JP2013092540A5 - - Google Patents

Download PDF

Info

Publication number
JP2013092540A5
JP2013092540A5 JP2013022496A JP2013022496A JP2013092540A5 JP 2013092540 A5 JP2013092540 A5 JP 2013092540A5 JP 2013022496 A JP2013022496 A JP 2013022496A JP 2013022496 A JP2013022496 A JP 2013022496A JP 2013092540 A5 JP2013092540 A5 JP 2013092540A5
Authority
JP
Japan
Prior art keywords
dye
pixel location
intracellular compartment
image
intensity value
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013022496A
Other languages
English (en)
Japanese (ja)
Other versions
JP5612142B2 (ja
JP2013092540A (ja
Filing date
Publication date
Priority claimed from US10/062,308 external-priority patent/US7219016B2/en
Application filed filed Critical
Publication of JP2013092540A publication Critical patent/JP2013092540A/ja
Publication of JP2013092540A5 publication Critical patent/JP2013092540A5/ja
Application granted granted Critical
Publication of JP5612142B2 publication Critical patent/JP5612142B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2013022496A 2001-04-20 2013-02-07 細胞および組織の自動分析のための方法 Expired - Lifetime JP5612142B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US28515501P 2001-04-20 2001-04-20
US60/285,155 2001-04-20
US33472301P 2001-10-31 2001-10-31
US60/334,723 2001-10-31
US10/062,308 US7219016B2 (en) 2001-04-20 2002-02-01 Systems and methods for automated analysis of cells and tissues
US10/062,308 2002-02-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011049130A Division JP5290340B2 (ja) 2001-04-20 2011-03-07 細胞および組織の自動分析のための方法

Publications (3)

Publication Number Publication Date
JP2013092540A JP2013092540A (ja) 2013-05-16
JP2013092540A5 true JP2013092540A5 (https=) 2013-06-27
JP5612142B2 JP5612142B2 (ja) 2014-10-22

Family

ID=27370253

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2002583976A Expired - Lifetime JP4433674B2 (ja) 2001-04-20 2002-04-19 細胞および組織の自動分析のためのシステムおよび方法
JP2008000078A Expired - Lifetime JP4873574B2 (ja) 2001-04-20 2008-01-04 細胞および組織の自動分析のためのシステムおよび方法
JP2011049130A Expired - Lifetime JP5290340B2 (ja) 2001-04-20 2011-03-07 細胞および組織の自動分析のための方法
JP2013022496A Expired - Lifetime JP5612142B2 (ja) 2001-04-20 2013-02-07 細胞および組織の自動分析のための方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2002583976A Expired - Lifetime JP4433674B2 (ja) 2001-04-20 2002-04-19 細胞および組織の自動分析のためのシステムおよび方法
JP2008000078A Expired - Lifetime JP4873574B2 (ja) 2001-04-20 2008-01-04 細胞および組織の自動分析のためのシステムおよび方法
JP2011049130A Expired - Lifetime JP5290340B2 (ja) 2001-04-20 2011-03-07 細胞および組織の自動分析のための方法

Country Status (7)

Country Link
US (8) US7219016B2 (https=)
EP (1) EP1390747B1 (https=)
JP (4) JP4433674B2 (https=)
AU (1) AU2002311827B9 (https=)
CA (1) CA2442604C (https=)
ES (1) ES2493765T3 (https=)
WO (1) WO2002086498A1 (https=)

Families Citing this family (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5161052B2 (ja) * 2008-12-04 2013-03-13 オリンパス株式会社 顕微鏡システム、標本観察方法およびプログラム
US7391929B2 (en) * 2000-02-11 2008-06-24 Sony Corporation Masking tool
KR20030094281A (ko) * 2001-03-12 2003-12-11 모노젠, 인크. 세포에 기초한 질병상태의 검출 및 질병상태의 구별
US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US7695919B2 (en) * 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
GB0130862D0 (en) * 2001-12-22 2002-02-06 P W Allen & Company Ltd Method of examining potential cellular abnormalities
WO2003106154A1 (ja) 2002-06-18 2003-12-24 株式会社アマダ プレス機械における、サーボドライブシステム及び連続加工システム
GB0229734D0 (en) * 2002-12-23 2003-01-29 Qinetiq Ltd Grading oestrogen and progesterone receptors expression
AU2004235298A1 (en) * 2003-04-25 2004-11-11 Janssen Pharmaceutica N.V. Preservation of RNA in a biological sample
JP2004347454A (ja) * 2003-05-22 2004-12-09 Mitsubishi Rayon Co Ltd シェーディング補正方法
US8068988B2 (en) 2003-09-08 2011-11-29 Ventana Medical Systems, Inc. Method for automated processing of digital images of tissue micro-arrays (TMA)
