JP2013501508A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013501508A5 JP2013501508A5 JP2012524151A JP2012524151A JP2013501508A5 JP 2013501508 A5 JP2013501508 A5 JP 2013501508A5 JP 2012524151 A JP2012524151 A JP 2012524151A JP 2012524151 A JP2012524151 A JP 2012524151A JP 2013501508 A5 JP2013501508 A5 JP 2013501508A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- anchor
- reporter
- nucleic acid
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23418909P | 2009-08-14 | 2009-08-14 | |
| US61/234,189 | 2009-08-14 | ||
| PCT/EP2010/004963 WO2011018232A1 (en) | 2009-08-14 | 2010-08-13 | Format of probes to detect nucleic acid differences |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501508A JP2013501508A (ja) | 2013-01-17 |
| JP2013501508A5 true JP2013501508A5 (https=) | 2013-07-04 |
| JP5632476B2 JP5632476B2 (ja) | 2014-11-26 |
Family
ID=43027741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524151A Active JP5632476B2 (ja) | 2009-08-14 | 2010-08-13 | 核酸の違いを検出するためのプローブの形式 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8409802B2 (https=) |
| EP (1) | EP2464745B1 (https=) |
| JP (1) | JP5632476B2 (https=) |
| CN (2) | CN107254540B (https=) |
| CA (1) | CA2770241C (https=) |
| ES (1) | ES2608455T3 (https=) |
| WO (1) | WO2011018232A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8409802B2 (en) | 2009-08-14 | 2013-04-02 | Roche Molecular Systems, Inc. | Format of probes to detect nucleic acid differences |
| ES2986436T3 (es) | 2011-04-15 | 2024-11-11 | Univ Johns Hopkins | Sistema de secuenciación segura |
| KR20210056458A (ko) * | 2011-05-04 | 2021-05-18 | 바이오셉트 인코포레이티드 | 핵산 서열 변이체를 검출하는 방법 |
| JP5503021B2 (ja) * | 2011-09-14 | 2014-05-28 | 日本碍子株式会社 | 標的核酸の検出方法 |
| GB201116131D0 (en) * | 2011-09-19 | 2011-11-02 | Epistem Ltd | Probe |
| JP2014533506A (ja) * | 2011-11-16 | 2014-12-15 | キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 高度に相同的なゲノム領域での突然変異の検出 |
| JP6196611B2 (ja) * | 2012-03-05 | 2017-09-13 | 日本碍子株式会社 | 標的核酸の検出方法 |
| ES2886507T5 (es) | 2012-10-29 | 2024-11-15 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| US9637791B2 (en) * | 2013-12-20 | 2017-05-02 | Roche Molecular Systems, Inc. | Multiplexed nucleic acid target identification by strucutre based probe cleavage |
| WO2016098595A1 (ja) * | 2014-12-19 | 2016-06-23 | 栄研化学株式会社 | 一塩基多型検出用オリゴヌクレオチドプローブ及び一塩基多型検出方法 |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| KR20180053679A (ko) * | 2015-09-03 | 2018-05-23 | 나노스트링 테크놀로지스, 인크. | 단일 뉴클레오타이드 해상도를 가진 다가 프로브 |
| US20190211377A1 (en) * | 2016-12-22 | 2019-07-11 | Roche Molecular Systems, Inc. | Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| EP4103748A4 (en) | 2020-02-14 | 2024-03-13 | The Johns Hopkins University | METHOD AND MATERIALS FOR ASSESSING NUCLEIC ACIDS |
| CN117778575A (zh) * | 2023-12-25 | 2024-03-29 | 深圳海普洛斯医学检验实验室 | 一种用于检测SNV位点的TaqMan探针及其应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5994069A (en) * | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| AU3222793A (en) | 1991-11-26 | 1993-06-28 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
| WO1999037806A2 (en) * | 1998-01-27 | 1999-07-29 | Cytocell Limited | Modified nucleic acid probes and uses thereof |
| AU762728B2 (en) | 1998-07-02 | 2003-07-03 | Gen-Probe Incorporated | Molecular torches |
| US6207379B1 (en) | 1998-09-11 | 2001-03-27 | One Lambda | Method for amplification of DNA |
| DE60025172T2 (de) | 1999-03-18 | 2006-09-21 | Exiqon A/S | Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben |
| US6734291B2 (en) | 1999-03-24 | 2004-05-11 | Exiqon A/S | Synthesis of [2.2.1]bicyclo nucleosides |
| DE60029314T2 (de) | 1999-03-24 | 2007-07-12 | Exiqon A/S | Verbesserte Synthese für -2.2.1. I Bicyclo-Nukleoside |
| US6383752B1 (en) * | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| JP2003517842A (ja) * | 1999-12-21 | 2003-06-03 | オーソ−クリニカル・ダイアグノスティックス・インコーポレイテッド | 核酸の検出方法 |
| US6451588B1 (en) | 2000-06-30 | 2002-09-17 | Pe Corporation (Ny) | Multipartite high-affinity nucleic acid probes |
