬유증의 예방 또는 치료용 조성물 |
| US10806016B2 (en) | 2017-07-25 | 2020-10-13 | Kla Corporation | High power broadband illumination source |
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| US20200289613A1 (en) * | 2017-11-04 | 2020-09-17 | Aravive Biologics, Inc. | Methods of treating metastatic cancers using axl decoy receptors |
| US11067389B2 (en) | 2018-03-13 | 2021-07-20 | Kla Corporation | Overlay metrology system and method |
| US10714327B2 (en) | 2018-03-19 | 2020-07-14 | Kla-Tencor Corporation | System and method for pumping laser sustained plasma and enhancing selected wavelengths of output illumination |
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| US11262591B2 (en) | 2018-11-09 | 2022-03-01 | Kla Corporation | System and method for pumping laser sustained plasma with an illumination source having modified pupil power distribution |
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| CN110982791A (zh) * | 2019-12-26 | 2020-04-10 | 百泰生物药业有限公司 | 一种分泌axl抗体的杂交瘤细胞的制备筛选方法 |
| US11761969B2 (en) | 2020-01-21 | 2023-09-19 | Kla Corporation | System and method for analyzing a sample with a dynamic recipe based on iterative experimentation and feedback |
| US11848350B2 (en) | 2020-04-08 | 2023-12-19 | Kla Corporation | Back-illuminated sensor and a method of manufacturing a sensor using a silicon on insulator wafer |
| KR20230050349A (ko) * | 2020-07-19 | 2023-04-14 | 아라바이브 인크. | Axl 유인 수용체를 이용한 암의 진단 방법 |
| WO2025264067A1 (ko) * | 2024-06-21 | 2025-12-26 | 기초과학연구원 | Axl의 세포내 도메인 또는 이의 유래 단편 및 이를 이용한 오토파지 조절 용도 |
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| US9074192B2 (en) * | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| CA2786149C (en) | 2010-01-22 | 2019-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| BR112012027995A2 (pt) | 2010-06-18 | 2017-01-10 | Genentech Inc | anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl |
| WO2013090776A1 (en) | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
| PT3326622T (pt) * | 2012-12-14 | 2021-04-07 | Univ Leland Stanford Junior | Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática |
| US20150315552A1 (en) * | 2012-12-14 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL Signaling in Primary Tumor Therapy |
-
2011
- 2011-01-21 CA CA2786149A patent/CA2786149C/en active Active
- 2011-01-21 BR BR112012018022A patent/BR112012018022A2/pt not_active Application Discontinuation
- 2011-01-21 PT PT117352641T patent/PT2525824T/pt unknown
- 2011-01-21 KR KR1020207023736A patent/KR20200100866A/ko not_active Ceased
- 2011-01-21 CN CN201180014940.0A patent/CN103154020B/zh not_active Expired - Fee Related
- 2011-01-21 CN CN201610819620.7A patent/CN107082805A/zh active Pending
- 2011-01-21 RU RU2012136113/10A patent/RU2556822C2/ru active
- 2011-01-21 EP EP11735264.1A patent/EP2525824B1/en active Active
- 2011-01-21 DK DK17159334.6T patent/DK3241840T3/da active
- 2011-01-21 CA CA 3056999 patent/CA3056999A1/en not_active Abandoned
- 2011-01-21 KR KR1020197004772A patent/KR20190019220A/ko not_active Ceased
- 2011-01-21 KR KR1020127021717A patent/KR101951410B1/ko not_active Expired - Fee Related
- 2011-01-21 DK DK11735264.1T patent/DK2525824T3/en active
- 2011-01-21 JP JP2012550170A patent/JP5965322B2/ja not_active Expired - Fee Related
- 2011-01-21 ES ES11735264.1T patent/ES2632345T3/es active Active
- 2011-01-21 WO PCT/US2011/022125 patent/WO2011091305A2/en not_active Ceased
- 2011-01-21 AU AU2011207381A patent/AU2011207381B2/en not_active Ceased
- 2011-01-21 PT PT171593346T patent/PT3241840T/pt unknown
- 2011-01-21 ES ES17159334T patent/ES2928111T3/es active Active
- 2011-01-21 EP EP17159334.6A patent/EP3241840B1/en active Active
-
2012
- 2012-06-29 ZA ZA2012/04866A patent/ZA201204866B/en unknown
- 2012-07-20 US US13/554,954 patent/US8618254B2/en not_active Expired - Fee Related
-
2013
- 2013-07-24 US US13/950,111 patent/US9266947B2/en active Active
- 2013-10-15 ZA ZA2013/07676A patent/ZA201307676B/en unknown
-
2016
- 2016-08-08 AU AU2016213693A patent/AU2016213693A1/en not_active Abandoned
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