JP2007523598A5 - - Google Patents
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- Publication number
- JP2007523598A5 JP2007523598A5 JP2006501345A JP2006501345A JP2007523598A5 JP 2007523598 A5 JP2007523598 A5 JP 2007523598A5 JP 2006501345 A JP2006501345 A JP 2006501345A JP 2006501345 A JP2006501345 A JP 2006501345A JP 2007523598 A5 JP2007523598 A5 JP 2007523598A5
- Authority
- JP
- Japan
- Prior art keywords
- protein complex
- isolated protein
- igf
- seq
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000028416 insulin-like growth factor binding Human genes 0.000 claims description 7
- 108091022911 insulin-like growth factor binding Proteins 0.000 claims description 7
- 230000012292 cell migration Effects 0.000 claims description 6
- 230000004663 cell proliferation Effects 0.000 claims description 6
- 239000005557 antagonist Substances 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010020718 hyperplasia Diseases 0.000 claims description 2
- 230000002390 hyperplastic effect Effects 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims 55
- 108090000623 proteins and genes Proteins 0.000 claims 55
- 102100035140 Vitronectin Human genes 0.000 claims 33
- 108010031318 Vitronectin Proteins 0.000 claims 33
- 102000006495 integrins Human genes 0.000 claims 18
- 108010044426 integrins Proteins 0.000 claims 18
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 15
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 102100037362 Fibronectin Human genes 0.000 claims 11
- 108010067306 Fibronectins Proteins 0.000 claims 11
- 239000003102 growth factor Substances 0.000 claims 11
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 10
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 10
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 7
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 5
- 238000011065 in-situ storage Methods 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 4
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 3
- 230000002068 genetic effect Effects 0.000 claims 3
- 230000033001 locomotion Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 claims 2
- 101000840566 Homo sapiens Insulin-like growth factor-binding protein 5 Proteins 0.000 claims 2
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 claims 2
- 102100029225 Insulin-like growth factor-binding protein 5 Human genes 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229960002897 heparin Drugs 0.000 claims 2
- 229920000669 heparin Polymers 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000032544 Cicatrix Diseases 0.000 claims 1
- 101001081567 Homo sapiens Insulin-like growth factor-binding protein 1 Proteins 0.000 claims 1
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 claims 1
- 101000840572 Homo sapiens Insulin-like growth factor-binding protein 4 Proteins 0.000 claims 1
- 101000840582 Homo sapiens Insulin-like growth factor-binding protein 6 Proteins 0.000 claims 1
- 102100027636 Insulin-like growth factor-binding protein 1 Human genes 0.000 claims 1
- 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 claims 1
- 102100029224 Insulin-like growth factor-binding protein 4 Human genes 0.000 claims 1
- 102100029180 Insulin-like growth factor-binding protein 6 Human genes 0.000 claims 1
- 102000007474 Multiprotein Complexes Human genes 0.000 claims 1
- 108010085220 Multiprotein Complexes Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102220625480 RING finger protein 24_T50E_mutation Human genes 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000028718 growth factor binding proteins Human genes 0.000 claims 1
- 108091009353 growth factor binding proteins Proteins 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 102200145452 rs121908580 Human genes 0.000 claims 1
- 102200094314 rs74315399 Human genes 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003900481 | 2003-02-05 | ||
| AU2003900481A AU2003900481A0 (en) | 2003-02-05 | 2003-02-05 | Synthetic modulators of cell migration and growth |
