JP2013509381A5 - - Google Patents
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- Publication number
- JP2013509381A5 JP2013509381A5 JP2012535840A JP2012535840A JP2013509381A5 JP 2013509381 A5 JP2013509381 A5 JP 2013509381A5 JP 2012535840 A JP2012535840 A JP 2012535840A JP 2012535840 A JP2012535840 A JP 2012535840A JP 2013509381 A5 JP2013509381 A5 JP 2013509381A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticles
- ethylene oxide
- moiety
- hydroxyphosphonate
- polymer hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002105 nanoparticle Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 6
- 125000006850 spacer group Chemical group 0.000 claims description 4
- 238000000034 method Methods 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 239000002616 MRI contrast agent Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 description 2
- 150000003512 tertiary amines Chemical class 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 150000001412 amines Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical group 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 150000001261 hydroxy acids Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/609,799 | 2009-10-30 | ||
| US12/609,799 US9205155B2 (en) | 2009-10-30 | 2009-10-30 | Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents |
| PCT/EP2010/066429 WO2011051422A2 (en) | 2009-10-30 | 2010-10-29 | Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013509381A JP2013509381A (ja) | 2013-03-14 |
| JP2013509381A5 true JP2013509381A5 (https=) | 2016-09-01 |
| JP5997609B2 JP5997609B2 (ja) | 2016-09-28 |
Family
ID=43480950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535840A Active JP5997609B2 (ja) | 2009-10-30 | 2010-10-29 | 親水性のα−ヒドロキシホスホン酸コンジュゲートによる水不溶性ナノ粒子の処理、こうして修飾されたナノ粒子、及び造影剤としてのそれの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9205155B2 (https=) |
| EP (1) | EP2493512B1 (https=) |
| JP (1) | JP5997609B2 (https=) |
| KR (1) | KR20120101362A (https=) |
| CN (1) | CN102639153B (https=) |
| AU (1) | AU2010311437A1 (https=) |
| BR (1) | BR112012010113A2 (https=) |
| CA (1) | CA2777871A1 (https=) |
| ES (1) | ES2720152T3 (https=) |
| IN (1) | IN2012DN02804A (https=) |
| MX (1) | MX2012005022A (https=) |
| RU (1) | RU2012116880A (https=) |
| WO (1) | WO2011051422A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8986836B2 (en) * | 2009-03-19 | 2015-03-24 | Ohio University | Microspheres and their methods of preparation |
| US8920681B2 (en) * | 2009-12-30 | 2014-12-30 | Korea University Research And Business Foundation | Electrically conductive polymers with enhanced conductivity |
| BR112013013929A2 (pt) * | 2010-12-15 | 2016-09-13 | Gen Electric | composição de nanopartícula, e, processos para fabricar uma composição de nanopartícula e de formação de imagem de diagnóstico |
| US8889103B2 (en) | 2010-12-15 | 2014-11-18 | General Electric Company | Diagnostic agent composition and associated methods thereof |
| US8895068B2 (en) | 2010-12-15 | 2014-11-25 | General Electric Company | Nanoparticle composition and associated methods thereof |
| US9474810B2 (en) * | 2012-03-02 | 2016-10-25 | General Electric Company | Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells |
| US9251937B2 (en) | 2012-06-29 | 2016-02-02 | General Electric Company | Heat stable nanoparticle preparations and associated methods thereof |
| MY201491A (en) * | 2017-06-28 | 2024-02-27 | Riken | Nanoparticle, contrast agent for magnetic resonance imaging containing same, and ligand compound |
| US20190001001A1 (en) * | 2017-07-03 | 2019-01-03 | General Electric Company | Drug design for application-dependent payload, controlled pharmacokinetic distribution, and renal clearance |
