KR101930916B1 - 피브로넥틴：성장 인자 키메라 - Google Patents

피브로넥틴：성장 인자 키메라 Download PDF

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Publication number
KR101930916B1
KR101930916B1 KR1020127016766A KR20127016766A KR101930916B1 KR 101930916 B1 KR101930916 B1 KR 101930916B1 KR 1020127016766 A KR1020127016766 A KR 1020127016766A KR 20127016766 A KR20127016766 A KR 20127016766A KR 101930916 B1 KR101930916 B1 KR 101930916B1
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Korean (ko)
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KR20120114277A (ko
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지 업톤
론쿠이젠 데릭 반
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티슈 테라피스 리미티드
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Priority claimed from US12/627,647 external-priority patent/US20100143442A1/en
Priority claimed from US12/793,386 external-priority patent/US8871709B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
KR1020127016766A 2009-11-30 2010-11-30 피브로넥틴：성장 인자 키메라 Expired - Fee Related KR101930916B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/627,647 US20100143442A1 (en) 2003-02-05 2009-11-30 Growth factor complexes and modulation of cell migration and growth
US12/627,647 2009-11-30
US12/793,386 2010-06-03
US12/793,386 US8871709B2 (en) 2003-02-05 2010-06-03 Synthetic chimeric proteins comprising epidermal growth factor and vitronectin
PCT/AU2010/001613 WO2011063477A1 (en) 2009-11-30 2010-11-30 Fibronectin: growth factor chimeras

Publications (2)

Publication Number Publication Date
KR20120114277A KR20120114277A (ko) 2012-10-16
KR101930916B1 true KR101930916B1 (ko) 2018-12-19

Family

ID=44065756

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127016766A Expired - Fee Related KR101930916B1 (ko) 2009-11-30 2010-11-30 피브로넥틴：성장 인자 키메라

Country Status (12)

Country Link
EP (1) EP2507261B1 (enExample)
JP (1) JP2013511960A (enExample)
KR (1) KR101930916B1 (enExample)
CN (1) CN102725308A (enExample)
AU (1) AU2010324554B2 (enExample)
BR (1) BR112012013035A8 (enExample)
CA (1) CA2781474C (enExample)
ES (1) ES2619938T3 (enExample)
NZ (1) NZ600454A (enExample)
RU (1) RU2012127364A (enExample)
WO (1) WO2011063477A1 (enExample)
ZA (1) ZA201203915B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220028520A (ko) * 2020-08-28 2022-03-08 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871709B2 (en) * 2003-02-05 2014-10-28 Queensland University of Technolgy Synthetic chimeric proteins comprising epidermal growth factor and vitronectin
CN103834664B (zh) * 2014-03-27 2016-05-04 吉林大学 重组表皮生长因子egf及其制备方法
WO2018071709A1 (en) * 2016-10-14 2018-04-19 Neomatrix Therapeutics, Inc Peptides derived from fibronectin with improved bioactivity and reduced susceptibility to neutrophil elastase degradation
WO2019010533A1 (en) * 2017-07-12 2019-01-17 Factor Therapeutics Limited TREATMENT OF OCULAR DISORDERS
CN110123732A (zh) * 2019-04-03 2019-08-16 广州市拉凯尔干细胞研究所 一种含有纤连蛋白化妆品原料制备方法
CN119264240B (zh) * 2024-09-10 2025-03-25 浙江诸暨聚源生物技术有限公司 功能增强的重组纤连蛋白及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054359A1 (en) 1998-04-17 1999-10-28 Gropep Limited Matrix binding factor
WO2000055206A1 (en) 1999-03-18 2000-09-21 The Hope Heart Institute Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4843000A (en) 1979-12-26 1989-06-27 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4849338A (en) 1982-07-16 1989-07-18 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
WO1990000569A1 (en) 1988-07-15 1990-01-25 Central Sydney Area Health Service Acid-labile subunit (als) of insulin-like-growth factor (igf) binding protein complex
US6090790A (en) 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
JP2866134B2 (ja) * 1990-02-05 1999-03-08 寳酒造株式会社 機能性ポリペプチド
WO1992001813A1 (en) 1990-07-25 1992-02-06 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
JP2829405B2 (ja) * 1991-10-14 1998-11-25 寳酒造株式会社 機能性ポリペプチド
US5958764A (en) 1992-04-30 1999-09-28 Baylor College Of Medicine Specific expression vectors and methods of use
WO1994018232A1 (en) 1993-02-12 1994-08-18 Repligen Corporation Methods for generating broadly neutralizing anti-hiv antibodies and antigens capable of eliciting same
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
AUPM672594A0 (en) 1994-07-08 1994-08-04 Royal Children's Hospital Research Foundation A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders
US5824547A (en) * 1994-11-29 1998-10-20 Takara Shuzo Co., Ltd. Method for production of transfected cells
ES2259182T3 (es) * 1995-11-13 2006-09-16 Takara Bio Inc. Metodo de introduccion de genes en celulas diana por medio de retrovirus.
US6143495A (en) 1995-11-21 2000-11-07 Yale University Unimolecular segment amplification and sequencing
US5752019A (en) 1995-12-22 1998-05-12 International Business Machines Corporation System and method for confirmationally-flexible molecular identification
US5835382A (en) 1996-04-26 1998-11-10 The Scripps Research Institute Small molecule mimetics of erythropoietin
US6077987A (en) 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
AU3192299A (en) 1998-03-18 1999-10-11 Wake Forest University Improved implantable biomaterials, compositions and methods for their preparation and uses thereof
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
AU2003900481A0 (en) * 2003-02-05 2003-02-20 Queensland University Of Technology Synthetic modulators of cell migration and growth
JP2008125460A (ja) * 2006-11-22 2008-06-05 Institute Of Physical & Chemical Research フィブリン結合性成長因子
WO2008157483A2 (en) * 2007-06-14 2008-12-24 The Research Foundation Of State University Of New York Polypeptides and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054359A1 (en) 1998-04-17 1999-10-28 Gropep Limited Matrix binding factor
WO2000055206A1 (en) 1999-03-18 2000-09-21 The Hope Heart Institute Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Biotechnology Letters. 2004, Vol.26, pp.1837-1840*
Blood. 1999, Vol.938, No.4, pp.1221-1230
Chi-Rosso, G. 등, The Journal of Biological Chemistry Vol.272, No,50, pp.31447-31452 (1997)*
FEBS. 1992, Vol.298, No.2,3, pp.126-128
R. Clark et al., Journal of investigative dermatology, Vol.121, No.4, pp.695-705 (2003.10.)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220028520A (ko) * 2020-08-28 2022-03-08 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도
KR102440312B1 (ko) 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Also Published As

Publication number Publication date
AU2010324554B2 (en) 2014-07-31
BR112012013035A8 (pt) 2018-04-03
NZ600454A (en) 2014-10-31
RU2012127364A (ru) 2014-01-10
WO2011063477A1 (en) 2011-06-03
AU2010324554A1 (en) 2012-06-21
EP2507261A4 (en) 2013-04-10
JP2013511960A (ja) 2013-04-11
ZA201203915B (en) 2018-11-28
EP2507261B1 (en) 2016-12-21
CA2781474C (en) 2019-06-18
CN102725308A (zh) 2012-10-10
ES2619938T3 (es) 2017-06-27
CA2781474A1 (en) 2011-06-03
KR20120114277A (ko) 2012-10-16
BR112012013035A2 (pt) 2017-05-16
EP2507261A1 (en) 2012-10-10

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