HUE055414T2 - Eljárás aktivált hepatocita növekedési faktor (HGF) elõállítására - Google Patents
Eljárás aktivált hepatocita növekedési faktor (HGF) elõállításáraInfo
- Publication number
- HUE055414T2 HUE055414T2 HUE17766718A HUE17766718A HUE055414T2 HU E055414 T2 HUE055414 T2 HU E055414T2 HU E17766718 A HUE17766718 A HU E17766718A HU E17766718 A HUE17766718 A HU E17766718A HU E055414 T2 HUE055414 T2 HU E055414T2
- Authority
- HU
- Hungary
- Prior art keywords
- hgf
- growth factor
- hepatocyte growth
- producing activated
- activated hepatocyte
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21034—Plasma kallikrein (3.4.21.34)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016054128 | 2016-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE055414T2 true HUE055414T2 (hu) | 2021-11-29 |
Family
ID=59850449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17766718A HUE055414T2 (hu) | 2016-03-17 | 2017-03-15 | Eljárás aktivált hepatocita növekedési faktor (HGF) elõállítására |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11548926B2 (hu) |
| EP (1) | EP3431590B1 (hu) |
| JP (1) | JP6861201B2 (hu) |
| KR (1) | KR102275262B1 (hu) |
| CN (1) | CN109196099B (hu) |
| AU (1) | AU2017232582B2 (hu) |
| CA (1) | CA3014567C (hu) |
| DK (1) | DK3431590T3 (hu) |
| ES (1) | ES2894477T3 (hu) |
| HU (1) | HUE055414T2 (hu) |
| IL (1) | IL261066B (hu) |
| LT (1) | LT3431590T (hu) |
| MX (1) | MX2018010283A (hu) |
| RU (1) | RU2747977C2 (hu) |
| SG (1) | SG11201806843UA (hu) |
| WO (1) | WO2017159722A1 (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3431590B1 (en) | 2016-03-17 | 2021-07-28 | Eisai R&D Management Co., Ltd. | Method for producing activated hepatocyte growth factor (hgf) |
| CN110607304A (zh) * | 2019-07-25 | 2019-12-24 | 广州凌腾生物医药有限公司 | 肝细胞生长因子的重组表达方法 |
| CN110606883A (zh) * | 2019-07-25 | 2019-12-24 | 广州凌腾生物医药有限公司 | 肝细胞生长因子的制备方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2564486B2 (ja) | 1986-07-14 | 1996-12-18 | 修治 橋本 | 肝細胞増殖因子 |
| NZ232813A (en) | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| JP2706704B2 (ja) | 1989-06-05 | 1998-01-28 | 敏一 中村 | 組換ヒト肝実質細胞増殖因子 |
| JP3036782B2 (ja) | 1990-04-03 | 2000-04-24 | 三菱化学株式会社 | ヒト肝実質細胞増殖因子の生産方法および該因子を産生する形質転換体 |
| JP2577091B2 (ja) | 1989-08-11 | 1997-01-29 | 三菱化学株式会社 | 肝実質細胞増殖因子及びそれをコードする遺伝子 |
| JP2777678B2 (ja) | 1990-06-11 | 1998-07-23 | 敏一 中村 | 組換ヒト肝実質細胞増殖因子及びその製造方法 |
| JP3072628B2 (ja) | 1990-11-19 | 2000-07-31 | 敏一 中村 | ヒト肝実質細胞増殖因子をコードする染色体ｄｎａ |
| JP3213985B2 (ja) | 1991-10-18 | 2001-10-02 | 三菱化学株式会社 | 新規なタンパク質 |
| CA2102463A1 (en) * | 1992-11-05 | 1994-05-06 | Mitsubishi Chemical Corporation | Protein and gene encoding said protein |
| JP3232714B2 (ja) | 1992-11-20 | 2001-11-26 | 三菱化学株式会社 | 新規なタンパク質およびそれをコードする遺伝子 |
| JP3698721B2 (ja) | 1993-02-23 | 2005-09-21 | ジェネンテク・インコーポレイテッド | 有機溶媒を用いて処理したポリペプチドの賦形剤安定化 |
