JP2013513564A5 - - Google Patents
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- Publication number
- JP2013513564A5 JP2013513564A5 JP2012542487A JP2012542487A JP2013513564A5 JP 2013513564 A5 JP2013513564 A5 JP 2013513564A5 JP 2012542487 A JP2012542487 A JP 2012542487A JP 2012542487 A JP2012542487 A JP 2012542487A JP 2013513564 A5 JP2013513564 A5 JP 2013513564A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- methyl
- pyridinyl
- phenyl
- imidazolidinedione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0921760A GB0921760D0 (en) | 2009-12-11 | 2009-12-11 | Novel compounds |
| GB0921760.5 | 2009-12-11 | ||
| GB1012924.5 | 2010-07-30 | ||
| GBGB1012924.5A GB201012924D0 (en) | 2010-07-30 | 2010-07-30 | Novel compounds |
| PCT/EP2010/068946 WO2011069951A1 (en) | 2009-12-11 | 2010-12-06 | Imidazolidinedione derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513564A JP2013513564A (ja) | 2013-04-22 |
| JP2013513564A5 true JP2013513564A5 (enExample) | 2014-02-06 |
| JP5788404B2 JP5788404B2 (ja) | 2015-09-30 |
Family
ID=43446689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542487A Expired - Fee Related JP5788404B2 (ja) | 2009-12-11 | 2010-12-06 | イミダゾリジンジオン誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US8722695B2 (enExample) |
| EP (1) | EP2509961B1 (enExample) |
| JP (1) | JP5788404B2 (enExample) |
| KR (1) | KR101735675B1 (enExample) |
| CN (1) | CN102753533B (enExample) |
| AU (1) | AU2010330048B9 (enExample) |
| BR (1) | BR112012015868A2 (enExample) |
| CA (1) | CA2781685C (enExample) |
| DK (1) | DK2509961T3 (enExample) |
| EA (1) | EA019970B8 (enExample) |
| ES (1) | ES2575215T3 (enExample) |
| IL (1) | IL219628A (enExample) |
| MX (1) | MX2012006615A (enExample) |
| PL (1) | PL2509961T3 (enExample) |
| WO (1) | WO2011069951A1 (enExample) |
| ZA (1) | ZA201203233B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8519176B1 (en) * | 2009-10-05 | 2013-08-27 | Boehringer Ingelheim International Gmbh | Process for preparation of substituted P-aminophenol |
| PL2509961T3 (pl) | 2009-12-11 | 2016-09-30 | Pochodne imidazolidynodionu | |
| RS54369B1 (sr) | 2010-10-08 | 2016-04-28 | Nivalis Therapeutics, Inc. | Nova jedinjenja hinolina supstituisana kao inhibitori s-nitrosoglutathione reduktaze |
| US9346790B2 (en) | 2010-12-06 | 2016-05-24 | Autifony Therapeutics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
| GB201209986D0 (en) | 2012-06-06 | 2012-07-18 | Autifony Therapeutics Ltd | Novel compounds |
| JP6008953B2 (ja) * | 2011-06-07 | 2016-10-19 | アウトイフオンイ トヘラペウトイクス リミテッド | Kv3阻害剤としてのヒダントイン誘導体 |
| PL2788339T3 (pl) * | 2011-12-06 | 2016-09-30 | Pochodne hydantoiny przydatne jako inhibitory KV3 | |
| BR112014028718A2 (pt) * | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
| US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
| WO2013182851A1 (en) * | 2012-06-06 | 2013-12-12 | Autifony Therapeutics Limited | Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required |
| AU2014312756B2 (en) * | 2013-08-29 | 2018-11-22 | Kyoto Pharmaceutical Industries, Ltd. | Novel aromatic compound and use thereof |
| DK3372585T3 (da) * | 2014-12-19 | 2022-05-30 | Aragon Pharmaceuticals Inc | Fremgangsmåde til fremstillingen af en diarylthiohydantoinforbindelse |
| GB201521751D0 (en) * | 2015-12-10 | 2016-01-27 | Autifony Therapeutics Ltd | Novel uses |
| CN105837453A (zh) * | 2016-03-31 | 2016-08-10 | 常州大学 | 一种3,5-二氯-4’-硝基二苯醚的合成方法 |
| GB201613163D0 (en) | 2016-07-29 | 2016-09-14 | Autifony Therapeutics Ltd | Novel compounds |
| CN108101811A (zh) * | 2016-11-25 | 2018-06-01 | 斯福瑞(南通)制药有限公司 | 生产n-叔丁氧羰基-2-氨基-3,3-二甲基丁酸的方法 |
