JP2013505917A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013505917A5 JP2013505917A5 JP2012530282A JP2012530282A JP2013505917A5 JP 2013505917 A5 JP2013505917 A5 JP 2013505917A5 JP 2012530282 A JP2012530282 A JP 2012530282A JP 2012530282 A JP2012530282 A JP 2012530282A JP 2013505917 A5 JP2013505917 A5 JP 2013505917A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- heterocyclyl
- alkyl
- heteroaryl
- och
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002947 alkylene group Chemical group 0.000 claims 46
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 33
- 125000000623 heterocyclic group Chemical group 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- -1 1-isopropyl-pyrrolidin-3-ylmethyl Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 125000004452 carbocyclyl group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 3
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- LWZYUACNWRVDDJ-UHFFFAOYSA-N 1-benzoxepine Chemical group O1C=CC=CC2=CC=CC=C12 LWZYUACNWRVDDJ-UHFFFAOYSA-N 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 1
- 125000004564 2,3-dihydrobenzofuran-2-yl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004571 thiomorpholin-4-yl group Chemical group N1(CCSCC1)* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24638109P | 2009-09-28 | 2009-09-28 | |
| US61/246,381 | 2009-09-28 | ||
| US33068510P | 2010-05-03 | 2010-05-03 | |
| US61/330,685 | 2010-05-03 | ||
| PCT/EP2010/064208 WO2011036280A1 (en) | 2009-09-28 | 2010-09-27 | Benzoxazepin pi3k inhibitor compounds and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228826A Division JP5625101B2 (ja) | 2009-09-28 | 2013-11-01 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505917A JP2013505917A (ja) | 2013-02-21 |
| JP2013505917A5 true JP2013505917A5 (https=) | 2013-12-19 |
| JP5540101B2 JP5540101B2 (ja) | 2014-07-02 |
Family
ID=43037239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530282A Active JP5540101B2 (ja) | 2009-09-28 | 2010-09-27 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
| JP2013228826A Active JP5625101B2 (ja) | 2009-09-28 | 2013-11-01 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228826A Active JP5625101B2 (ja) | 2009-09-28 | 2013-11-01 | ベンゾオキサゼピンｐｉ３ｋ阻害剤化合物及び使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US8242104B2 (https=) |
| EP (3) | EP2483278B1 (https=) |
| JP (2) | JP5540101B2 (https=) |
| KR (1) | KR101428346B1 (https=) |
| CN (2) | CN102762576B (https=) |
| AR (1) | AR078187A1 (https=) |
| AU (1) | AU2010299816C1 (https=) |
| BR (1) | BR112012006807A2 (https=) |
| CA (1) | CA2772691C (https=) |
| CL (1) | CL2012000754A1 (https=) |
| CO (1) | CO6491026A2 (https=) |
| CR (1) | CR20120121A (https=) |
| DK (1) | DK2483278T3 (https=) |
| EC (1) | ECSP12011755A (https=) |
| ES (2) | ES2570569T3 (https=) |
| HR (1) | HRP20140229T1 (https=) |
| IL (2) | IL217558A (https=) |
| MA (1) | MA33531B1 (https=) |
| MX (1) | MX2012003591A (https=) |
| MY (2) | MY160064A (https=) |
| NZ (1) | NZ597833A (https=) |
| PE (1) | PE20121025A1 (https=) |
| PL (1) | PL2483278T3 (https=) |
| PT (1) | PT2483278E (https=) |
| RS (1) | RS53164B (https=) |
| RU (2) | RU2654068C1 (https=) |
| SG (1) | SG10201405049RA (https=) |
| SI (1) | SI2483278T1 (https=) |
| TW (1) | TWI423980B (https=) |
| WO (1) | WO2011036280A1 (https=) |
