JP2013512281A5 - - Google Patents
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- Publication number
- JP2013512281A5 JP2013512281A5 JP2012542165A JP2012542165A JP2013512281A5 JP 2013512281 A5 JP2013512281 A5 JP 2013512281A5 JP 2012542165 A JP2012542165 A JP 2012542165A JP 2012542165 A JP2012542165 A JP 2012542165A JP 2013512281 A5 JP2013512281 A5 JP 2013512281A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- ylamino
- methyl
- tetrazol
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26564809P | 2009-12-01 | 2009-12-01 | |
| US61/265,648 | 2009-12-01 | ||
| US36646910P | 2010-07-21 | 2010-07-21 | |
| US61/366,469 | 2010-07-21 | ||
| US40596810P | 2010-10-22 | 2010-10-22 | |
| US61/405,968 | 2010-10-22 | ||
| PCT/US2010/058597 WO2011068898A1 (en) | 2009-12-01 | 2010-12-01 | Protein kinase c inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512281A JP2013512281A (ja) | 2013-04-11 |
| JP2013512281A5 true JP2013512281A5 (enExample) | 2014-01-23 |
| JP5802677B2 JP5802677B2 (ja) | 2015-10-28 |
Family
ID=43902714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542165A Expired - Fee Related JP5802677B2 (ja) | 2009-12-01 | 2010-12-01 | プロテインキナーゼｃ阻害剤およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110130415A1 (enExample) |
| EP (1) | EP2507227B1 (enExample) |
| JP (1) | JP5802677B2 (enExample) |
| CA (1) | CA2780759A1 (enExample) |
| WO (1) | WO2011068898A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1663242B1 (en) * | 2003-08-07 | 2011-04-27 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents |
| JP6035238B2 (ja) | 2010-07-21 | 2016-11-30 | ライジェル ファーマシューティカルズ， インコーポレイテッド | プロテインキナーゼｃ阻害剤およびその使用 |
| WO2012075316A2 (en) | 2010-12-01 | 2012-06-07 | Rigel Pharmaceuticals, Inc. | Cyclopropyl mida boronate |
| HRP20240097T1 (hr) | 2011-04-22 | 2024-03-29 | Signal Pharmaceuticals, Llc | Supstituirani diaminokarboksamid i diaminokarbonitril pirimidini, njihovi pripravci i postupci liječenja s njima |
| US20140186372A1 (en) * | 2011-06-16 | 2014-07-03 | La Jolla Institute For Allergy And Immunology | Compositions targeting pkc-theta and uses and methods of treating pkc-theta pathologies, adverse immune responses and diseases |
| GB201200555D0 (en) * | 2012-01-13 | 2012-02-29 | Univ Birmingham | Peptide |
| US9839671B2 (en) | 2012-01-13 | 2017-12-12 | The University Of Birmingham | Peptide and uses therefor |
| WO2013152198A1 (en) * | 2012-04-04 | 2013-10-10 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| US8754251B2 (en) | 2012-06-06 | 2014-06-17 | Rigel Pharmaceuticals, Inc. | Cyclopropyl PIDA boronate |
| CA2892677A1 (en) | 2012-12-04 | 2014-06-12 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| CA2904610A1 (en) | 2013-03-14 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| BR112015031291A2 (pt) | 2013-06-20 | 2017-07-25 | Bayer Cropscience Ag | derivados de sulfureto de arila e derivados de arilalquil sulfóxido como acaricidas e inseticidas |
| EP3064492B1 (en) * | 2013-10-28 | 2018-12-26 | Sumitomo Chemical Company, Limited | Tetrazolinone compound and application for same |
| NZ715903A (en) | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
| DE112015001514T5 (de) | 2014-03-28 | 2016-12-29 | Sumitomo Chemical Company, Limited | Verfahren zur Herstellung einer Tetrazolinonverbindung |
| JP6517319B2 (ja) | 2014-03-28 | 2019-05-22 | キャリター・サイエンシーズ・リミテッド・ライアビリティ・カンパニーＣａｌｉｔｏｒ Ｓｃｉｅｎｃｅｓ， Ｌｌｃ | 置換されたヘテロアリール化合物および使用方法 |
| JO3589B1 (ar) * | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| EP3206691B1 (en) | 2014-10-14 | 2018-09-19 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| WO2016100310A1 (en) | 2014-12-16 | 2016-06-23 | Signal Pharmaceuticals, Llc | Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide |
| EP3233808B1 (en) | 2014-12-16 | 2021-07-14 | Signal Pharmaceuticals, LLC | Medical uses comprising methods for measurement of inhibition of c-jun n-terminal kinase in skin |
| CA2974900A1 (en) | 2015-01-26 | 2016-08-04 | Rigel Pharmaceuticals, Inc. | Tetrazolones as carboxylic acid bioisosteres |
| CA2975260C (en) | 2015-01-29 | 2024-05-21 | Signal Pharmaceuticals Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| ES2994877T3 (en) | 2015-07-24 | 2025-02-03 | Celgene Corp | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
| EP3347097B1 (en) | 2015-09-11 | 2021-02-24 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora |
| WO2017096303A2 (en) | 2015-12-04 | 2017-06-08 | Portola Pharmaceuticals, Inc. | Cerdulatinib for treating hematological cancers |
| CN106316864A (zh) * | 2016-08-22 | 2017-01-11 | 苏州天马精细化学品股份有限公司 | 4‑甲基‑3‑三氟甲基苯胺的制备方法 |
| US11225470B2 (en) | 2016-11-28 | 2022-01-18 | Sumitomo Chemical Company, Limited | Tetrazolinone compounds and its use as pest control agents |
| WO2019099311A1 (en) | 2017-11-19 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| EP3560913A1 (en) | 2018-04-25 | 2019-10-30 | Dynamit Nobel GmbH Explosivstoff- und Systemtechnik | Process for the production of tetrazolinones |
| EP3788035B1 (en) | 2018-05-04 | 2024-08-07 | Alexion Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| EP3788033A1 (en) | 2018-05-04 | 2021-03-10 | Portola Pharmaceuticals, Inc. | Synthesis of cerdulatinib |
| EP3616724A1 (en) | 2018-08-27 | 2020-03-04 | SmartDyeLivery GmbH | Pkc inhibitors for the treatment of septic cholestasis with ctm targeting |
| EP3616725A1 (en) | 2018-08-27 | 2020-03-04 | SmartDyeLivery GmbH | Pkc inhibitors for the treatment of septic cholestasis with polymethine dye targeting |
| WO2025097025A1 (en) * | 2023-11-03 | 2025-05-08 | Evommune, Inc. | Protein kinase c (pkc) theta inhibitor compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5136868A (en) * | 1983-11-04 | 1992-08-11 | Fmc Corporation | Herbicidal 1-aryl-4-substituted-1,4-dihydro-5h-tetrazol-5-ones and sulfur analogs thereof |
| JPH0782258A (ja) | 1993-09-14 | 1995-03-28 | Nippon Bayeragrochem Kk | １−置換−テトラゾール−５−オン類の製造方法 |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| GEP20032999B (en) * | 1999-01-13 | 2003-06-25 | Warner Lambert Co | 1-Heterocycle Substituted Diarylamines |
| DK1438053T3 (da) * | 2001-10-17 | 2008-12-08 | Boehringer Ingelheim Pharma | Pyrimidinderivater, lægemiddel indeholdende disse forbindelser, deres anvendelse og fremgangsmåder til deres fremstilling |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| BR0313059B8 (pt) * | 2002-07-29 | 2021-07-27 | Rigel Pharmaceuticals | composto, e, composição farmacêutica |
| AU2003290688B8 (en) | 2002-11-08 | 2008-04-24 | Tolerx, Inc. | Molecules preferentially associated with effector T cells and methods of their use |
| CN102358738A (zh) | 2003-07-30 | 2012-02-22 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途 |
| EP1663242B1 (en) * | 2003-08-07 | 2011-04-27 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents |
| WO2005020921A2 (en) * | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | C-kit modulators and methods of use |
| KR20060127415A (ko) | 2003-12-24 | 2006-12-12 | 와이어쓰 | 천식의 치료방법 |
| US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
| EP2054392A2 (en) * | 2006-06-15 | 2009-05-06 | Boehringer Ingelheim International GmbH | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha |
| CN101903357A (zh) | 2007-07-17 | 2010-12-01 | 里格尔药品股份有限公司 | 作为pkc抑制剂的环状胺取代的嘧啶二胺 |
| NZ603525A (en) * | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| ES2635504T3 (es) * | 2009-01-21 | 2017-10-04 | Rigel Pharmaceuticals, Inc. | Derivados de N2-(3-piridilo o fenil)-N4-(4-piperidil)-2,4-pirimidinadiamina útiles en el tratamiento de enfermedades inflamatorias, toimmunitarias o proliferativas |
-
2010
- 2010-12-01 US US12/958,284 patent/US20110130415A1/en not_active Abandoned
- 2010-12-01 WO PCT/US2010/058597 patent/WO2011068898A1/en not_active Ceased
- 2010-12-01 CA CA2780759A patent/CA2780759A1/en not_active Abandoned
- 2010-12-01 EP EP10796518.8A patent/EP2507227B1/en not_active Not-in-force
- 2010-12-01 JP JP2012542165A patent/JP5802677B2/ja not_active Expired - Fee Related
-
2016
- 2016-09-09 US US15/261,294 patent/US9732070B2/en not_active Expired - Fee Related
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