| US20200039970A1 (en) | 2016-12-16 | 2020-02-06 | Autifony Therapeutics Limited | Hydantoin modulators of kv3 channels |
| WO2018204164A1 (en) | 2017-05-02 | 2018-11-08 | Fmc Corporation | Pyrimidinyloxy benzo-fused compounds as herbicides |
| WO2018220762A1 (ja) * | 2017-05-31 | 2018-12-06 | 大塚製薬株式会社 | ピリミジン化合物 |
| CA3110251A1 (en) * | 2018-09-21 | 2019-11-28 | Bionomics Limited | Substituted-pyridinyl compounds and uses thereof |
| HRP20241318T1 (hr) | 2018-10-16 | 2024-12-20 | Autifony Therapeutics Limited | Novi spojevi |
| US12358901B2 (en) | 2018-10-16 | 2025-07-15 | Autifony Therapeutics Limited | KV3 modulators |
| CN113166076A (zh) | 2018-11-30 | 2021-07-23 | 大塚制药株式会社 | 用于治疗癫痫的杂环化合物 |
| JP6870064B2 (ja) * | 2018-11-30 | 2021-05-12 | 大塚製薬株式会社 | ピリミジン化合物の医薬用途 |
| EP3947365B1 (en) * | 2019-03-25 | 2025-10-01 | Bionomics Limited | Substituted-n-heteroaryl compounds and uses thereof |
| PH12022551955A1 (en) | 2020-02-06 | 2023-10-23 | Autifony Therapeutics Ltd | Novel compound |
| EP3901152A1 (en) * | 2020-04-23 | 2021-10-27 | F. Hoffmann-La Roche AG | Kv3 enhancers for the treatment of cognitive disorders |
| GB2594931A (en) * | 2020-05-06 | 2021-11-17 | Syngenta Crop Protection Ag | Improvements in or relating to organic compounds |
| IL310160A (en) | 2021-08-10 | 2024-03-01 | Autifony Therapeutics Ltd | potassium channel modulators |
| CN114605331A (zh) * | 2022-03-17 | 2022-06-10 | 上海健康医学院 | 一种尼鲁米特及其中间体的制备方法 |
| JP2025512828A (ja) * | 2022-03-28 | 2025-04-22 | バイエル・アクチエンゲゼルシヤフト | 置換2-アミノアジンおよびその塩、ならびにその除草性活性物質としての使用 |
| WO2024121552A1 (en) | 2022-12-06 | 2024-06-13 | Autifony Therapeutics Limited | Compounds for the treatment of centra nervous system disorders |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1147725A (en) * | 1966-03-30 | 1969-04-02 | Mitsui Kagaku Kogyo Kabushiki | Novel halodiphenylethers for use as herbicides |
| US4099007A (en) * | 1969-04-02 | 1978-07-04 | Hoechst Aktiengesellschaft | N,n-substituted 2,4,5-triketoimidazolidines and a process for their preparation |
| DE2916647A1 (de) * | 1979-04-25 | 1980-11-06 | Basf Ag | Parabansaeurederivate |
| DE3015090A1 (de) | 1980-04-19 | 1981-10-22 | Basf Ag, 6700 Ludwigshafen | ]-(trihalogenmethyl-sulfenyl)-4-aryl-1,2,4-triazolidin-5-one, verfahren zu ihrer herstellung, diese enthaltende fungizide und verfahren zur bekaempfung von pilzen mit diesen verbindungen |
| DE3133405A1 (de) | 1981-08-24 | 1983-03-10 | Basf Ag, 6700 Ludwigshafen | 1-(trihalogenmethyl-sulfenyl)-4-aryl-1,2,4-triazolidin-5-one und diese enthaltende fungizide |
| US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
| JP2514945B2 (ja) | 1987-02-05 | 1996-07-10 | 三井石油化学工業株式会社 | 芳香族アミン誘導体 |
| DE3810848A1 (de) | 1988-03-30 | 1989-10-19 | Boehringer Ingelheim Kg | Neue 2,3,4-substituierte imidazole und 3,4,5-substituierte 1,2,4-triazole, ihre herstellung und verwendung |
| DE3836175A1 (de) | 1988-10-24 | 1990-05-03 | Bayer Ag | Fluor enthaltende phenole |
| WO1991004027A1 (en) | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
| US6002016A (en) * | 1991-12-20 | 1999-12-14 | Rhone-Poulenc Agrochimie | Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones |
| FR2706456B1 (fr) * | 1993-06-18 | 1996-06-28 | Rhone Poulenc Agrochimie | Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides. |
| DK123493D0 (da) | 1993-11-01 | 1993-11-01 | Lundbeck & Co As H | Compounds |
| MX9708802A (es) | 1995-05-17 | 1998-02-28 | Du Pont | Amidas ciclicas fungicidas. |
| WO1996036229A1 (en) | 1995-05-17 | 1996-11-21 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
