JP2015180693A5 - - Google Patents
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- Publication number
- JP2015180693A5 JP2015180693A5 JP2015135207A JP2015135207A JP2015180693A5 JP 2015180693 A5 JP2015180693 A5 JP 2015180693A5 JP 2015135207 A JP2015135207 A JP 2015135207A JP 2015135207 A JP2015135207 A JP 2015135207A JP 2015180693 A5 JP2015180693 A5 JP 2015180693A5
- Authority
- JP
- Japan
- Prior art keywords
- aromatic
- peptide
- cationic peptide
- isolated
- dmt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000002107 myocardial effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44477703P | 2003-02-04 | 2003-02-04 | |
| US60/444,777 | 2003-02-04 | ||
| US53569004P | 2004-01-08 | 2004-01-08 | |
| US60/535,690 | 2004-01-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013182343A Division JP5837542B2 (ja) | 2003-02-04 | 2013-09-03 | ミトコンドリア透過性転移の阻止方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017025764A Division JP2017095519A (ja) | 2003-02-04 | 2017-02-15 | ミトコンドリア透過性転移の阻止方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015180693A JP2015180693A (ja) | 2015-10-15 |
| JP2015180693A5 true JP2015180693A5 (enExample) | 2016-06-09 |
| JP6166312B2 JP6166312B2 (ja) | 2017-07-19 |
Family
ID=32853391
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503317A Expired - Lifetime JP4838114B2 (ja) | 2003-02-04 | 2004-02-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2010241738A Expired - Lifetime JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
| JP2013182343A Expired - Lifetime JP5837542B2 (ja) | 2003-02-04 | 2013-09-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2014202889A Expired - Lifetime JP6126059B2 (ja) | 2003-02-04 | 2014-10-01 | ミトコンドリア透過性転移の阻止方法 |
| JP2015135207A Expired - Lifetime JP6166312B2 (ja) | 2003-02-04 | 2015-07-06 | ミトコンドリア透過性転移の阻止方法 |
| JP2017025764A Pending JP2017095519A (ja) | 2003-02-04 | 2017-02-15 | ミトコンドリア透過性転移の阻止方法 |
| JP2019001256A Pending JP2019089773A (ja) | 2003-02-04 | 2019-01-08 | ミトコンドリア透過性転移の阻止方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503317A Expired - Lifetime JP4838114B2 (ja) | 2003-02-04 | 2004-02-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2010241738A Expired - Lifetime JP5775285B2 (ja) | 2003-02-04 | 2010-10-28 | ミトコンドリア透過性転移の阻止方法 |
| JP2013182343A Expired - Lifetime JP5837542B2 (ja) | 2003-02-04 | 2013-09-03 | ミトコンドリア透過性転移の阻止方法 |
| JP2014202889A Expired - Lifetime JP6126059B2 (ja) | 2003-02-04 | 2014-10-01 | ミトコンドリア透過性転移の阻止方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017025764A Pending JP2017095519A (ja) | 2003-02-04 | 2017-02-15 | ミトコンドリア透過性転移の阻止方法 |
| JP2019001256A Pending JP2019089773A (ja) | 2003-02-04 | 2019-01-08 | ミトコンドリア透過性転移の阻止方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US7576061B2 (enExample) |
| EP (9) | EP2865385B1 (enExample) |
| JP (7) | JP4838114B2 (enExample) |
| CN (3) | CN102784383B (enExample) |
| AU (1) | AU2004209663B2 (enExample) |
| CA (1) | CA2515080C (enExample) |
| CY (2) | CY1114959T1 (enExample) |
| DK (3) | DK1599216T3 (enExample) |
| ES (3) | ES2436011T3 (enExample) |
| HU (1) | HUE027110T2 (enExample) |
| PT (2) | PT1599216E (enExample) |
| SI (1) | SI2656854T1 (enExample) |
| WO (1) | WO2004070054A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2865385B1 (en) | 2003-02-04 | 2016-11-16 | Cornell Research Foundation, Inc. | Uses of aromatic-cationic peptide |