WO2005027015A2 (en) 2003-09-10 2005-03-24 Bioimagene, Inc. Method and system for quantitatively analyzing biological samples
US7805003B1 (en) 2003-11-18 2010-09-28 Adobe Systems Incorporated Identifying one or more objects within an image
LT3173073T (lt) 2004-05-03 2025-01-10 Ipsen Biopharm Ltd. Liposomos, skirtos vaistų pristatymui
WO2005114578A1 (en) * 2004-05-21 2005-12-01 Bioimagene, Inc. Method and system for automated quantitation of tissue micro-array (tma) digital image analysis
CA2579292A1 (en) * 2004-09-03 2006-03-23 The Scripps Research Institute Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
US8064661B2 (en) 2004-11-09 2011-11-22 Kaneka Corporation Cell culture device, image processing device and cell detecting system
EP1836557A4 (en) * 2004-11-19 2009-01-21 Trillium Diagnostics Llc SOFTWARE-INTEGRATED FLOW CYTOMETRY TEST FOR QUANTITATING THE HUMAN POLYMORPH-ACID LEUKOCYTIC FC RI RECEPTOR (CD64)
WO2006133460A2 (en) * 2005-06-09 2006-12-14 Yale University Methods for diagnosing and treating breast cancer based on a her/er ratio
EP1958006B1 (en) * 2005-11-10 2011-05-11 Microsoft Corporation Discover biological features using composite images
WO2007074929A1 (ja) * 2005-12-27 2007-07-05 Olympus Corporation 生物由来の被験試料の画像を取得する装置及び方法
US20090170091A1 (en) * 2006-01-17 2009-07-02 Kenneth Giuliano Method For Predicting Biological Systems Responses
US8131112B1 (en) * 2006-01-23 2012-03-06 Sandia Corporation Method for detecting cancer in a single cell using mitochondrial correlation microscopy
US20070191675A1 (en) * 2006-02-13 2007-08-16 Joel Gerardo Diaz Sanchez Actinic light colposcope and method to detect lesions in the lower female genital tract produced by human papilloma virus using an actinic light colposcope
EP2012801A4 (en) 2006-04-24 2009-08-05 Gloucester Pharmaceuticals Inc GEMCITABINE COMBINATION THERAPY
US8367351B2 (en) 2006-05-05 2013-02-05 Historx, Inc. Methods for determining signal transduction activity in tumors
EP2027465A2 (en) 2006-05-17 2009-02-25 Cellumen, Inc. Method for automated tissue analysis
WO2007139895A2 (en) * 2006-05-24 2007-12-06 Cellumen, Inc. Method for modeling a disease
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
WO2007144386A1 (de) * 2006-06-14 2007-12-21 Evotec Technologies Gmbh Verfahren zur aufnahme und auswertung von bildsequenzen
EP2046971B1 (en) * 2006-06-30 2012-04-04 University Of Southern California Quantifiable internal reference standards for immunohistochemistry and uses thereof
JP2009544007A (ja) * 2006-07-13 2009-12-10 イェール・ユニバーシティー バイオマーカーの細胞内局在性に基づいて癌予後を行う方法
US8131476B2 (en) * 2006-08-07 2012-03-06 General Electric Company System and method for co-registering multi-channel images of a tissue micro array
US20080032321A1 (en) * 2006-08-07 2008-02-07 General Electric Company System and methods for analyzing images of tissue samples
US8060348B2 (en) * 2006-08-07 2011-11-15 General Electric Company Systems for analyzing tissue samples
JP5548890B2 (ja) * 2006-09-05 2014-07-16 ジャンセン ダイアグノスティックス,エルエルシー 細胞の画像を格付けするための方法
JP5021254B2 (ja) * 2006-09-06 2012-09-05 オリンパス株式会社 顕微鏡装置の制御方法、顕微鏡装置
WO2008060483A2 (en) * 2006-11-10 2008-05-22 Cellumen, Inc. Protein-protein interaction biosensors and methods of use thereof
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
WO2010017822A1 (en) * 2008-08-15 2010-02-18 Visiopharm A/S A method and a system for determining a target in a biological sample by image analysis
US9697582B2 (en) 2006-11-16 2017-07-04 Visiopharm A/S Methods for obtaining and analyzing images
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US9008378B2 (en) * 2006-12-20 2015-04-14 The Board Of Trustees Of The Leland Stanford Junior University Arrangement and imaging of biological samples
EP2109856B1 (en) * 2007-02-05 2019-01-16 Siemens Healthcare Diagnostics Inc. System and method for cell analysis in microscopy