| ZA (1) | ZA201202199B (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2642586T3 (es) * | 2009-07-27 | 2017-11-16 | Gilead Sciences, Inc. | Compuestos heterocíclicos condensados como moduladores de canales iónicos |
| MY160064A (en) * | 2009-09-28 | 2017-02-15 | Hoffmann La Roche | Benzoxazepin pi3k inhibitor compounds and methods of use |
| US8263633B2 (en) * | 2009-09-28 | 2012-09-11 | F. Hoffman-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
| EP2588197B1 (en) | 2010-07-02 | 2014-11-05 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| US9090628B2 (en) | 2011-03-21 | 2015-07-28 | Genentech, Inc. | Benzoxazepin compounds selective for PI3K P110 delta and methods of use |
| KR20140033377A (ko) | 2011-05-10 | 2014-03-18 | 길리애드 사이언시즈, 인코포레이티드 | 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물 |
| WO2012156379A1 (en) | 2011-05-13 | 2012-11-22 | Universität Zürich | PIK3/P110α INHIBITORS FOR PREVENTION OF RESTENOSIS BY APPLICATION AS AN IMPLANT COATING |
| NO3175985T3 (https=) * | 2011-07-01 | 2018-04-28 | ||
| UY34171A (es) | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal iónico |
| IL301603A (en) | 2011-10-14 | 2023-05-01 | Genentech Inc | Pertuzumab, trastuzumab, docetaxel and carboplatin for use in the preoperative treatment of a patient |
| US9034866B2 (en) * | 2012-02-17 | 2015-05-19 | Genentech, Inc. | Tricyclic compounds and methods of use therefor |
| BR112014028376A2 (pt) * | 2012-06-08 | 2018-04-24 | Hoffmann La Roche | métodos para o tratamento de um distúrbio hiperproliferativo, para a determinação dos compostos, para monitorar, para optimizar a eficácia terapêutica e de identificação de um biomarcador; formulação farmacêutica; utilização de uma combinação terapêutica e de gdc-0032, artigo de manufatura, produto e invenção |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| CN102775395A (zh) * | 2012-07-12 | 2012-11-14 | 江苏七洲绿色化工股份有限公司 | 一种丙环唑的制备方法及丙环唑中间体 |
| CN104870454B (zh) * | 2012-08-07 | 2020-03-03 | 詹森药业有限公司 | 用于制备杂环酯衍生物的方法 |
| MX2015011438A (es) * | 2013-03-13 | 2016-02-03 | Hoffmann La Roche | Procedimiento para preparar compuestos benzoxazepina. |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| KR20180093138A (ko) | 2013-12-16 | 2018-08-20 | 에프. 호프만-라 로슈 아게 | 2-(4-(2-(1-이소프로필-3-메틸-1H-1,2,4-트라이아졸-5-일)-5,6-다이하이드로벤조[f]이미다조[1,2-d][1,4]옥사제핀-9-일)-1H-피라졸-1-일)-2-메틸프로판아미드의 다형체, 이의 제조 방법 및 이의 약학적 용도 |
| WO2015136016A2 (en) | 2014-03-13 | 2015-09-17 | F. Hoffmann-La Roche Ag | Therapeutic combinations with estrogen receptor modulators |
| TW201636329A (zh) | 2015-02-02 | 2016-10-16 | 佛瑪治療公司 | 作為ｈｄａｃ抑制劑之雙環［４，６，０］異羥肟酸 |
| PL3292116T3 (pl) | 2015-02-02 | 2022-02-21 | Valo Health, Inc. | 3-arylo-4-amidobicykliczne kwasy [4,5,0]hydroksamowe jako inhibitory hdac |
| AR104068A1 (es) | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
| CN107531721B (zh) * | 2015-04-30 | 2020-07-17 | 诺华股份有限公司 | 用于调节法尼醇x受体的稠合的三环吡唑衍生物 |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
| HK1249866A1 (zh) | 2015-06-29 | 2018-11-16 | 豪夫迈‧罗氏有限公司 | 用他塞利昔布进行治疗的方法 |
| CN111848643A (zh) * | 2015-07-02 | 2020-10-30 | 豪夫迈·罗氏有限公司 | 苯并氧氮杂*噁唑烷酮化合物及其使用方法 |
| AU2016287463B2 (en) * | 2015-07-02 | 2020-07-02 | F. Hoffmann-La Roche Ag | Benzoxazepin oxazolidinone compounds and methods of use |
| EP3347361B1 (en) * | 2015-09-08 | 2020-08-05 | H. Hoffnabb-La Roche Ag | Tricyclic pi3k inhibitor compounds and methods of use |
| US9721369B2 (en) * | 2015-09-15 | 2017-08-01 | Facebook, Inc. | Systems and methods for utilizing multiple map portions from multiple map data sources |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| BR112019006445A2 (pt) | 2016-09-29 | 2019-10-01 | Bayer Ag | novos derivados de 5-imidazolilmetil substituídos |
| WO2018109204A1 (en) * | 2016-12-15 | 2018-06-21 | F. Hoffmann-La Roche Ag | Process for the preparation of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino) propanamide |
| PT3589661T (pt) | 2017-03-02 | 2024-01-29 | Genentech Inc | Tratamento com adjuvante de cancro da mama positivo para her2 |
| ES3027566T3 (en) * | 2017-04-28 | 2025-06-16 | Hoffmann La Roche | Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production |
| SG11202003635TA (en) * | 2017-10-26 | 2020-05-28 | Xynomic Pharmaceuticals Inc | Crystalline salts of a b-raf kinase inhibitor |
| CN114835729B (zh) * | 2018-05-30 | 2024-05-31 | 江苏豪森药业集团有限公司 | 含三并环类衍生物抑制剂、其制备方法和应用 |
| CN111909157B (zh) | 2019-05-07 | 2023-02-03 | 南京药石科技股份有限公司 | Ezh2抑制剂及其用途 |
| CN114599656A (zh) * | 2019-11-04 | 2022-06-07 | 贝达药业股份有限公司 | 咪唑烷酮类化合物及其制备方法与应用 |
| JP2023501324A (ja) * | 2019-11-04 | 2023-01-18 | 貝達薬業股▲ふん▼有限公司 | イミダゾリジノン類化合物、並びにその調製方法及び使用 |
| TWI886177B (zh) * | 2019-11-25 | 2025-06-11 | 大陸商上海翰森生物醫藥科技有限公司 | 含三并環類衍生物的鹽或晶型及其醫藥組成物 |
| JP7652935B2 (ja) * | 2021-05-03 | 2025-03-27 | 山東軒竹医薬科技有限公司 | 三環式ユビキチン特異的プロテアーゼ１阻害剤及びその使用 |
| MX2023013305A (es) | 2021-05-13 | 2024-01-31 | Betta Pharmaceuticals Co Ltd | Compuesto polimorfo de imidazolidinona, método de preparación del mismo y uso del mismo. |
| MX2023013919A (es) | 2021-05-28 | 2023-12-08 | Genentech Inc | Proceso para la preparacion de compuestos de benzoxazepin oxazolidinona. |
| WO2024104435A1 (zh) * | 2022-11-17 | 2024-05-23 | 微境生物医药科技(上海)有限公司 | 三并环类PI3Kα抑制剂及其制备方法和医药用途 |
| CN116003280B (zh) * | 2022-12-30 | 2024-11-19 | 合肥工业大学 | 一种芳基甲酰胺类化合物的光化学合成方法 |
| WO2025082533A1 (zh) * | 2023-10-21 | 2025-04-24 | 上海轶诺药业有限公司 | 一种稠环化合物及其制备和应用 |
| WO2025237374A1 (zh) * | 2024-05-16 | 2025-11-20 | 微境生物医药科技(上海)有限公司 | PI3Kα抑制剂及其制备方法和医药用途 |
| EP4686476A1 (en) | 2024-07-31 | 2026-02-04 | Klostermeier, Stefanie | Phosphoinositide 3 kinase (pi3k) inhibitor for use in the treatment of neurological diseases |
| WO2026027658A1 (en) | 2024-07-31 | 2026-02-05 | Klostermeier Stefanie | Phosphoinositide 3 kinase (pi3k) inhibitor for use in the treatment of neurological diseases |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| GB8504702D0 (en) | 1985-02-23 | 1985-03-27 | Zyma Sa | Tricyclic compounds |
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| FR2677356B1 (fr) | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| EP0638071B1 (en) | 1992-12-28 | 1997-04-09 | Eisai Co., Ltd. | Heterocyclic carbonic acid derivatives which bind to retinoid receptors (rar) |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| US5985799A (en) | 1995-11-17 | 1999-11-16 | E.I. Du Pont De Nemours And Company | Tricyclic herbicidal heterocycles |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| DE19908533A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| DE19908538A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| DE19908535A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen Thiazol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE19908537A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| US7273880B2 (en) | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
