JP2013517259A5 - - Google Patents
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- Publication number
- JP2013517259A5 JP2013517259A5 JP2012548460A JP2012548460A JP2013517259A5 JP 2013517259 A5 JP2013517259 A5 JP 2013517259A5 JP 2012548460 A JP2012548460 A JP 2012548460A JP 2012548460 A JP2012548460 A JP 2012548460A JP 2013517259 A5 JP2013517259 A5 JP 2013517259A5
- Authority
- JP
- Japan
- Prior art keywords
- gla
- polypeptide
- protein
- factor
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical compound OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102100022641 Coagulation factor IX Human genes 0.000 claims 5
- 108010076282 Factor IX Proteins 0.000 claims 5
- 229960004222 factor ix Drugs 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 3
- 229910001424 calcium ion Inorganic materials 0.000 claims 3
- UHBYWPGGCSDKFX-UHFFFAOYSA-N carboxyglutamic acid Chemical compound OC(=O)C(N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-UHFFFAOYSA-N 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 239000012149 elution buffer Substances 0.000 claims 2
- 239000006167 equilibration buffer Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 229920002684 Sepharose Polymers 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000011534 wash buffer Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10150980 | 2010-01-18 | ||
| EP10150980.0 | 2010-01-18 | ||
| US29701110P | 2010-01-21 | 2010-01-21 | |
| US61/297,011 | 2010-01-21 | ||
| PCT/EP2011/050594 WO2011086197A1 (en) | 2010-01-18 | 2011-01-18 | Purification of blood coagulation factors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517259A JP2013517259A (ja) | 2013-05-16 |
| JP2013517259A5 true JP2013517259A5 (enExample) | 2014-03-06 |
| JP6250931B2 JP6250931B2 (ja) | 2017-12-20 |
Family
ID=42173365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548460A Expired - Fee Related JP6250931B2 (ja) | 2010-01-18 | 2011-01-18 | 血液凝固因子の精製 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9896677B2 (enExample) |
| EP (1) | EP2526115B1 (enExample) |
| JP (1) | JP6250931B2 (enExample) |
| KR (1) | KR20120118028A (enExample) |
| CN (1) | CN102939299B (enExample) |
| BR (1) | BR112012017696A2 (enExample) |
| RU (1) | RU2012133474A (enExample) |
| WO (1) | WO2011086197A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2526115B1 (en) * | 2010-01-18 | 2018-08-01 | Novo Nordisk Health Care AG | Purification of blood coagulation factors |
| CN103539852B (zh) * | 2012-07-12 | 2015-08-12 | 上海泰龙生物医药科技有限公司 | 一种从细胞培养液中分离纯化重组人凝血八因子的方法 |
| CN107880126B (zh) | 2012-12-21 | 2021-03-30 | 西雅图基因公司 | 抗ntb-a抗体及相关组合物和方法 |
| US10643423B2 (en) | 2016-09-23 | 2020-05-05 | Sg Gaming, Inc. | System and digital table for binding a mobile device to a position at the table for transactions |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258938B1 (en) | 1983-10-28 | 2001-07-10 | Ne Medical Center Hospital, Inc. | Method for the purification and isolation of blood clotting proteins using conformation specific antibodies |
| US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
| FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
| US4981952A (en) | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
| EP0573605B1 (en) | 1991-03-01 | 2000-08-30 | Rhone-Poulenc Rorer International (Holdings) Inc. | Preparation of factor ix |
| IT1262899B (it) | 1992-03-27 | 1996-07-22 | Sclavo Spa | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
| DE4406515C1 (de) | 1994-02-28 | 1995-10-19 | Immuno Ag | Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine |
| US6451987B1 (en) | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
| SE0000675D0 (sv) | 2000-03-02 | 2000-03-02 | Protease Ab | Monoclonal antibodies |
| KR101204712B1 (ko) | 2003-03-18 | 2012-11-27 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Ｇｌａ-잔기 함유 세린 프로테아제의 제조 방법 |
| JP2008525381A (ja) | 2004-12-23 | 2008-07-17 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 関心のあるビタミンｋ依存性タンパク質を含んでなる組成物中におけるタンパク質混入物の量の減少 |
| DE602006017882D1 (de) | 2005-12-02 | 2010-12-09 | Univ Wake Forest Health Sciences | Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine |
| EP2125866B1 (en) | 2007-02-28 | 2013-05-22 | Baxter International Inc. | Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules |
| AU2009324204B2 (en) | 2008-12-02 | 2014-10-16 | Novo Nordisk Health Care Ag | Polypeptide purification |
| EP2526115B1 (en) * | 2010-01-18 | 2018-08-01 | Novo Nordisk Health Care AG | Purification of blood coagulation factors |
-
2011
- 2011-01-18 EP EP11700547.0A patent/EP2526115B1/en not_active Not-in-force
- 2011-01-18 BR BR112012017696A patent/BR112012017696A2/pt not_active IP Right Cessation
- 2011-01-18 RU RU2012133474/10A patent/RU2012133474A/ru unknown
- 2011-01-18 KR KR1020127020380A patent/KR20120118028A/ko not_active Withdrawn
- 2011-01-18 JP JP2012548460A patent/JP6250931B2/ja not_active Expired - Fee Related
- 2011-01-18 US US13/522,548 patent/US9896677B2/en active Active
- 2011-01-18 WO PCT/EP2011/050594 patent/WO2011086197A1/en not_active Ceased
- 2011-01-18 CN CN201180006396.5A patent/CN102939299B/zh not_active Expired - Fee Related
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