| PCT/AU2004/000117 WO2004069871A1 (en) | 2003-02-05 | 2004-02-05 | Growth factor complexes and modulation of cell migration and growth |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011005233A Division JP2011120595A (ja) | 2003-02-05 | 2011-01-13 | 成長因子複合体ならびに細胞の移動および増殖の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007523598A JP2007523598A (ja) | 2007-08-23 |
| JP2007523598A5 true JP2007523598A5 (enExample) | 2010-05-06 |
| JP4717799B2 JP4717799B2 (ja) | 2011-07-06 |
Family
ID=30005181
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006501345A Expired - Lifetime JP4717799B2 (ja) | 2003-02-05 | 2004-02-05 | 成長因子複合体ならびに細胞の移動および増殖の調節 |
| JP2011005233A Pending JP2011120595A (ja) | 2003-02-05 | 2011-01-13 | 成長因子複合体ならびに細胞の移動および増殖の調節 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011005233A Pending JP2011120595A (ja) | 2003-02-05 | 2011-01-13 | 成長因子複合体ならびに細胞の移動および増殖の調節 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7659367B2 (enExample) |
| EP (3) | EP2357195B1 (enExample) |
| JP (2) | JP4717799B2 (enExample) |
| KR (2) | KR101175687B1 (enExample) |
| CN (1) | CN1774448B (enExample) |
| AT (1) | ATE521636T1 (enExample) |
| AU (1) | AU2003900481A0 (enExample) |
| CA (1) | CA2515335C (enExample) |
| DK (1) | DK1594895T3 (enExample) |
| ES (1) | ES2372388T3 (enExample) |
| NZ (1) | NZ541738A (enExample) |
| WO (1) | WO2004069871A1 (enExample) |
| ZA (1) | ZA200506991B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8871709B2 (en) * | 2003-02-05 | 2014-10-28 | Queensland University of Technolgy | Synthetic chimeric proteins comprising epidermal growth factor and vitronectin |
| AU2003903896A0 (en) * | 2003-07-28 | 2003-08-07 | Queensland University Of Technology | Skin regeneration system |
| US20070004036A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for keratinocyte culture |
| US20070004037A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for culturing keratinocytes |
| US20070003541A1 (en) * | 2005-07-01 | 2007-01-04 | Rodolfo Faudoa | Methods and compositions for therapeutics |
| US20070128685A1 (en) * | 2005-07-01 | 2007-06-07 | Rodolfo Faudoa | Methods and compositions for cell culture |
| US20090087907A1 (en) * | 2005-07-29 | 2009-04-02 | Alice Pebay | Compositions and Methods for Growth of Pluripotent Cells |
| US20100076489A1 (en) * | 2007-03-06 | 2010-03-25 | Joshua Stopek | Wound closure material |
| WO2008109123A2 (en) * | 2007-03-06 | 2008-09-12 | Tyco Healthcare Group Lp | Wound closure material |
| KR20110139736A (ko) | 2009-03-19 | 2011-12-29 | 퀸스랜드 유니버시티 오브 테크놀로지 | 성장 인자 시그널링을 위한 표적 및 치료 방법 |
| KR101930916B1 (ko) * | 2009-11-30 | 2018-12-19 | 티슈 테라피스 리미티드 | 피브로넥틴：성장 인자 키메라 |
| US9133266B2 (en) * | 2011-05-06 | 2015-09-15 | Wisconsin Alumni Research Foundation | Vitronectin-derived cell culture substrate and uses thereof |
| LT2782598T (lt) | 2011-11-23 | 2020-07-27 | In3Bio Ltd. | Rekombinantiniai baltymai ir jų terapinis panaudojimas |
| BR112015024758A2 (pt) * | 2013-03-29 | 2017-10-24 | Merrimack Pharmaceuticals Inc | proteínas de fusão de ligação à cartilagem |
| KR101558498B1 (ko) | 2013-04-26 | 2015-10-12 | 건국대학교 산학협력단 | 노년황반변성의 진단, 치료 및 예방용 조성물 및 노년황반변성에 대한 진단 방법 |
| WO2015037622A1 (ja) * | 2013-09-10 | 2015-03-19 | 富士フイルム株式会社 | 多能性幹細胞の培養方法、培養用キット及び多能性幹細胞培養用培地 |
| WO2016105332A1 (en) * | 2014-12-22 | 2016-06-30 | Avon Products, Inc. | Peptides and their use in the treatment of skin |
| WO2016105375A1 (en) * | 2014-12-23 | 2016-06-30 | Avon Products, Inc. | Peptides and their use in the treatment of skin |
| US20170281507A1 (en) * | 2014-12-23 | 2017-10-05 | Avon Products, Inc. | Peptides and Their Use in the Treatment of Skin |
| US11299531B2 (en) * | 2015-03-11 | 2022-04-12 | Allgenesis Biotherapeutics Inc. | Fusion protein comprising a ligand binding domain of VEGF and PDGF |
| WO2019010533A1 (en) * | 2017-07-12 | 2019-01-17 | Factor Therapeutics Limited | TREATMENT OF OCULAR DISORDERS |
