JP2012136542A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012136542A5 JP2012136542A5 JP2012045015A JP2012045015A JP2012136542A5 JP 2012136542 A5 JP2012136542 A5 JP 2012136542A5 JP 2012045015 A JP2012045015 A JP 2012045015A JP 2012045015 A JP2012045015 A JP 2012045015A JP 2012136542 A5 JP2012136542 A5 JP 2012136542A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- rna molecule
- sequence
- composition
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 9
- 241000711549 Hepacivirus C Species 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60857404P | 2004-09-10 | 2004-09-10 | |
| US60/608,574 | 2004-09-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531467A Division JP2008512500A (ja) | 2004-09-10 | 2005-09-12 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012136542A JP2012136542A (ja) | 2012-07-19 |
| JP2012136542A5 true JP2012136542A5 (OSRAM) | 2013-05-30 |
Family
ID=36060681
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531467A Withdrawn JP2008512500A (ja) | 2004-09-10 | 2005-09-12 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
| JP2012045015A Pending JP2012136542A (ja) | 2004-09-10 | 2012-03-01 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531467A Withdrawn JP2008512500A (ja) | 2004-09-10 | 2005-09-12 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20090170794A1 (OSRAM) |
| EP (1) | EP1793835A4 (OSRAM) |
| JP (2) | JP2008512500A (OSRAM) |
| IL (1) | IL190114A0 (OSRAM) |
| WO (1) | WO2006031901A2 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008512500A (ja) | 2004-09-10 | 2008-04-24 | ソマジェニックス インコーポレーティッド | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
| EP1849865B1 (en) * | 2005-01-28 | 2013-05-22 | Haplopharma Inc. | RNAi MEDICINE HAVING NO ADVERSE EFFECTS |
| CN102827841A (zh) * | 2005-09-12 | 2012-12-19 | 索马根尼科斯公司 | 利用小干扰rna抑制病毒基因表达 |
| EP3042959A1 (en) * | 2007-01-16 | 2016-07-13 | The University of Queensland | Method of inducing an immune response |
| DK2308514T3 (da) | 2007-03-23 | 2013-09-02 | To Bbb Holding B V | Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren |
| JP5149528B2 (ja) * | 2007-03-30 | 2013-02-20 | 学校法人東京医科大学 | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| US8058069B2 (en) | 2008-04-15 | 2011-11-15 | Protiva Biotherapeutics, Inc. | Lipid formulations for nucleic acid delivery |
| US8680064B2 (en) * | 2008-09-15 | 2014-03-25 | The Board Of Trustees Of The Leland Stanford Junior University | ShRNA gene therapy for treatment of ischemic heart disease |
| CN102245772A (zh) | 2008-10-15 | 2011-11-16 | 索马根尼科斯公司 | 抑制基因表达的短发卡rna |
| CN105907756A (zh) * | 2008-12-18 | 2016-08-31 | 戴瑟纳制药公司 | 延长的dicer酶底物和特异性抑制基因表达的方法 |
| BR112012000565A2 (pt) * | 2009-06-19 | 2016-11-16 | Commw Scient Ind Res Org | ensaio de vírus. |
| EP2449114B9 (en) | 2009-07-01 | 2017-04-19 | Protiva Biotherapeutics Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| WO2011008730A2 (en) | 2009-07-13 | 2011-01-20 | Somagenics Inc. | Chemical modification of small hairpin rnas for inhibition of gene expression |
| AU2011242576B2 (en) | 2010-04-23 | 2016-03-31 | Cold Spring Harbor Laboratory | Novel structurally designed shRNAs |
| CA2818662C (en) * | 2010-10-22 | 2021-07-06 | Sungkyunkwan University Foundation For Corporate Collaboration | Nucleic acid molecule inducing rna interference, and uses thereof |
| US20120308642A1 (en) * | 2011-05-27 | 2012-12-06 | Xavier University Of Louisiana | Inhibiting hepatitis c viral replication with sirna combinations |
| JP6137484B2 (ja) * | 2011-11-02 | 2017-05-31 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| WO2013126803A1 (en) | 2012-02-24 | 2013-08-29 | Protiva Biotherapeutics Inc. | Trialkyl cationic lipids and methods of use thereof |
| EP3514236A1 (en) | 2012-05-22 | 2019-07-24 | Olix Pharmaceuticals, Inc. | Rna-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor |
| US10695548B1 (en) * | 2013-02-14 | 2020-06-30 | Transderm, Inc. | Gene silencing in skin using self-delivery siRNA delivered by a meso device |
| EP3128008B1 (en) * | 2014-04-04 | 2024-05-29 | Bioneer Corporation | Double-stranded oligo rna and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases |
| EP3377630A4 (en) | 2015-11-16 | 2020-01-01 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| WO2017134526A1 (en) | 2016-02-02 | 2017-08-10 | Olix Pharmaceuticals, Inc. | Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb |
| CN108779463B (zh) | 2016-02-02 | 2022-05-24 | 奥利克斯医药有限公司 | 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘 |
| WO2017178883A2 (en) | 2016-04-11 | 2017-10-19 | Olix Pharmaceuticals, Inc. | Treatment of idiopathic pulmonary fibrosis using rna complexes that target connective tissue growth factor |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| US11591600B2 (en) | 2017-02-10 | 2023-02-28 | OliX Pharmaceuticals. Inc. | Long double-stranded RNA for RNA interference |