WO2008108059A1 (ja) * 2007-03-01 2008-09-12 Nec Corporation 乳癌病理画像診断支援システム、乳癌病理画像診断支援方法、乳癌病理画像診断支援プログラム、及び、乳癌病理画像診断支援プログラムを記録した記録媒体
US20080286881A1 (en) * 2007-05-14 2008-11-20 Apel William A Compositions and methods for combining report antibodies
CA2690612C (en) * 2007-05-14 2016-07-05 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
US8351674B2 (en) * 2007-05-31 2013-01-08 Battelle Energy Alliance, Llc Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture
ES2599902T3 (es) 2007-06-15 2017-02-06 Novartis Ag Sistema y método de microscopio para obtener datos de muestra normalizados
US20090155767A1 (en) * 2007-06-29 2009-06-18 Rimm David L Methods for a predictive diagnostic test for tamoxifen
WO2009005816A1 (en) * 2007-07-03 2009-01-08 Yale University Methods for differential diagnosis of melanocytic lesions
CA2604317C (en) * 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) * 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
WO2009029810A1 (en) * 2007-08-31 2009-03-05 Historx, Inc. Automatic exposure time selection for imaging tissue
JP5040597B2 (ja) * 2007-11-06 2012-10-03 日本電気株式会社 評価システム、評価方法および評価プログラム
US8031924B2 (en) * 2007-11-30 2011-10-04 General Electric Company Methods and systems for removing autofluorescence from images
US8139831B2 (en) * 2007-12-06 2012-03-20 Siemens Aktiengesellschaft System and method for unsupervised detection and gleason grading of prostate cancer whole mounts using NIR fluorscence
CN103033922A (zh) 2008-01-02 2013-04-10 加利福尼亚大学董事会 高数值孔径远程显微镜设备
US8070398B2 (en) * 2008-02-19 2011-12-06 Irwin Industrial Tool Company Multi-blade self feed bit
US8189884B2 (en) * 2008-03-26 2012-05-29 General Electric Company Methods for assessing molecular expression of subcellular molecules
US8135187B2 (en) 2008-03-26 2012-03-13 General Electric Company Method and apparatus for removing tissue autofluorescence
JP5551702B2 (ja) * 2008-09-16 2014-07-16 ヒストロックス,インコーポレイテッド. バイオマーカー発現の再現性のある定量
US8729239B2 (en) 2009-04-09 2014-05-20 Nuclea Biotechnologies, Inc. Antibodies against fatty acid synthase
US8685891B2 (en) 2009-08-27 2014-04-01 Nuclea Biotechnologies, Inc. Method and assay for determining FAS expression
US9410965B2 (en) * 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US8969009B2 (en) * 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
US9001200B2 (en) 2010-01-12 2015-04-07 Bio-Rad Laboratories, Inc. Cell characterization using multiple focus planes
WO2011104692A2 (en) * 2010-02-25 2011-09-01 Robin Medical Inc. Cryogenic biopsy system and method
US10702251B2 (en) 2010-02-25 2020-07-07 Robin Medical Inc. Cryogenic biopsy system and method
CN102792147B (zh) * 2010-03-10 2015-05-13 贝克曼考尔特公司 在颗粒分析器中产生脉冲参数
NZ605526A (en) 2010-07-12 2015-04-24 Celgene Corp Romidepsin solid forms and uses thereof
EP2601513B1 (en) 2010-08-05 2014-05-14 Cambridge Research & Instrumentation, Inc. Enhancing visual assessment of samples
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
WO2012058638A2 (en) 2010-10-29 2012-05-03 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
US9535068B2 (en) * 2010-11-12 2017-01-03 William Marsh Rice University Oral cancer point of care diagnostics
US20130344510A1 (en) 2010-12-03 2013-12-26 Uti Limited Partnership Identification of cancer patients likely to benefit from radiation therapy
US9092850B2 (en) * 2011-01-21 2015-07-28 Carnegie Mellon University Identifying location biomarkers
KR20120102447A (ko) * 2011-03-08 2012-09-18 삼성전자주식회사 진단장치 및 방법
US10018631B2 (en) 2011-03-17 2018-07-10 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
JP5372068B2 (ja) * 2011-05-20 2013-12-18 キヤノン株式会社 撮像システム、画像処理装置
US20130095483A1 (en) * 2011-10-17 2013-04-18 Nuclea Biotechnologies, Inc. Predictive biomarkers for breast cancer
JP6162707B2 (ja) 2011-10-24 2017-07-12 ハロザイム インコーポレイテッド 抗ヒアルロナン剤治療のためのコンパニオン診断およびその使用方法
MX350807B (es) 2011-11-29 2017-09-20 Genentech Inc Composiciones y metodos para el analisis de cancer de prostata.