| ZA200509229B (en) * | 2003-05-01 | 2007-03-28 | Cornell Res Foundation Inc | Method and carrier complexes for delivering molecules to cells |
| CA2971928C (en) | 2004-01-23 | 2019-01-08 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| AU2014203126B2 (en) * | 2005-09-16 | 2016-03-10 | Cornell Research Foundation, Inc. | Methods for reducing cd36 expression |
| EP3260127B1 (en) * | 2005-09-16 | 2019-05-01 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method of treating cerebral ischemia |
| PL2252312T3 (pl) | 2008-02-07 | 2014-10-31 | Univ Cornell | Sposoby zapobiegania lub leczenia insulinooporności |
| JP5677096B2 (ja) | 2008-02-26 | 2015-02-25 | コーネル ユニヴァーシティー | 急性腎障害を予防および治療するための方法 |
| DE102008061044A1 (de) * | 2008-12-11 | 2010-06-17 | Henkel Ag & Co. Kgaa | Zusammensetzung mit antioxidativ wirksamen Peptiden |
| EP3563862B1 (en) * | 2009-03-20 | 2021-05-05 | The General Hospital Corporation d/b/a Massachusetts General Hospital | D-arg-2'6'-dimethyltyrosine-lys-phe-nh2 for use in the prevention of secondary complications of burn injuries |
| CN105031605A (zh) * | 2009-08-12 | 2015-11-11 | 康奈尔大学 | 预防或治疗代谢综合症的方法 |
| EP3150215A1 (en) | 2009-08-24 | 2017-04-05 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating opthalmic conditions |
| CN102711785A (zh) * | 2009-10-05 | 2012-10-03 | 康奈尔大学 | 预防或治疗心力衰竭的方法 |
| EP3100739A1 (en) * | 2009-12-31 | 2016-12-07 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| CN103751763A (zh) * | 2009-12-31 | 2014-04-30 | 康肽德生物医药技术有限公司 | 用于预防或治疗血管阻塞损伤的方法 |
| CN104725472A (zh) * | 2010-01-25 | 2015-06-24 | 康奈尔大学 | 芳香族阳离子肽及其用途 |
| WO2011106717A1 (en) * | 2010-02-26 | 2011-09-01 | University Of Florida Research Foundation, Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3560508A1 (en) * | 2010-03-15 | 2019-10-30 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| US20110245183A1 (en) * | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| US20110245182A1 (en) | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| EP3290433A1 (en) * | 2010-05-03 | 2018-03-07 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| CN105879008A (zh) * | 2010-07-09 | 2016-08-24 | 康德生物医疗技术公司 | 预防或治疗缺血/再灌注损伤之后无复流的方法 |
| WO2014137496A1 (en) * | 2013-03-08 | 2014-09-12 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| US20160176930A1 (en) | 2010-07-09 | 2016-06-23 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| US20120083452A1 (en) | 2010-09-30 | 2012-04-05 | Perricone Nicholas V | Topical Anesthetic Uses of Szeto-Schiller Peptides |
| EP3488941A1 (en) * | 2011-03-24 | 2019-05-29 | Cornell University | Aromatic-cationic peptides and uses of same |
| EP2758411A2 (en) * | 2011-09-19 | 2014-07-30 | Gencia Corporation | Modified creatine compounds |
| CN107496899A (zh) * | 2011-09-29 | 2017-12-22 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| WO2013059071A1 (en) * | 2011-10-17 | 2013-04-25 | Cornell University | Aromatic-cationic peptides and uses of same |
| EP2788013A4 (en) * | 2011-12-09 | 2015-08-19 | Stealth Peptides Int Inc | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
| EP3170506B1 (en) | 2012-03-30 | 2018-05-16 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment neuropathy |
| CN104661670A (zh) * | 2012-08-02 | 2015-05-27 | 康肽德生物医药技术有限公司 | 用于治疗动脉粥样硬化的方法 |
