JP2013132393A - プレフィルドシリンジ用外筒の製造方法 - Google Patents
プレフィルドシリンジ用外筒の製造方法 Download PDFInfo
- Publication number
- JP2013132393A JP2013132393A JP2011284400A JP2011284400A JP2013132393A JP 2013132393 A JP2013132393 A JP 2013132393A JP 2011284400 A JP2011284400 A JP 2011284400A JP 2011284400 A JP2011284400 A JP 2011284400A JP 2013132393 A JP2013132393 A JP 2013132393A
- Authority
- JP
- Japan
- Prior art keywords
- outer cylinder
- prefilled syringe
- cyclic olefin
- prefilled
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940071643 prefilled syringe Drugs 0.000 title claims abstract description 93
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims abstract description 29
- 229920005672 polyolefin resin Polymers 0.000 claims abstract description 37
- 125000004122 cyclic group Chemical group 0.000 claims abstract description 36
- 230000003746 surface roughness Effects 0.000 claims abstract description 27
- 239000011342 resin composition Substances 0.000 claims abstract description 16
- 238000001746 injection moulding Methods 0.000 claims abstract description 6
- 238000002834 transmittance Methods 0.000 claims abstract description 6
- 238000000576 coating method Methods 0.000 claims description 13
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 239000011248 coating agent Substances 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 4
- 229910010037 TiAlN Inorganic materials 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 229910052804 chromium Inorganic materials 0.000 claims description 3
- 229910052719 titanium Inorganic materials 0.000 claims description 3
- 229910052726 zirconium Inorganic materials 0.000 claims description 3
- 229910052759 nickel Inorganic materials 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 9
- 238000000465 moulding Methods 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- -1 polypropylene Polymers 0.000 description 23
- 239000003814 drug Substances 0.000 description 18
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 15
- 229920005989 resin Polymers 0.000 description 13
- 239000011347 resin Substances 0.000 description 13
- 239000004711 α-olefin Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 150000002430 hydrocarbons Chemical group 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 238000007334 copolymerization reaction Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical compound C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 description 3
- 238000005240 physical vapour deposition Methods 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
- 102000005591 NIMA-Interacting Peptidylprolyl Isomerase Human genes 0.000 description 2
- 108010059419 NIMA-Interacting Peptidylprolyl Isomerase Proteins 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 125000004018 acid anhydride group Chemical group 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005229 chemical vapour deposition Methods 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007772 electroless plating Methods 0.000 description 2
