JP2013501524A5 - - Google Patents

Info

Publication number

JP2013501524A5

JP2013501524A5 JP2012524838A JP2012524838A JP2013501524A5 JP 2013501524 A5 JP2013501524 A5 JP 2013501524A5 JP 2012524838 A JP2012524838 A JP 2012524838A JP 2012524838 A JP2012524838 A JP 2012524838A JP 2013501524 A5 JP2013501524 A5 JP 2013501524A5

Authority

JP

Japan

Prior art keywords

polynucleotide

composition

adiponectin

adipoq

oligonucleotide

Prior art date

2010-08-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108091034117 Oligonucleotide Proteins 0.000 claims 35
• 108091033319 polynucleotide Proteins 0.000 claims 33
• 102000040430 polynucleotide Human genes 0.000 claims 33
• 239000002157 polynucleotide Substances 0.000 claims 33
• 239000000203 mixture Substances 0.000 claims 31
• 108010076365 Adiponectin Proteins 0.000 claims 28
• 102000011690 Adiponectin Human genes 0.000 claims 28
• 125000003729 nucleotide group Chemical group 0.000 claims 21
• 150000007523 nucleic acids Chemical group 0.000 claims 16
• 230000004048 modification Effects 0.000 claims 15
• 238000012986 modification Methods 0.000 claims 15
• 239000002773 nucleotide Substances 0.000 claims 15
• 230000000692 anti-sense effect Effects 0.000 claims 14
• 239000000074 antisense oligonucleotide Substances 0.000 claims 13
• 238000012230 antisense oligonucleotides Methods 0.000 claims 13
• 238000001727 in vivo Methods 0.000 claims 12
• 102000039446 nucleic acids Human genes 0.000 claims 11
• 108020004707 nucleic acids Proteins 0.000 claims 11
• 238000000338 in vitro Methods 0.000 claims 10
• -1 methoxyethyl Chemical group 0.000 claims 9
• 230000000295 complement effect Effects 0.000 claims 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• 108091093037 Peptide nucleic acid Proteins 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 4
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 3
• 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 3
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 3
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 3
• 206010022489 Insulin Resistance Diseases 0.000 claims 3
• 229910019142 PO4 Inorganic materials 0.000 claims 3
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 3
• 125000005600 alkyl phosphonate group Chemical group 0.000 claims 3
• 125000002619 bicyclic group Chemical group 0.000 claims 3
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 3
• 208000035475 disorder Diseases 0.000 claims 3
• 239000010452 phosphate Substances 0.000 claims 3
• PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 3
• 201000001320 Atherosclerosis Diseases 0.000 claims 2
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
• 108020004459 Small interfering RNA Proteins 0.000 claims 2
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
• 210000004962 mammalian cell Anatomy 0.000 claims 2
• 239000004055 small Interfering RNA Substances 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• 206010001580 Albuminuria Diseases 0.000 claims 1
• 108700028369 Alleles Proteins 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• QCMYYKRYFNMIEC-UHFFFAOYSA-N COP(O)=O Chemical class COP(O)=O QCMYYKRYFNMIEC-UHFFFAOYSA-N 0.000 claims 1
• 108091026890 Coding region Proteins 0.000 claims 1
• 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
• 241000233866 Fungi Species 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 206010061598 Immunodeficiency Diseases 0.000 claims 1
• 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 108010029485 Protein Isoforms Proteins 0.000 claims 1
• 102000001708 Protein Isoforms Human genes 0.000 claims 1
• 108091081021 Sense strand Proteins 0.000 claims 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000035269 cancer or benign tumor Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
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• 239000012634 fragment Substances 0.000 claims 1
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• 208000019622 heart disease Diseases 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 230000007813 immunodeficiency Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 208000019423 liver disease Diseases 0.000 claims 1
• 238000002844 melting Methods 0.000 claims 1
• 230000008018 melting Effects 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1