CN102791739B - 肝细胞生长因子激活剂的调控物 - Google Patents

肝细胞生长因子激活剂的调控物 Download PDF

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Publication number
CN102791739B
CN102791739B CN201080055074.5A CN201080055074A CN102791739B CN 102791739 B CN102791739 B CN 102791739B CN 201080055074 A CN201080055074 A CN 201080055074A CN 102791739 B CN102791739 B CN 102791739B
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CN
China
Prior art keywords
antibody
hgfa
sequence
seq
antibody fragment
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Expired - Fee Related
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CN201080055074.5A
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English (en)
Chinese (zh)
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CN102791739A (zh
Inventor
R.甘尼桑
D.科赫霍弗
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN102791739A publication Critical patent/CN102791739A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080055074.5A 2009-10-19 2010-10-18 肝细胞生长因子激活剂的调控物 Expired - Fee Related CN102791739B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25297309P 2009-10-19 2009-10-19
US61/252,973 2009-10-19
PCT/US2010/053054 WO2011049868A1 (en) 2009-10-19 2010-10-18 Modulators of hepatocyte growth factor activator

Publications (2)

Publication Number Publication Date
CN102791739A CN102791739A (zh) 2012-11-21
CN102791739B true CN102791739B (zh) 2014-10-15

Family

ID=43216178

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080055074.5A Expired - Fee Related CN102791739B (zh) 2009-10-19 2010-10-18 肝细胞生长因子激活剂的调控物

Country Status (12)

Country Link
US (1) US8759491B2 (enExample)
EP (1) EP2491058A1 (enExample)
JP (1) JP5889794B2 (enExample)
KR (1) KR20120106940A (enExample)
CN (1) CN102791739B (enExample)
AR (1) AR078667A1 (enExample)
BR (1) BR112012009245A2 (enExample)
CA (1) CA2771817A1 (enExample)
MX (1) MX2012002013A (enExample)
RU (1) RU2012120693A (enExample)
TW (1) TW201119677A (enExample)
WO (1) WO2011049868A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110206704A1 (en) * 2009-10-19 2011-08-25 Genentech, Inc. Methods and compositions for modulating hepatocyte growth factor activator
US11547743B2 (en) 2014-04-28 2023-01-10 Eisai R&D Management Co., Ltd. Lyophilized formulation of HGF
HUE055414T2 (hu) 2016-03-17 2021-11-29 Eisai R&D Man Co Ltd Eljárás aktivált hepatocita növekedési faktor (HGF) elõállítására
EP3492105A4 (en) 2016-07-26 2020-02-26 Nihon University THERAPEUTIC AGENT FOR PERIODONTITIS.
WO2023142096A1 (en) * 2022-01-30 2023-08-03 Westlake University Composition and method for preventing and/or treating clostridioides difficile infections caused by clade 2 strains

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CN101035810A (zh) * 2004-10-04 2007-09-12 健泰科生物技术公司 肝细胞生长因子激活剂的调控物

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Also Published As

Publication number Publication date
RU2012120693A (ru) 2013-12-20
MX2012002013A (es) 2012-03-16
WO2011049868A1 (en) 2011-04-28
JP2013507962A (ja) 2013-03-07
EP2491058A1 (en) 2012-08-29
HK1178180A1 (en) 2013-09-06
US20110091477A1 (en) 2011-04-21
CN102791739A (zh) 2012-11-21
CA2771817A1 (en) 2011-04-28
US8759491B2 (en) 2014-06-24
TW201119677A (en) 2011-06-16
KR20120106940A (ko) 2012-09-27
JP5889794B2 (ja) 2016-03-22
BR112012009245A2 (pt) 2019-09-24
AR078667A1 (es) 2011-11-23

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