CN102725308A - 纤连蛋白:生长因子嵌合物 - Google Patents

纤连蛋白:生长因子嵌合物 Download PDF

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Publication number
CN102725308A
CN102725308A CN201080062313XA CN201080062313A CN102725308A CN 102725308 A CN102725308 A CN 102725308A CN 201080062313X A CN201080062313X A CN 201080062313XA CN 201080062313 A CN201080062313 A CN 201080062313A CN 102725308 A CN102725308 A CN 102725308A
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CN
China
Prior art keywords
protein complex
growth factor
igf
sequence
isolating protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201080062313XA
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English (en)
Chinese (zh)
Inventor
Z·厄普顿
D·范隆科胡伊恩
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Queensland University of Technology QUT
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Queensland University of Technology QUT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/627,647 external-priority patent/US20100143442A1/en
Priority claimed from US12/793,386 external-priority patent/US8871709B2/en
Application filed by Queensland University of Technology QUT filed Critical Queensland University of Technology QUT
Publication of CN102725308A publication Critical patent/CN102725308A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
CN201080062313XA 2009-11-30 2010-11-30 纤连蛋白:生长因子嵌合物 Pending CN102725308A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/627,647 US20100143442A1 (en) 2003-02-05 2009-11-30 Growth factor complexes and modulation of cell migration and growth
US12/627,647 2009-11-30
US12/793,386 US8871709B2 (en) 2003-02-05 2010-06-03 Synthetic chimeric proteins comprising epidermal growth factor and vitronectin
US12/793,386 2010-06-03
PCT/AU2010/001613 WO2011063477A1 (en) 2009-11-30 2010-11-30 Fibronectin: growth factor chimeras

Publications (1)

Publication Number Publication Date
CN102725308A true CN102725308A (zh) 2012-10-10

Family

ID=44065756

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080062313XA Pending CN102725308A (zh) 2009-11-30 2010-11-30 纤连蛋白:生长因子嵌合物

Country Status (12)

Country Link
EP (1) EP2507261B1 (enExample)
JP (1) JP2013511960A (enExample)
KR (1) KR101930916B1 (enExample)
CN (1) CN102725308A (enExample)
AU (1) AU2010324554B2 (enExample)
BR (1) BR112012013035A8 (enExample)
CA (1) CA2781474C (enExample)
ES (1) ES2619938T3 (enExample)
NZ (1) NZ600454A (enExample)
RU (1) RU2012127364A (enExample)
WO (1) WO2011063477A1 (enExample)
ZA (1) ZA201203915B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110023325A (zh) * 2016-10-14 2019-07-16 尼优美特里克斯医疗有限公司 具有提高的生物活性和降低的对嗜中性粒细胞弹性蛋白酶降解易感性的来源于纤连蛋白的肽
CN110123732A (zh) * 2019-04-03 2019-08-16 广州市拉凯尔干细胞研究所 一种含有纤连蛋白化妆品原料制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871709B2 (en) * 2003-02-05 2014-10-28 Queensland University of Technolgy Synthetic chimeric proteins comprising epidermal growth factor and vitronectin
CN103834664B (zh) * 2014-03-27 2016-05-04 吉林大学 重组表皮生长因子egf及其制备方法
WO2019010533A1 (en) * 2017-07-12 2019-01-17 Factor Therapeutics Limited TREATMENT OF OCULAR DISORDERS
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도
CN119264240B (zh) * 2024-09-10 2025-03-25 浙江诸暨聚源生物技术有限公司 功能增强的重组纤连蛋白及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03232898A (ja) * 1990-02-05 1991-10-16 Takara Shuzo Co Ltd 機能性ポリペプチド
US5302701A (en) * 1991-10-14 1994-04-12 Takara Shuzo Co., Ltd. Polypeptide having human fibronectin-like cell adhesive activity
WO1996017073A1 (en) * 1994-11-29 1996-06-06 Takara Shuzo Co., Ltd. Process for producing transformed cell
WO1997018318A1 (fr) * 1995-11-13 1997-05-22 Takara Shuzo Co., Ltd. Procede d'introduction de genes dans des cellules cibles au moyen de retrovirus
CN1774448A (zh) * 2003-02-05 2006-05-17 昆士兰技术大学 生长因子复合物及细胞迁移和生长的调节

