JP2013063940A - 骨粗鬆症予防または改善剤 - Google Patents
骨粗鬆症予防または改善剤 Download PDFInfo
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Abstract
【解決手段】麦類の成熟期前の緑葉の搾汁成分を有効成分として含有することを特徴とする。
【選択図】なし
Description
合成)などを行い骨量を高く維持することが重要であり、特にカルシウムの積極的な摂取が必要であることが報告がされている(非特許文献1)。
(骨粗鬆症予防または改善剤の調製)
成熟期前の大麦若葉の緑葉の機械的粉砕物から粗大固形分を分離除去して得られた青汁を中和処理し噴霧乾燥を行なった大麦若葉の緑葉の搾汁噴霧乾燥粉末(大麦若葉末)を5kg調製した。
13週齢の雌性Wistar系ラット(静岡実験動物農業共同組合)を使用した。飼育は室温23±1℃、湿度60±10%、12時間ごとの明暗サイクルの環境下で、1.12%Ca含有の固形飼料(オリエンタル酵母工業株式会社)を自由摂取させた。1週間の馴化期間後、ペントバルビタールナトリウム30mg/kg麻酔下で卵巣摘出手術(Ovariectomy:OVX)を常法に従って行い骨粗鬆症モデルラットを作製した。
骨粗鬆症モデルラットへの大麦若葉末の投与は、調製した大麦若葉末に蒸留水を加えて青汁を作製し、大麦若葉末の投与量が0mg/kg、50mg/kg、150mg/kg、500mg/kgになるように各群に胃ゾンデを用いて強制的に経口投与した。なお、大麦若葉末0mg/kg投与群(蒸留水のみの投与群)はコントロール群とした。また、sham群は経口投与を行なわなかった。経口投与は、手術の1週間後から1日1回、36週間にわたり行なった。体重・摂餌量・節水量の測定は1週間に1回行なった。
Claims (2)
- 麦類の成熟期前の緑葉の搾汁成分を有効成分として含有することを特徴とする骨粗鬆症予防または改善剤。
- 麦類の成熟期前の緑葉の搾汁成分を有効成分として含有し、骨重量の増加作用を有することを特徴とする骨粗鬆症予防または改善剤。
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JP5740642B1 (ja) * | 2013-05-29 | 2015-06-24 | 株式会社東洋新薬 | 飲食用組成物、飲食用組成物の呈味を改善する方法及び色を改善する方法、乳酸菌増殖用組成物、大麦の茎葉の栽培方法、阿蘇産又は黒ボク土を用いて栽培した大麦の茎葉 |
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