JP2013506695A - リゾホスファチジン酸受容体アンタゴニストとしての化合物 - Google Patents

リゾホスファチジン酸受容体アンタゴニストとしての化合物 Download PDF

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JP2013506695A
JP2013506695A JP2012532368A JP2012532368A JP2013506695A JP 2013506695 A JP2013506695 A JP 2013506695A JP 2012532368 A JP2012532368 A JP 2012532368A JP 2012532368 A JP2012532368 A JP 2012532368A JP 2013506695 A JP2013506695 A JP 2013506695A
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methyl
isoxazol
phenyl
compound
biphenyl
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トーマス・ジョン・シーダース
ルーシー・ザオ
ジニー・エム・アルーダ
ブライアン・アンドリュー・スターンズ
イェン・ファム・トルン
ジル・メリッサ・スコット
ジョン・ハワード・ハッチンソン
ニコラス・サイモン・ストック
デボラ・ボルコッツ
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アミラ ファーマシューティカルス，インコーポレーテッド
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2012532368A 2009-10-01 2010-10-01 リゾホスファチジン酸受容体アンタゴニストとしての化合物 Pending JP2013506695A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24786109P 2009-10-01 2009-10-01
US61/247,861 2009-10-01
PCT/US2010/051199 WO2011041729A2 (en) 2009-10-01 2010-10-01 Compounds as lysophosphatidic acid receptor antagonists

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JP2013506695A true JP2013506695A (ja) 2013-02-28

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JP2012532368A Pending JP2013506695A (ja) 2009-10-01 2010-10-01 リゾホスファチジン酸受容体アンタゴニストとしての化合物
JP2012532357A Pending JP2013506694A (ja) 2009-10-01 2010-10-01 リゾホスファチジン酸受容体アンタゴニストとしての化合物

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US (3) US9090573B2 (en:Method)
EP (2) EP2483253A4 (en:Method)
JP (2) JP2013506695A (en:Method)
CN (2) CN102639515A (en:Method)
AR (1) AR078497A1 (en:Method)
GB (1) GB2474120B (en:Method)
IN (2) IN2012DN02735A (en:Method)
TW (1) TWI401082B (en:Method)
UY (1) UY32926A (en:Method)
WO (2) WO2011041694A2 (en:Method)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013506694A (ja) * 2009-10-01 2013-02-28 アミラ ファーマシューティカルス，インコーポレーテッド リゾホスファチジン酸受容体アンタゴニストとしての化合物
JP2016515536A (ja) * 2013-03-15 2016-05-30 エピゲン バイオサイエンシズ, インコーポレイテッドEpigen Biosciences, Inc. 疾患の治療に有用な複素環化合物

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068775A2 (en) 2008-12-11 2010-06-17 Amira Pharmaceuticals, Inc. Alkyne antagonists of lysophosphatidic acid receptors
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
JP2013501064A (ja) 2009-08-04 2013-01-10 アミラ ファーマシューティカルス，インコーポレーテッド リゾホスファチジン酸受容体アンタゴニストとしての化合物
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
CA2820817A1 (en) 2010-12-07 2012-06-14 Amira Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonists and uses thereof
WO2012138797A1 (en) 2011-04-05 2012-10-11 Amira Pharmaceuticals, Inc. 3- or 5 - bi phenyl - 4 - ylisoxazole - based compounds useful for the treatment of fibrosis, pain, cancer and respiratory, allergic, nervous system or cardiovascular disorders
WO2013020622A1 (en) * 2011-08-08 2013-02-14 Merck Patent Gmbh N-(benzimimdazol-2-yl)-cyclopropane carboxamides as lysophosphatidic acid antagonists
HK1199259A1 (en) 2011-08-15 2015-06-26 Intermune, Inc. Lysophosphatidic acid receptor antagonists
WO2013070879A1 (en) * 2011-11-10 2013-05-16 Bristol-Myers Squibb Company Methods for treating spinal cord injury with lpa receptor antagonists
CN103987858A (zh) 2011-11-22 2014-08-13 英特芒尼公司 诊断和治疗特发性肺纤维化的方法
JP2015505536A (ja) 2012-01-20 2015-02-23 アクセラ インク． 疾患の処置のための置換された複素環化合物
RU2649398C2 (ru) 2012-12-28 2018-04-03 Убе Индастриз, Лтд. Галогензамещенное гетероциклическое соединение
WO2014159814A1 (en) * 2013-03-13 2014-10-02 Patricia Oliver Formulations and tablets for treatment or prevention of neurological disorders
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