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US4843000A (en) 1979-12-26 1989-06-27 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4849338A (en) 1982-07-16 1989-07-18 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
CA1341598C (en) 1988-07-15 2009-09-29 Central Sydney Area Health Service Acid-labile sub-unit (als) of insulin-like growth factor binding proteincomplex
US6090790A (en) 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
AU649066B2 (en) 1990-07-25 1994-05-12 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5958764A (en) 1992-04-30 1999-09-28 Baylor College Of Medicine Specific expression vectors and methods of use
AU6136694A (en) 1993-02-12 1994-08-29 Repligen Corporation Methods for generating broadly neutralizing anti-hiv antibodies and antigens capable of eliciting same
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
AUPM672594A0 (en) 1994-07-08 1994-08-04 Royal Children's Hospital Research Foundation A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders
JP3974941B2 (ja) 1995-11-21 2007-09-12 イェール ユニバーシティ 単分子セグメントの増幅および検出
US5752019A (en) 1995-12-22 1998-05-12 International Business Machines Corporation System and method for confirmationally-flexible molecular identification
US5835382A (en) 1996-04-26 1998-11-10 The Scripps Research Institute Small molecule mimetics of erythropoietin
US6077987A (en) 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
WO1999047070A1 (en) 1998-03-18 1999-09-23 Wake Forest University Improved implantable biomaterials, compositions and methods for their preparation and uses thereof
AUPP298498A0 (en) 1998-04-17 1998-05-07 Gropep Pty Ltd Matrix binding factor
US6436897B2 (en) 1998-06-01 2002-08-20 Celtrix Pharmaceuticals, Inc. Pharmaceutical formulations for IGF/IGFBP
WO2000055206A1 (en) 1999-03-18 2000-09-21 The Hope Heart Institute Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor
JP2008125460A (ja) * 2006-11-22 2008-06-05 Institute Of Physical & Chemical Research フィブリン結合性成長因子
US8759300B2 (en) * 2007-06-14 2014-06-24 The Research Foundation For The State University Of New York Polypeptides and methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03232898A (ja) * 1990-02-05 1991-10-16 Takara Shuzo Co Ltd 機能性ポリペプチド
US5302701A (en) * 1991-10-14 1994-04-12 Takara Shuzo Co., Ltd. Polypeptide having human fibronectin-like cell adhesive activity
WO1996017073A1 (en) * 1994-11-29 1996-06-06 Takara Shuzo Co., Ltd. Process for producing transformed cell
WO1997018318A1 (fr) * 1995-11-13 1997-05-22 Takara Shuzo Co., Ltd. Procede d'introduction de genes dans des cellules cibles au moyen de retrovirus
CN1774448A (zh) * 2003-02-05 2006-05-17 昆士兰技术大学 生长因子复合物及细胞迁移和生长的调节

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AMIT SHARMA，ET AL: "Crystal structure of a heparin- and integrin-binding", 《THE EMBO JOURNAL》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110023325A (zh) * 2016-10-14 2019-07-16 尼优美特里克斯医疗有限公司 具有提高的生物活性和降低的对嗜中性粒细胞弹性蛋白酶降解易感性的来源于纤连蛋白的肽
CN110023325B (zh) * 2016-10-14 2023-07-04 尼优美特里克斯医疗有限公司 具有提高的生物活性和降低的对嗜中性粒细胞弹性蛋白酶降解易感性的来源于纤连蛋白的肽
CN110123732A (zh) * 2019-04-03 2019-08-16 广州市拉凯尔干细胞研究所 一种含有纤连蛋白化妆品原料制备方法

Also Published As

Publication number Publication date
ZA201203915B (en) 2018-11-28
EP2507261B1 (en) 2016-12-21
CA2781474C (en) 2019-06-18
BR112012013035A8 (pt) 2018-04-03
ES2619938T3 (es) 2017-06-27
KR101930916B1 (ko) 2018-12-19
EP2507261A1 (en) 2012-10-10
AU2010324554A1 (en) 2012-06-21
EP2507261A4 (en) 2013-04-10
NZ600454A (en) 2014-10-31
RU2012127364A (ru) 2014-01-10
WO2011063477A1 (en) 2011-06-03
KR20120114277A (ko) 2012-10-16
JP2013511960A (ja) 2013-04-11
AU2010324554B2 (en) 2014-07-31
BR112012013035A2 (pt) 2017-05-16
CA2781474A1 (en) 2011-06-03

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Application publication date: 20121010