| WO2001064675A1 (en) | 2000-03-03 | 2001-09-07 | Novartis Ag | Condensed thiazolamines and their use as neuropeptide y5 antagonists |
| WO2002076926A1 (en) | 2001-02-02 | 2002-10-03 | Schering Corporation | 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists |
| TWI232863B (en) * | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
| BR0312780A (pt) | 2002-07-19 | 2005-05-03 | Pharmacia Corp | Compostos de tiofeno-carboxamida substituìda para o tratamento de inflamação |
| JP2006516990A (ja) * | 2003-02-07 | 2006-07-13 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | 抗菌剤として使用するための、三環式の環でｎ置換したオキサゾリジノン誘導体 |
| TW200510356A (en) * | 2003-08-01 | 2005-03-16 | Takeda Chemical Industries Ltd | Benzoxaepine compounds |
| US20050239767A1 (en) | 2003-10-28 | 2005-10-27 | Chan Michael K | Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands |
| EP1765830B1 (en) * | 2004-07-01 | 2010-09-22 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| EP2343303A1 (de) | 2004-10-07 | 2011-07-13 | Boehringer Ingelheim International GmbH | PI3-Kinase Inhibitoren |
| SI1934174T1 (sl) | 2005-10-07 | 2011-08-31 | Exelixis Inc | Inhibitorji MEK in postopki za njihovo uporabo |
| US20070238718A1 (en) * | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| GB0610866D0 (en) * | 2006-06-02 | 2006-07-12 | Hammersmith Imanet Ltd | Novel in vivo imaging compounds |
| US20080026171A1 (en) * | 2006-07-28 | 2008-01-31 | Alcan Packaging Flexible France | Coextruded film with polylactic acid (PLA) and Ethylene Vinyl Acetate (EVA) |
| CA2659956C (en) | 2006-08-04 | 2016-01-05 | Lewis C. Cantley | Inhibitors of pyruvate kinase and methods of treating disease |
| US8779154B2 (en) | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| AR064693A1 (es) * | 2006-12-29 | 2009-04-22 | Abbott Gmbh & Co Kg | Compuestos carboxamidas y su utilizacion en la elaboracion de un medicamento para el tratamiento de enfermedades asociadas a alta actividad de calpaina. |
| AU2008302703B2 (en) | 2007-09-19 | 2013-11-07 | The Regents Of The University Of California | Positron emission tomography probes for imaging immune activation and selected cancers |
| MX2010010659A (es) * | 2008-03-31 | 2010-10-26 | Genentech Inc | Compuestos de benzopirano y benzoxepina, inhibidores de fosfoinoinositida 3-cinasas y metodos para utilizarlos. |
| JP5579724B2 (ja) * | 2008-10-17 | 2014-08-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ホスファチジルイノシトール−３−キナーゼ（ｐｉ−３キナーゼ）阻害剤としてのテトラ−アザ−複素環 |
| MY160064A (en) * | 2009-09-28 | 2017-02-15 | Hoffmann La Roche | Benzoxazepin pi3k inhibitor compounds and methods of use |
| US8263633B2 (en) * | 2009-09-28 | 2012-09-11 | F. Hoffman-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
-
2010
- 2010-09-27 MY MYPI2012000823A patent/MY160064A/en unknown
- 2010-09-27 RU RU2016105810A patent/RU2654068C1/ru active
- 2010-09-27 BR BR112012006807-5A patent/BR112012006807A2/pt not_active Application Discontinuation
- 2010-09-27 EP EP10757213.3A patent/EP2483278B1/en active Active
- 2010-09-27 EP EP13193562.9A patent/EP2711368B1/en active Active
- 2010-09-27 SG SG10201405049RA patent/SG10201405049RA/en unknown
- 2010-09-27 KR KR1020127010974A patent/KR101428346B1/ko active Active
- 2010-09-27 RU RU2012117398/04A patent/RU2600927C2/ru active
- 2010-09-27 EP EP20140190276 patent/EP2845592A1/en not_active Withdrawn
- 2010-09-27 MY MYPI2015002473A patent/MY184074A/en unknown