| CN101074450A (zh) * | 2001-09-24 | 2007-11-21 | 一兰姆达公司 | 诊断探针检测系统 |
| GB2395557A (en) | 2002-11-22 | 2004-05-26 | Dynal Biotech Ltd | Nucleic acid probes |
| CN1515692A (zh) * | 2003-01-02 | 2004-07-28 | 缪金明 | “锚定点灯”式寡核苷酸芯片的检测技术 |
| JP2006525027A (ja) | 2003-05-01 | 2006-11-09 | ジェン−プロウブ インコーポレイテッド | 分子スイッチを含むオリゴヌクレオチド |
| DE10356837A1 (de) * | 2003-12-05 | 2005-06-30 | Dmitry Cherkasov | Modifizierte Nukleotide und Nukleoside |
| US7745125B2 (en) * | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| JP2008520245A (ja) * | 2004-11-23 | 2008-06-19 | ワン，シャオ・ビン | 切断−増幅法による核酸多様性の検出 |
| WO2007008276A2 (en) * | 2005-05-03 | 2007-01-18 | Ensemble Discovery Corporation | Turnover probes and use thereof for nucleic acid detection |
| US20080076131A1 (en) * | 2005-12-02 | 2008-03-27 | Chagovetz Alexander M | Methods and devices for nucleic acid amplification on a surface |
| DE602006016984D1 (de) | 2005-12-12 | 2010-10-28 | Us Gov Health & Human Serv | Sonde zum sequenzieren von nukleinsäure und verwendungsverfahren |
| CA2648702A1 (en) | 2006-04-04 | 2007-10-11 | Arcxis Biotechnologies, Inc. | Cooperative probes and methods of using them |
| CN100564542C (zh) * | 2006-11-03 | 2009-12-02 | 罗光华 | 检测脱氧核糖核酸的单核苷酸多态性的方法 |
| US20080131880A1 (en) | 2006-11-22 | 2008-06-05 | Bortolin Laura T | PNA-DNA oligomers and methods of use thereof |
| JP4486704B2 (ja) | 2008-07-11 | 2010-06-23 | 三井金属鉱業株式会社 | 脱酸素剤 |
| US20100159452A1 (en) * | 2008-12-22 | 2010-06-24 | Roche Molecular Systems, Inc. | Method For Detecting a Target Nucleic Acid in a Sample |
| US8409802B2 (en) | 2009-08-14 | 2013-04-02 | Roche Molecular Systems, Inc. | Format of probes to detect nucleic acid differences |
-
2010
- 2010-08-09 US US12/852,936 patent/US8409802B2/en active Active
- 2010-08-13 ES ES10745171.8T patent/ES2608455T3/es active Active
- 2010-08-13 CN CN201710655783.0A patent/CN107254540B/zh active Active
- 2010-08-13 CN CN2010800360045A patent/CN102471805A/zh active Pending
- 2010-08-13 CA CA2770241A patent/CA2770241C/en active Active
- 2010-08-13 WO PCT/EP2010/004963 patent/WO2011018232A1/en not_active Ceased
- 2010-08-13 JP JP2012524151A patent/JP5632476B2/ja active Active
- 2010-08-13 EP EP10745171.8A patent/EP2464745B1/en active Active
-
2013
- 2013-03-06 US US13/786,749 patent/US9068225B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013501508A5 (https=) | ||
| JP6434932B2 (ja) | トーホールドプライマーデュプレックスの組成物およびその使用方法 | |
| CA3076518A1 (en) | Crispr effector system based diagnostics | |
| WO2010117420A3 (en) | Fret-labeled compounds and uses therefor | |
| JP6144623B2 (ja) | 核酸測定用の核酸プローブ | |
| RU2019138698A (ru) | Способы и композиции для днк-профилирования | |
| JP2012529904A5 (https=) | ||
| WO2009135093A3 (en) | Rnase-h-based assays utilizing modified rna monomers | |
| SG194722A1 (en) | Probe based nucleic acid detection | |
| JP2014500729A5 (https=) | ||
| WO2006128010A3 (en) | Quantification of nucleic acids and proteins using oligonucleotide mass tags | |
| WO2007127992A3 (en) | Use of base-modified deoxynucleoside triphosphates | |
| JP2016537005A5 (https=) | ||
| JP2010539940A5 (https=) | ||
| WO2012046981A3 (en) | Real time pcr detection of single nucleotide polymorphisms | |
| AU2009355009A8 (en) | THD primer target detection | |
| HRP20200321T1 (hr) | Detekcija ciljne nukleinske kiseline i varijanti | |
| WO2008016615A3 (en) | Methods for high sensitivity detection of genetic polymorphisms | |
| JP2014530011A5 (https=) | ||
| WO2008063655A3 (en) | Dna methylation markers and methods of use | |
| WO2010013771A1 (ja) | ユニバーサルな核酸プローブセットおよびその使用方法 | |
| WO2011006306A1 (zh) | 锁核酸和小沟结合物共修饰的核酸片段 | |
| WO2008061311A3 (en) | Improved hybridisation of nucleic acids | |
| WO2010138960A3 (en) | Methods and systems for single-molecule rna expression profiling | |
| WO2008119046A3 (en) | Methods and compositions for multiplexing detection of nucleic acid sequences within an array element |