JP2013517224A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013517224A5 JP2013517224A5 JP2012548306A JP2012548306A JP2013517224A5 JP 2013517224 A5 JP2013517224 A5 JP 2013517224A5 JP 2012548306 A JP2012548306 A JP 2012548306A JP 2012548306 A JP2012548306 A JP 2012548306A JP 2013517224 A5 JP2013517224 A5 JP 2013517224A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- compound according
- pharmaceutical formulation
- amino acids
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- -1 cyclic organic compound Chemical class 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N ornithyl group Chemical group N[C@@H](CCCN)C(=O)O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000009325 pulmonary function Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000006798 ring closing metathesis reaction Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0004110A AT509267A1 (de) | 2010-01-14 | 2010-01-14 | Organische verbindungen zur regulierung von vektoriellen ionenkanälen |
| ATA41/2010 | 2010-01-14 | ||
| PCT/AT2011/000014 WO2011085423A1 (de) | 2010-01-14 | 2011-01-12 | Zyklische peptide zur regulierung von vektoriellen ionenkanälen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517224A JP2013517224A (ja) | 2013-05-16 |
| JP2013517224A5 true JP2013517224A5 (enExample) | 2013-10-17 |
| JP5771220B2 JP5771220B2 (ja) | 2015-08-26 |
Family
ID=43970939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548306A Active JP5771220B2 (ja) | 2010-01-14 | 2011-01-12 | ベクトルイオンチャネルを調節するための有機化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8754049B2 (enExample) |
| EP (1) | EP2523968B1 (enExample) |
| JP (1) | JP5771220B2 (enExample) |
| KR (1) | KR101865420B1 (enExample) |
| CN (1) | CN102770442B (enExample) |
| AT (1) | AT509267A1 (enExample) |
| AU (1) | AU2011206907B2 (enExample) |
| BR (1) | BR112012017093A2 (enExample) |
| CA (1) | CA2785185C (enExample) |
| DK (1) | DK2523968T3 (enExample) |
| ES (1) | ES2525381T3 (enExample) |
| IL (1) | IL220924B (enExample) |
| NZ (1) | NZ600818A (enExample) |
| PL (1) | PL2523968T3 (enExample) |
| RU (1) | RU2538597C2 (enExample) |
| WO (1) | WO2011085423A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2679239A1 (de) | 2012-06-28 | 2014-01-01 | Apeptico Forschung und Entwicklung GmbH | Pharmazeutische Zusammensetzung zur Behandlung der durch Sauerstoffarmut und verringerten Luftdruck vermittelten pulmonalen Form der Höhenkrankheit |
| JP6335279B2 (ja) * | 2013-04-23 | 2018-05-30 | アペプティコ フオルシユング ウント アントウィクラング ゲーエムベーハー | 式ｘ１−ｇｑｒｅｔｐｅｇａｅａｋｐｗｙ−ｘ２の環状ペプチドを含んでなる医薬組成物および体外肺処置のための使用 |
| US12004506B2 (en) | 2013-04-23 | 2024-06-11 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment |
| DK2988768T3 (da) * | 2013-04-23 | 2021-06-21 | Apeptico Forschung & Entwicklung Gmbh | Lyofilisat indeholdende et cyklisk peptid med Formel X1-GQRETPEGAEAKPWY-X2 til behandling af pulmonære ødemer |
| WO2015132294A1 (en) * | 2014-03-04 | 2015-09-11 | Apeptico Forschung Und Entwicklung Gmbh | Attenuation of intrapulmonary inflammation |
| CN108025038B (zh) * | 2015-09-14 | 2022-02-01 | 阿佩普蒂科研究和开发有限责任公司 | 治疗1b型pha的环状多肽 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968753A (en) * | 1994-06-14 | 1999-10-19 | Nexell Therapeutics, Inc. | Positive and positive/negative cell selection mediated by peptide release |
| NZ509604A (en) | 1998-08-14 | 2003-05-30 | Innogenetics N | TNF-derived peptides for use in treating oedema |
| FR2839514A1 (fr) * | 2002-05-07 | 2003-11-14 | Centre Nat Rech Scient | Nouveaux peptides cycliques, leur utilisation comme agents anti-microbiens |
| EP1781323B1 (en) | 2004-08-06 | 2010-02-17 | Nycomed GmbH | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
| CN101003520A (zh) * | 2007-01-12 | 2007-07-25 | 陈志龙 | 一种缬氨酸丁酰联苯化合物 |
| CN101007791A (zh) * | 2007-01-12 | 2007-08-01 | 东华大学 | 一种氨基酸联苯化合物 |