- 125000003700 epoxy group Chemical group 0.000 description 2
- 125000004185 ester group Chemical group 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 description 2
- 238000007517 polishing process Methods 0.000 description 2
- 125000003367 polycyclic group Chemical group 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 238000007740 vapor deposition Methods 0.000 description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical group OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- OFNISBHGPNMTMS-UHFFFAOYSA-N 3-methylideneoxolane-2,5-dione Chemical compound C=C1CC(=O)OC1=O OFNISBHGPNMTMS-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000006061 abrasive grain Substances 0.000 description 1
- 125000001118 alkylidene group Chemical group 0.000 description 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 101150059062 apln gene Proteins 0.000 description 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000012661 block copolymerization Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 238000001659 ion-beam spectroscopy Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000001755 magnetron sputter deposition Methods 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000012968 metallocene catalyst Substances 0.000 description 1
- 238000005649 metathesis reaction Methods 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 239000002667 nucleating agent Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000005268 plasma chemical vapour deposition Methods 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000002685 polymerization catalyst Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
Abstract
【解決手段】環状オレフィン樹脂組成物を射出成形してなるプレフィルドシリンジ用外筒を製造する方法において、プレフィルドシリンジ用外筒を成形するための、射出成形用金型のコアの表面粗さが特定の範囲に調整し、プレフィルドシリンジ用外筒の側壁に対して垂直に入射する波長450nmの光が前記側壁を透過したときの光線透過率が70%以上であるプレフィルドシリンジ用外筒を製造する。
【選択図】図1
Description
図1はプレフィルドシリンジを模式的に示す図であり、(a)は斜視図であり、(b)は(a)のMM断面図である。プレフィルドシリンジ1は、プレフィルドシリンジ用外筒10、プレフィルドシリンジ用外筒10の一端と連結したカニューレ20、プレフィルドシリンジ用外筒10の他端からプレフィルドシリンジ用外筒10の内部に進退可能に挿通されたプランジャー30とを備える。
本発明のプレフィルドシリンジ用外筒の製造方法は、環状オレフィン樹脂組成物を射出成形してなるプレフィルドシリンジ用外筒の製造方法である。
プレフィルドシリンジ用外筒の原料となる環状オレフィン樹脂組成物について説明する。環状オレフィン樹脂組成物には環状オレフィン樹脂が含まれる。
R9とR10、R11とR12は、一体化して2価の炭化水素基を形成してもよく、
R9又はR10と、R11又はR12とは、互いに環を形成していてもよい。
また、nは、0又は正の整数を示し、
nが2以上の場合には、R5〜R8は、それぞれの繰り返し単位の中で、それぞれ同一でも異なっていてもよい。)
本発明のプレフィルドシリンジ用外筒は射出成形法で製造される。射出成形の製造条件は特に限定されず、使用する環状オレフィン樹脂組成物に応じて適宜設定する。
本発明の製造方法で製造されたプレフィルドシリンジは、透明性が高い。具体的には、プレフィルドシリンジ用外筒の側壁に対して垂直に入射する波長450nmの光が側壁を透過したときの光線透過率が70%以上である。
本実施例では、図1に示す形状のプレフィルドシリンジ用外筒を製造する。このプレフィルドシリンジ用外筒の寸法は、図2(a)に示した。また、図2(a)に示す通り、実施例で製造したプレフィルドシリンジ用外筒は、内壁面の抜き勾配が0度である。
コア表面の表面粗さRz、潤滑性硬質皮膜の表面の表面粗さRzを、株式会社キーエンス社製の「超深度カラー3D形状測定顕微鏡 VK−9500」を用いて、JIS B 0601−1994に準拠した方法で測定した。測定結果を表1に示した。なお、表1中の単位はμmである。
環状オレフィン樹脂組成物として、ノルボルネンとエチレンとの共重合体(TOPAS6013S−04、Topas Advanced Polymers社製、ガラス転移温度138℃)を用い、実施例及び比較例のプレフィルドシリンジ用外筒を製造した。なお、製造条件は、金型温度が105℃、シリンダー温度が280℃である。
実施例1〜6、比較例1のプレフィルドシリンジ用外筒の透明性は、日本分光株式会社製「紫外可視分光光度計 V−570」に「積分球装置 ISN−470型」をセットした装置を用いて測定した。サンプルはプレフィルドシリンジ用外筒が延びる方向にシリンジを半分に切断し、ここから2分割された円筒形状のサンプルを切り出した(ここでは、ルアー部とプレフィルドシリンジ用外筒との連結位置から17.5mm付近を切り出した)。切り出したサンプルを図3に示すようにサンプル固定ホルダーにセットし、450nmの光に対する光線透過率を測定した。測定結果を表1に示した。表1中の単位は%である。