ES2678211T3 (es) 2012-03-27 2018-08-09 Ventana Medical Systems, Inc. Conjugados de señalización y procedimientos de uso
US11573235B2 (en) 2012-03-30 2023-02-07 Leica Microsystems Cms Gmbh Methods for generating an image of a biological sample
WO2013161155A1 (ja) * 2012-04-23 2013-10-31 日本電気株式会社 画像計測装置、画像計測方法、および、画像計測用プログラム
JP5870851B2 (ja) * 2012-05-29 2016-03-01 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
EP2864794A4 (en) * 2012-06-20 2016-03-02 Merrimack Pharmaceuticals Inc MARKER QUANTIFICATION IN INDIVIDUAL CELLS IN TISSUE CUTS
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
WO2014043253A1 (en) * 2012-09-11 2014-03-20 Neogenomics Laboratories Automated fish reader using learning machines
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
EP2927311B1 (en) * 2012-11-28 2019-11-20 Japan Science And Technology Agency Cell observation device, cell observation method and program thereof
US10778913B2 (en) 2013-03-12 2020-09-15 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
US9915660B2 (en) 2013-03-15 2018-03-13 Morphotek, Inc. Methods for determining prognosis of colorectal cancer
US9064304B2 (en) 2013-03-18 2015-06-23 General Electric Company Image quality assessment of microscopy images
US20140307931A1 (en) * 2013-04-15 2014-10-16 Massachusetts Institute Of Technology Fully automated system and method for image segmentation and quality control of protein microarrays
WO2014197622A2 (en) 2013-06-04 2014-12-11 The Regents Of The University Of California Liver-mimetic device and method for simulation of hepatic function using such device
CA2919833A1 (en) 2013-07-30 2015-02-05 President And Fellows Of Harvard College Quantitative dna-based imaging and super-resolution imaging
US10831013B2 (en) 2013-08-26 2020-11-10 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
CA2921325C (en) * 2013-10-07 2020-05-12 Ventana Medical Systems, Inc. Systems and methods for comprehensive multi-assay tissue analysis
GB201318598D0 (en) * 2013-10-21 2013-12-04 Univ Leicester Improvements in or relating to super-resolution microscopy
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
WO2015117067A1 (en) * 2014-01-31 2015-08-06 The General Hospital Corporation Dba Massachusetts General Hospital Methods of treating and imaging tumor micrometastases using photoactivatable immunoconjugates
WO2015124777A1 (en) * 2014-02-21 2015-08-27 Ventana Medical Systems, Inc. Medical image analysis for identifying biomarker-positive tumor cells
CA2940115C (en) 2014-02-24 2023-03-14 Ventana Medical Systems, Inc. Methods, kits, and systems for scoring the immune response to cancer by simultaneous detection of cd3, cd8, cd20 and foxp3
US10294510B2 (en) 2014-03-11 2019-05-21 President And Fellows Of Harvard College High-throughput and highly multiplexed imaging with programmable nucleic acid probes
WO2015146896A1 (ja) * 2014-03-24 2015-10-01 コニカミノルタ株式会社 多重免疫染色法に基づく生体物質の定量方法
WO2015175433A1 (en) 2014-05-12 2015-11-19 Cellomics, Inc. Automated imaging of chromophore labeled samples
PT3186281T (pt) 2014-08-28 2019-07-10 Halozyme Inc Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica
WO2016044483A1 (en) 2014-09-16 2016-03-24 The Regents Of The University Of California Method for fabrication of microwells for controlled formation of 3-dimensional multicellular-shapes
JP6499506B2 (ja) * 2015-04-30 2019-04-10 富士フイルム株式会社 撮像装置および方法並びに撮像制御プログラム
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
KR102557419B1 (ko) 2015-08-07 2023-07-19 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 단백질-단백질 상호작용의 초해상도 영상화
JP7042739B2 (ja) 2015-08-20 2022-03-28 イプセン バイオファーム リミティド 癌処置のためのリポソーム型イリノテカン及びparp阻害薬を使用する併用療法
TW202400181A (zh) 2015-08-21 2024-01-01 英商益普生生物製藥有限公司 使用包含微脂伊立替康(irinotecan)及奧沙利鉑(oxaliplatin)之組合療法治療轉移性胰臟癌的方法
JP6791951B2 (ja) 2015-08-27 2020-11-25 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 肺ガンを患っている患者の生存時間を予測するための方法
