JP2013507962A5 - - Google Patents

Info

Publication number

JP2013507962A5

JP2013507962A5 JP2012535264A JP2012535264A JP2013507962A5 JP 2013507962 A5 JP2013507962 A5 JP 2013507962A5 JP 2012535264 A JP2012535264 A JP 2012535264A JP 2012535264 A JP2012535264 A JP 2012535264A JP 2013507962 A5 JP2013507962 A5 JP 2013507962A5

Authority

JP

Japan

Prior art keywords

antibody

seq

sequence

hvr

hgfa

Prior art date

2010-10-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 claims 5
• 101710085796 Hepatocyte growth factor activator Proteins 0.000 claims 4
• 102100031465 Hepatocyte growth factor activator Human genes 0.000 claims 4
• 230000002401 inhibitory effect Effects 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 230000033115 angiogenesis Effects 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 230000004663 cell proliferation Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102220582564 4-hydroxy-2-oxoglutarate aldolase, mitochondrial_N78A_mutation Human genes 0.000 claims 1
• 101001066338 Homo sapiens Hepatocyte growth factor activator Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102220492945 Nuclear RNA export factor 1_R71A_mutation Human genes 0.000 claims 1
• 102220506801 Vitelline membrane outer layer protein 1 homolog_N73T_mutation Human genes 0.000 claims 1
• PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229940127121 immunoconjugate Drugs 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1