JP2013500720A5 - - Google Patents
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- Publication number
- JP2013500720A5 JP2013500720A5 JP2012523037A JP2012523037A JP2013500720A5 JP 2013500720 A5 JP2013500720 A5 JP 2013500720A5 JP 2012523037 A JP2012523037 A JP 2012523037A JP 2012523037 A JP2012523037 A JP 2012523037A JP 2013500720 A5 JP2013500720 A5 JP 2013500720A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza virus
- gene segment
- type
- virus gene
- coding region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000712461 unidentified influenza virus Species 0.000 claims 100
- 108090000623 proteins and genes Proteins 0.000 claims 80
- 108091026890 Coding region Proteins 0.000 claims 37
- 239000002773 nucleotide Substances 0.000 claims 25
- 125000003729 nucleotide group Chemical group 0.000 claims 25
- 108700026244 Open Reading Frames Proteins 0.000 claims 24
- 230000000295 complement effect Effects 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 19
- 108091092724 Noncoding DNA Proteins 0.000 claims 16
- 108091081024 Start codon Proteins 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 108020005067 RNA Splice Sites Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 101150106774 9 gene Proteins 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000037432 silent mutation Effects 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22985809P | 2009-07-30 | 2009-07-30 | |
| US61/229,858 | 2009-07-30 | ||
| PCT/US2010/043697 WO2011014645A1 (en) | 2009-07-30 | 2010-07-29 | Influenza viruses and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500720A JP2013500720A (ja) | 2013-01-10 |
| JP2013500720A5 true JP2013500720A5 (OSRAM) | 2013-09-12 |
| JP5845180B2 JP5845180B2 (ja) | 2016-01-20 |
Family
ID=42937563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523037A Active JP5845180B2 (ja) | 2009-07-30 | 2010-07-29 | インフルエンザウイルス及びそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8828406B2 (OSRAM) |
| EP (1) | EP2459585B1 (OSRAM) |
| JP (1) | JP5845180B2 (OSRAM) |
| CA (1) | CA2805505C (OSRAM) |
| WO (1) | WO2011014645A1 (OSRAM) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| AU2010254136B2 (en) | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| BR112012020839A2 (pt) | 2010-02-18 | 2017-11-21 | Sinai School Medicine | vacinas para uso na profilaxe e tratamento de doença de vírus da influenza |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2013526849A (ja) | 2010-03-30 | 2013-06-27 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
| US20130189303A1 (en) * | 2011-08-02 | 2013-07-25 | Yan Zhou | Recombinant swine influenza virus and uses thereof |
| WO2013032942A1 (en) | 2011-08-26 | 2013-03-07 | Yoshihiro Kawaoka | Influenza viruses with mutant pb2 gene segment as live attenuated vaccines |
| EP2751260A2 (en) * | 2011-09-02 | 2014-07-09 | Westfälische Wilhelms-Universität Münster | Live attenuated influenza virus |
| BR112014006694A2 (pt) | 2011-09-20 | 2020-11-17 | Mount Sinai School Of Medicine | vacinas contra o vírus influenza e usos dessas |
| JP2016508133A (ja) | 2012-12-18 | 2016-03-17 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン及びその使用 |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| WO2015002978A2 (en) * | 2013-07-02 | 2015-01-08 | The Trustees Of The University Of Pennsylvania | Methods for rapid ribonucleic acid fluorescence in situ hybridization |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| RU2628690C2 (ru) * | 2015-11-06 | 2017-08-21 | Общество С Ограниченной Ответственностью 'Фарминтерпрайсез' | Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний |
| EP3417056A1 (en) | 2016-02-19 | 2018-12-26 | Wisconsin Alumni Research Foundation (WARF) | Improved influenza b virus replication for vaccine development |
| EP4556571A3 (en) | 2016-02-26 | 2025-09-03 | Abbott Diagnostics Scarborough, Inc. | Redox labeled oligonucleotide probes and their use |
| JP7237344B2 (ja) | 2016-06-15 | 2023-03-13 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルス血球凝集素タンパク質及びその使用 |
| US11596683B2 (en) | 2016-07-12 | 2023-03-07 | Duke University | Engineered influenza polynucleotides, viruses, vaccines and methods of making and using the same |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
| JP2021500891A (ja) | 2017-10-25 | 2021-01-14 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| US12419946B2 (en) | 2019-02-07 | 2025-09-23 | Duke University | Stabilized 9 and 10 segmented influenza viruses as a vaccine platform and methods of making and using same |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US20220249652A1 (en) * | 2019-06-26 | 2022-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus neuraminidase and uses thereof |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| WO2022087127A1 (en) * | 2020-10-20 | 2022-04-28 | Duke University | Replication incompetent influenza vaccine platform for foreign protein delivery |
| CN113073115B (zh) * | 2021-06-08 | 2021-10-01 | 北京溯本源和生物科技有限公司 | 一种包装重组流感病毒的重组载体和重组流感病毒及其构建方法和应用 |
| CN115724920A (zh) * | 2021-12-31 | 2023-03-03 | 中国人民解放军军事科学院军事医学研究院 | 冠状病毒和流感病毒的二联核酸疫苗 |
| WO2025019631A1 (en) | 2023-07-19 | 2025-01-23 | Icahn School Of Medicine At Mount Sinai | Immunogenic compositions containing inactivated influenza a virus and cpg oligonucleotide adjuvant and uses thereof |
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| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US4693981A (en) | 1983-12-20 | 1987-09-15 | Advanced Genetics Research Institute | Preparation of inactivated viral vaccines |
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| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
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| KR20070086344A (ko) * | 2004-11-19 | 2007-08-27 | 위스콘신 얼럼나이 리서어치 화운데이션 | 탠덤 전사 유닛을 갖는 재조합 인플루엔자 벡터 |
| WO2006088481A2 (en) * | 2005-02-15 | 2006-08-24 | Mount Sinai School Of Medicine Of New York University | Genetically engineered equine influenza virus and uses thereof |
| EA016217B1 (ru) * | 2005-12-02 | 2012-03-30 | Маунт Синай Скул Оф Медсин | Химерные вирусы, представляющие неприродные поверхностные белки, и их применение |
| US8173657B2 (en) | 2006-03-23 | 2012-05-08 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| WO2007109812A2 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
| WO2008032219A2 (en) | 2006-09-11 | 2008-03-20 | Novartis Ag | Making influenza virus vaccines without using eggs |
-
2010
- 2010-07-29 EP EP10748161.6A patent/EP2459585B1/en active Active
- 2010-07-29 CA CA2805505A patent/CA2805505C/en active Active
- 2010-07-29 JP JP2012523037A patent/JP5845180B2/ja active Active
- 2010-07-29 US US13/387,485 patent/US8828406B2/en active Active
- 2010-07-29 WO PCT/US2010/043697 patent/WO2011014645A1/en not_active Ceased
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