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
EP4647126A3 (en) 2015-10-16 2026-02-11 Ipsen Biopharm Ltd. Stabilizing camptothecin pharmaceutical compositions
WO2017067944A1 (en) 2015-10-19 2017-04-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from triple negative breast cancer
EP3365000B1 (en) 2015-10-23 2020-06-10 Novartis AG Method of deriving a value for percent biomarker positivity for selected cells present in a field of view
WO2017070582A1 (en) * 2015-10-23 2017-04-27 Novartis Ag Computer method and system for deriving cell-to-cell spatial proximities
EP3365677B1 (en) * 2015-10-23 2021-03-31 Novartis AG Computer processes behind an enhanced version of aqua
US20180327499A1 (en) 2015-11-13 2018-11-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti- nkg2d single domain antibodies and uses thereof
WO2017091658A1 (en) 2015-11-25 2017-06-01 Cernostics, Inc. Methods of predicting progression of barrett's esophagus
EP3400443B1 (en) 2016-01-04 2020-09-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of pd-1 and tim-3 as a measure for cd8+ cells in predicting and treating renal cell carcinoma
JP6902040B2 (ja) 2016-01-28 2021-07-14 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 免疫チェックポイント阻害剤の効力を増強する方法
EP3203413A1 (en) * 2016-02-08 2017-08-09 Ecole Polytechnique Federale De Lausanne (Epfl) Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof
WO2017202962A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
WO2018011107A1 (en) 2016-07-11 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of er-alpha 46 in methods and kits for assessing the status of breast cancer
WO2018046736A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
JP6646552B2 (ja) * 2016-09-13 2020-02-14 株式会社日立ハイテクノロジーズ 画像診断支援装置、画像診断支援方法及び試料分析システム
CN110402163A (zh) 2016-11-02 2019-11-01 易普森生物制药有限公司 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌
WO2018094113A1 (en) 2016-11-16 2018-05-24 University Of Washington Systems and methods for cyclic fluorescence imaging
IL266652B2 (en) * 2016-11-16 2024-11-01 Nanosomix Inc Quantification of subpopulations of exosomes and diagnosis of neurodegenerative disorders
CN118345145A (zh) 2016-12-09 2024-07-16 乌尔蒂维尤股份有限公司 用于使用标记的核酸成像剂进行多路复用成像的改进方法
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2019043138A1 (en) 2017-09-01 2019-03-07 INSERM (Institut National de la Santé et de la Recherche Médicale) METHOD FOR PREDICTING OUTCOME OF CANCER
JP6404425B2 (ja) * 2017-09-27 2018-10-10 株式会社日立エルジーデータストレージ 光画像計測装置
WO2019089858A2 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
WO2019101871A1 (en) 2017-11-23 2019-05-31 Inserm (Institut National De La Sante Et De La Recherche Medicale) A new marker for predicting the sensitivity to pi3k inhibitors
EP4285838B1 (en) * 2017-12-05 2025-08-13 Devicor Medical Products, Inc. Biopsy device with applied imaging
JP7239936B2 (ja) 2018-01-30 2023-03-15 国立研究開発法人理化学研究所 マスク構造最適化装置、マスク構造最適化方法およびプログラム
US20210030703A1 (en) 2018-03-12 2021-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers
US11515009B2 (en) 2018-03-19 2022-11-29 International Business Machines Corporation Biomarker quantification in a tissue sample
JP7084193B2 (ja) * 2018-04-10 2022-06-14 ザイオソフト株式会社 医用画像処理装置、医用画像処理方法、及び医用画像処理プログラム
WO2019197683A1 (en) 2018-04-13 2019-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer
WO2019207030A1 (en) 2018-04-26 2019-10-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer
CN108896363A (zh) * 2018-05-28 2018-11-27 杭州智微信息科技有限公司 一种骨髓涂片数字化的流程方法
WO2020048942A1 (en) 2018-09-04 2020-03-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing cytotoxic t lymphocyte-dependent immune responses
EP3853251A1 (en) 2018-09-19 2021-07-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of cancers resistant to immune checkpoint therapy