- 2010-09-27 US US12/890,812 patent/US8242104B2/en active Active
- 2010-09-27 MX MX2012003591A patent/MX2012003591A/es active IP Right Grant
- 2010-09-27 ES ES13193562T patent/ES2570569T3/es active Active
- 2010-09-27 ES ES10757213.3T patent/ES2444779T3/es active Active
- 2010-09-27 SI SI201030536T patent/SI2483278T1/sl unknown
- 2010-09-27 PL PL10757213T patent/PL2483278T3/pl unknown
- 2010-09-27 TW TW099132661A patent/TWI423980B/zh active
- 2010-09-27 PE PE2012000390A patent/PE20121025A1/es active IP Right Grant
- 2010-09-27 PT PT107572133T patent/PT2483278E/pt unknown
- 2010-09-27 CN CN201080053938.XA patent/CN102762576B/zh active Active
- 2010-09-27 HR HRP20140229AT patent/HRP20140229T1/hr unknown
- 2010-09-27 RS RS20140060A patent/RS53164B/sr unknown
- 2010-09-27 DK DK10757213.3T patent/DK2483278T3/da active
- 2010-09-27 CN CN201510043641.XA patent/CN104744491B/zh active Active
- 2010-09-27 JP JP2012530282A patent/JP5540101B2/ja active Active
- 2010-09-27 NZ NZ597833A patent/NZ597833A/en unknown
- 2010-09-27 CA CA2772691A patent/CA2772691C/en active Active
- 2010-09-27 WO PCT/EP2010/064208 patent/WO2011036280A1/en not_active Ceased
- 2010-09-27 AU AU2010299816A patent/AU2010299816C1/en active Active
- 2010-09-27 AR ARP100103491A patent/AR078187A1/es unknown
-
2012
- 2012-01-10 CO CO12002995A patent/CO6491026A2/es active IP Right Grant
- 2012-01-16 IL IL217558A patent/IL217558A/en active IP Right Grant
- 2012-02-15 MA MA34637A patent/MA33531B1/fr unknown
- 2012-03-13 CR CR20120121A patent/CR20120121A/es unknown
- 2012-03-26 ZA ZA2012/02199A patent/ZA201202199B/en unknown
- 2012-03-27 CL CL2012000754A patent/CL2012000754A1/es unknown
- 2012-03-28 EC ECSP12011755 patent/ECSP12011755A/es unknown
- 2012-05-22 US US13/477,587 patent/US8343955B2/en active Active
- 2012-11-20 US US13/681,763 patent/US8586574B2/en active Active
-
2013
- 2013-10-07 US US14/047,206 patent/US8785626B2/en active Active
- 2013-11-01 JP JP2013228826A patent/JP5625101B2/ja active Active
-
2014
- 2014-06-05 US US14/297,142 patent/US9198918B2/en active Active
-
2015
- 2015-05-28 IL IL239081A patent/IL239081B/en active IP Right Grant
- 2015-11-03 US US14/930,929 patent/US9546178B2/en active Active
-
2016
- 2016-12-05 US US15/368,937 patent/US9670228B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013505917A5 (https=) | ||
| RU2012117398A (ru) | Бензоксазепиновые ингибиторы pi3 и способы применения | |
| CN114430739A (zh) | Egfr抑制剂、组合物及其制备方法 | |
| JP2011522866A5 (https=) | ||
| JP2019510798A5 (https=) | ||
| RU2017112518A (ru) | Пиридоновые и азапиридоновые соединения и способы применения | |
| JP2012511588A5 (https=) | ||
| JP2016514718A5 (https=) | ||
| JP2014520863A5 (https=) | ||
| JP2013508382A5 (https=) | ||
| CN112204027A (zh) | Erk 抑制剂及其应用 | |
| RU2005134652A (ru) | Конденсированные n-гетероциклические соединения и их применение в качестве антагонистов рецепторов crf | |
| JP2014533745A5 (https=) | ||
| JP2015517566A5 (https=) | ||
| JP2016519096A5 (https=) | ||
| JP2013534902A5 (https=) | ||
| RU2012117394A (ru) | Бензоксепиновые ингибиторы pi3 и способы применения | |
| JP2008520702A5 (https=) | ||
| JP2011510995A5 (https=) | ||
| RU2011100786A (ru) | Производные имидазопиридина в качестве ингибиторов рецепторных тирозинкиназ | |
| JP2011507849A5 (https=) | ||
| JP2013542996A5 (https=) | ||
| JP2011517457A5 (https=) | ||
| JP2014532070A5 (https=) | ||
| JP2013505930A5 (https=) |