JP2013516479A5 - - Google Patents
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- Publication number
- JP2013516479A5 JP2013516479A5 JP2012548125A JP2012548125A JP2013516479A5 JP 2013516479 A5 JP2013516479 A5 JP 2013516479A5 JP 2012548125 A JP2012548125 A JP 2012548125A JP 2012548125 A JP2012548125 A JP 2012548125A JP 2013516479 A5 JP2013516479 A5 JP 2013516479A5
- Authority
- JP
- Japan
- Prior art keywords
- unsaturated bond
- contain
- branched
- lower alkyl
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29277610P | 2010-01-06 | 2010-01-06 | |
| US61/292,776 | 2010-01-06 | ||
| PCT/US2011/020414 WO2011085126A2 (en) | 2010-01-06 | 2011-01-06 | Methods and compositions of targeted drug development |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013516479A JP2013516479A (ja) | 2013-05-13 |
| JP2013516479A5 true JP2013516479A5 (https=) | 2014-11-06 |
Family
ID=44306150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548125A Pending JP2013516479A (ja) | 2010-01-06 | 2011-01-06 | 標的薬物を開発する方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8618302B2 (https=) |
| EP (2) | EP2521551A4 (https=) |
| JP (1) | JP2013516479A (https=) |
| KR (1) | KR20130027080A (https=) |
| CN (1) | CN102811723A (https=) |
| AU (1) | AU2011204368B2 (https=) |
| CA (2) | CA2786289A1 (https=) |
| MX (1) | MX2012007872A (https=) |
| SG (1) | SG182343A1 (https=) |
| WO (2) | WO2011085129A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8658170B2 (en) | 2010-01-06 | 2014-02-25 | Joseph P. Errico | Combination therapy with MDM2 and EFGR inhibitors |
| AU2011204368B2 (en) * | 2010-01-06 | 2014-11-27 | Joseph P. Errico | Methods and compositions of targeted drug development |
| EP2536709A4 (en) * | 2010-02-17 | 2013-11-27 | Univ Cornell | PROLYL HYDROXYLASE HEMMER AND USE METHOD THEREFOR |
| HUP1000243A2 (en) * | 2010-05-06 | 2012-01-30 | Avidin Kft | 8-hidroxy-quinoline derivatives |
| AU2011255627A1 (en) * | 2010-05-18 | 2012-12-06 | Eastern Virginia Medical School | Inhibitors of human 12-lipoxygenase |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| EP2596366A4 (en) * | 2010-07-21 | 2014-04-16 | Joseph P Errico | COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS |
| EP2716292B1 (en) * | 2011-05-23 | 2017-09-06 | ONCO Biomedical Technology (Suzhou) Co., Ltd | Cdc42 inhibitor and uses thereof |
| US8710043B2 (en) | 2011-06-24 | 2014-04-29 | Amgen Inc. | TRPM8 antagonists and their use in treatments |
| EP2723718A1 (en) | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| CN102503945A (zh) * | 2011-11-28 | 2012-06-20 | 华东理工大学 | 能够抑制表皮生长因子受体的化合物及其应用 |
| CA2873902A1 (en) * | 2012-05-18 | 2013-11-21 | Georgetown University | Methods and systems for populating and searching a drug informatics database |
| US20150150869A1 (en) * | 2012-06-20 | 2015-06-04 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| EP2922544B1 (en) | 2012-11-21 | 2018-08-01 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| CA2912313A1 (en) | 2013-05-14 | 2014-11-20 | Active Biotech Ab | N-(heteroaryl)-sulfonamide derivatives useful as s100-inhibitors |
