JP2012533299A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012533299A5 JP2012533299A5 JP2012520638A JP2012520638A JP2012533299A5 JP 2012533299 A5 JP2012533299 A5 JP 2012533299A5 JP 2012520638 A JP2012520638 A JP 2012520638A JP 2012520638 A JP2012520638 A JP 2012520638A JP 2012533299 A5 JP2012533299 A5 JP 2012533299A5
- Authority
- JP
- Japan
- Prior art keywords
- expression vector
- promoter
- nucleic acid
- acid sequence
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22568709P | 2009-07-15 | 2009-07-15 | |
| US61/225,687 | 2009-07-15 | ||
| US28759909P | 2009-12-17 | 2009-12-17 | |
| US61/287,599 | 2009-12-17 | ||
| PCT/US2010/036247 WO2011008348A2 (en) | 2009-07-15 | 2010-05-26 | Dual vector for inhibition of human immunodeficiency virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015163281A Division JP6247259B2 (ja) | 2009-07-15 | 2015-08-21 | ヒト免疫不全ウイルス阻害のための二重ベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012533299A JP2012533299A (ja) | 2012-12-27 |
| JP2012533299A5 true JP2012533299A5 (enExample) | 2013-07-11 |
| JP5828838B2 JP5828838B2 (ja) | 2015-12-09 |
Family
ID=42797105
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520638A Expired - Fee Related JP5828838B2 (ja) | 2009-07-15 | 2010-05-26 | ヒト免疫不全ウイルス阻害のための二重ベクター |
| JP2015163281A Expired - Fee Related JP6247259B2 (ja) | 2009-07-15 | 2015-08-21 | ヒト免疫不全ウイルス阻害のための二重ベクター |
| JP2017220978A Expired - Fee Related JP6529141B2 (ja) | 2009-07-15 | 2017-11-16 | ヒト免疫不全ウイルス阻害のための二重ベクター |
| JP2019089588A Expired - Fee Related JP6840189B2 (ja) | 2009-07-15 | 2019-05-10 | ヒト免疫不全ウイルス阻害のための二重ベクター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015163281A Expired - Fee Related JP6247259B2 (ja) | 2009-07-15 | 2015-08-21 | ヒト免疫不全ウイルス阻害のための二重ベクター |
| JP2017220978A Expired - Fee Related JP6529141B2 (ja) | 2009-07-15 | 2017-11-16 | ヒト免疫不全ウイルス阻害のための二重ベクター |
| JP2019089588A Expired - Fee Related JP6840189B2 (ja) | 2009-07-15 | 2019-05-10 | ヒト免疫不全ウイルス阻害のための二重ベクター |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20120201794A1 (enExample) |
| EP (4) | EP2949208B1 (enExample) |
| JP (4) | JP5828838B2 (enExample) |
| AU (1) | AU2010274031B2 (enExample) |
| CA (1) | CA2767972A1 (enExample) |
| DK (2) | DK3329772T3 (enExample) |
| ES (3) | ES2657737T3 (enExample) |
| RU (2) | RU2015133046A (enExample) |
| WO (1) | WO2011008348A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12709753B2 (en) | 2018-01-09 | 2026-08-18 | American Gene Technologies International Inc. | HIV immunotherapy with no pre-immunization step |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8909195D0 (en) | 1989-04-22 | 1989-09-13 | Cambridge Consultants | Scoring system |
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| GB201012410D0 (en) * | 2010-07-23 | 2010-09-08 | Medical Res Council | Intracellular immunity |
| AP2014007348A0 (en) * | 2011-06-29 | 2014-01-31 | Ronilu Dev Corp | Prevention and treatment of HIV infection |
| EP3563859B1 (en) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| EP3027755B1 (en) * | 2013-08-02 | 2019-10-09 | The Regents of The University of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
| WO2016014837A1 (en) * | 2014-07-25 | 2016-01-28 | Sangamo Biosciences, Inc. | Gene editing for hiv gene therapy |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| DK3294893T5 (da) | 2015-05-13 | 2024-10-07 | Csl Behring Gene Therapy Inc | Bioproduktion af lentivirale vektorer |
| CN108026593A (zh) * | 2015-05-18 | 2018-05-11 | 卡琳缪恩股份有限公司 | 区分hiv-1与慢病毒载体的方法 |
| CA2986469A1 (en) * | 2015-05-18 | 2016-11-24 | Calimmune, Inc. | Gene therapeutic for the treatment of hiv and uses thereof |
| US11980663B2 (en) | 2015-07-08 | 2024-05-14 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| IL297238B2 (en) | 2016-01-15 | 2024-08-01 | American Gene Tech Int Inc | Methods and preparations for gamma-delta T-cell activation |
| JP7153332B2 (ja) * | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖワクチン接種および免疫療法 |
| ES2911448T3 (es) | 2016-03-09 | 2022-05-19 | American Gene Tech Int Inc | Vectores combinados y métodos para el tratamiento del cáncer |
