JP2012050465A5 - - Google Patents
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- Publication number
- JP2012050465A5 JP2012050465A5 JP2011270236A JP2011270236A JP2012050465A5 JP 2012050465 A5 JP2012050465 A5 JP 2012050465A5 JP 2011270236 A JP2011270236 A JP 2011270236A JP 2011270236 A JP2011270236 A JP 2011270236A JP 2012050465 A5 JP2012050465 A5 JP 2012050465A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- inhibitor
- mammal
- dna segment
- segment encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101001081555 Homo sapiens Plasma protease C1 inhibitor Proteins 0.000 claims 39
- 102000044507 human SERPING1 Human genes 0.000 claims 39
- 102000055157 Complement C1 Inhibitor Human genes 0.000 claims 16
- 108700040183 Complement C1 Inhibitor Proteins 0.000 claims 16
- 241000124008 Mammalia Species 0.000 claims 15
- 210000004216 mammary stem cell Anatomy 0.000 claims 15
- 239000008267 milk Substances 0.000 claims 14
- 210000004080 milk Anatomy 0.000 claims 14
- 235000013336 milk Nutrition 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 8
- 210000000481 breast Anatomy 0.000 claims 8
- 230000001105 regulatory effect Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 201000007120 C1 inhibitor deficiency Diseases 0.000 claims 4
- 206010019860 Hereditary angioedema Diseases 0.000 claims 4
- 238000005342 ion exchange Methods 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 102000003839 Human Proteins Human genes 0.000 claims 3
- 108090000144 Human Proteins Proteins 0.000 claims 3
- 238000005349 anion exchange Methods 0.000 claims 3
- 238000005341 cation exchange Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000005075 mammary gland Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17931000P | 2000-01-31 | 2000-01-31 | |
| US60/179,310 | 2000-01-31 | ||
| EP00200320.0 | 2000-01-31 | ||
| EP00200320 | 2000-01-31 | ||
| US18758000P | 2000-03-07 | 2000-03-07 | |
| US60/187,580 | 2000-03-07 | ||
| EP00200810 | 2000-03-07 | ||
| EP00200810.0 | 2000-03-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001557910A Division JP2003521914A (ja) | 2000-01-31 | 2001-01-31 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075150A Division JP2014121337A (ja) | 2000-01-31 | 2014-04-01 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012050465A JP2012050465A (ja) | 2012-03-15 |
| JP2012050465A5 true JP2012050465A5 (enExample) | 2013-07-04 |
Family
ID=27439989
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011270236A Pending JP2012050465A (ja) | 2000-01-31 | 2011-12-09 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
| JP2014075150A Pending JP2014121337A (ja) | 2000-01-31 | 2014-04-01 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075150A Pending JP2014121337A (ja) | 2000-01-31 | 2014-04-01 | トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US7067713B2 (enExample) |
| JP (2) | JP2012050465A (enExample) |
| BE (1) | BE2010C040I2 (enExample) |
| FR (1) | FR10C0054I2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003301332B2 (en) * | 2002-10-17 | 2008-06-12 | Pharming Intellectual Property B.V. | Protein modification |
| PT1626736T (pt) * | 2003-05-16 | 2020-10-13 | Pharming Intellectual Property B V | Inibidor c1 com curta meia-vida para tratamento transitório |
| US8841259B2 (en) * | 2005-02-24 | 2014-09-23 | Joslin Diabetes Center | Compositions and methods for treating vascular permeability |
| SI2380587T1 (en) * | 2005-12-21 | 2018-03-30 | Pharming Intellectual Property B.V. | Use of a C1 inhibitor to prevent ischemic reperfusion injury |
| FR2901707B1 (fr) * | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
| FR2904558B1 (fr) * | 2006-08-01 | 2008-10-17 | Lab Francais Du Fractionnement | "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees" |
| US20100119512A1 (en) * | 2007-01-25 | 2010-05-13 | Joslin Diabetes Center | Methods of diagnosing, treating, and preventing increased vascular permeability |
| WO2014113712A1 (en) | 2013-01-20 | 2014-07-24 | Dyax Corp. | Evaluation and treatment of bradykinin-mediated disorders |