| JP2577091Y2 (ja) | 1993-06-23 | 1998-07-23 | 賢一 片山 | 分流装置の合成樹脂製サドル |
| JP3680114B2 (ja) * | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| JP2747979B2 (ja) | 1994-08-19 | 1998-05-06 | 雪印乳業株式会社 | ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬 |
| JP3927248B2 (ja) | 1995-07-11 | 2007-06-06 | 第一製薬株式会社 | Ｈｇｆ凍結乾燥製剤 |
| JP2859577B2 (ja) | 1996-03-27 | 1999-02-17 | 三菱化学株式会社 | 肝実質細胞増殖因子 |
| JP4463885B2 (ja) | 1996-12-05 | 2010-05-19 | 敏一 中村 | 劇症肝炎疾患治療剤 |
| JP2980888B2 (ja) | 1998-07-09 | 1999-11-22 | 三菱化学株式会社 | 肝実質細胞増殖因子をコードする遺伝子 |
| CN100448482C (zh) | 1999-05-31 | 2009-01-07 | 三菱化学株式会社 | Hgf冻干制剂 |
| JP3072628U (ja) | 2000-02-17 | 2000-10-24 | 輝夫 尾形 | ステンドグラス製文字入り記念楯 |
| US7045602B2 (en) * | 2000-12-05 | 2006-05-16 | Mitsubishi Chemical Corporation | Specific antibody directed to active hepatocyte growth factor activator and method for using the same |
| JP4090236B2 (ja) * | 2000-12-05 | 2008-05-28 | 三菱化学株式会社 | 活性型肝細胞増殖因子アクティベーターに対する特異的抗体とその使用法 |
| DE10204792A1 (de) | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
| NZ551908A (en) | 2004-07-26 | 2009-10-30 | Genentech Inc | Methods and compositions for modulating hepatocyte growth factor HGF activation |
| WO2006063300A2 (en) * | 2004-12-10 | 2006-06-15 | Genentech, Inc. | Crystal structure of hepatocyte growth factor activator complexed with kunitz domain inhibitor |
| EP1954714A2 (en) * | 2005-11-10 | 2008-08-13 | Receptor Biologix, Inc. | Hepatocyte growth factor intron fusion proteins |
| JP5093783B2 (ja) | 2006-04-20 | 2012-12-12 | クリングルファーマ株式会社 | Ｈｇｆ前駆体蛋白質改変体及びその活性型蛋白質 |
| JP2010513462A (ja) | 2006-12-20 | 2010-04-30 | バイエル・ヘルスケア・エルエルシー | 第ＶＩＩおよび第ＶＩＩａ因子組成物 |
| WO2008102452A1 (ja) | 2007-02-22 | 2008-08-28 | Kringle Pharma Inc. | Ｈｇｆ製剤 |
| KR101581986B1 (ko) | 2008-10-29 | 2016-01-04 | 아블린쓰 엔.브이. | 단일 도메인 항원 결합 분자의 제형 |
| CN101649320B (zh) * | 2009-09-15 | 2011-06-15 | 上海交通大学医学院附属仁济医院 | 重组人源hgf激活因子及其应用 |
| JP5889794B2 (ja) | 2009-10-19 | 2016-03-22 | ジェネンテック， インコーポレイテッド | 肝細胞増殖因子アクチベーターの調節 |
| WO2011102845A1 (en) | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| JP2012051822A (ja) | 2010-08-31 | 2012-03-15 | Institute Of Physical & Chemical Research | 肺癌診断用ポリペプチド、肺癌の検出方法、および治療効果の評価方法 |
| US9272018B2 (en) | 2011-04-18 | 2016-03-01 | Kyoto University | Acute hepatic insufficiency depressant and method for evaluating drug efficacy thereof |
| US20130071931A1 (en) | 2011-08-02 | 2013-03-21 | National Cancer Center | Process for hepatic differentiation from induced hepatic stem cells, and induced hepatic progenitor cells differentiated thereby |
| WO2013110531A1 (en) * | 2012-01-23 | 2013-08-01 | Ablynx Nv | Sequences directed against hepatocyte growth factor (hgf) and polypeptides comprising the same for the treatment of cancers and/or tumors |
| CN105209074A (zh) | 2012-10-20 | 2015-12-30 | 得克萨斯大学体系董事会 | 癌细胞陷阱 |
