DK2501805T3 - Yeast strains producing mammalian-like complex N-Glycans - Google Patents

Yeast strains producing mammalian-like complex N-Glycans Download PDF

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Publication number
DK2501805T3
DK2501805T3 DK10812879.4T DK10812879T DK2501805T3 DK 2501805 T3 DK2501805 T3 DK 2501805T3 DK 10812879 T DK10812879 T DK 10812879T DK 2501805 T3 DK2501805 T3 DK 2501805T3
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nucleic acid
glycans
cell
acid encoding
transferase
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DK10812879.4T
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Danish (da)
English (en)
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Wouter Vervecken
Steven Christian Jozef Geysens
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Oxyrane Uk Ltd
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477Hemicellulases not provided in a preceding group
    • C12N9/2488Mannanases
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    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
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    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
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    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01133Xylosylprotein 4-beta-galactosyltransferase (2.4.1.133)
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    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024Alpha-mannosidase (3.2.1.24)
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    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01084Glucan 1,3-alpha-glucosidase (3.2.1.84), i.e. mutanase
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    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01114Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (3.2.1.114)

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DK10812879.4T 2009-11-19 2010-11-19 Yeast strains producing mammalian-like complex N-Glycans DK2501805T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26282809P 2009-11-19 2009-11-19
PCT/IB2010/003154 WO2011061629A2 (en) 2009-11-19 2010-11-19 Yeast strains producing mammalian-like complex n-glycans

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DK2501805T3 true DK2501805T3 (en) 2019-04-15

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US (3) US20130053550A1 (enExample)
EP (1) EP2501805B1 (enExample)
JP (1) JP2013511272A (enExample)
KR (1) KR20130055555A (enExample)
CN (1) CN102834509A (enExample)
BR (1) BR112012011980A2 (enExample)
CA (1) CA2781240A1 (enExample)
DK (1) DK2501805T3 (enExample)
WO (1) WO2011061629A2 (enExample)

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US20150337273A1 (en) 2015-11-26
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CN102834509A (zh) 2012-12-19
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US20130053550A1 (en) 2013-02-28
US10287557B2 (en) 2019-05-14
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KR20130055555A (ko) 2013-05-28
JP2013511272A (ja) 2013-04-04
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