| US11577977B2 (en) * | 2017-09-26 | 2023-02-14 | The Board Of Trustees Of The University Of Arkansas | Composite zero valent iron nanoparticles and applications thereof |
| CN110734460B (zh) * | 2019-10-22 | 2022-03-29 | 华南师范大学 | 一类磺酸-膦酸配体的制备及其用途 |
| CN118748269B (zh) * | 2024-08-05 | 2025-10-31 | 瑞固(衢州)新材料科技有限公司 | 一种硫化物固态电解质及其制备方法与电池 |
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| JPS5651493A (en) | 1979-10-02 | 1981-05-09 | Yoshitomi Pharmaceut Ind Ltd | Diphosphoglycerol and its preparation |
| JPS6043217A (ja) | 1983-08-19 | 1985-03-07 | Toshiba Corp | 磁気記録媒体 |
| DE3343586A1 (de) | 1983-11-29 | 1985-06-05 | Herbert Dr. 1000 Berlin Pilgrimm | Verfahren zur entkeimung eines mediums und vorrichtung zur durchfuehrung |
| DE3440190A1 (de) | 1984-11-01 | 1986-05-15 | Michel-Kim, Herwig, 1000 Berlin | Verfahren und vorrichtung zur erzeugung von stickstoffduenger und stickstoffangereicherter biomasse aus luft |
| DE3443810A1 (de) | 1984-11-28 | 1986-05-28 | Herbert Dr. 1000 Berlin Pilgrimm | Verfahren zur entkeimung eines mediums |
| DE3624626A1 (de) | 1986-07-18 | 1988-01-28 | Pilgrimm Herbert | Verfahren zur abtrennung von stoffen aus einem stoffgemisch unter verwendung von magnetischen fluessigkeiten |
| DE3709852A1 (de) | 1987-03-24 | 1988-10-06 | Silica Gel Gmbh Adsorptions Te | Stabile magnetische fluessigkeitszusammensetzungen und verfahren zu ihrer herstellung und ihre verwendung |
| DE3709851A1 (de) * | 1987-03-24 | 1988-10-06 | Silica Gel Gmbh Adsorptions Te | Nmr-diagnostische fluessigkeitszusammensetzungen |
| DE4309333A1 (de) | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
| ATE156706T1 (de) * | 1993-03-17 | 1997-08-15 | Silica Gel Gmbh | Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben |
| US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| EP0772776B1 (de) * | 1994-07-27 | 2000-03-22 | Herbert Dr. Pilgrimm | Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung |
| DE19612001A1 (de) * | 1996-03-18 | 1997-09-25 | Silica Gel Gmbh Adsorptions Te | Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung |
| DE19726282A1 (de) | 1997-06-20 | 1998-12-24 | Inst Neue Mat Gemein Gmbh | Nanoskalige Teilchen mit einem von mindestens zwei Schalen umgebenen eisenoxid-haltigen Kern |
| DE10016559A1 (de) | 2000-04-03 | 2001-10-18 | Eucro Europe Contract Res Gmbh | System für den Transport von Aktivstoffen in einem biologischen System |
| ATE472511T1 (de) | 2001-08-16 | 2010-07-15 | Essilor Int | Verfahren zur herstellung stabiler dispersionen metallischer nanopartikel, stabile dispersion hergestellt auf basis dieses verfahrens und beschichtungszusammensetzungen enthaltend diese dispersionen |
| DE10222481A1 (de) * | 2002-05-22 | 2003-12-04 | Eucro Europe Contract Res Gmbh | Kontrastmittel für die Verwendung in bildgebenden Verfahren |
| US6797380B2 (en) | 2002-07-31 | 2004-09-28 | General Electric Company | Nanoparticle having an inorganic core |
| JP2006502572A (ja) * | 2002-10-09 | 2006-01-19 | フェロファーマ ゲーエムベーハー フォルシュングスラボア | 安定化超常磁性粒子 |
| US7560160B2 (en) * | 2002-11-25 | 2009-07-14 | Materials Modification, Inc. | Multifunctional particulate material, fluid, and composition |
| FR2848850B1 (fr) * | 2002-12-20 | 2005-06-24 | Guerbet Sa | Nouvelles compositions de particules magnetiques recouvertes de derives gem-bisphosphonates. |
| US20040161435A1 (en) | 2003-02-14 | 2004-08-19 | Gupta Shyam K. | Skin Firming Anti-Aging Cosmetic Mask Compositions |
| DE10323816A1 (de) * | 2003-05-23 | 2004-12-09 | Basf Ag | Verfahren zur Herstellung von Mischoxiden mit mittleren Durchmessern kleiner als 10 Nanometer |
