AU2010274031B2 - Dual vector for inhibition of human immunodeficiency virus - Google Patents

Dual vector for inhibition of human immunodeficiency virus Download PDF

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Publication number
AU2010274031B2
AU2010274031B2 AU2010274031A AU2010274031A AU2010274031B2 AU 2010274031 B2 AU2010274031 B2 AU 2010274031B2 AU 2010274031 A AU2010274031 A AU 2010274031A AU 2010274031 A AU2010274031 A AU 2010274031A AU 2010274031 B2 AU2010274031 B2 AU 2010274031B2
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AU
Australia
Prior art keywords
hiv
cells
nucleic acid
expression vector
vector
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Ceased
Application number
AU2010274031A
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English (en)
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AU2010274031A1 (en
Inventor
Dong Sung An
Maureen Boyd
Louis Randall Breton
Irvin Chen
Michelle Millington
Geoffrey P. Symonds
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CSL Behring Gene Therapy Inc
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CSL Behring Gene Therapy Inc
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Application filed by CSL Behring Gene Therapy Inc filed Critical CSL Behring Gene Therapy Inc
Publication of AU2010274031A1 publication Critical patent/AU2010274031A1/en
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Publication of AU2010274031B2 publication Critical patent/AU2010274031B2/en
Priority to AU2015213417A priority Critical patent/AU2015213417B2/en
Priority to AU2017254831A priority patent/AU2017254831B2/en
Assigned to CSL BEHRING GENE THERAPY, INC. reassignment CSL BEHRING GENE THERAPY, INC. Request to Amend Deed and Register Assignors: CALIMMUNE INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2320/30—Special therapeutic applications
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    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2740/16071—Demonstrated in vivo effect
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    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16171—Demonstrated in vivo effect
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    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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AU2010274031A 2009-07-15 2010-05-26 Dual vector for inhibition of human immunodeficiency virus Ceased AU2010274031B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2015213417A AU2015213417B2 (en) 2009-07-15 2015-08-17 Dual vector for inhibition of human immunodeficiency virus
AU2017254831A AU2017254831B2 (en) 2009-07-15 2017-10-31 Dual vector for inhibition of human immunodeficiency virus

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22568709P 2009-07-15 2009-07-15
US61/225,687 2009-07-15
US28759909P 2009-12-17 2009-12-17
US61/287,599 2009-12-17
PCT/US2010/036247 WO2011008348A2 (en) 2009-07-15 2010-05-26 Dual vector for inhibition of human immunodeficiency virus

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Application Number Title Priority Date Filing Date
AU2015213417A Division AU2015213417B2 (en) 2009-07-15 2015-08-17 Dual vector for inhibition of human immunodeficiency virus

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AU2010274031A1 AU2010274031A1 (en) 2012-02-02
AU2010274031B2 true AU2010274031B2 (en) 2015-07-16

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AU2010274031A Ceased AU2010274031B2 (en) 2009-07-15 2010-05-26 Dual vector for inhibition of human immunodeficiency virus

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US (3) US20120201794A1 (enExample)
EP (4) EP2949208B1 (enExample)
JP (4) JP5828838B2 (enExample)
AU (1) AU2010274031B2 (enExample)
CA (1) CA2767972A1 (enExample)
DK (2) DK3329772T3 (enExample)
ES (3) ES2657737T3 (enExample)
RU (2) RU2015133046A (enExample)
WO (1) WO2011008348A2 (enExample)

Families Citing this family (45)

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GB8909195D0 (en) 1989-04-22 1989-09-13 Cambridge Consultants Scoring system
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