JP2013511272A5 - - Google Patents
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- JP2013511272A5 JP2013511272A5 JP2012539436A JP2012539436A JP2013511272A5 JP 2013511272 A5 JP2013511272 A5 JP 2013511272A5 JP 2012539436 A JP2012539436 A JP 2012539436A JP 2012539436 A JP2012539436 A JP 2012539436A JP 2013511272 A5 JP2013511272 A5 JP 2013511272A5
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- Prior art keywords
- glcnac
- cell
- nucleic acid
- acid encoding
- protein
- Prior art date
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- 210000004027 cell Anatomy 0.000 claims description 179
- 102000004169 proteins and genes Human genes 0.000 claims description 129
- 108090000623 proteins and genes Proteins 0.000 claims description 129
- 102000039446 nucleic acids Human genes 0.000 claims description 109
- 108020004707 nucleic acids Proteins 0.000 claims description 109
- 150000007523 nucleic acids Chemical class 0.000 claims description 109
- 238000000034 method Methods 0.000 claims description 102
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims description 66
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims description 66
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims description 66
- 108060003306 Galactosyltransferase Proteins 0.000 claims description 59
- 102000030902 Galactosyltransferase Human genes 0.000 claims description 59
- 108010070113 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase I Proteins 0.000 claims description 45
- 230000008685 targeting Effects 0.000 claims description 42
- 101000918297 Caenorhabditis elegans Exostosin-2 homolog Proteins 0.000 claims description 38
- 239000002773 nucleotide Substances 0.000 claims description 32
- 125000003729 nucleotide group Chemical group 0.000 claims description 32
- 108010009689 mannosyl-oligosaccharide 1,2-alpha-mannosidase Proteins 0.000 claims description 26
- 102100021771 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Human genes 0.000 claims description 25
- 230000000694 effects Effects 0.000 claims description 24
- 108010083819 mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidase Proteins 0.000 claims description 24
- GRHWEVYJIHXESA-HBHDJDHDSA-N beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->3)-[beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)-beta-D-GlcpNAc Chemical compound O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@H]4[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O4)O)[C@@H](CO)O3)NC(C)=O)[C@H](O)[C@@H](CO[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O[C@H]4[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O4)O)[C@@H](CO)O3)NC(C)=O)O2)O)[C@@H](CO)O1 GRHWEVYJIHXESA-HBHDJDHDSA-N 0.000 claims description 22
- 230000003834 intracellular effect Effects 0.000 claims description 22
- 241000235015 Yarrowia lipolytica Species 0.000 claims description 18
- WYUKJASPBYYQRJ-VSJOFRJTSA-N beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->3)-[beta-D-GlcpNAc-(1->2)-alpha-D-Manp-(1->6)]-beta-D-Manp-(1->4)-beta-GlcpNAc-(1->4)-beta-D-GlcpNAc Chemical compound O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)NC(C)=O)[C@H](O)[C@@H](CO[C@@H]3[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)NC(C)=O)O2)O)[C@@H](CO)O1 WYUKJASPBYYQRJ-VSJOFRJTSA-N 0.000 claims description 18
- 102000003886 Glycoproteins Human genes 0.000 claims description 17
- 108090000288 Glycoproteins Proteins 0.000 claims description 17
- 108010029607 4-nitrophenyl-alpha-glucosidase Proteins 0.000 claims description 16
- 210000002288 golgi apparatus Anatomy 0.000 claims description 16
- 101150061302 och1 gene Proteins 0.000 claims description 16
- 108010017836 1,3-alpha-D-glucan synthase Proteins 0.000 claims description 12
- 230000002950 deficient Effects 0.000 claims description 11
- 102100039059 Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase Human genes 0.000 claims description 8
- 101000958975 Homo sapiens Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase Proteins 0.000 claims description 8
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims description 8
- 102000003951 Erythropoietin Human genes 0.000 claims description 6
- 108090000394 Erythropoietin Proteins 0.000 claims description 6
- 102000009109 Fc receptors Human genes 0.000 claims description 6
- 108010087819 Fc receptors Proteins 0.000 claims description 6
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 6
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 6
- 102000003996 Interferon-beta Human genes 0.000 claims description 6
- 108090000467 Interferon-beta Proteins 0.000 claims description 6
- 102000008070 Interferon-gamma Human genes 0.000 claims description 6
- 108010074328 Interferon-gamma Proteins 0.000 claims description 6
- 229940105423 erythropoietin Drugs 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 229960003130 interferon gamma Drugs 0.000 claims description 6
- 229960001388 interferon-beta Drugs 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- INOZZBHURUDQQR-AJNGGQMLSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoic acid Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC1=CN=CN1 INOZZBHURUDQQR-AJNGGQMLSA-N 0.000 claims description 4