EP3860578A1 (en) 2018-10-01 2021-08-11 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of inhibitors of stress granule formation for targeting the regulation of immune responses
WO2020120592A1 (en) 2018-12-12 2020-06-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for predicting and treating melanoma
US20220047556A1 (en) 2018-12-17 2022-02-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sulconazole as a furin inhibitor
CN113574386A (zh) 2019-01-03 2021-10-29 国家医疗保健研究所 用于增强癌症患者的cd8+t细胞依赖性免疫应答的方法和药物组合物
ES2850277B2 (es) 2019-01-10 2025-10-15 Innovacorium Inc Composiciones de administración farmacéutica y usos de las mismas
CN115943306A (zh) 2019-03-29 2023-04-07 乐天医药生技股份有限公司 用于光免疫疗法的方法和相关生物标志物
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220160692A1 (en) 2019-04-09 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
SG11202112712RA (en) 2019-06-03 2021-12-30 Inst Nat Sante Rech Med Methods for modulating a treatment regimen
WO2020245208A1 (en) 2019-06-04 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
WO2021074391A1 (en) 2019-10-17 2021-04-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing nasal intestinal type adenocarcinomas
US10652484B1 (en) 2019-10-18 2020-05-12 Center For Quantitative Cytometry Method to obtain data cubes of low intensity intrinsic spectral images when imaging under high illumination conditions without the use of filters
US10670512B1 (en) 2019-10-18 2020-06-02 Center For Quantitative Cytometry Apparatus to perform intrinsic hyper-spectral flow cytometry
AU2020372024B2 (en) 2019-10-22 2026-03-12 S.D. Sight Diagnostics Ltd Accounting for errors in optical measurements
JP7759874B2 (ja) * 2019-11-11 2025-10-24 ミルテニー バイオテック ベー.フェー. ウント コー. カー・ゲー シリアルマルチチャネル顕微鏡
CA3160692A1 (en) * 2019-12-12 2021-06-17 S.D. Sight Diagnostics Ltd Off-focus microscopic images of a sample
AU2020400400B2 (en) 2019-12-12 2026-03-19 S.D. Sight Diagnostics Ltd Detecting platelets in a blood sample
BR112022011312A2 (pt) 2019-12-12 2022-08-23 S D Sight Diagnostics Ltd Análise de um analito disposto dentro de um meio
US20230076415A1 (en) 2020-01-17 2023-03-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating melanoma
WO2021170777A1 (en) 2020-02-28 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
US11551360B2 (en) 2020-04-28 2023-01-10 QATAR UNIVERSITY, Office of Academic Research Device and method for cancer detection
JP2023526468A (ja) * 2020-05-20 2023-06-21 ロシュ・ダイアグノスティクス・ヘマトロジー・インコーポレイテッド スライド上にプリントされたバイオマーカーおよびロマノフスキー型染色サンプルを調製するための自動化プラットフォームの使用
JPWO2021241061A1 (https=) * 2020-05-29 2021-12-02
US20230235408A1 (en) 2020-06-30 2023-07-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies
EP4172628A1 (en) 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery
CN112201300B (zh) * 2020-10-23 2022-05-13 天津大学 基于深度图像特征和阈值学习策略的蛋白质亚细胞定位的方法
WO2022200303A1 (en) 2021-03-23 2022-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of t cell-lymphomas
WO2022229136A1 (en) 2021-04-27 2022-11-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of lymph node metastasis and/or recurrence of patients suffering from a t1 cancer treated by endoscopic resection
KR20240118776A (ko) * 2021-11-17 2024-08-05 벡톤 디킨슨 앤드 컴퍼니 유세포 분석기에서 데이터 수집 매개변수의 동적 실시간 조정을 위한 방법
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
US20250035635A1 (en) 2022-03-17 2025-01-30 Institut National De La Sante Et De La Recherche Medicale Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer
WO2023198648A1 (en) 2022-04-11 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t-cell malignancies
WO2023198874A1 (en) 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t cell-lymphomas
WO2024003310A1 (en) 2022-06-30 2024-01-04 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of acute lymphoblastic leukemia
JP2025526336A (ja) 2022-07-22 2025-08-13 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル T細胞悪性腫瘍におけるバイオマーカー及びバイオターゲットとしてのgarp
