CN102770442B - 用于调节载体离子通道的有机化合物 - Google Patents

用于调节载体离子通道的有机化合物 Download PDF

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Publication number
CN102770442B
CN102770442B CN201180005765.9A CN201180005765A CN102770442B CN 102770442 B CN102770442 B CN 102770442B CN 201180005765 A CN201180005765 A CN 201180005765A CN 102770442 B CN102770442 B CN 102770442B
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amino acid
seq
compound
acid
terminal
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Chinese (zh)
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CN102770442A (zh
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B.菲舍尔
R.卢卡斯
S.佐佐斯
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Apeptico Forschung und Entwicklung GmbH
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Apeptico Forschung und Entwicklung GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180005765.9A 2010-01-14 2011-01-12 用于调节载体离子通道的有机化合物 Active CN102770442B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0004110A AT509267A1 (de) 2010-01-14 2010-01-14 Organische verbindungen zur regulierung von vektoriellen ionenkanälen
ATA41/2010 2010-01-14
PCT/AT2011/000014 WO2011085423A1 (de) 2010-01-14 2011-01-12 Zyklische peptide zur regulierung von vektoriellen ionenkanälen

Publications (2)

Publication Number Publication Date
CN102770442A CN102770442A (zh) 2012-11-07
CN102770442B true CN102770442B (zh) 2015-09-23

Family

ID=43970939

Family Applications (1)

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CN201180005765.9A Active CN102770442B (zh) 2010-01-14 2011-01-12 用于调节载体离子通道的有机化合物

Country Status (16)

Country Link
US (1) US8754049B2 (enExample)
EP (1) EP2523968B1 (enExample)
JP (1) JP5771220B2 (enExample)
KR (1) KR101865420B1 (enExample)
CN (1) CN102770442B (enExample)
AT (1) AT509267A1 (enExample)
AU (1) AU2011206907B2 (enExample)
BR (1) BR112012017093A2 (enExample)
CA (1) CA2785185C (enExample)
DK (1) DK2523968T3 (enExample)
ES (1) ES2525381T3 (enExample)
IL (1) IL220924B (enExample)
NZ (1) NZ600818A (enExample)
PL (1) PL2523968T3 (enExample)
RU (1) RU2538597C2 (enExample)
WO (1) WO2011085423A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2679239A1 (de) 2012-06-28 2014-01-01 Apeptico Forschung und Entwicklung GmbH Pharmazeutische Zusammensetzung zur Behandlung der durch Sauerstoffarmut und verringerten Luftdruck vermittelten pulmonalen Form der Höhenkrankheit
JP6335279B2 (ja) * 2013-04-23 2018-05-30 アペプティコ フオルシユング ウント アントウィクラング ゲーエムベーハー 式ｘ１−ｇｑｒｅｔｐｅｇａｅａｋｐｗｙ−ｘ２の環状ペプチドを含んでなる医薬組成物および体外肺処置のための使用
US12004506B2 (en) 2013-04-23 2024-06-11 Apeptico Forschung Und Entwicklung Gmbh Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment
DK2988768T3 (da) * 2013-04-23 2021-06-21 Apeptico Forschung & Entwicklung Gmbh Lyofilisat indeholdende et cyklisk peptid med Formel X1-GQRETPEGAEAKPWY-X2 til behandling af pulmonære ødemer
WO2015132294A1 (en) * 2014-03-04 2015-09-11 Apeptico Forschung Und Entwicklung Gmbh Attenuation of intrapulmonary inflammation
CN108025038B (zh) * 2015-09-14 2022-02-01 阿佩普蒂科研究和开发有限责任公司 治疗1b型pha的环状多肽

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101003520A (zh) * 2007-01-12 2007-07-25 陈志龙 一种缬氨酸丁酰联苯化合物
CN101007791A (zh) * 2007-01-12 2007-08-01 东华大学 一种氨基酸联苯化合物
CN101298432A (zh) * 2008-05-30 2008-11-05 广州市星业科技发展有限公司 L-吡咯烷酮羧酸钠的制备方法
WO2009073909A1 (de) * 2007-12-12 2009-06-18 Apeptico Forschung Und Entwicklung Gmbh Zyklisches, cystein-freies protein

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968753A (en) * 1994-06-14 1999-10-19 Nexell Therapeutics, Inc. Positive and positive/negative cell selection mediated by peptide release
NZ509604A (en) 1998-08-14 2003-05-30 Innogenetics N TNF-derived peptides for use in treating oedema
FR2839514A1 (fr) * 2002-05-07 2003-11-14 Centre Nat Rech Scient Nouveaux peptides cycliques, leur utilisation comme agents anti-microbiens
EP1781323B1 (en) 2004-08-06 2010-02-17 Nycomed GmbH Composition comprising a pulmonary surfactant and a tnf-derived peptide
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
AT506151B1 (de) * 2007-12-12 2010-01-15 Apeptico Forschung Und Entwick Fusionsprotein
WO2009149278A1 (en) * 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AT507953B1 (de) * 2009-03-05 2011-02-15 Apeptico Forschung & Entwicklung Gmbh Verfahren zur vermeidung und zur behandlung einer hyperpermeabilität
DK2397151T3 (en) * 2010-06-21 2015-05-18 Apeptico Forschung & Entwicklung Gmbh The treatment of the vascular complications of diabetes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101003520A (zh) * 2007-01-12 2007-07-25 陈志龙 一种缬氨酸丁酰联苯化合物
CN101007791A (zh) * 2007-01-12 2007-08-01 东华大学 一种氨基酸联苯化合物
WO2009073909A1 (de) * 2007-12-12 2009-06-18 Apeptico Forschung Und Entwicklung Gmbh Zyklisches, cystein-freies protein
CN101298432A (zh) * 2008-05-30 2008-11-05 广州市星业科技发展有限公司 L-吡咯烷酮羧酸钠的制备方法

Also Published As

Publication number Publication date
EP2523968A1 (de) 2012-11-21
JP2013517224A (ja) 2013-05-16
EP2523968B1 (de) 2014-09-10
ES2525381T3 (es) 2014-12-23
AU2011206907B2 (en) 2016-06-02
HK1174341A1 (en) 2013-06-07
WO2011085423A1 (de) 2011-07-21
RU2012134322A (ru) 2014-02-20
US20130072444A1 (en) 2013-03-21
CA2785185A1 (en) 2011-07-21
IL220924B (en) 2018-04-30
AT509267A1 (de) 2011-07-15
AU2011206907A1 (en) 2012-06-21
CN102770442A (zh) 2012-11-07
RU2538597C2 (ru) 2015-01-10
BR112012017093A2 (pt) 2016-11-29
NZ600818A (en) 2014-02-28
DK2523968T3 (da) 2014-11-03
PL2523968T3 (pl) 2015-03-31
KR20120134100A (ko) 2012-12-11
JP5771220B2 (ja) 2015-08-26
CA2785185C (en) 2019-02-19
US8754049B2 (en) 2014-06-17
KR101865420B1 (ko) 2018-07-13

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