- 102100032086 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase Human genes 0.000 claims description 4
- 101000776319 Homo sapiens Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase Proteins 0.000 claims description 4
- 108010022308 beta-1,4-galactosyltransferase I Proteins 0.000 claims description 4
- 230000003197 catalytic effect Effects 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 4
- 108010041601 histidyl-aspartyl-glutamyl-leucine Proteins 0.000 claims description 4
- 208000002352 blister Diseases 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 description 59
- 241000680806 Blastobotrys adeninivorans Species 0.000 description 3
- 108010054377 Mannosidases Proteins 0.000 description 2
- 102000001696 Mannosidases Human genes 0.000 description 2
- 101710163270 Nuclease Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 108010090473 UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase Proteins 0.000 description 1
- 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26282809P | 2009-11-19 | 2009-11-19 | |
| US61/262,828 | 2009-11-19 | ||
| PCT/IB2010/003154 WO2011061629A2 (en) | 2009-11-19 | 2010-11-19 | Yeast strains producing mammalian-like complex n-glycans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511272A JP2013511272A (ja) | 2013-04-04 |
| JP2013511272A5 true JP2013511272A5 (enExample) | 2014-01-09 |
Family
ID=44060124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539436A Pending JP2013511272A (ja) | 2009-11-19 | 2010-11-19 | 哺乳類様複合ｎ−グリカンを生成する酵母株 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20130053550A1 (enExample) |
| EP (1) | EP2501805B1 (enExample) |
| JP (1) | JP2013511272A (enExample) |
| KR (1) | KR20130055555A (enExample) |
| CN (1) | CN102834509A (enExample) |
| BR (1) | BR112012011980A2 (enExample) |
| CA (1) | CA2781240A1 (enExample) |
| DK (1) | DK2501805T3 (enExample) |
| WO (1) | WO2011061629A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170091174A (ko) | 2007-04-03 | 2017-08-08 | 옥시레인 유케이 리미티드 | 분자의 글리코실화 |
| WO2011039634A2 (en) | 2009-09-29 | 2011-04-07 | Universiteit Gent | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
| WO2011061629A2 (en) | 2009-11-19 | 2011-05-26 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
| KR101979220B1 (ko) | 2010-09-29 | 2019-05-16 | 옥시레인 유케이 리미티드 | 인산화된 n-글리칸들의 탈-만노실화 |
| KR101983572B1 (ko) | 2010-09-29 | 2019-05-29 | 옥시레인 유케이 리미티드 | 만노스-1-포스포-6-만노스 결합의 캡핑제거 및 인산화 n-글리칸의 탈만노실이 가능한 만노시다제 및 당단백질의 활용을 통한 포유류 세포의 촉진방법 |
| WO2013098651A1 (en) | 2011-12-30 | 2013-07-04 | Oxyrane Uk Limited | Methods and materials for reducing degradation of recombinant proteins |
| DK2800809T3 (en) * | 2012-01-05 | 2018-05-22 | Glykos Finland Oy | PROTEASE-DEFECTED FILAMENTARY FUNGAL CELLS AND PROCEDURES FOR USE THEREOF |
| CA2867237C (en) | 2012-03-15 | 2024-01-02 | Wouter Vervecken | Methods and materials for treatment of pompe's disease |
| SI2991683T1 (sl) | 2013-05-02 | 2020-01-31 | Glykos Finland Oy | Konjugati glikoproteina ali glikana s toksično obremenitvijo |
| WO2015057064A1 (en) * | 2013-10-14 | 2015-04-23 | Synaffix B.V. | Modified glycoprotein, protein-conjugate and process for the preparation thereof |
| EP3110947B1 (en) | 2014-02-24 | 2019-09-04 | Novogy Inc. | Diacylglycerol acyl transferase (dga1) polynucleotides, and methods of increasing yeast cell lipid production by overexpression of heterologous dga1 |
| EP3172333B1 (en) | 2014-07-21 | 2020-05-13 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| WO2017191208A1 (en) * | 2016-05-03 | 2017-11-09 | Vib Vzw | Means and methods for generating complex glycans derived from fungal engineered hosts |
| EP3784701A4 (en) | 2018-04-24 | 2022-06-08 | National Research Council of Canada | THERAPEUTIC COMPOUNDS CROSSING THE BLOOD-BRAIN BARRIER AND THEIR USES |
| WO2020060948A1 (en) | 2018-09-17 | 2020-03-26 | Levadura Biotechnology, Inc. | Production of cannabinoids in yeast using a fatty acid feedstock |
| KR102167388B1 (ko) * | 2020-01-15 | 2020-10-19 | 코스맥스 주식회사 | 신규 로도스포리디움 토룰로이데스 균주 및 그 균주 배양액을 포함하는 화장료 조성물 |
| CN116042562B (zh) * | 2022-03-11 | 2023-10-20 | 山东恒鲁生物科技有限公司 | 重组酵母菌及其应用 |
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-
2010
- 2010-11-19 WO PCT/IB2010/003154 patent/WO2011061629A2/en not_active Ceased
- 2010-11-19 KR KR1020127015208A patent/KR20130055555A/ko not_active Withdrawn
- 2010-11-19 CN CN2010800618574A patent/CN102834509A/zh active Pending
- 2010-11-19 JP JP2012539436A patent/JP2013511272A/ja active Pending
- 2010-11-19 DK DK10812879.4T patent/DK2501805T3/en active
- 2010-11-19 EP EP10812879.4A patent/EP2501805B1/en active Active
- 2010-11-19 US US13/510,527 patent/US20130053550A1/en not_active Abandoned
- 2010-11-19 CA CA2781240A patent/CA2781240A1/en not_active Abandoned
- 2010-11-19 BR BR112012011980-0A patent/BR112012011980A2/pt not_active Application Discontinuation
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2015
- 2015-03-06 US US14/641,002 patent/US10287557B2/en active Active
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2019
- 2019-04-11 US US16/381,523 patent/US11225646B2/en active Active
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