JP2013212418A5 - - Google Patents
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- JP2013212418A5 JP2013212418A5 JP2013147882A JP2013147882A JP2013212418A5 JP 2013212418 A5 JP2013212418 A5 JP 2013212418A5 JP 2013147882 A JP2013147882 A JP 2013147882A JP 2013147882 A JP2013147882 A JP 2013147882A JP 2013212418 A5 JP2013212418 A5 JP 2013212418A5
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- surgical mesh
- mesh
- poly
- prosthesis
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- 多孔質外科用製織メッシュ又は編成メッシュを含む外科用メッシュ補綴具であって、
前記外科用メッシュは、ポリプロピレン、ポリエステルまたはポリアミドを含む生体適合性材料を含有し、生分解性ポリマー被膜で被覆され、
前記被膜は、(i)前記メッシュにその未被覆の剛性の少なくとも1.1倍の剛性を一時的に付与し、(ii)前記メッシュの気孔率を実質的に変化させずに前記メッシュ上に配置され、(iii)患者の体内で生分解して前記メッシュが実質的にその未被覆の剛性に戻ることができ、(iv)前記被膜が乾燥、硬化または固化した後に前記メッシュを前記ポーチの形状に保持するのに十分な強度を有し、及び(v)10,000〜200,000ダルトンの分子量を有し、
前記被膜が、前記ポリマー被膜に混和できる、抗線維症薬、抗菌剤、麻酔薬、鎮痛剤、抗炎症剤、およびロイコトリエン阻害剤よりなる群から選ばれる少なくとも1種の薬剤をさらに含有する、外科用メッシュ補綴具。 - 前記多孔質メッシュは0.4mm及び3mmの孔を含む、請求項1に記載の外科用メッシュ補綴具。
- 前記メッシュは再吸収することができる、請求項1に記載の外科用メッシュ補綴具。
- 前記メッシュは再吸収することができない、請求項1に記載の外科用メッシュ補綴具。
- 前記非再吸収性メッシュが編成ポリプロピレンである、請求項4に記載の外科用メッシュ補綴具。
- 前記被膜が前記メッシュの片面または両面に配置されている、請求項1に記載の外科用メッシュ補綴具。
- 前記被膜が実質的に全ての前記メッシュに配置されている、請求項1に記載の外科用メッシュ補綴具。
- 前記生分解性ポリマーが、ポリ乳酸、ポリグリコール酸、ポリ(L−ラクチド)、ポリ(D,L−ラクチド)、ポリグリコール酸、ポリ(L−ラクチド−コ−D,L−ラクチド)、ポリ(L−ラクチド−コ−グリコリド)、ポリ(D,L−ラクチド−コ−グリコリド)、ポリ(グリコリド−コ−トリメチレンカーボネート)、ポリ(D,L−ラクチド−コ−カプロラクトン)、ポリ(グリコリド−コ−カプロラクトン)、ポリオキサエステル、ポリジオキサノン、ポリプロピレンフマレート、ポリ(エチルグルタメート−コ−グルタミン酸)、ポリ(tert−ブチルオキシ−カルボニルメチルグルタメート)、ポリカプロラクトン、ポリカプロラクトン−コ−ブチルアクリレート、ポリヒドロキシブチレート、ポリ(ホスファゼン)、ポリ(リン酸エステル)、ポリ(アミノ酸)、ポリデプシペプチド、無水マレイン酸コポリマー、ポリイミノカーボネート、ポリ[(97.5%ジメチルトリメチレンカーボネート)−コ−(2.5%トリメチレンカーボネート)]、ポリ(オルトエステル)、チロシン誘導ポリアリレート、チロシン誘導ポリカーボネート、チロシン誘導ポリイミノカーボネート、チロシン誘導ポリホスホネート、タンパク質、ならびに上記のいずれかのブレンドよりなる群から選ばれる、請求項1に記載の外科用メッシュ補綴具。
- 前記生分解性ポリマーがチロシン誘導ジフェノールモノマー単位を含む、請求項1に記載の外科用メッシュ補綴具。
- 前記生分解性ポリマーがポリアリレート、ポリカーボネート、ポリイミノカーボネート、またはポリホスホネートである、請求項9に記載の外科用メッシュ補綴具。
- 前記ポリアリレートが約1%〜約30%のデスアミノチロシル−チロシン(DT)を含有する、デスアミノチロシル−チロシン(DT)とデスアミノチロシル−チロシルエステル(DTE)スクシネートとのコポリマーである、請求項10に記載の外科用メッシュ補綴具。
- 前記ポリアリレートがデスアミノチロシル−チロシン(DT)とデスアミノチロシル−チロシルエステル(DTエステル)とのランダムコポリマーであって、このコポリマーが約0.001%〜約80%のDTを含有し、前記エステル部分が炭素数18までの分岐または非分岐アルキル、アルキルアリール、またはアルキレンエーテル基でよく、その任意の基が場合によりポリアルキレンオキシドを内部に有していてもよい、請求項10に記載の外科用メッシュ補綴具。
- 前記ポリアリレートが4−ヒドロキシベンゾイル−チロシン(BT)と4−ヒドロキシベンゾイル−チロシルエステル(BTエステル)とのランダムコポリマーであって、このコポリマーが約0.001%〜約80%のBTを含有し、前記エステル部分が炭素数18までの分岐または非分岐アルキル、アルキルアリール、またはアルキレンエーテル基でよく、その任意の基が場合によりポリアルキレンオキシドを内部に有していてもよい、請求項10に記載の外科用メッシュ補綴具。
- 前記メッシュが移植後約1週間の間は患者の体内でその最初の剛性を保持する、請求項1に記載の外科用メッシュ補綴具。
- 前記薬剤が抗菌剤である、請求項1に記載の外科用メッシュ補綴具。
- 前記抗菌剤がリファンピン、ミノサイクリン、銀/クロルヘキシジン、バンコマイシン、セファロスポリン類、ゲンタマイシン、トリクロサンおよびそれらの混合物よりなる群から選ばれる、請求項15に記載の外科用メッシュ補綴具。
- 前記少なくとも1種の薬剤がリファンピンを別の抗菌剤と組合わせて含む、請求項1に記載の外科用メッシュ補綴具。
- 前記別の抗菌剤がミノサイクリンHClである、請求項17に記載の外科用メッシュ補綴具。
- 多孔質製織又は編成外科用メッシュと被膜とを含む、被覆された外科用メッシュ補綴具であって、
前記多孔質製織又は編成外科用メッシュは、ポリプロピレン、ポリエステルまたはポリアミドフィラメントを含む生体適合性材料を含有し、前記フィラメントで囲まれた前記多孔質メッシュの孔と前記フィラメントにより形成された交接点を画成し、前記外科用メッシュが剛性を有し、
前記被膜が前記外科用メッシュの前記フィラメントと前記交接点に配置され、
前記被膜が、
(i)チロシン誘導ポリアリレートを含み、
(ii)抗菌剤、麻酔薬、抗炎症剤、ロイコトリエン阻害剤又は鎮痛剤を含む活性剤を含み、
(iii)前記メッシュにその未被覆の剛性の少なくとも1.1倍優れた剛性を付与し、
(iv)生理学的溶液中で生分解して前記メッシュが実質的にその未被覆の剛性に戻ることができ、
前記孔が前記被覆された外科用メッシュにおいて約0.4mm〜約3mmのサイズを有する、外科用メッシュ補綴具。 - 前記抗菌剤が、トリクロサン、クロルヘキシジン、リファンピン、ミノサイクリン、バンコマイシン、ゲンタマイシン、又はセファロスポリン類を含む、請求項19に記載の外科用メッシュ補綴具。
- 前記麻酔薬が、リコダイン、ブピバカイン、又はメピバカインを含む、請求項19に記載の外科用メッシュ補綴具。
- 前記抗炎症剤が、テトラヒドロコルチゾール、酢酸コルチゾン、ヒドロコルチゾン、プロポキシフェン、メチルプレドニゾロン、デキサメタゾン、ベクロメタゾン、又はフロ酸モメタゾンを含む、請求項19に記載の外科用メッシュ補綴具。
- 前記ロイコトリエン阻害剤が、ロイコトリエン受容体拮抗剤を含む、請求項19に記載の外科用メッシュ補綴具。
- 前記鎮痛剤が、ブピバカイン、アセタミノフェン、クロニジン、ベンゾジアゼピン、リコダイン、トラマドール、カルバマゼピン、メペリジン、ザレプロン、マレイン酸トリミプラミン、ブプレノルフィン、ナルブフィン、ペンタゾカイン、フェンタニル、プロポキシフェン、ヒドロモルフォン、メタドン、モルヒネ、レボルファノール、又はヒドロコドンを含む、請求項19に記載の外科用メッシュ補綴具。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US77182706P | 2006-02-08 | 2006-02-08 | |
US60/771,827 | 2006-02-08 |
Related Parent Applications (1)
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JP2010502992A Division JP5367692B2 (ja) | 2006-02-08 | 2007-02-08 | 一時的補剛メッシュ補綴具 |
Publications (3)
Publication Number | Publication Date |
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JP2013212418A JP2013212418A (ja) | 2013-10-17 |
JP2013212418A5 true JP2013212418A5 (ja) | 2014-01-09 |
JP5796911B2 JP5796911B2 (ja) | 2015-10-21 |
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JP2010502992A Active JP5367692B2 (ja) | 2006-02-08 | 2007-02-08 | 一時的補剛メッシュ補綴具 |
JP2013147882A Active JP5796911B2 (ja) | 2006-02-08 | 2013-07-16 | 一時的補剛メッシュ補綴具 |
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JP2010502992A Active JP5367692B2 (ja) | 2006-02-08 | 2007-02-08 | 一時的補剛メッシュ補綴具 |
Country Status (6)
Country | Link |
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US (5) | US8636753B2 (ja) |
EP (1) | EP2114298B1 (ja) |
JP (2) | JP5367692B2 (ja) |
AU (1) | AU2007344645B2 (ja) |
MX (1) | MX2008010126A (ja) |
WO (1) | WO2009113972A2 (ja) |
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WO2008157092A1 (en) * | 2007-06-20 | 2008-12-24 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
EP2166981B1 (en) * | 2007-06-21 | 2016-09-07 | Tyrx, Inc. | Phenyl ester side chains to increase polymer resorptivity |
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2007
- 2007-02-08 WO PCT/US2007/061885 patent/WO2009113972A2/en active Application Filing
- 2007-02-08 JP JP2010502992A patent/JP5367692B2/ja active Active
- 2007-02-08 AU AU2007344645A patent/AU2007344645B2/en active Active
- 2007-02-08 EP EP07756801.2A patent/EP2114298B1/en active Active
- 2007-02-08 US US11/672,929 patent/US8636753B2/en active Active
- 2007-02-08 MX MX2008010126A patent/MX2008010126A/es not_active Application Discontinuation
- 2007-11-06 US US11/936,049 patent/US20090018559A1/en not_active Abandoned
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2013
- 2013-07-16 JP JP2013147882A patent/JP5796911B2/ja active Active
- 2013-09-23 US US14/033,979 patent/US9457129B2/en active Active
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2016
- 2016-07-26 US US15/219,780 patent/US9987116B2/en active Active
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2018
- 2018-05-09 US US15/975,273 patent/US10765500B2/en active Active
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