| JP7709981B2 (ja) | 2020-03-17 | 2025-07-17 | ジェネヴァント サイエンシズ ゲーエムベーハー | 肝星細胞への治療薬の脂質ナノ粒子送達のためのカチオン性脂質 |
| US20240148663A1 (en) | 2020-12-18 | 2024-05-09 | Genevant Sciences Gmbh | Peg lipids and lipid nanoparticles |
| EP4466250B1 (en) | 2022-01-31 | 2025-03-26 | Genevant Sciences Gmbh | Ionizable cationic lipids for lipid nanoparticles |
| WO2025052278A1 (en) | 2023-09-05 | 2025-03-13 | Genevant Sciences Gmbh | Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
| WO2025133951A1 (en) | 2023-12-21 | 2025-06-26 | Genevant Sciences Gmbh | Ionizable lipids suitable for lipid nanoparticles |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| EP0759979A4 (en) * | 1994-05-10 | 1999-10-20 | Gen Hospital Corp | THE ANTISENSE INHIBITION OF HEPATITIS C VIRUS |
| US20030228597A1 (en) * | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| RU2322500C2 (ru) * | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
| US20040209831A1 (en) * | 2002-02-20 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA) |
| US10590418B2 (en) | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| CA2454183C (en) * | 2001-07-23 | 2016-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
| US7294504B1 (en) * | 2001-12-27 | 2007-11-13 | Allele Biotechnology & Pharmaceuticals, Inc. | Methods and compositions for DNA mediated gene silencing |
| EP1430157B1 (en) * | 2002-02-20 | 2011-08-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2004027030A2 (en) * | 2002-09-18 | 2004-04-01 | Isis Pharmaceuticals, Inc. | Efficient reduction of target rna’s by single- and double-stranded oligomeric compounds |
| JP4228071B2 (ja) * | 2003-04-09 | 2009-02-25 | 独立行政法人産業技術総合研究所 | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| WO2005028646A1 (ja) * | 2003-09-22 | 2005-03-31 | Riken | 効率的なdna逆位反復構造の調製方法 |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| JP2008512500A (ja) | 2004-09-10 | 2008-04-24 | ソマジェニックス インコーポレーティッド | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
| US20060142228A1 (en) | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| CN102245772A (zh) * | 2008-10-15 | 2011-11-16 | 索马根尼科斯公司 | 抑制基因表达的短发卡rna |
-
2005
- 2005-09-12 JP JP2007531467A patent/JP2008512500A/ja not_active Withdrawn
- 2005-09-12 WO PCT/US2005/032768 patent/WO2006031901A2/en not_active Ceased
- 2005-09-12 EP EP05809901A patent/EP1793835A4/en not_active Withdrawn
- 2005-09-12 US US11/662,506 patent/US20090170794A1/en not_active Abandoned
-
2006
- 2006-06-01 US US11/444,901 patent/US7902351B2/en not_active Expired - Fee Related
-
2008
- 2008-03-11 IL IL190114A patent/IL190114A0/en unknown
-
2011
- 2011-03-02 US US13/039,100 patent/US8426380B2/en not_active Expired - Fee Related
-
2012
- 2012-01-27 US US13/360,442 patent/US20120220033A1/en not_active Abandoned
- 2012-03-01 JP JP2012045015A patent/JP2012136542A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012136542A5 (OSRAM) | ||
| Zheng et al. | Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome | |
| HRP20190995T1 (hr) | LIJEČENJE HBV-a | |
| Carbonell et al. | Multi‐targeting of viral RNAs with synthetic trans‐acting small interfering RNAs enhances plant antiviral resistance | |
| EA201391394A1 (ru) | Композиции и способы ингибирования экспрессии генов вируса гепатита в | |
| Alabi et al. | High‐throughput sequence analysis of small RNA s in grapevine (V itis vinifera L.) affected by grapevine leafroll disease | |
| ZA202003137B (en) | Nucleic acid, composition and conjugate containing same, and preparation method and use | |
| JP2012223202A5 (OSRAM) | ||
| RU2019100094A (ru) | МОЛЕКУЛЫ НУКЛЕИНОВЫХ КИСЛОТ ДЛЯ УМЕНЬШЕНИЯ УРОВНЯ мРНК PAPD5 ИЛИ PAPD7 ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИОННОГО ГЕПАТИТА В | |
| Mollaie et al. | RNAi and miRNA in viral infections and cancers | |
| JP2016116520A5 (OSRAM) | ||
| JP2014527401A5 (OSRAM) | ||
| WO2006121464A3 (en) | Compositions for treating respiratory viral infections and their use | |
| NZ604094A (en) | Double stranded rna compounds to rhoa and use thereof | |
| Lin et al. | Global analyses of small interfering RNAs derived from Bamboo mosaic virus and its associated satellite RNAs in different plants | |
| CN112760320B (zh) | 有效抑制猪流行性腹泻病毒复制的外源性人工miRNA及其用途 | |
| RU2016119354A (ru) | Мирнк и их применение в способах и композициях для ингибирования экспрессии гена orai1 | |
| CN115820638B (zh) | 一种抑制水禽源禽呼肠孤病毒复制的外源性人工miRNA及其应用 | |
| Hemida et al. | Exploiting the therapeutic potential of microRNAs in viral diseases: expectations and limitations | |
| Wang et al. | Pathogenic roles of m6A modification in viral infection and virus-driven carcinogenesis | |
| WO2013162350A3 (en) | Circular antiviral rna | |
| JP2010265270A5 (OSRAM) | ||
| JP2010270119A5 (OSRAM) | ||
| Feng et al. | In silico analysis the complementarity of tomato microRNA/microRNA* sequences with cucumber mosaic virus (CMV) genomic RNAs | |
| EA201490160A1 (ru) | Конструкции для сайленсинга гена p0 и применение |