JP2013523778A5 - - Google Patents
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- Publication number
- JP2013523778A5 JP2013523778A5 JP2013502918A JP2013502918A JP2013523778A5 JP 2013523778 A5 JP2013523778 A5 JP 2013523778A5 JP 2013502918 A JP2013502918 A JP 2013502918A JP 2013502918 A JP2013502918 A JP 2013502918A JP 2013523778 A5 JP2013523778 A5 JP 2013523778A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- substituted
- ccnp38
- amino acid
- ccn3 peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700024729 Nephroblastoma Overexpressed Proteins 0.000 claims 19
- 235000001014 amino acid Nutrition 0.000 claims 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 6
- 235000018417 cysteine Nutrition 0.000 claims 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 5
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- 150000001945 cysteines Chemical class 0.000 claims 3
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 3
- 101150036984 CCN3 gene Proteins 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 102000047330 Nephroblastoma Overexpressed Human genes 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000007306 turnover Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34169410P | 2010-04-02 | 2010-04-02 | |
| US61/341,694 | 2010-04-02 | ||
| PCT/US2011/031121 WO2011123858A2 (en) | 2010-04-02 | 2011-04-04 | Ccn3 peptides and analogs thereof for therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523778A JP2013523778A (ja) | 2013-06-17 |
| JP2013523778A5 true JP2013523778A5 (enExample) | 2014-03-20 |
| JP5939584B2 JP5939584B2 (ja) | 2016-06-22 |
Family
ID=44712870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013502918A Expired - Fee Related JP5939584B2 (ja) | 2010-04-02 | 2011-04-04 | 治療用ｃｃｎ３ペプチドおよびそれらの類似体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8518395B2 (enExample) |
| EP (1) | EP2552462B1 (enExample) |
| JP (1) | JP5939584B2 (enExample) |
| CN (1) | CN102947326B (enExample) |
| DK (1) | DK2552462T3 (enExample) |
| ES (1) | ES2561437T3 (enExample) |
| WO (1) | WO2011123858A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9114112B2 (en) * | 2010-04-02 | 2015-08-25 | Rosalind Franklin University Of Medicine And Science | CCN3 and CCN3 peptides and analogs thereof for therapeutic uses |
| CN104749371B (zh) * | 2013-12-30 | 2016-09-28 | 神州细胞工程有限公司 | 人肾母细胞瘤过度表达基因编码蛋白酶联免疫试剂盒 |
| KR101576904B1 (ko) * | 2014-07-31 | 2015-12-14 | (주)케어젠 | 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도 |
| US10028906B2 (en) * | 2016-03-22 | 2018-07-24 | Rosalind Franklin University Of Medicine And Science | Method and kit for treating a solid tumor and associated desmoplasia |
| CN108795867A (zh) * | 2018-06-05 | 2018-11-13 | 华东理工大学 | 用于构建结肠癌细胞腹膜转移体外三维模型的方法 |
| EP3711772A1 (en) * | 2019-03-20 | 2020-09-23 | Oslo Universitetssykehus HF | Recombinant proteins and fusion proteins |
| CN115433776B (zh) * | 2022-09-30 | 2023-12-22 | 中国医学科学院阜外医院 | Ccn3在调控血管平滑肌细胞钙化中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE485834T1 (de) | 1998-09-08 | 2010-11-15 | Ford Henry Health System | Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten |
| US20030059768A1 (en) | 2000-02-25 | 2003-03-27 | Corine Vernet | Novel polypeptides and nucleic acids encoding same |
| US20040009940A1 (en) | 2000-10-20 | 2004-01-15 | Coleman Michael E. | Gene delivery formulations and methods for treatment of ischemic conditions |
| FR2825928B1 (fr) | 2001-06-18 | 2004-04-02 | Ecole Norm Superieure Cachan | Composition pharmaceutique pour le diagnostic, la prevention ou le traitement d'une pathologie tumorale, comprenant un agent modulateur de l'etat polymerisation de l'actine |
| EP1382347A1 (en) | 2002-07-17 | 2004-01-21 | UNIVERSITE PARIS 7 - Denis DIDEROT | Use of CCN protein family members for the treatment of disorder associated to an altered calcium and/or sodium flux |
| EP1608970A4 (en) | 2003-03-31 | 2006-06-14 | Munin Corp | CCN3 COMPOSITIONS AND METHODS |
| FR2858234B1 (fr) * | 2003-08-01 | 2007-09-14 | Centre Nat Rech Scient | Nouvel agent anti-angiogenique et son utilisation, notamment dans le cadre du traitement des cancers |
| CA2582224A1 (en) * | 2004-09-28 | 2006-04-06 | Lester F. Lau | Compositions and methods for modulating tissue regeneration and chemotactic responses |
| DK1841316T3 (da) * | 2005-01-10 | 2011-08-08 | Univ Rosalind Franklin Medicine & Science | CCN3-protein til anvendelse ved behandling og diagnose af nyresygdomme |
| US7780949B2 (en) * | 2005-01-10 | 2010-08-24 | Rosalind Franklin University Of Medicine And Science | Regulation of CCN2 by CCN3 and its therapeutic and diagnostic potential in fibrosis, sclerosis and other diseases |
| GB0618748D0 (en) * | 2006-09-22 | 2006-11-01 | Univ Belfast | Peptide |
-
2011
- 2011-04-04 CN CN201180026057.3A patent/CN102947326B/zh not_active Expired - Fee Related
- 2011-04-04 WO PCT/US2011/031121 patent/WO2011123858A2/en not_active Ceased
- 2011-04-04 JP JP2013502918A patent/JP5939584B2/ja not_active Expired - Fee Related
- 2011-04-04 US US13/079,693 patent/US8518395B2/en active Active
- 2011-04-04 DK DK11763563.1T patent/DK2552462T3/en active
- 2011-04-04 ES ES11763563.1T patent/ES2561437T3/es active Active
- 2011-04-04 EP EP11763563.1A patent/EP2552462B1/en not_active Not-in-force
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