| BR112015019348A2 (pt) | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Métodos para produção de proteína com glicosilação modificada e com sialilação aumentada, para aumentar a atividade de sialil transferase na glândula mamária e para produzir sialil transferase, proteína com glicosilação modificada ou proteína com sialilação aumentada, composição, sialil transferase, mamífero transgênico, e, célula epitelial mamária |
| AU2014217561B2 (en) | 2013-02-13 | 2018-11-15 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Highly galactosylated anti-TNF-alpha antibodies and uses thereof |
| ME03326B (me) | 2013-03-15 | 2019-10-20 | Shire Viropharma Inc | C1-inh kompozicije i postupci za prevenciju i liječenje poremećaja koji su povezani sa deficijencijom inhibitora c1 esteraze |
| KR20250066486A (ko) * | 2013-10-21 | 2025-05-13 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| PL3060908T3 (pl) | 2013-10-21 | 2021-10-25 | Takeda Pharmaceutical Company Limited | Diagnoza i leczenie chorób autoimmunologicznych |
| CA2933612A1 (en) * | 2013-12-24 | 2015-07-02 | Lfb Usa, Inc. | Transgenic production of heparin |
| CN108025047B (zh) * | 2015-05-28 | 2021-11-19 | 康奈尔大学 | 腺相关病毒介导的c1ei递送作为用于血管性水肿的疗法 |
| KR20180014051A (ko) | 2015-05-28 | 2018-02-07 | 코넬 유니버시티 | 혈관 부종 치료제로서의 아데노-관련 바이러스 매개 c1e1의 전달 |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| CA3002747A1 (en) | 2015-10-19 | 2017-04-27 | Dyax Corp. | Immunoassay to detect cleaved high molecular weight kininogen |
| US20190175683A1 (en) | 2016-08-05 | 2019-06-13 | Csl Behring Gmbh | Pharmaceutical formulations of c1 esterase inhibitor |
| BR112019023737A2 (pt) * | 2017-05-16 | 2020-05-26 | Octapharma Ag | Preparação de inibidor de c1-esterase (c1-inh), kit que consiste em um primeiro receptáculo contendo a preparação de c1-inh, kit que consiste em uma seringa pré-cheia com a preparação de c1-inh, kit que consiste em um dispositivo adequado para aplicação subcutânea, tal como um injetor no corpo e uso de histidina para aumentar a biodisponibilidade de c1-inh administrado por via subcutânea |
| US20200390872A1 (en) * | 2018-02-28 | 2020-12-17 | Pharming Intellectual Property B.V. | Treatment and prevention of pre-eclampsia |
| EP3895726A1 (en) | 2020-04-17 | 2021-10-20 | Pharming Intellectual Property BV | Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress |
| EP4366761A1 (en) | 2021-07-09 | 2024-05-15 | Pharming Intellectual Property B.V. | Using c1 esterase inhibitor to treat viral infection-related symptoms |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601034B1 (fr) | 1986-07-03 | 1989-11-17 | Pasteur Institut | Inhibiteur de l'activite de la c1-esterase plasmatique (c1-inhibiteur) et d'autres enzymes proteolytiques du groupe des proteases a serine, son procede de preparation, acides nucleiques codant pour cet inhibiteur, methodes de detection d'affections correlees aux defauts dudit inhibiteur a l'aide d'anticorps ou de sondes nucleotidiques et medicaments contenant ledit inhibiteur de synthese |
| EP0497833A1 (en) | 1989-10-27 | 1992-08-12 | Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis | C1 inhibitor muteins and uses thereof |
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| WO1992022320A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
| DE4244735A1 (de) | 1992-08-24 | 1994-03-31 | Behringwerke Ag | Verwendung von C1-Inaktivator zur Bekämpfung von Komplikationen bei der Anwendung von Zytokinen, endogenen Mediatoren, gentechnisch produzierten Mediator-Hybriden oder Wachstumsfaktoren im Rahmen der therapeutischen Anwendung dieser Substanzen |
| US6713662B1 (en) | 1994-07-27 | 2004-03-30 | Pharming Intellectual Property B.V. | Production of collagen in the milk of transgenic mammals |
| GB9807464D0 (en) * | 1998-04-07 | 1998-06-10 | Pharming Bv | Purification of human acid µ-glucosidase |
| DK1252184T3 (da) * | 2000-01-31 | 2008-02-04 | Pharming Intellectual Pty Bv | Human C1-inhibitor produceret i mælk af transgene dyr |
-
2001
- 2001-01-31 US US10/181,704 patent/US7067713B2/en active Active
-
2005
- 2005-03-22 US US11/087,789 patent/US20050223416A1/en not_active Abandoned
-
2010
- 2010-12-08 BE BE2010C040C patent/BE2010C040I2/fr unknown
- 2010-12-16 FR FR10C0054C patent/FR10C0054I2/fr active Active
-
2011
- 2011-12-09 JP JP2011270236A patent/JP2012050465A/ja active Pending
-
2014
- 2014-04-01 JP JP2014075150A patent/JP2014121337A/ja active Pending
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