JP2013501056A5 - - Google Patents
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- JP2013501056A5 JP2013501056A5 JP2012523680A JP2012523680A JP2013501056A5 JP 2013501056 A5 JP2013501056 A5 JP 2013501056A5 JP 2012523680 A JP2012523680 A JP 2012523680A JP 2012523680 A JP2012523680 A JP 2012523680A JP 2013501056 A5 JP2013501056 A5 JP 2013501056A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- compound
- polyomavirus
- subject
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 6
- 241001505332 Polyomavirus sp. Species 0.000 claims 4
- 239000003018 immunosuppressive agent Substances 0.000 claims 4
- 206010061598 Immunodeficiency Diseases 0.000 claims 3
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 2
- 229960002170 azathioprine Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 229940125721 immunosuppressive agent Drugs 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- WNWVKZTYMQWFHE-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound [CH2]CN1CCOCC1 WNWVKZTYMQWFHE-UHFFFAOYSA-N 0.000 claims 1
- 229940124296 CD52 monoclonal antibody Drugs 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 108010092160 Dactinomycin Proteins 0.000 claims 1
- 108010008165 Etanercept Proteins 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 241000829111 Human polyomavirus 1 Species 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 230000001494 anti-thymocyte effect Effects 0.000 claims 1
- 229960004669 basiliximab Drugs 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229960002806 daclizumab Drugs 0.000 claims 1
- 229960000640 dactinomycin Drugs 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 229960000556 fingolimod Drugs 0.000 claims 1
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- -1 infliximab Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 1
- 229960001428 mercaptopurine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 1
- 229950007856 mofetil Drugs 0.000 claims 1
- 229940014456 mycophenolate Drugs 0.000 claims 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 229940079023 tysabri Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23093109P | 2009-08-03 | 2009-08-03 | |
| US61/230,931 | 2009-08-03 | ||
| PCT/US2010/044093 WO2011017253A1 (en) | 2009-08-03 | 2010-08-02 | Composition and methods of treating viral infections and viral induced tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013501056A JP2013501056A (ja) | 2013-01-10 |
| JP2013501056A5 true JP2013501056A5 (https=) | 2013-09-12 |
Family
ID=43544613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523680A Pending JP2013501056A (ja) | 2009-08-03 | 2010-08-02 | ウイルス感染およびウイルス誘発腫瘍を治療する組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120164104A1 (https=) |
| EP (1) | EP2462152A4 (https=) |
| JP (1) | JP2013501056A (https=) |
| AU (1) | AU2010279678B2 (https=) |
| BR (1) | BR112012002551A2 (https=) |
| CA (1) | CA2770282A1 (https=) |
| WO (1) | WO2011017253A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008535862A (ja) | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| WO2009079481A2 (en) | 2007-12-14 | 2009-06-25 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods to diagnose and immunize against the virus causing human merkel cell carcinoma |
| EP2254582B1 (en) | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Methods of treating viral infections |
| WO2009111486A2 (en) * | 2008-03-04 | 2009-09-11 | The Regents Of The University Of California | Reversing the immune decline of aging by a nutraceutical antioxidant in mice |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| WO2011053812A1 (en) * | 2009-10-30 | 2011-05-05 | Chimerix, Inc. | Methods of treating viral associated diseases |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| US9278135B2 (en) | 2010-04-26 | 2016-03-08 | Chimerix Inc. | Methods of treating retroviral infections and related dosage regimes |
| ES2604137T3 (es) * | 2010-08-31 | 2017-03-03 | Chimerix, Inc. | Derivados de éster de fosfonato y métodos de síntesis de los mismos |
| WO2013063436A1 (en) * | 2011-10-26 | 2013-05-02 | Chimerix, Inc. | Hexadecyloxypropyl cidofovir for the treatment of double-stranded dna virus infection |
| ES2874774T3 (es) | 2011-12-22 | 2021-11-05 | Geron Corp | Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| EA201892769A3 (ru) | 2013-03-15 | 2019-08-30 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Сложные диэфиры ациклических нуклеозидфосфонатов |
| WO2014146218A1 (zh) * | 2013-03-22 | 2014-09-25 | 当代绿能科技股份有限公司 | 马替麦考酚酯或其盐类用于制备抗流感病毒之药物的用途 |
| DK2999476T3 (en) | 2013-11-15 | 2018-09-03 | Chimerix Inc | MORPHIC FORMS OF HEXADECYLOXYPROPYL PHOSPHONATE TESTERS |
| BR112017005111B1 (pt) | 2014-09-15 | 2023-02-14 | The Regents Of The University Of California | Compostos análogos de nucleotídeo acíclico, composição farmacêutica contendo tais compostos, e usos da composição no tratamento de uma infecção por papilomavírus |
| EP3212656B1 (en) | 2014-10-27 | 2019-06-05 | Concert Pharmaceuticals Inc. | Pyrimidine phosphonic acid esters bearing at least one deuterium atom |
| GB201509431D0 (en) * | 2015-06-01 | 2015-07-15 | Equigerminal Sa | Antiviral composition |
| WO2017048956A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Nucleotide analogs |
| EP4295853A3 (en) | 2016-06-28 | 2024-03-06 | Emergent BioDefense Operations Lansing LLC | Formulations of brincidofovir |
| AU2020334152A1 (en) | 2019-08-22 | 2022-03-24 | Emory University | Nucleoside prodrugs and uses related thereto |
| CN113288896A (zh) * | 2021-05-28 | 2021-08-24 | 成都中医药大学 | 槐定碱在制备抗疱疹病毒的药物中的用途 |
| IL318465A (en) | 2022-07-21 | 2025-03-01 | Antiva Biosciences Inc | Compositions and dosage forms for the treatment of HPV infection and HPV-induced neoplasia |
| WO2024048657A1 (ja) * | 2022-08-31 | 2024-03-07 | シンバイオ製薬株式会社 | リンパ腫の治療用医薬組成物 |
| JP7827310B2 (ja) * | 2022-08-31 | 2026-03-10 | シンバイオ製薬株式会社 | リンパ腫の治療用医薬組成物 |
| WO2024047811A1 (ja) * | 2022-08-31 | 2024-03-07 | シンバイオ製薬株式会社 | リンパ腫の治療用医薬組成物 |
| EP4699610A1 (en) | 2023-04-21 | 2026-02-25 | SymBio Pharmaceuticals Limited | Pharmaceutical composition for treating glioma |
| CN119080836B (zh) * | 2024-11-07 | 2025-04-15 | 上海柯君医药科技有限公司 | 一种正痘病毒抑制剂及其应用 |
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| JP2008535862A (ja) | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
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| ES2600792T3 (es) * | 2006-05-03 | 2017-02-10 | Chimerix, Inc. | Alcoxialquilésteres metabólicamente estables de fosfonatos, fosfonatos nucleosídicos y fosfatos nucleosídicos antivirales o antiproliferativos |
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-
2010
- 2010-08-02 WO PCT/US2010/044093 patent/WO2011017253A1/en not_active Ceased
- 2010-08-02 BR BR112012002551A patent/BR112012002551A2/pt not_active IP Right Cessation
- 2010-08-02 CA CA2770282A patent/CA2770282A1/en not_active Abandoned
- 2010-08-02 US US13/388,771 patent/US20120164104A1/en not_active Abandoned
- 2010-08-02 JP JP2012523680A patent/JP2013501056A/ja active Pending
- 2010-08-02 EP EP10806986A patent/EP2462152A4/en not_active Withdrawn
- 2010-08-02 AU AU2010279678A patent/AU2010279678B2/en active Active
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