| RU2506946C1 (ru) | 2012-11-28 | 2014-02-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации | Технология лиофилизации обогащенной тромбоцитами плазмы с сохранением жизнеспособности факторов tgf pdgf vegf |
| CA2947396C (en) | 2014-04-28 | 2021-10-19 | Eisai R&D Management Co., Ltd. | Lyophilized formulation of hgf |
| EP3431590B1 (en) | 2016-03-17 | 2021-07-28 | Eisai R&D Management Co., Ltd. | Method for producing activated hepatocyte growth factor (hgf) |
| US20200341014A1 (en) | 2016-03-18 | 2020-10-29 | Eisai R&D Management Co., Ltd. | PD Marker of Hepatocyte Growth Factor (HGF) |
| CN208371461U (zh) | 2017-08-21 | 2019-01-15 | 潍坊鸿旺工贸有限公司 | 一种晾衣架用连接构件及晾衣架 |
-
2017
- 2017-03-15 EP EP17766718.5A patent/EP3431590B1/en active Active
- 2017-03-15 KR KR1020187024470A patent/KR102275262B1/ko active IP Right Grant
- 2017-03-15 CA CA3014567A patent/CA3014567C/en active Active
- 2017-03-15 LT LTEPPCT/JP2017/010355T patent/LT3431590T/lt unknown
- 2017-03-15 US US16/078,568 patent/US11548926B2/en active Active
- 2017-03-15 RU RU2018130530A patent/RU2747977C2/ru active
- 2017-03-15 AU AU2017232582A patent/AU2017232582B2/en active Active
- 2017-03-15 JP JP2018505972A patent/JP6861201B2/ja active Active
- 2017-03-15 HU HUE17766718A patent/HUE055414T2/hu unknown
- 2017-03-15 MX MX2018010283A patent/MX2018010283A/es unknown
- 2017-03-15 DK DK17766718.5T patent/DK3431590T3/da active
- 2017-03-15 ES ES17766718T patent/ES2894477T3/es active Active
- 2017-03-15 SG SG11201806843UA patent/SG11201806843UA/en unknown
- 2017-03-15 CN CN201780013057.7A patent/CN109196099B/zh active Active
- 2017-03-15 WO PCT/JP2017/010355 patent/WO2017159722A1/ja active Application Filing
-
2018
- 2018-08-08 IL IL261066A patent/IL261066B/en unknown
-
2022
- 2022-05-05 US US17/737,343 patent/US20220267393A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL261066B (en) | 2021-08-31 |
| SG11201806843UA (en) | 2018-09-27 |
| CN109196099A (zh) | 2019-01-11 |
| RU2747977C2 (ru) | 2021-05-18 |
| KR20180127322A (ko) | 2018-11-28 |
| EP3431590A1 (en) | 2019-01-23 |
| KR102275262B1 (ko) | 2021-07-12 |
| IL261066A (en) | 2018-10-31 |
| DK3431590T3 (da) | 2021-10-11 |
| AU2017232582B2 (en) | 2022-07-14 |
| JPWO2017159722A1 (ja) | 2019-01-24 |
| RU2018130530A3 (hu) | 2020-08-13 |
| AU2017232582A1 (en) | 2018-08-30 |
| US11548926B2 (en) | 2023-01-10 |
| RU2018130530A (ru) | 2020-04-17 |
| JP6861201B2 (ja) | 2021-04-21 |
| WO2017159722A1 (ja) | 2017-09-21 |
| US20220267393A1 (en) | 2022-08-25 |
| CA3014567A1 (en) | 2017-09-21 |
| EP3431590A4 (en) | 2019-11-20 |
| CA3014567C (en) | 2024-02-20 |
| LT3431590T (lt) | 2021-09-10 |
| US20190062390A1 (en) | 2019-02-28 |
| CN109196099B (zh) | 2022-01-11 |
| ES2894477T3 (es) | 2022-02-14 |
| EP3431590B1 (en) | 2021-07-28 |
| MX2018010283A (es) | 2019-01-31 |
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