| CN105861559B (zh) * | 2016-04-11 | 2018-05-01 | 苏州奥特铭医药科技有限公司 | 一种能直接反应i型干扰素应答的慢病毒载体及其制备方法与应用 |
| US10584337B2 (en) | 2016-05-18 | 2020-03-10 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| IL297576B2 (en) | 2016-05-18 | 2024-02-01 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
| WO2017213697A1 (en) | 2016-06-08 | 2017-12-14 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
| CN106086075B (zh) * | 2016-06-23 | 2019-08-06 | 福建医科大学 | CXCR4RNAi慢病毒载体的构建方法 |
| CA3028982A1 (en) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| WO2018017882A1 (en) | 2016-07-21 | 2018-01-25 | American Gene Technologies International Inc. | Viral vectors for treating parkinson's disease |
| KR20230093381A (ko) * | 2017-01-09 | 2023-06-27 | 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 | 예비-면역화 단계가 없는 hiv 면역요법 |
| CA3049980A1 (en) | 2017-01-23 | 2018-07-26 | Regeneron Pharmaceuticals, Inc. | Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof |
| US11820999B2 (en) | 2017-04-03 | 2023-11-21 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| CA3059348A1 (en) | 2017-04-11 | 2018-10-18 | Regeneron Pharmaceuticals, Inc. | Assays for screening activity of modulators of members of the hydroxysteroid (17-beta) dehydrogenase (hsd17b) family |
| MX2019013172A (es) | 2017-05-05 | 2020-09-07 | Voyager Therapeutics Inc | Composiciones y metodos para tratar la enfermedad de huntington. |
| EP3618839A4 (en) | 2017-05-05 | 2021-06-09 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| US12559769B2 (en) | 2017-06-16 | 2026-02-24 | American Gene Technologies International Inc. | Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells |
| CA3070242A1 (en) | 2017-07-18 | 2019-01-24 | Calimmune, Inc. | Compositions and methods for treating beta-hemoglobinopathies |
| AU2018348195B2 (en) | 2017-10-11 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation |
| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| JP7568507B2 (ja) * | 2017-11-15 | 2024-10-16 | ウィヤード・サイエンス・エルエルシー | 非骨髄破壊的な骨髄再構成のための方法および組成物 |
| MY207352A (en) | 2018-03-21 | 2025-02-21 | Regeneron Pharma | 17-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof |
| CA3106403A1 (en) | 2018-07-15 | 2020-01-23 | Enochian BioPharma, Inc. | Methods and compositions using recombinant dendritic cells for cancer therapy |
| EP3876952A4 (en) | 2018-11-05 | 2022-08-24 | American Gene Technologies International Inc. | VECTOR SYSTEM FOR EXPRESSING REGULATORY RNA |
| US12365873B2 (en) * | 2021-01-28 | 2025-07-22 | Allogene Therapeutics, Inc. | Methods for transducing immune cells |
| RU2768032C1 (ru) * | 2021-09-02 | 2022-03-23 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Генетическая конструкция для экспрессии генов mNG_CD4-CXCR4, рекомбинантная плазмида rVSV_mNG_CD4-CXCR4 и рекомбинантный штамм вируса везикулярного стоматита rVSV_mNG_CD4-CXCR4, обеспечивающий таргетный виролизис клеток, экспонирующих на своей поверхности белки gp120/gp 41 ВИЧ-1 тропности X4 |
| RU2769125C1 (ru) * | 2021-09-02 | 2022-03-28 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Генетическая конструкция для экспрессии генов mNG_CD4-CCR5, рекомбинантная плазмида rVSV_mNG_CD4-CCR5 и рекомбинантный штамм вируса везикулярного стоматита rVSV_mNG_CD4-CCR5, обеспечивающий таргетный виролизис клеток, экспонирующих на своей поверхности белки gp120/gp41 ВИЧ-1 тропности R5 |
| AU2023292959A1 (en) * | 2022-06-15 | 2024-12-19 | Cedars-Sinai Medical Center | Noncoding rna agents (bcyrn1 and derivatives thereof) to treat diseases of immunity |
| WO2026039311A1 (en) * | 2024-08-10 | 2026-02-19 | Vectorgen | Lentiviral vector for treating human immunodeficiency virus infection |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4965204A (en) | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
| US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US5677136A (en) | 1994-11-14 | 1997-10-14 | Systemix, Inc. | Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US7737124B2 (en) * | 2001-09-13 | 2010-06-15 | California Institute Of Technology | Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell |
| US7850990B2 (en) * | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| RU2324738C2 (ru) * | 2006-06-16 | 2008-05-20 | Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора) | ГЕНЕТИЧЕСКАЯ КОНСТРУКЦИЯ НА ОСНОВЕ ВЕКТОРНОЙ ПЛАЗМИДЫ pEGFP-N1, ПРОДУЦИРУЮЩАЯ siPHK-ИНГИБИТОРЫ РЕПРОДУКЦИИ ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА 1 ТИПА (ЕЕ ВАРИАНТЫ) |
| CN101841399B (zh) * | 2009-03-16 | 2013-08-07 | 上海贝尔股份有限公司 | 多基站协作接收网络中实现同步上行harq进程的方法和装置 |
| EP2456786B2 (en) * | 2009-07-24 | 2017-04-19 | Immune Design Corp | Lentiviral vectors pseudotyped with a sindbis virus envelope glycoprotein |
-
2010
- 2010-05-26 US US13/384,206 patent/US20120201794A1/en not_active Abandoned
- 2010-05-26 EP EP15166660.9A patent/EP2949208B1/en not_active Not-in-force
- 2010-05-26 WO PCT/US2010/036247 patent/WO2011008348A2/en not_active Ceased
- 2010-05-26 ES ES15166660.9T patent/ES2657737T3/es active Active
- 2010-05-26 RU RU2015133046A patent/RU2015133046A/ru not_active Application Discontinuation
- 2010-05-26 DK DK17197440.5T patent/DK3329772T3/da active
- 2010-05-26 RU RU2012105281/10A patent/RU2562868C2/ru active
- 2010-05-26 ES ES10720980.1T patent/ES2546663T3/es active Active
- 2010-05-26 DK DK15166660.9T patent/DK2949208T3/en active
- 2010-05-26 EP EP19198486.3A patent/EP3659435A1/en not_active Withdrawn
- 2010-05-26 AU AU2010274031A patent/AU2010274031B2/en not_active Ceased
- 2010-05-26 EP EP10720980.1A patent/EP2453735B1/en not_active Not-in-force
- 2010-05-26 EP EP17197440.5A patent/EP3329772B1/en active Active
- 2010-05-26 JP JP2012520638A patent/JP5828838B2/ja not_active Expired - Fee Related
- 2010-05-26 ES ES17197440T patent/ES2770627T3/es active Active
- 2010-05-26 CA CA2767972A patent/CA2767972A1/en not_active Abandoned
-
2015
- 2015-08-21 JP JP2015163281A patent/JP6247259B2/ja not_active Expired - Fee Related
-
2016
- 2016-05-09 US US15/150,373 patent/US20160243169A1/en not_active Abandoned
-
2017
- 2017-11-16 JP JP2017220978A patent/JP6529141B2/ja not_active Expired - Fee Related
-
2019
- 2019-05-10 JP JP2019089588A patent/JP6840189B2/ja not_active Expired - Fee Related
-
2021
- 2021-07-07 US US17/368,947 patent/US20220016176A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12709753B2 (en) | 2018-01-09 | 2026-08-18 | American Gene Technologies International Inc. | HIV immunotherapy with no pre-immunization step |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2012105281A (ru) | Двойной вектор для подавления вируса иммунодефицита человека | |
| AU2014296059B2 (en) | Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors | |
| JP2023071897A (ja) | Ｈｉｖ感染のｒｎａガイド処置のための方法および組成物 | |
| Bobbin et al. | RNA interference approaches for treatment of HIV-1 infection | |
| WO2017132112A1 (en) | Methods and compositions for rna-guided treatment of hiv infection | |
| US20210032627A1 (en) | Gene therapeutic for the treatment of hiv and uses thereof | |
| TW201602349A (zh) | 抗ｈｉｖ幹細胞及其用途 | |
| JP2018518196A5 (enExample) | ||
| Riley et al. | Cell-mediated immunity to target the persistent human immunodeficiency virus reservoir | |
| CN115720520A (zh) | 用于预防和/或治疗哺乳动物疾病的组合物和方法 | |
| Khalid et al. | Stem cell therapy and its significance in HIV infection | |
| US20200061117A1 (en) | Protective Chimeric Antigen Receptor Stem Cell Gene Therapy for Viral Infection | |
| Lori et al. | Gene therapy approaches to HIV infection | |
| AU2017254831B2 (en) | Dual vector for inhibition of human immunodeficiency virus | |
| Re et al. | Chimeric Antigen Receptor-Modified Immune Cells for Eradication of HIV Reservoirs | |
| Sasson et al. | Site‐specific host gene modification by zinc finger nucleases: pointing the way to drug free control of HIV‐1? | |
| CN118103076A (zh) | 可用于疾病治疗的慢病毒载体 | |
| Matamoros | Inhibition of CCR5 and CXCR4 prevents HIV infection | |
| Ledger et al. | Cell-Delivered Gene Therapy for HIV | |
| JPH1118779A (ja) | 新規核酸及びそのエイズ発症抑制剤としての用途 | |
| HK1221488B (en) | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors | |
| TW200838873A (en) | Inhibition of HIV replication and expression of p24 with eIF-5A |