CA2770241C - Method and probes to detect nucleic acid differences - Google Patents

Method and probes to detect nucleic acid differences Download PDF

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Publication number
CA2770241C
CA2770241C CA2770241A CA2770241A CA2770241C CA 2770241 C CA2770241 C CA 2770241C CA 2770241 A CA2770241 A CA 2770241A CA 2770241 A CA2770241 A CA 2770241A CA 2770241 C CA2770241 C CA 2770241C
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nucleic acid
reporter
anchor
probe
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CA2770241A
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English (en)
French (fr)
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CA2770241A1 (en
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Stephen Gordon Will
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2770241A 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences Active CA2770241C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23418909P 2009-08-14 2009-08-14
US61/234,189 2009-08-14
PCT/EP2010/004963 WO2011018232A1 (en) 2009-08-14 2010-08-13 Format of probes to detect nucleic acid differences

Publications (2)

Publication Number Publication Date
CA2770241A1 CA2770241A1 (en) 2011-02-17
CA2770241C true CA2770241C (en) 2016-03-29

Family

ID=43027741

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2770241A Active CA2770241C (en) 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences

Country Status (7)

Country Link
US (2) US8409802B2 (https=)
EP (1) EP2464745B1 (https=)
JP (1) JP5632476B2 (https=)
CN (2) CN107254540B (https=)
CA (1) CA2770241C (https=)
ES (1) ES2608455T3 (https=)
WO (1) WO2011018232A1 (https=)

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US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences
ES2986436T3 (es) 2011-04-15 2024-11-11 Univ Johns Hopkins Sistema de secuenciación segura
KR20210056458A (ko) * 2011-05-04 2021-05-18 바이오셉트 인코포레이티드 핵산 서열 변이체를 검출하는 방법
JP5503021B2 (ja) * 2011-09-14 2014-05-28 日本碍子株式会社 標的核酸の検出方法
GB201116131D0 (en) * 2011-09-19 2011-11-02 Epistem Ltd Probe
JP2014533506A (ja) * 2011-11-16 2014-12-15 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 高度に相同的なゲノム領域での突然変異の検出
JP6196611B2 (ja) * 2012-03-05 2017-09-13 日本碍子株式会社 標的核酸の検出方法
ES2886507T5 (es) 2012-10-29 2024-11-15 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
US9637791B2 (en) * 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
WO2016098595A1 (ja) * 2014-12-19 2016-06-23 栄研化学株式会社 一塩基多型検出用オリゴヌクレオチドプローブ及び一塩基多型検出方法
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
KR20180053679A (ko) * 2015-09-03 2018-05-23 나노스트링 테크놀로지스, 인크. 단일 뉴클레오타이드 해상도를 가진 다가 프로브
US20190211377A1 (en) * 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
CN111868260B (zh) 2017-08-07 2025-02-21 约翰斯霍普金斯大学 用于评估和治疗癌症的方法和材料
EP4103748A4 (en) 2020-02-14 2024-03-13 The Johns Hopkins University METHOD AND MATERIALS FOR ASSESSING NUCLEIC ACIDS
CN117778575A (zh) * 2023-12-25 2024-03-29 深圳海普洛斯医学检验实验室 一种用于检测SNV位点的TaqMan探针及其应用

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US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
DE3529478A1 (de) 1985-08-16 1987-02-19 Boehringer Mannheim Gmbh 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
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Also Published As

Publication number Publication date
US20130266938A1 (en) 2013-10-10
US8409802B2 (en) 2013-04-02
JP2013501508A (ja) 2013-01-17
CN107254540B (zh) 2021-11-16
CN102471805A (zh) 2012-05-23
CN107254540A (zh) 2017-10-17
ES2608455T3 (es) 2017-04-11
WO2011018232A1 (en) 2011-02-17
JP5632476B2 (ja) 2014-11-26
EP2464745B1 (en) 2016-11-09
US20110039264A1 (en) 2011-02-17
US9068225B2 (en) 2015-06-30
EP2464745A1 (en) 2012-06-20
CA2770241A1 (en) 2011-02-17

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