| WO2015017788A1 (en) | 2013-08-01 | 2015-02-05 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
| KR20160128288A (ko) * | 2013-10-07 | 2016-11-07 | 리서치 파운데이션 오브 더 시티 유니버시티 오브 뉴욕 | 수계 약리작용단을 이용하는 방법 |
| WO2015066305A1 (en) | 2013-10-30 | 2015-05-07 | Eutropics Pharmaceuticals, Inc. | Methods for determining chemosensitivity and chemotoxicity |
| CN104016908B (zh) * | 2014-04-03 | 2016-04-20 | 定陶县友帮化工有限公司 | 一种2-氨基-3,5-二氯吡啶的合成方法 |
| CN104402831B (zh) * | 2014-10-24 | 2016-08-17 | 郑州大学 | 含酰脲结构单元的-5-氰基嘧啶衍生物及其制备方法和用途 |
| CN104744439A (zh) * | 2015-02-10 | 2015-07-01 | 南开大学 | 8-羟基喹啉类ntr1小分子拮抗剂及应用 |
| HUP1500098A2 (hu) * | 2015-03-09 | 2016-09-28 | Avidin Kft | 8-hidroxikinolin származékok új enantiomerjei és szintézisük |
| WO2017066245A1 (en) * | 2015-10-12 | 2017-04-20 | Health Research, Inc. | Methods for inducing apoptosis in cancer cells |
| EP3388419A1 (en) * | 2017-04-12 | 2018-10-17 | Leadiant Biosciences SA | Gli1 inhibitors and uses thereof |
| WO2019043635A1 (en) | 2017-09-01 | 2019-03-07 | Richter Gedeon Nyrt. | COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE |
| CN113226323B (zh) * | 2018-11-15 | 2024-12-31 | 法国古士塔柏罗斯学院 | 马德辛衍生化合物、组合物及其用于治疗癌症的用途 |
| TW202218665A (zh) | 2020-09-21 | 2022-05-16 | 德國阿爾伯特路德維希弗萊堡大學 | 用於治療或預防造血細胞移植後血液科贅瘤(neoplasm)復發之mdm2抑制劑 |
| CN112250637A (zh) * | 2020-10-30 | 2021-01-22 | 中山大学 | 虚拟筛选的化合物在制备抗肿瘤药物中的应用及其药物 |
| CN114195691B (zh) * | 2021-12-16 | 2023-10-20 | 贵州大学 | 一种含酰胺的阿魏酸衍生物及其制备方法和应用 |
| WO2024073624A2 (en) * | 2022-09-28 | 2024-04-04 | The Research Foundation For The State University Of New York | Antiproliferative betti bases and prodrugs thereof |
| CN115572266B (zh) * | 2022-10-24 | 2023-10-03 | 南方医科大学 | 一种蛋白抑制剂、一种试剂组及其应用 |
| CN120463779B (zh) * | 2025-07-10 | 2025-09-19 | 南京农业大学三亚研究院 | 真菌效应子药靶Nep1及基于该药靶的高通量药物分子筛选和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3641474A (en) | 1970-05-11 | 1972-02-08 | Rca Corp | Semiconductor mounting structure |
| US6664288B1 (en) | 1999-04-14 | 2003-12-16 | Dana Farber Cancer Institute, Inc. | Method and composition for the treatment of cancer |
| US6465448B1 (en) | 1999-08-13 | 2002-10-15 | Case Western Reserve University | Methoxyamine potentiation of temozolomide anti-cancer activity |
| US6931325B2 (en) | 2001-02-07 | 2005-08-16 | Regents Of The University Of Michigan | Three dimensional protein mapping |
| EP1479693A4 (en) | 2002-02-05 | 2005-07-27 | Japan Science & Tech Agency | EGF / EGFR COMPLEX |
| US6916455B2 (en) | 2002-08-14 | 2005-07-12 | The Regents Of The University Of California | Protein crystallography prescreen kit |
| US20080305041A1 (en) | 2004-11-19 | 2008-12-11 | Bioquanta Corp. | Pf4 Pharmacophores and Their Uses |
| CN102206216B (zh) * | 2005-06-22 | 2014-11-12 | 普莱希科公司 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
| US7754724B2 (en) * | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
| EP2606890A1 (en) | 2006-04-05 | 2013-06-26 | Novartis AG | Combinations comprising BCR-ABL/C-KIT/PDGF-R TK inhibitors for treating cancer |