WO2024023283A1 (en) 2022-07-29 2024-02-01 Institut National de la Santé et de la Recherche Médicale Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas
JP2025536268A (ja) 2022-10-12 2025-11-05 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル T細胞悪性腫瘍におけるバイオマーカー及びバイオターゲットとしてのcd81
WO2024153636A1 (en) 2023-01-17 2024-07-25 Institut National de la Santé et de la Recherche Médicale Vasorin as a biomarker and biotarget in nephrology
WO2025045894A1 (en) 2023-08-28 2025-03-06 Institut National de la Santé et de la Recherche Médicale Methods and kits for diagnosing cause of nephrotic syndrome and guiding therapy
WO2026013072A1 (en) 2024-07-09 2026-01-15 Institut National de la Santé et de la Recherche Médicale Methods for predicting the health state of a subject from fibroblasts

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26420A (en) 1859-12-13 Improvement in seeding-machines
US4998284A (en) 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
JP2628302B2 (ja) * 1987-04-14 1997-07-09 富士レビオ株式会社 凝集判定方法および装置
US5386819A (en) 1990-03-29 1995-02-07 Olympus Optical Co., Ltd. Method and apparatus for inhibiting a scattered component in a light having passed through an examined object
JP2852096B2 (ja) * 1990-03-29 1999-01-27 オリンパス光学工業株式会社 被検体通過中の散乱光成分抑制方法およびその装置
JPH0474950A (ja) * 1990-07-16 1992-03-10 Hitachi Ltd 発光検出型遺伝物質検出装置
US5936731A (en) 1991-02-22 1999-08-10 Applied Spectral Imaging Ltd. Method for simultaneous detection of multiple fluorophores for in situ hybridization and chromosome painting
US5784162A (en) 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US6026174A (en) * 1992-10-14 2000-02-15 Accumed International, Inc. System and method for automatically detecting malignant cells and cells having malignancy-associated changes
US6229649B1 (en) 1994-10-04 2001-05-08 The United States Of America As Represented By The Secretary Of The Air Force Pseudo deconvolution method of recovering a distorted optical image
AU700085B2 (en) * 1995-07-19 1998-12-24 Veracel Inc. Multi-spectral segmentation for image analysis
US6151405A (en) * 1996-11-27 2000-11-21 Chromavision Medical Systems, Inc. System and method for cellular specimen grading
DE69627183T2 (de) * 1995-11-30 2004-01-29 Chromavision Med Sys Inc Verfahren zur automatischen bildanalyse biologischer proben
US5998151A (en) 1995-12-01 1999-12-07 The United States Of America As Represented By The Department Of Health And Human Services Methods for predicting the efficacy of a chemotherapeutic regimen for gastrointestinal cancers using antibodies specific for thymidylate synthase
US6165734A (en) 1995-12-12 2000-12-26 Applied Spectral Imaging Ltd. In-situ method of analyzing cells
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6727071B1 (en) * 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
JP2001525186A (ja) * 1997-11-27 2001-12-11 マックス−プランク−ゲゼルシャフト ツール フォルデルング デル ヴィッセンシャフテン エー.ファウ. 相互作用分子の同定および特性決定
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
KR100560588B1 (ko) * 1998-03-16 2006-03-16 에머샘 바이오사이언시즈 코프 공초점 마이크로스코피 영상 시스템
US6492325B1 (en) 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
US6337472B1 (en) 1998-10-19 2002-01-08 The University Of Texas System Board Of Regents Light imaging microscope having spatially resolved images
WO2000024940A1 (en) 1998-10-28 2000-05-04 Vysis, Inc. Cellular arrays and methods of detecting and using genetic disorder markers
US7666609B1 (en) 1998-12-01 2010-02-23 Shanghai Cp Guojian Pharmaceutical Co. Ltd. Method and composition for diagnosis of melanocytic lesions
US6351712B1 (en) * 1998-12-28 2002-02-26 Rosetta Inpharmatics, Inc. Statistical combining of cell expression profiles
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
JP2000283853A (ja) * 1999-03-31 2000-10-13 Mitsubishi Electric Corp 波面センサ
WO2000060126A2 (en) * 1999-04-08 2000-10-12 Sir Mortimer B. Davis Jewish General Hospital Quantitative assay for expression of genes in microarray