10 プレフィルドシリンジ用外筒
101 ルアー
102 フランジ
20 カニューレ
201 ストッパー
30 プランジャー
Claims (5)
- 環状オレフィン樹脂組成物を射出成形してなるプレフィルドシリンジ用外筒を製造する方法であって、
射出成形金型を構成するコアの表面粗さRzが50μm以下の射出成形用金型を用い、
プレフィルドシリンジ用外筒の側壁に対して垂直に入射する波長450nmの光が前記側壁を透過したときの光線透過率が70%以上であるプレフィルドシリンジ用外筒の製造方法。 - 前記表面粗さは30μm以上である請求項1に記載のプレフィルドシリンジ用外筒の製造方法。
- 射出成形金型を構成するコアの抜き勾配が実質的に0度である請求項1又は2に記載のプレフィルドシリンジ用外筒の製造方法。
- 前記コア表面には、Ti、Cr、Zr、C、Al及びNiから選択される少なくとも一種の元素を含む潤滑性硬質皮膜が形成されている請求項1から3のいずれかに記載のプレフィルドシリンジ用外筒の製造方法。
- 前記潤滑性硬質皮膜は、ダイヤモンドライクカーボン(DLC)、CrN、TiN、TiC、TiCN、TiAlN、TiCrN、AlCrN、ZrN、又はNiから選択される少なくとも一種から構成される請求項4に記載のプレフィルドシリンジ用外筒の製造方法。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011284400A JP6128731B2 (ja) | 2011-12-26 | 2011-12-26 | プレフィルドシリンジ用外筒の製造方法 |
CN201280064342.9A CN104039294A (zh) | 2011-12-26 | 2012-11-07 | 预充式注射器用外筒的制造方法 |
PCT/JP2012/078884 WO2013099446A1 (ja) | 2011-12-26 | 2012-11-07 | プレフィルドシリンジ用外筒の製造方法 |
KR1020147013273A KR102011381B1 (ko) | 2011-12-26 | 2012-11-07 | 프리필드시린지용 외통(外筒)의 제조방법 |
TW101144106A TWI621455B (zh) | 2011-12-26 | 2012-11-26 | 預填注射器用外筒的製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011284400A JP6128731B2 (ja) | 2011-12-26 | 2011-12-26 | プレフィルドシリンジ用外筒の製造方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013132393A true JP2013132393A (ja) | 2013-07-08 |
JP2013132393A5 JP2013132393A5 (ja) | 2014-12-04 |
JP6128731B2 JP6128731B2 (ja) | 2017-05-17 |
Family
ID=48696946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011284400A Expired - Fee Related JP6128731B2 (ja) | 2011-12-26 | 2011-12-26 | プレフィルドシリンジ用外筒の製造方法 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP6128731B2 (ja) |
KR (1) | KR102011381B1 (ja) |
CN (1) | CN104039294A (ja) |
TW (1) | TWI621455B (ja) |
WO (1) | WO2013099446A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112451797B (zh) * | 2020-11-05 | 2023-04-18 | 山东永聚医药科技有限公司 | 高分子预灌封注射器 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0884773A (ja) * | 1994-09-14 | 1996-04-02 | Taisei Kako Kk | 非晶性樹脂製の抜き勾配を有しない注射筒及びその射出成形方法 |
JP2001287227A (ja) * | 2000-04-06 | 2001-10-16 | Polyplastics Co | 成形用金型及び成形方法 |
JP2005137771A (ja) * | 2003-11-10 | 2005-06-02 | Daikyo Seiko Ltd | 薬液接触面に固着したフッ素含有層が形成された医療用機器及びその製造方法 |
JP2006077274A (ja) * | 2004-09-08 | 2006-03-23 | Sanyo Special Steel Co Ltd | 鏡面性に優れたプラスチック金型用鋼 |
WO2008149707A1 (ja) * | 2007-06-01 | 2008-12-11 | Itoh Optical Industrial Co., Ltd. | Dlc膜及びdlcコート金型 |
WO2011125657A1 (ja) * | 2010-03-31 | 2011-10-13 | 日立ツール株式会社 | 耐食性に優れた被覆物品の製造方法および被覆物品 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11164887A (ja) | 1997-12-05 | 1999-06-22 | Nippon Zeon Co Ltd | 筒状成形体 |
BRPI0719556A2 (pt) * | 2006-12-18 | 2013-12-10 | Daiichi Sankyo Co Ltd | Tubo externo de seringa para solução química preenchida e formulação de seringa selada e processo para a sua produção |
CN201453652U (zh) * | 2009-06-18 | 2010-05-12 | 李炜平 | 一种环状聚烯烃制药剂瓶 |
-
2011
- 2011-12-26 JP JP2011284400A patent/JP6128731B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-07 KR KR1020147013273A patent/KR102011381B1/ko active IP Right Grant