| EP2009023A1 (en) * | 2007-06-04 | 2008-12-31 | Rentschler Beteiligungs GmbH | Novel peptides and their use for the treatment of edema |
| AT506151B1 (de) * | 2007-12-12 | 2010-01-15 | Apeptico Forschung Und Entwick | Fusionsprotein |
| AT506150B1 (de) * | 2007-12-12 | 2010-01-15 | Apeptico Forschung Und Entwick | Zyklisches und cystein-freies peptid |
| CN101298432B (zh) * | 2008-05-30 | 2010-12-22 | 广州市星业科技发展有限公司 | L-吡咯烷酮羧酸钠的制备方法 |
| WO2009149278A1 (en) * | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AT507953B1 (de) * | 2009-03-05 | 2011-02-15 | Apeptico Forschung & Entwicklung Gmbh | Verfahren zur vermeidung und zur behandlung einer hyperpermeabilität |
| DK2397151T3 (en) * | 2010-06-21 | 2015-05-18 | Apeptico Forschung & Entwicklung Gmbh | The treatment of the vascular complications of diabetes |
-
2010
- 2010-01-14 AT AT0004110A patent/AT509267A1/de not_active Application Discontinuation
-
2011
- 2011-01-12 WO PCT/AT2011/000014 patent/WO2011085423A1/de not_active Ceased
- 2011-01-12 CA CA2785185A patent/CA2785185C/en active Active
- 2011-01-12 PL PL11705798T patent/PL2523968T3/pl unknown
- 2011-01-12 BR BR112012017093A patent/BR112012017093A2/pt not_active IP Right Cessation
- 2011-01-12 ES ES11705798.4T patent/ES2525381T3/es active Active
- 2011-01-12 EP EP11705798.4A patent/EP2523968B1/de active Active
- 2011-01-12 DK DK11705798.4T patent/DK2523968T3/da active
- 2011-01-12 AU AU2011206907A patent/AU2011206907B2/en not_active Ceased
- 2011-01-12 US US13/522,204 patent/US8754049B2/en active Active
- 2011-01-12 NZ NZ600818A patent/NZ600818A/en not_active IP Right Cessation
- 2011-01-12 KR KR1020127018445A patent/KR101865420B1/ko active Active
- 2011-01-12 CN CN201180005765.9A patent/CN102770442B/zh active Active
- 2011-01-12 JP JP2012548306A patent/JP5771220B2/ja active Active
- 2011-01-12 RU RU2012134322/04A patent/RU2538597C2/ru not_active IP Right Cessation
-
2012
- 2012-07-12 IL IL220924A patent/IL220924B/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013517224A5 (enExample) | ||
| JP2014051497A5 (enExample) | ||
| WO2013188792A3 (en) | Neuroactive steroids, compositions, and uses thereof | |
| IL259851A (en) | Compounds and methods of inhibiting antidepressant nhe mediator in the treatment of disorders associated with fluid retention or overload of salts and gastrointestinal disorders | |
| UA113165C2 (xx) | Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат | |
| JP2017537066A5 (enExample) | ||
| WO2016134301A3 (en) | Neuroactive steroids, compositions, and uses thereof | |
| WO2009133141A3 (en) | New therapeutic approaches for treating alzheimer disease and related disorders through a modulation of angiogenesis | |
| JP2015180693A5 (enExample) | ||
| AR107864A1 (es) | ÁCIDO 7a,11b-DIHIDROXI-6a-ETIL-5b-COLAN-24-OICO Y COMPOSICIONES FARMACÉUTICAS | |
| EA201270225A1 (ru) | СОЕДИНЕНИЯ ДЛЯ УМЕНЬШЕНИЯ ПРОДУКЦИИ β-АМИЛОИДА | |
| EA201270824A1 (ru) | Соединения для уменьшения продукции бета-амилоида | |
| MX2015013813A (es) | Vacuna de conjugado de peptido-antigeno de wt1. | |
| JP2010534684A5 (enExample) | ||
| NZ703120A (en) | Pharmaceutical compositions comprising rifaximin and amino acids, preparation method and use thereof | |
| JP2018516904A5 (enExample) | ||
| JP2012517969A5 (enExample) | ||
| JP2013532130A5 (enExample) | ||
| JP2016534081A5 (ja) | ゾレドロン酸の増強された経口バイオアベイラビリティーを有する経口剤形を調製する方法 | |
| HRP20191941T1 (hr) | Spojevi ppar, namijenjeni upotrebi u liječenju fibrotskih bolesti | |
| NO20092567L (no) | Acetylendenvater og deres anvendelse til binding og avbilding av amyloidplakker | |
| JP2012529293A5 (enExample) | ||
| JP2019512693A5 (enExample) | ||
| WO2018160178A8 (en) | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof | |
| JP2013523778A5 (enExample) |