CN1384949A (zh) * 1999-04-13 2002-12-11 色品视觉医学体系股份有限公司 组织重现和图像自动分析
AU7494900A (en) 1999-09-17 2001-04-17 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Signal counting for in situ hybridization
EP1135680A4 (en) 1999-09-24 2004-12-15 Ventana Med Syst Inc HIGH-PERFORMANCE SYSTEM FOR EVALUATING THE CLINICAL BENEFIT OF TARGET MOLECULAR MOLECULES IN TISSUE SAMPLES
US7050087B2 (en) * 2000-12-06 2006-05-23 Bioview Ltd. Data acquisition and display system and method
US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
AU2002324422A1 (en) 2001-02-21 2002-12-23 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
FI20020653A0 (fi) 2002-04-05 2002-04-05 Taipale Automotive Oy Menetelmä ajoneuvoa ajavan henkilön sekä hänen ajotapansa tunnistamiseksi
US20060024692A1 (en) 2002-09-30 2006-02-02 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancers
ES2425749T3 (es) 2004-03-31 2013-10-17 The General Hospital Corporation Método para determinar la respuesta del cáncer a tratamientos dirigidos al receptor del factor de crecimiento epidérmico
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
EP1872124A4 (en) 2005-04-19 2008-06-11 Prediction Sciences Llc DIAGNOSIS MARKET FOR BREAST CANCER TREATMENT AND PROGRESSION AND METHOD OF USE THEREOF
GB0524190D0 (en) 2005-11-28 2006-01-04 Helse Stavanger Hf Method
JP2009544007A (ja) 2006-07-13 2009-12-10 イェール・ユニバーシティー バイオマーカーの細胞内局在性に基づいて癌予後を行う方法
CA2688477C (en) 2007-06-01 2020-12-22 The Regents Of The University Of California Multigene prognostic assay for lung cancer
US20090155767A1 (en) 2007-06-29 2009-06-18 Rimm David L Methods for a predictive diagnostic test for tamoxifen
WO2009005816A1 (en) 2007-07-03 2009-01-08 Yale University Methods for differential diagnosis of melanocytic lesions
WO2011047019A1 (en) 2009-10-13 2011-04-21 Yale University An objective, quantitative method to predict histological subtype in non-small cell lung cancer
CA2779484A1 (en) 2009-10-30 2011-05-05 Yale University A melanoma prognostic model using tissue microarrays and genetic algorithms
WO2012116122A2 (en) 2011-02-22 2012-08-30 Yale University A protein expression-based classifier for prediction of recurrence in adenocarcinoma

Similar Documents

Publication Publication Date Title
JP2013092540A5 (https=)
CN103134782B (zh) 图像获取装置和图像获取方法
JP5540102B2 (ja) 高められた病理学的決定のための複数モダリティコントラストおよび明視野コンテキスト表現、および組織内の複数検体検出
US10083340B2 (en) Automated cell segmentation quality control
JP2022066215A (ja) デジタル病理学に関する較正スライド
US10929972B2 (en) Devices, systems and methods for automated quantitative scoring of digitized tissue images
WO2022004500A1 (ja) 情報処理装置、情報処理方法、プログラム、顕微鏡システム及び解析システム
CN102147523B (zh) 双ccd感光元件生物数字显微镜及其摄影图像处理方法
JP2025163067A (ja) 自動蛍光イメージング及び単一細胞セグメンテーション
US20240393248A1 (en) Information processing device, biological sample observation system, and image generation method
D’Antuono Basic digital image acquisition, design, processing, analysis, management, and presentation
WO2023157756A1 (ja) 情報処理装置、生体試料解析システム及び生体試料解析方法
JP2022535798A (ja) ハイパースペクトル定量的イメージング・サイトメトリ・システム
WO2023149296A1 (ja) 情報処理装置、生体試料観察システム及び画像生成方法
Mascalchi et al. Which elements to build co-localization workflows? From metrology to analysis
JP7683329B2 (ja) 情報処理装置、生体試料解析方法、生体試料検出装置、および生体試料検出システム
US8963105B2 (en) Image obtaining apparatus, image obtaining method, and image obtaining program
JP7841533B2 (ja) 情報処理装置、生体試料観察システム及び画像生成方法
WO2011087778A1 (en) Automated quantitative multidimensional volumetric analysis and visualization
WO2023189393A1 (ja) 生体試料観察システム、情報処理装置及び画像生成方法
Woo et al. High-throughput high-dynamic range imaging by spatiotemporally structured illumination
De Mey et al. Fast 4D microscopy
US20260104579A1 (en) Method for microscopy imaging
WO2024209965A1 (ja) 陽性判定方法、画像解析システムおよび情報処理装置
Essaulova et al. Hyperspectral imaging for flow cytometry