- 2012-11-07 WO PCT/JP2012/078884 patent/WO2013099446A1/ja active Application Filing
- 2012-11-07 CN CN201280064342.9A patent/CN104039294A/zh active Pending
- 2012-11-26 TW TW101144106A patent/TWI621455B/zh not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0884773A (ja) * | 1994-09-14 | 1996-04-02 | Taisei Kako Kk | 非晶性樹脂製の抜き勾配を有しない注射筒及びその射出成形方法 |
JP2001287227A (ja) * | 2000-04-06 | 2001-10-16 | Polyplastics Co | 成形用金型及び成形方法 |
JP2005137771A (ja) * | 2003-11-10 | 2005-06-02 | Daikyo Seiko Ltd | 薬液接触面に固着したフッ素含有層が形成された医療用機器及びその製造方法 |
JP2006077274A (ja) * | 2004-09-08 | 2006-03-23 | Sanyo Special Steel Co Ltd | 鏡面性に優れたプラスチック金型用鋼 |
WO2008149707A1 (ja) * | 2007-06-01 | 2008-12-11 | Itoh Optical Industrial Co., Ltd. | Dlc膜及びdlcコート金型 |
WO2011125657A1 (ja) * | 2010-03-31 | 2011-10-13 | 日立ツール株式会社 | 耐食性に優れた被覆物品の製造方法および被覆物品 |
Also Published As
Publication number | Publication date |
---|---|
CN104039294A (zh) | 2014-09-10 |
TW201334823A (zh) | 2013-09-01 |
TWI621455B (zh) | 2018-04-21 |
KR102011381B1 (ko) | 2019-08-16 |
KR20140106512A (ko) | 2014-09-03 |
JP6128731B2 (ja) | 2017-05-17 |
WO2013099446A1 (ja) | 2013-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102962914A (zh) | 预充式注射器用垫片的模具 | |
KR20120107098A (ko) | 광학 필름 및 복합 편광판 | |
JP6128731B2 (ja) | プレフィルドシリンジ用外筒の製造方法 | |
WO2013099447A1 (ja) | プレフィルドシリンジ用外筒の製造方法、及び射出成形用金型の製造方法 | |
US20200164147A1 (en) | Syringe barrel and syringe | |
TWI737670B (zh) | 光學透鏡的製造方法 | |
WO2006101235A1 (ja) | 樹脂スタンパ | |
JP6779095B2 (ja) | 賦形加飾シートの製造方法 | |
JP2016087110A (ja) | 医療用器具 | |
JP5345826B2 (ja) | 導光板 | |
JP2016022145A (ja) | 医療用器具 | |
JP2010031253A (ja) | 溶融押出用環状オレフィン系樹脂組成物及びそれを用いたフィルム | |
WO2011162098A1 (ja) | 成形体の製造方法 | |
JP2004149639A (ja) | 光学フィルム及びその製造方法 | |
JP2016059635A (ja) | プレフィルドシリンジ | |
JP2016533210A (ja) | 射出成形壁構造体のための方法及び装置 | |
TWI248861B (en) | Injection molding equipment, component member used for the sake, and surface treatment method | |
JP2006327110A (ja) | 光学フィルムの製造方法、光学フィルム及び位相差フィルム | |
JPWO2015037585A1 (ja) | 光学素子 | |
JP2019178349A (ja) | ガスバリア性成形体の製造方法 | |
JP2019177497A (ja) | ガスバリア性成形体 | |
JP6949551B2 (ja) | バックグラインド用基体フィルム | |
JP2011113025A (ja) | 偏光板および積層光学部材 | |
KR20180128902A (ko) | 복층 광학 필름 및 그 제조 방법 | |
JP2012255816A (ja) | 導光板及び導光板の平面度を向上させる方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141022 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141022 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150901 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151027 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160315 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160523 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20160601 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20160722 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170127 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170411 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6128731 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |