JP2013511960A5 - - Google Patents

Info

Publication number

JP2013511960A5

JP2013511960A5 JP2012540231A JP2012540231A JP2013511960A5 JP 2013511960 A5 JP2013511960 A5 JP 2013511960A5 JP 2012540231 A JP2012540231 A JP 2012540231A JP 2012540231 A JP2012540231 A JP 2012540231A JP 2013511960 A5 JP2013511960 A5 JP 2013511960A5

Authority

JP

Japan

Prior art keywords

isolated protein

protein complex

seq

growth factor

sequence

Prior art date

2010-11-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 102000004169 proteins and genes Human genes 0.000 claims 19
• 108090000623 proteins and genes Proteins 0.000 claims 19
• 102100037362 Fibronectin Human genes 0.000 claims 14
• 108010067306 Fibronectins Proteins 0.000 claims 14
• 150000001413 amino acids Chemical group 0.000 claims 7
• 102000006495 integrins Human genes 0.000 claims 4
• 108010044426 integrins Proteins 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 230000002068 genetic effect Effects 0.000 claims 3
• 239000003102 growth factor Substances 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 2
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 2
• 230000012292 cell migration Effects 0.000 claims 2
• 230000004663 cell proliferation Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 102000004864 Fibroblast growth factor 10 Human genes 0.000 claims 1
• 108090001047 Fibroblast growth factor 10 Proteins 0.000 claims 1
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 1
• PBYFVIQRFLNQCO-GUBZILKMSA-N Gln-Pro-Gln Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O PBYFVIQRFLNQCO-GUBZILKMSA-N 0.000 claims 1
• PAWIVEIWWYGBAM-YUMQZZPRSA-N Gly-Leu-Ala Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O PAWIVEIWWYGBAM-YUMQZZPRSA-N 0.000 claims 1
• 102000009465 Growth Factor Receptors Human genes 0.000 claims 1
• 108010009202 Growth Factor Receptors Proteins 0.000 claims 1
• HNDWYLYAYNBWMP-AJNGGQMLSA-N Leu-Ile-Lys Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(C)C)N HNDWYLYAYNBWMP-AJNGGQMLSA-N 0.000 claims 1
• IRVONVRHHJXWTK-RWMBFGLXSA-N Met-Lys-Pro Chemical compound CSCC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)O)N IRVONVRHHJXWTK-RWMBFGLXSA-N 0.000 claims 1
• 102000007474 Multiprotein Complexes Human genes 0.000 claims 1
• 108010085220 Multiprotein Complexes Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 238000003776 cleavage reaction Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 210000002919 epithelial cell Anatomy 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 108010078144 glutaminyl-glycine Proteins 0.000 claims 1
• 239000007943 implant Substances 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000011065 in-situ storage Methods 0.000 claims 1
• 102000028416 insulin-like growth factor binding Human genes 0.000 claims 1
• 108091022911 insulin-like growth factor binding Proteins 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 108010022588 methionyl-lysyl-proline Proteins 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1