JP2013518041A5 - - Google Patents
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- Publication number
- JP2013518041A5 JP2013518041A5 JP2012549413A JP2012549413A JP2013518041A5 JP 2013518041 A5 JP2013518041 A5 JP 2013518041A5 JP 2012549413 A JP2012549413 A JP 2012549413A JP 2012549413 A JP2012549413 A JP 2012549413A JP 2013518041 A5 JP2013518041 A5 JP 2013518041A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline
- crystalline form
- ray powder
- powder diffraction
- differential scanning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000634 powder X-ray diffraction Methods 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 34
- 238000000113 differential scanning calorimetry Methods 0.000 claims 34
- 239000011541 reaction mixture Substances 0.000 claims 30
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 21
- 238000000034 method Methods 0.000 claims 21
- 239000012458 free base Substances 0.000 claims 18
- 238000010438 heat treatment Methods 0.000 claims 17
- FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical group [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 claims 16
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 9
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 8
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 5
- 229910019142 PO4 Inorganic materials 0.000 claims 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 5
- 239000010452 phosphate Substances 0.000 claims 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 4
- 230000001363 autoimmune Effects 0.000 claims 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 150000003839 salts Chemical group 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 3
- 229940077388 benzenesulfonate Drugs 0.000 claims 3
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 229940116298 l- malic acid Drugs 0.000 claims 2
- 229940049920 malate Drugs 0.000 claims 2
- 235000011090 malic acid Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- ULHLNVIDIVAORK-BXRBKJIMSA-N (2S)-2-hydroxybutanedioic acid Chemical group OC(=O)[C@@H](O)CC(O)=O.OC(=O)[C@@H](O)CC(O)=O ULHLNVIDIVAORK-BXRBKJIMSA-N 0.000 claims 1
- OAKURXIZZOAYBC-UHFFFAOYSA-M 3-oxopropanoate Chemical compound [O-]C(=O)CC=O OAKURXIZZOAYBC-UHFFFAOYSA-M 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims 1
- 229940092714 benzenesulfonic acid Drugs 0.000 claims 1
- 229940061631 citric acid acetate Drugs 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 229940114119 gentisate Drugs 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 150000003892 tartrate salts Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1001075.9 | 2010-01-22 | ||
| GBGB1001075.9A GB201001075D0 (en) | 2010-01-22 | 2010-01-22 | Crystalline forms |
| PCT/GB2011/000087 WO2011089401A1 (en) | 2010-01-22 | 2011-01-24 | Crystalline forms of a purine derivative |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016026263A Division JP6114849B2 (ja) | 2010-01-22 | 2016-02-15 | プリン誘導体の結晶性形態 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518041A JP2013518041A (ja) | 2013-05-20 |
| JP2013518041A5 true JP2013518041A5 (OSRAM) | 2014-03-06 |
| JP5951506B2 JP5951506B2 (ja) | 2016-07-13 |
Family
ID=42045946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549413A Active JP5951506B2 (ja) | 2010-01-22 | 2011-01-24 | プリン誘導体の結晶性形態 |
| JP2016026263A Expired - Fee Related JP6114849B2 (ja) | 2010-01-22 | 2016-02-15 | プリン誘導体の結晶性形態 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016026263A Expired - Fee Related JP6114849B2 (ja) | 2010-01-22 | 2016-02-15 | プリン誘導体の結晶性形態 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8889861B2 (OSRAM) |
| EP (2) | EP3150602B1 (OSRAM) |
| JP (2) | JP5951506B2 (OSRAM) |
| KR (2) | KR101860806B1 (OSRAM) |
| CN (2) | CN107400134B (OSRAM) |
| ES (2) | ES2694289T3 (OSRAM) |
| GB (1) | GB201001075D0 (OSRAM) |
| PL (2) | PL3150602T3 (OSRAM) |
| SG (2) | SG10201500451TA (OSRAM) |
| TR (1) | TR201816159T4 (OSRAM) |
| WO (1) | WO2011089401A1 (OSRAM) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8608797B2 (en) | 2005-03-17 | 2013-12-17 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
| US8333777B2 (en) | 2005-04-22 | 2012-12-18 | Benvenue Medical, Inc. | Catheter-based tissue remodeling devices and methods |
| US9974653B2 (en) | 2006-12-05 | 2018-05-22 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| WO2010004546A1 (en) | 2008-06-16 | 2010-01-14 | Valtech Cardio, Ltd. | Annuloplasty devices and methods of delivery therefor |