| EP4532532A1 (en) * | 2022-06-02 | 2025-04-09 | Avant Meats Company Limited | Genetically engineered yeast cells, recombinant proteins produced thereof and applications thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US592904A (en) | 1897-11-02 | Drill | ||
| US4843000A (en) | 1979-12-26 | 1989-06-27 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4849338A (en) | 1982-07-16 | 1989-07-18 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| CA1341598C (en) | 1988-07-15 | 2009-09-29 | Central Sydney Area Health Service | Acid-labile sub-unit (als) of insulin-like growth factor binding proteincomplex |
| US6090790A (en) | 1989-12-14 | 2000-07-18 | Eriksson; Elof | Gene delivery by microneedle injection |
| JP2866134B2 (ja) * | 1990-02-05 | 1999-03-08 | 寳酒造株式会社 | 機能性ポリペプチド |
| AU649066B2 (en) | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| JP2829405B2 (ja) * | 1991-10-14 | 1998-11-25 | 寳酒造株式会社 | 機能性ポリペプチド |
| US5958764A (en) | 1992-04-30 | 1999-09-28 | Baylor College Of Medicine | Specific expression vectors and methods of use |
| AU6136694A (en) | 1993-02-12 | 1994-08-29 | Repligen Corporation | Methods for generating broadly neutralizing anti-hiv antibodies and antigens capable of eliciting same |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5962427A (en) | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
| AUPM672594A0 (en) | 1994-07-08 | 1994-08-04 | Royal Children's Hospital Research Foundation | A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders |
| JP3974941B2 (ja) | 1995-11-21 | 2007-09-12 | イェール ユニバーシティ | 単分子セグメントの増幅および検出 |
| US5752019A (en) | 1995-12-22 | 1998-05-12 | International Business Machines Corporation | System and method for confirmationally-flexible molecular identification |
| US5835382A (en) | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
| US6077987A (en) | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
| WO1999047070A1 (en) | 1998-03-18 | 1999-09-23 | Wake Forest University | Improved implantable biomaterials, compositions and methods for their preparation and uses thereof |
| US6436897B2 (en) | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
| JP2001190280A (ja) * | 1999-02-19 | 2001-07-17 | Terumo Corp | コラーゲン結合性生理活性ポリペプチド |
| WO2000055206A1 (en) * | 1999-03-18 | 2000-09-21 | The Hope Heart Institute | Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor |
| JP2002060400A (ja) * | 2000-08-17 | 2002-02-26 | Terumo Corp | コラーゲン結合活性および血管新生調節活性を有するハイブリッドポリペプチド |
| AUPR030900A0 (en) * | 2000-09-22 | 2000-10-12 | Queensland University Of Technology | Growth factor complex |
-
2003
- 2003-02-05 AU AU2003900481A patent/AU2003900481A0/en not_active Abandoned
-
2004
- 2004-02-05 CA CA2515335A patent/CA2515335C/en not_active Expired - Fee Related
- 2004-02-05 EP EP10191855.5A patent/EP2357195B1/en not_active Expired - Lifetime
- 2004-02-05 KR KR1020057014530A patent/KR101175687B1/ko not_active Expired - Fee Related
- 2004-02-05 DK DK04708282.1T patent/DK1594895T3/da active
- 2004-02-05 EP EP10191678A patent/EP2357194A1/en not_active Withdrawn
- 2004-02-05 JP JP2006501345A patent/JP4717799B2/ja not_active Expired - Lifetime
- 2004-02-05 WO PCT/AU2004/000117 patent/WO2004069871A1/en not_active Ceased
- 2004-02-05 EP EP04708282A patent/EP1594895B1/en not_active Expired - Lifetime
- 2004-02-05 NZ NZ541738A patent/NZ541738A/xx not_active IP Right Cessation
- 2004-02-05 CN CN2004800093227A patent/CN1774448B/zh not_active Expired - Fee Related
- 2004-02-05 ES ES04708282T patent/ES2372388T3/es not_active Expired - Lifetime
- 2004-02-05 AT AT04708282T patent/ATE521636T1/de active
- 2004-02-05 US US10/544,796 patent/US7659367B2/en not_active Expired - Fee Related
- 2004-02-05 KR KR1020127007401A patent/KR101179678B1/ko not_active Expired - Fee Related
-
2005
- 2005-08-31 ZA ZA200506991A patent/ZA200506991B/en unknown
-
2011
- 2011-01-13 JP JP2011005233A patent/JP2011120595A/ja active Pending
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