| WO2007139946A2 (en) | 2006-05-25 | 2007-12-06 | University Of Tennessee Research Foundation | Gpcr ligands identified by computational modeling |
| RU2009106461A (ru) | 2006-07-25 | 2010-08-27 | Энвиво Фармасьютикалз, Инк. (Us) | Хинолиновые производные |
| EP2056823A2 (en) | 2006-08-23 | 2009-05-13 | Wyeth | 8-hydroxyquinoline compounds and methods thereof |
| EP3085367A3 (en) * | 2007-03-20 | 2017-01-25 | Brandeis University | Compositions for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related |
| US8183236B2 (en) * | 2007-04-12 | 2012-05-22 | University Of Southern California | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics |
| US8138356B2 (en) * | 2007-10-16 | 2012-03-20 | Angiogeney, Inc. | Chemical inhibitors of inhibitors of differentiation |
| US8119656B2 (en) * | 2007-12-07 | 2012-02-21 | The Board Of Regents Of The University Of Texas System | Inhibitors of the influenza virus non-structural 1 protein |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009117484A2 (en) * | 2008-03-18 | 2009-09-24 | University Of South Florida | Small molecule e2f inhibitor |
| WO2009137597A1 (en) * | 2008-05-06 | 2009-11-12 | The Trustees Of Columbia University In The City Of New York | COMPOUNDS THAT INHIBIT PRODUCTION OF sAPPβ AND Aβ AND USES THEREOF |
| US10301265B2 (en) * | 2008-05-28 | 2019-05-28 | Virginia I. Roxas-Duncan | Small molecule inhibitors of botulinum neurotoxins |
| US8563580B2 (en) * | 2008-09-23 | 2013-10-22 | Georgetown University | Flavivirus inhibitors and methods for their use |
| AR077892A1 (es) | 2009-08-20 | 2011-09-28 | Vifor Int Ag | Quinolinas antagonistas de la hepcidina |
| AU2011204368B2 (en) * | 2010-01-06 | 2014-11-27 | Joseph P. Errico | Methods and compositions of targeted drug development |
-
2011
- 2011-01-06 AU AU2011204368A patent/AU2011204368B2/en not_active Ceased
- 2011-01-06 JP JP2012548125A patent/JP2013516479A/ja active Pending
- 2011-01-06 WO PCT/US2011/020418 patent/WO2011085129A2/en not_active Ceased
- 2011-01-06 EP EP20110732163 patent/EP2521551A4/en not_active Withdrawn
- 2011-01-06 WO PCT/US2011/020414 patent/WO2011085126A2/en not_active Ceased
- 2011-01-06 SG SG2012049292A patent/SG182343A1/en unknown
- 2011-01-06 KR KR1020127020466A patent/KR20130027080A/ko not_active Withdrawn
- 2011-01-06 CN CN2011800126057A patent/CN102811723A/zh active Pending
- 2011-01-06 MX MX2012007872A patent/MX2012007872A/es active IP Right Grant
- 2011-01-06 CA CA2786289A patent/CA2786289A1/en not_active Abandoned
- 2011-01-06 EP EP11732160.4A patent/EP2521553A4/en not_active Withdrawn
- 2011-01-06 CA CA2786277A patent/CA2786277A1/en not_active Abandoned
- 2011-01-06 US US12/986,146 patent/US8618302B2/en not_active Expired - Fee Related
-
2013
- 2013-12-04 US US14/096,661 patent/US20140163069A1/en not_active Abandoned
- 2013-12-04 US US14/096,618 patent/US9073858B2/en not_active Expired - Fee Related
-
2014
- 2014-01-08 US US14/150,655 patent/US20140179681A1/en not_active Abandoned
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