| US20060018835A1 (en) * | 2004-04-02 | 2006-01-26 | General Electric Company | Nanoparticles with inorganic core and methods of using them |
| CN100334166C (zh) | 2005-01-26 | 2007-08-29 | 上海大学 | 一种纳米碳酸钙的改性方法 |
| US8084275B2 (en) * | 2005-02-08 | 2011-12-27 | Fujifilm Corporation | Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface |
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| EP1888311A4 (en) | 2005-05-12 | 2011-06-22 | Georgia Tech Res Inst | COATED METAL OXIDE NANOTEHICLES AND MANUFACTURING METHOD THEREFOR |
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| DE102006007888A1 (de) | 2006-02-21 | 2007-08-23 | Degussa Gmbh | Aluminiumoxid enthaltende Dispersion, Zubereitung enthaltend diese Dispersion und ein Melaminharz und mittels dieser Zubereitung hergestelles gehärtetes Produkt |
| WO2007133801A2 (en) | 2006-05-15 | 2007-11-22 | Dmitri B Kirpotin | Magnetic microparticles comprising organic substances |
| FR2904784B1 (fr) * | 2006-08-10 | 2010-09-03 | Surfactis Technologies | Procede de recouvrement de surfaces metalliques et minerales par de monocouches autoassemblees de composes bisphosphoniques et leurs utilisations |
| US20080299046A1 (en) | 2006-10-16 | 2008-12-04 | The Trustees Of Columbia University In The City Of New York | Methods for controlling surface functionality of metal oxide nanoparticles, metal oxide nanoparticles having controlled functionality, and uses thereof |
| US8258190B2 (en) | 2007-04-30 | 2012-09-04 | Intezyne Technologies, Inc. | Encapsulated contrast agents |
| US9072789B2 (en) | 2007-07-20 | 2015-07-07 | The Trustees Of Princeton University | Nano-particle surface modification |
| SG150405A1 (en) | 2007-08-29 | 2009-03-30 | Agency Science Tech & Res | Method of coating a particle |
| FR2921838A1 (fr) * | 2007-10-05 | 2009-04-10 | Guerbet Sa | Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile |
| KR20090038337A (ko) | 2007-10-15 | 2009-04-20 | 재단법인서울대학교산학협력재단 | 무기계 나노입자를 수계 매질에 분산시키는 생체적합성분산 안정화제 |
| CN101951890A (zh) | 2007-12-13 | 2011-01-19 | 阿杜罗生物技术公司 | 配体缀合的热疗感受器及其制备方法 |
| US20090226376A1 (en) * | 2008-03-05 | 2009-09-10 | General Electric Company | Novel Mixed Ligand Core/Shell Iron Oxide Nanoparticles for Inflammation Imaging |
| US8173198B2 (en) | 2008-07-23 | 2012-05-08 | Life Technologies Corporation | Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers |
| US20100166664A1 (en) | 2008-12-29 | 2010-07-01 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
-
2009
- 2009-10-30 US US12/609,799 patent/US9205155B2/en active Active
-
2010
- 2010-10-29 RU RU2012116880/15A patent/RU2012116880A/ru not_active Application Discontinuation
- 2010-10-29 WO PCT/EP2010/066429 patent/WO2011051422A2/en not_active Ceased
- 2010-10-29 AU AU2010311437A patent/AU2010311437A1/en not_active Abandoned
- 2010-10-29 IN IN2804DEN2012 patent/IN2012DN02804A/en unknown
- 2010-10-29 MX MX2012005022A patent/MX2012005022A/es not_active Application Discontinuation
- 2010-10-29 KR KR1020127010759A patent/KR20120101362A/ko not_active Withdrawn
- 2010-10-29 JP JP2012535840A patent/JP5997609B2/ja active Active
- 2010-10-29 ES ES10771742T patent/ES2720152T3/es active Active
- 2010-10-29 BR BR112012010113A patent/BR112012010113A2/pt not_active IP Right Cessation
- 2010-10-29 CA CA2777871A patent/CA2777871A1/en not_active Abandoned
- 2010-10-29 CN CN201080049469.4A patent/CN102639153B/zh active Active
- 2010-10-29 EP EP10771742.3A patent/EP2493512B1/en active Active
-
2015
- 2015-10-21 US US14/919,077 patent/US9827335B2/en active Active
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