| HUP9901228A3 (en) | 1995-06-20 | 2001-11-28 | Du Pont | Cyclic amides, their intermediates, arthropodicide and fungicide compositions containing theses compounds as active ingredients and use thereof |
| AU3889097A (en) | 1996-08-01 | 1998-02-25 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
| WO1998023155A1 (en) | 1996-11-26 | 1998-06-04 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
| JP2001506984A (ja) | 1996-11-26 | 2001-05-29 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | メチル置換された殺菌・殺カビ剤および殺節足動物剤 |
| WO1998033382A1 (en) | 1997-01-30 | 1998-08-06 | E.I. Du Pont De Nemours And Company | Fungicidal compositions |
| BRPI9807848B8 (pt) * | 1997-02-21 | 2016-05-31 | Bayer Schering Pharma Ag | compostos de arilsulfonamidas e análogos, bem como composição farmacêutica e uso dos mesmos. |
| JP4171549B2 (ja) | 1998-01-28 | 2008-10-22 | 大正製薬株式会社 | 含フッ素アミノ酸誘導体 |
| AR015733A1 (es) * | 1998-03-25 | 2001-05-16 | Otsuka Pharma Co Ltd | DERIVADO DE PIRIDINA, EL PRODUCTO Y LA COMPOSICIoN FARMACEUTICA QUE CONTIENE DICHO DERIVADO. |
| JP4194715B2 (ja) | 1998-08-31 | 2008-12-10 | 大正製薬株式会社 | 6−フルオロビシクロ[3.1.0]ヘキサン誘導体 |
| JP2000072731A (ja) | 1998-08-31 | 2000-03-07 | Taisho Pharmaceut Co Ltd | 4−置換−2−アミノビシクロ[3.1.0]ヘキサン−2,6−ジカルボン酸誘導体及び製薬用組成物 |
| GB9910577D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| KR20020012309A (ko) | 1999-07-23 | 2002-02-15 | 시오노 요시히코 | Th2 분화 억제제 |
| WO2001074331A1 (en) | 2000-04-04 | 2001-10-11 | Shionogi & Co., Ltd. | Oily compositions containing highly fat-soluble drugs |
| AU2001244610A1 (en) | 2000-04-05 | 2001-10-23 | Shionogi And Co., Ltd. | Oil-in-water microemulsions containing tricyclic compounds or preconcentrates thereof |
| FR2812633A1 (fr) | 2000-08-04 | 2002-02-08 | Aventis Cropscience Sa | Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides |
| GB0026838D0 (en) | 2000-11-02 | 2000-12-20 | Glaxo Group Ltd | Treatment method |
| JPWO2003048134A1 (ja) | 2001-12-05 | 2005-04-14 | 日本たばこ産業株式会社 | トリアゾール化合物及びその医薬用途 |
| TW200307539A (en) * | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| DE60322680D1 (de) | 2002-02-07 | 2008-09-18 | Univ Missouri | Opioid-rezeptor-aktive 4-(3-hydroxyphenyl) oder 4-(3-alkoxyphenyl)-1,2,4-triazol-verbindungen |
| IL165218A0 (en) * | 2002-05-16 | 2005-12-18 | Bayer Cropscience Gmbh | Pyridine carboxamide derivatives and their use as pesticides |
| AU2004236239A1 (en) | 2003-04-30 | 2004-11-18 | The Institutes For Pharmaceutical Discovery, Llc | Substituted heteroaryls as inhibitors of protein tyrosine phosphatases |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| GB0325175D0 (en) | 2003-10-28 | 2003-12-03 | Novartis Ag | Organic compounds |
| US7256208B2 (en) | 2003-11-13 | 2007-08-14 | Bristol-Myers Squibb Company | Monocyclic N-Aryl hydantoin modulators of androgen receptor function |
| GB0413879D0 (en) | 2004-06-21 | 2004-07-21 | Glaxo Group Ltd | Compounds |
| US20060211697A1 (en) | 2004-12-08 | 2006-09-21 | Liren Huang | 2-(2 Or 4-substituted aryloxy)-phenol derivatives as antibacterial agents |
| DE102005001411A1 (de) | 2005-01-12 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| SI2351772T1 (sl) | 2005-02-18 | 2016-11-30 | Glaxosmithkline Biologicals Sa | Proteini in nukleinske kisline iz Escherichia coli povezane z meningitisom/sepso |
| KR101782236B1 (ko) | 2005-05-13 | 2017-09-26 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴히단토인 화합물 |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| US20100113959A1 (en) | 2006-03-07 | 2010-05-06 | Beth Israel Deaconess Medical Center, Inc. | Transcranial magnetic stimulation (tms) methods and apparatus |
| PT2368550E (pt) | 2006-03-27 | 2013-12-03 | Univ California | Modulador do receptor de androgénios para o tratamento de cancro da próstata e doenças associadas ao receptor de androgénios |