| US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
| US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
| US8382829B1 (en) | 2008-03-10 | 2013-02-26 | Mitralign, Inc. | Method to reduce mitral regurgitation by cinching the commissure of the mitral valve |
| US10517719B2 (en) | 2008-12-22 | 2019-12-31 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
| US8545553B2 (en) | 2009-05-04 | 2013-10-01 | Valtech Cardio, Ltd. | Over-wire rotation tool |
| US8715342B2 (en) | 2009-05-07 | 2014-05-06 | Valtech Cardio, Ltd. | Annuloplasty ring with intra-ring anchoring |
| CN102341063B (zh) | 2008-12-22 | 2015-11-25 | 瓦尔泰克卡迪欧有限公司 | 可调瓣环成形装置及其调节机构 |
| US8241351B2 (en) | 2008-12-22 | 2012-08-14 | Valtech Cardio, Ltd. | Adjustable partial annuloplasty ring and mechanism therefor |
| US8353956B2 (en) | 2009-02-17 | 2013-01-15 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
| US9968452B2 (en) | 2009-05-04 | 2018-05-15 | Valtech Cardio, Ltd. | Annuloplasty ring delivery cathethers |
| WO2013069019A2 (en) | 2011-11-08 | 2013-05-16 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| US12485010B2 (en) | 2009-05-07 | 2025-12-02 | Edwards Lifesciences Innovation (Israel) Ltd. | Multiple anchor delivery tool |
| US10098737B2 (en) | 2009-10-29 | 2018-10-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
| US9180007B2 (en) | 2009-10-29 | 2015-11-10 | Valtech Cardio, Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
| WO2011067770A1 (en) | 2009-12-02 | 2011-06-09 | Valtech Cardio, Ltd. | Delivery tool for implantation of spool assembly coupled to a helical anchor |
| US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
| GB201001075D0 (en) | 2010-01-22 | 2010-03-10 | Cyclacel Ltd | Crystalline forms |
| US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
| US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
| EP3345573B1 (en) | 2011-06-23 | 2020-01-29 | Valtech Cardio, Ltd. | Closure element for use with annuloplasty structure |
| US8858623B2 (en) | 2011-11-04 | 2014-10-14 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
| CN105662505B (zh) | 2011-12-12 | 2018-03-30 | 戴维·阿隆 | 用来捆紧心脏瓣膜环的设备 |
| WO2014052818A1 (en) | 2012-09-29 | 2014-04-03 | Mitralign, Inc. | Plication lock delivery system and method of use thereof |
| WO2014064694A2 (en) | 2012-10-23 | 2014-05-01 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
| EP3730066A1 (en) | 2012-10-23 | 2020-10-28 | Valtech Cardio, Ltd. | Percutaneous tissue anchor techniques |
| US9730793B2 (en) | 2012-12-06 | 2017-08-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
| WO2014115149A2 (en) | 2013-01-24 | 2014-07-31 | Mitraltech Ltd. | Ventricularly-anchored prosthetic valves |
| WO2014134183A1 (en) | 2013-02-26 | 2014-09-04 | Mitralign, Inc. | Devices and methods for percutaneous tricuspid valve repair |
| US10449333B2 (en) | 2013-03-14 | 2019-10-22 | Valtech Cardio, Ltd. | Guidewire feeder |
| EP2968847B1 (en) | 2013-03-15 | 2023-03-08 | Edwards Lifesciences Corporation | Translation catheter systems |
| WO2014189830A1 (en) | 2013-05-20 | 2014-11-27 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Calcium channel agonists |
| US10070857B2 (en) | 2013-08-31 | 2018-09-11 | Mitralign, Inc. | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
| US10299793B2 (en) | 2013-10-23 | 2019-05-28 | Valtech Cardio, Ltd. | Anchor magazine |
| US9610162B2 (en) | 2013-12-26 | 2017-04-04 | Valtech Cardio, Ltd. | Implantation of flexible implant |
| WO2016016899A1 (en) | 2014-07-30 | 2016-02-04 | Mitraltech Ltd. | Articulatable prosthetic valve |
| US10195030B2 (en) | 2014-10-14 | 2019-02-05 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
| ES2978714T3 (es) | 2015-02-05 | 2024-09-18 | Cardiovalve Ltd | Válvula protésica con marcos de deslizamiento axial |
| US20160256269A1 (en) | 2015-03-05 | 2016-09-08 | Mitralign, Inc. | Devices for treating paravalvular leakage and methods use thereof |
| SG11201708397PA (en) | 2015-04-30 | 2017-11-29 | Valtech Cardio Ltd | Annuloplasty technologies |
| US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
| US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
| US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
| US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
| GB201611910D0 (en) | 2016-07-08 | 2016-08-24 | Valtech Cardio Ltd | Adjustable annuloplasty device with alternating peaks and troughs |