| MX2015005102A (es) * | 2012-10-22 | 2016-02-09 | Stealth Peptides Int Inc | Metodos para la reduccion de los riesgos asociados con el insuficiencia cardiaca y factores asociado con el mismo. |
| CN115990242A (zh) | 2013-03-01 | 2023-04-21 | 康德生物医疗有限公司 | 预防或治疗巴斯综合征的方法和组合物 |
| CN117752766A (zh) * | 2013-03-01 | 2024-03-26 | 康德生物医疗有限公司 | 治疗线粒体疾病的方法 |
| US9850278B2 (en) | 2013-04-25 | 2017-12-26 | Carmel-Haifa University Economic Corp. | Synthetic anti-inflammatory peptides and use thereof |
| WO2014209905A2 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods and compositions for detecting and diagnosing diseases and conditions |
| US20160193278A1 (en) * | 2013-08-01 | 2016-07-07 | Stealth Biotherapeutics Corp | Methods and compositions for preventing or treating leber's hereditary optic neuropathy |
| CA2920020C (en) | 2013-08-02 | 2023-03-14 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of friedreich's ataxia |
| CN106163537A (zh) * | 2013-09-30 | 2016-11-23 | 康奈尔大学 | 心磷脂靶向肽抑制β‑淀粉样蛋白寡聚物毒性 |
| CN106536056B (zh) | 2014-06-13 | 2021-07-16 | 儿童医学中心公司 | 分离线粒体的产品和方法 |
| PL3160984T3 (pl) | 2014-06-25 | 2021-10-25 | Flamma S.P.A. | Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylol- fenyloalaninoamidu |
| PL3160985T3 (pl) | 2014-06-30 | 2021-12-27 | Flamma S.P.A. | Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylo-l-fenyloalaninoamidu |
| WO2016004093A2 (en) * | 2014-07-01 | 2016-01-07 | Stealth Biotherapeutics Corp | Therapeutic compositions including galectin-3 inhibitors and uses thereof |
| CN104306954B (zh) * | 2014-09-25 | 2016-08-24 | 中山大学 | Wry三肽在制备治疗阿尔茨海默症药物中的用途 |
| US10603325B2 (en) | 2014-10-29 | 2020-03-31 | University Of Maryland | Methods of treating age-related symptoms in mammals and compositions therefor |
| WO2017015660A1 (en) * | 2015-07-23 | 2017-01-26 | Salk Institute For Biological Studies | Prevention and treatment of aging and neurodegenerative diseases |
| WO2017093897A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| EP3402490B1 (en) | 2016-01-15 | 2022-06-01 | The Children's Medical Center Corporation | Therapeutic use of mitochondria and combined mitochondrial agents |
| CN109476700A (zh) | 2016-03-11 | 2019-03-15 | 隐形生物治疗公司 | 结晶盐形式 |
| AU2017249218B2 (en) | 2016-04-11 | 2020-08-27 | Arcuate Therapeutics, Inc. | Chiral peptides |
| JP6427691B2 (ja) | 2016-11-30 | 2018-11-21 | 株式会社ダイセル | 撮像装置用レンズモジュール及びその製造方法 |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| WO2019033330A1 (en) | 2017-08-17 | 2019-02-21 | Xw Laboratories, Inc. | PREPARATION AND USES OF DERIVATIVES TRACERS OF OXYGEN REACTIVE SPECIES |
| EP3988561B1 (en) | 2017-09-04 | 2023-06-07 | XWPharma Ltd. | Preparation and use of reactive oxygen species scavenger |
| JP6958860B2 (ja) * | 2017-11-07 | 2021-11-02 | 学校法人自治医科大学 | ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途 |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| KR20210093957A (ko) * | 2018-12-18 | 2021-07-28 | 스텔스 바이오테라퓨틱스 코포레이션 | 미토콘드리아-표적화 펩타이드 |
| US20220347212A1 (en) * | 2019-05-02 | 2022-11-03 | Children`S Medical Center Corporation | Prophylactic and therapeutic use of mitochondria and combined mitochondrial agents |
| EP3771467A1 (en) | 2019-07-30 | 2021-02-03 | Fundacio Institut de Recerca de l'Hospital de la Santa Creu i sant Pau | Ss-31 for the prevention and/or treatment of aneurysm |
| WO2022055811A1 (en) | 2020-09-09 | 2022-03-17 | Social Profit Network | Methods and compositions for delivery of biotin to mitochondria |