| CN101460467B (zh) | 2006-03-29 | 2012-09-19 | 加利福尼亚大学董事会 | 二芳基硫代乙内酰脲化合物 |
| AU2007283113A1 (en) * | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
| BRPI0807717A2 (pt) | 2007-04-20 | 2014-05-20 | Deciphera Pharmaceuticals Llc | Inibidores de quinase úteis para o tratamento de doenças mieloproliferativas e outras doenças proliferativas. |
| WO2009097997A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| EP2252592A1 (de) | 2008-02-07 | 2010-11-24 | Sanofi-Aventis | Arylchalcogeno-arylalkyl-substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| WO2010027818A2 (en) | 2008-08-25 | 2010-03-11 | Dana-Farber Cancer Institute, Inc. | Conserved hemagglutinin epitope, antibodies to the epitope, and methods of use |
| BRPI0924121A2 (pt) | 2008-12-22 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| WO2010149765A1 (en) | 2009-06-26 | 2010-12-29 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Non human animal models for increased retinal vascular permeability |
| PL2509961T3 (pl) * | 2009-12-11 | 2016-09-30 | Pochodne imidazolidynodionu | |
| CA2780526A1 (en) | 2009-12-14 | 2011-06-23 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| US9346790B2 (en) * | 2010-12-06 | 2016-05-24 | Autifony Therapeutics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
| US8648118B2 (en) | 2010-12-17 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Bicyclic ring system substituted amide functionalised phenols as medicaments |
| US8648070B2 (en) | 2010-12-17 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments |
| JP6008953B2 (ja) * | 2011-06-07 | 2016-10-19 | アウトイフオンイ トヘラペウトイクス リミテッド | Kv3阻害剤としてのヒダントイン誘導体 |
| BR112014028718A2 (pt) | 2012-05-22 | 2017-06-27 | Autifony Therapeutics Ltd | derivados de hidantoína como inibidores de kv3 |
| US9422252B2 (en) * | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
-
2010
- 2010-12-06 PL PL10788314.2T patent/PL2509961T3/pl unknown
- 2010-12-06 EA EA201290310A patent/EA019970B8/ru not_active IP Right Cessation
- 2010-12-06 KR KR1020127018080A patent/KR101735675B1/ko not_active Expired - Fee Related
- 2010-12-06 JP JP2012542487A patent/JP5788404B2/ja not_active Expired - Fee Related
- 2010-12-06 MX MX2012006615A patent/MX2012006615A/es active IP Right Grant
- 2010-12-06 AU AU2010330048A patent/AU2010330048B9/en not_active Ceased
- 2010-12-06 CA CA2781685A patent/CA2781685C/en not_active Expired - Fee Related
- 2010-12-06 ES ES10788314.2T patent/ES2575215T3/es active Active
- 2010-12-06 CN CN201080056084.0A patent/CN102753533B/zh not_active Expired - Fee Related
- 2010-12-06 WO PCT/EP2010/068946 patent/WO2011069951A1/en not_active Ceased
- 2010-12-06 DK DK10788314.2T patent/DK2509961T3/en active
- 2010-12-06 US US13/515,097 patent/US8722695B2/en active Active
- 2010-12-06 EP EP10788314.2A patent/EP2509961B1/en active Active
- 2010-12-06 BR BR112012015868A patent/BR112012015868A2/pt active Search and Examination
-
2012
- 2012-05-04 ZA ZA2012/03233A patent/ZA201203233B/en unknown
- 2012-05-07 IL IL219628A patent/IL219628A/en active IP Right Grant
-
2014
- 2014-03-27 US US14/226,988 patent/US9216967B2/en active Active
-
2015
- 2015-11-09 US US14/935,939 patent/US20160058737A1/en not_active Abandoned
-
2016
- 2016-11-10 US US15/348,091 patent/US9849131B2/en active Active
-
2017
- 2017-10-02 US US15/722,623 patent/US10058551B2/en active Active
-
2018
- 2018-07-30 US US16/049,230 patent/US10632118B2/en active Active
-
2020
- 2020-01-30 US US16/777,668 patent/US20200163964A1/en not_active Abandoned
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