| GB201613219D0 (en) | 2016-08-01 | 2016-09-14 | Mitraltech Ltd | Minimally-invasive delivery systems |
| ES3018641T3 (es) | 2016-08-10 | 2025-05-16 | Cardiovalve Ltd | Válvula protésica con marcos concéntricos |
| KR102524773B1 (ko) * | 2017-01-26 | 2023-04-21 | 싸이클라셀 리미티드 | 퓨린 유도체의 제조 방법 |
| US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
| US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12064347B2 (en) | 2017-08-03 | 2024-08-20 | Cardiovalve Ltd. | Prosthetic heart valve |
| US12458493B2 (en) | 2017-09-19 | 2025-11-04 | Cardiovalve Ltd. | Prosthetic heart valve and delivery systems and methods |
| US10835221B2 (en) | 2017-11-02 | 2020-11-17 | Valtech Cardio, Ltd. | Implant-cinching devices and systems |
| US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
| EP3743015A1 (en) | 2018-01-24 | 2020-12-02 | Valtech Cardio, Ltd. | Contraction of an annuloplasty structure |
| WO2019145941A1 (en) | 2018-01-26 | 2019-08-01 | Valtech Cardio, Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
| EP3820406B1 (en) | 2018-07-12 | 2023-12-20 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty systems and locking tools therefor |
| AU2020284630A1 (en) | 2019-05-29 | 2021-11-18 | Edwards Lifesciences Innovation (Israel) Ltd. | Tissue anchor handling systems and methods |
| US12364606B2 (en) | 2019-07-23 | 2025-07-22 | Edwards Lifesciences Innovation (Israel) Ltd. | Fluoroscopic visualization of heart valve anatomy |
| CA3143177A1 (en) | 2019-08-28 | 2021-03-04 | Valtech Cardio, Ltd. | Low-profile steerable catheter |
| WO2021038559A1 (en) | 2019-08-30 | 2021-03-04 | Valtech Cardio, Ltd. | Anchor channel tip |
| KR20220066398A (ko) | 2019-09-25 | 2022-05-24 | 카디악 임플란츠 엘엘씨 | 심장 판막 고리 감소 시스템 |
| CA3142906A1 (en) | 2019-10-29 | 2021-05-06 | Valtech Cardio, Ltd. | Annuloplasty and tissue anchor technologies |
| GB202000901D0 (en) | 2020-01-22 | 2020-03-04 | Cyclacel Ltd | Process |
| WO2021161347A1 (en) * | 2020-02-15 | 2021-08-19 | Cipla Limited | Novel salts of nilotinib and polymorphic forms thereof |
| JP2023527304A (ja) | 2020-05-20 | 2023-06-28 | カーディアック・インプランツ・エルエルシー | 心臓弁輪に打ち込まれるアンカそれぞれを独立的に制御することによる心臓弁輪の直径の減少 |
| CA3182316A1 (en) | 2020-06-19 | 2021-12-23 | Edwards Lifesciences Innovation (Israel) Ltd. | Self-stopping tissue anchors |
| US12357459B2 (en) | 2020-12-03 | 2025-07-15 | Cardiovalve Ltd. | Transluminal delivery system |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA72748C2 (en) | 1998-11-10 | 2005-04-15 | Astrazeneca Ab | A novel crystalline form of omeprazole |
| ATE301123T1 (de) | 2001-06-27 | 2005-08-15 | Cyclacel Ltd | 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten |
| GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
| GB0219052D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
| GB0706633D0 (en) * | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | Combination |
| GB0706632D0 (en) | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | New purine derivatives |
| GB201001075D0 (en) | 2010-01-22 | 2010-03-10 | Cyclacel Ltd | Crystalline forms |
-
2010
- 2010-01-22 GB GBGB1001075.9A patent/GB201001075D0/en not_active Ceased
-
2011
- 2011-01-24 SG SG10201500451TA patent/SG10201500451TA/en unknown
- 2011-01-24 EP EP16186685.0A patent/EP3150602B1/en active Active
- 2011-01-24 JP JP2012549413A patent/JP5951506B2/ja active Active
- 2011-01-24 TR TR2018/16159T patent/TR201816159T4/tr unknown
- 2011-01-24 EP EP11701855.6A patent/EP2526101B1/en active Active
- 2011-01-24 ES ES16186685.0T patent/ES2694289T3/es active Active
- 2011-01-24 KR KR1020127021718A patent/KR101860806B1/ko active Active
- 2011-01-24 PL PL16186685T patent/PL3150602T3/pl unknown
- 2011-01-24 SG SG2012050696A patent/SG182439A1/en unknown
- 2011-01-24 PL PL11701855T patent/PL2526101T3/pl unknown
- 2011-01-24 ES ES11701855.6T patent/ES2613716T3/es active Active
- 2011-01-24 US US13/574,488 patent/US8889861B2/en active Active
- 2011-01-24 CN CN201710626907.2A patent/CN107400134B/zh active Active
- 2011-01-24 KR KR1020187014008A patent/KR101927083B1/ko active Active
- 2011-01-24 WO PCT/GB2011/000087 patent/WO2011089401A1/en not_active Ceased
- 2011-01-24 CN CN201180015141.5A patent/CN102985423B/zh active Active
-
2014
- 2014-10-27 US US14/524,686 patent/US9573951B2/en active Active
-
2016
- 2016-02-15 JP JP2016026263A patent/JP6114849B2/ja not_active Expired - Fee Related
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