| CN117881411A (zh) | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
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-
2004
- 2004-02-03 EP EP14186875.2A patent/EP2865385B1/en not_active Expired - Lifetime
- 2004-02-03 US US10/771,232 patent/US7576061B2/en active Active
- 2004-02-03 EP EP20210900.5A patent/EP3842055A1/en active Pending
- 2004-02-03 EP EP20130178043 patent/EP2656854B1/en not_active Expired - Lifetime
- 2004-02-03 JP JP2006503317A patent/JP4838114B2/ja not_active Expired - Lifetime
- 2004-02-03 ES ES04707809T patent/ES2436011T3/es not_active Expired - Lifetime
- 2004-02-03 EP EP17192437.6A patent/EP3305313A1/en not_active Withdrawn
- 2004-02-03 EP EP19207802.0A patent/EP3659618A1/en not_active Withdrawn
- 2004-02-03 DK DK04707809.2T patent/DK1599216T3/da active
- 2004-02-03 CN CN201210177633.0A patent/CN102784383B/zh not_active Expired - Lifetime
- 2004-02-03 CA CA2515080A patent/CA2515080C/en not_active Expired - Lifetime
- 2004-02-03 AU AU2004209663A patent/AU2004209663B2/en not_active Expired
- 2004-02-03 PT PT47078092T patent/PT1599216E/pt unknown
- 2004-02-03 DK DK14186875.2T patent/DK2865385T3/en active
- 2004-02-03 SI SI200432258T patent/SI2656854T1/sl unknown
- 2004-02-03 HU HUE13178043A patent/HUE027110T2/en unknown
- 2004-02-03 EP EP11009660.9A patent/EP2491943B1/en not_active Expired - Lifetime
- 2004-02-03 EP EP04707809.2A patent/EP1599216B9/en not_active Expired - Lifetime
- 2004-02-03 ES ES13178043.9T patent/ES2540897T3/es not_active Expired - Lifetime
- 2004-02-03 EP EP16192437.8A patent/EP3144009A1/en not_active Withdrawn
- 2004-02-03 DK DK13178043.9T patent/DK2656854T3/en active
- 2004-02-03 CN CN201410412683.1A patent/CN104225574B/zh not_active Expired - Lifetime
- 2004-02-03 CN CN2012100218642A patent/CN102617706A/zh active Pending
- 2004-02-03 WO PCT/US2004/003193 patent/WO2004070054A2/en not_active Ceased
- 2004-02-03 EP EP18199147.2A patent/EP3479838A1/en not_active Withdrawn
- 2004-02-03 PT PT131780439T patent/PT2656854E/pt unknown
- 2004-02-03 ES ES14186875.2T patent/ES2605504T3/es not_active Expired - Lifetime
-
2006
- 2006-06-30 US US11/427,804 patent/US7718620B2/en active Active
-
2010
- 2010-04-02 US US12/753,403 patent/US20100190718A1/en not_active Abandoned
- 2010-10-28 JP JP2010241738A patent/JP5775285B2/ja not_active Expired - Lifetime
-
2011
- 2011-09-28 US US13/247,648 patent/US8404646B2/en not_active Expired - Fee Related
-
2013
- 2013-02-27 US US13/778,994 patent/US8957030B2/en not_active Expired - Lifetime
- 2013-09-03 JP JP2013182343A patent/JP5837542B2/ja not_active Expired - Lifetime
-
2014
- 2014-01-24 CY CY20141100064T patent/CY1114959T1/el unknown
- 2014-10-01 JP JP2014202889A patent/JP6126059B2/ja not_active Expired - Lifetime
-
2015
- 2015-01-13 US US14/595,946 patent/US20150359838A1/en not_active Abandoned
- 2015-07-06 JP JP2015135207A patent/JP6166312B2/ja not_active Expired - Lifetime
- 2015-08-03 CY CY20151100675T patent/CY1116575T1/el unknown
-
2017
- 2017-02-15 JP JP2017025764A patent/JP2017095519A/ja active Pending
-
2019
- 2019-01-08 JP JP2019001256A patent/JP2019089773A/ja active Pending
- 2019-09-12 US US16/569,573 patent/US20200038472A1/en not_active Abandoned
-
2022
- 2022-02-10 US US17/668,744 patent/US20230293624A1/en not_active Abandoned
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