JP2012530509A5 - - Google Patents
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- Publication number
- JP2012530509A5 JP2012530509A5 JP2012516776A JP2012516776A JP2012530509A5 JP 2012530509 A5 JP2012530509 A5 JP 2012530509A5 JP 2012516776 A JP2012516776 A JP 2012516776A JP 2012516776 A JP2012516776 A JP 2012516776A JP 2012530509 A5 JP2012530509 A5 JP 2012530509A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- amino acid
- endolysin
- acid residues
- protein according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09163953.4 | 2009-06-26 | ||
| EP09163953 | 2009-06-26 | ||
| PCT/EP2010/059146 WO2010149792A2 (en) | 2009-06-26 | 2010-06-28 | Antimicrobial agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016113291A Division JP2017008033A (ja) | 2009-06-26 | 2016-06-07 | 抗微生物剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530509A JP2012530509A (ja) | 2012-12-06 |
| JP2012530509A5 true JP2012530509A5 (cg-RX-API-DMAC10.html) | 2013-08-15 |
| JP6034187B2 JP6034187B2 (ja) | 2016-11-30 |
Family
ID=42799668
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516776A Active JP6034187B2 (ja) | 2009-06-26 | 2010-06-28 | 抗微生物剤 |
| JP2016113291A Pending JP2017008033A (ja) | 2009-06-26 | 2016-06-07 | 抗微生物剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016113291A Pending JP2017008033A (ja) | 2009-06-26 | 2016-06-07 | 抗微生物剤 |
Country Status (17)
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| PL2445515T3 (pl) | 2009-06-26 | 2016-10-31 | Środki przeciwdrobnoustrojowe | |
| US20120195872A1 (en) | 2009-06-26 | 2012-08-02 | Lysando Ag | Antimicrobial agents |
| JP5847081B2 (ja) | 2009-08-24 | 2016-01-20 | カトリック ユニバーシテイト ルーベン ケイ．ユー． ルーベン アール アンド ディー | エンドリシンＯＢＰｇｐＬＹＳ |
| DK2563916T3 (en) * | 2010-04-27 | 2015-10-05 | Lysando Ag | METHOD FOR REDUCING biofilms |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| WO2012140676A2 (en) | 2011-04-12 | 2012-10-18 | Appaiah C B | Chimeric antibacterial polypeptides |
| US9068204B2 (en) | 2013-03-15 | 2015-06-30 | The United States Of America, As Represented By The Secretary Of Agriculture | Peptidoglycan hydrolase antimicrobials for eradicating lactobacilli that contaminate and reduce ethanol yields in biofuel fermentation |
| WO2015070911A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| WO2015070912A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015121443A1 (en) | 2014-02-14 | 2015-08-20 | Lysando Ag | Antimicrobial agents |
| US20170106058A1 (en) * | 2014-04-08 | 2017-04-20 | Lysando Ag | Pharmaceutical composition against chronic bacterial infections |
| BR112016030580B1 (pt) * | 2014-06-26 | 2023-12-19 | The Rockefeller University | Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas |
| CN105734029B (zh) * | 2014-12-12 | 2020-09-25 | 丰益(上海)生物技术研发中心有限公司 | 磷脂酶抗菌肽 |
| ES2934714T3 (es) | 2015-09-17 | 2023-02-24 | Contrafect Corp | Polipéptidos de lisina activos contra bacterias Gram-negativas |
| CN105175509A (zh) * | 2015-10-19 | 2015-12-23 | 河南科技学院 | 一种抗菌肽xyz-1及其应用 |
| CN109069578A (zh) * | 2016-02-29 | 2018-12-21 | 达纳-法伯癌症研究所股份有限公司 | 用于治疗感染的钉合的细胞内靶向抗微生物肽 |
| AU2017255962B2 (en) * | 2016-04-28 | 2023-02-23 | Lysando Ag | Antimicrobial agents against Salmonella bacteria |
| WO2018100408A1 (en) * | 2016-11-30 | 2018-06-07 | Sasinapas Co.,Ltd. | Modified peptides |
| AU2017375050B2 (en) * | 2016-12-16 | 2021-07-22 | Universidade Do Minho | Novel endolysin |
| US20180208938A1 (en) * | 2017-01-23 | 2018-07-26 | Innate Immunity LLC | Compositions and Methods for Protecting Plants Against Bacterial Infections |
| KR20240162610A (ko) * | 2017-04-03 | 2024-11-15 | 사시나파스 컴퍼니 리미티드 | 조작된 그람-음성 엔도리신 |
| AU2018304230A1 (en) | 2017-07-19 | 2020-02-06 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections |
| WO2019155002A1 (en) * | 2018-02-08 | 2019-08-15 | Institut Pasteur | Anti-prevotella bacteriocin methods and compositions |
| WO2019191633A2 (en) * | 2018-03-29 | 2019-10-03 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| CN108410840A (zh) * | 2018-04-03 | 2018-08-17 | 大连理工大学 | 一种铜绿假单胞菌噬菌体内溶素及其编码基因与应用 |
| JP6979210B2 (ja) * | 2018-04-26 | 2021-12-08 | 株式会社ニューギン | 遊技機 |
| US11958890B2 (en) | 2018-05-30 | 2024-04-16 | Lysando Ag | Antimicrobial proteins |
| US20210198645A1 (en) * | 2018-05-30 | 2021-07-01 | Lysando Ag | Novel antimicrobial fusion proteins |
| EP3840771A4 (en) * | 2018-08-23 | 2023-04-19 | Contrafect Corporation | POLYPEPTIDE CONSTRUCTS WITH LYSINE ANTIMICROBIAL PEPTIDE (AMP), LYSINE, ISOLATED POLYNUCLEOTIDES ENCODING THEREOF AND USES THEREOF |
| MX2021015563A (es) * | 2019-07-05 | 2022-03-17 | Contrafect Corp | Polipéptidos anti-microbianos, derivados de bacteriófago, y sus usos contra bacterias gramnegativas y acidorresistentes. |
| WO2021180892A1 (en) | 2020-03-11 | 2021-09-16 | Telum Therapeutics S.L. | New recombinant lysin and its use in the treatment of gram-negative bacterial infections |
| CN115942932A (zh) | 2020-03-19 | 2023-04-07 | 迈克瑞欧斯人体健康有限公司 | 感兴趣的稳定蛋白 |
| KR102286544B1 (ko) * | 2021-02-10 | 2021-08-05 | 주식회사 라이센텍 | 융합 폴리펩타이드 및 이를 포함하는 그람음성균에 대한 항생제 |
| CA3184447A1 (en) * | 2020-05-22 | 2021-11-25 | Lysentech Co., Ltd. | Novel polypeptide, fusion polypeptide, and antibiotic against gram-negative bacteria comprising same |
| WO2022011434A1 (en) * | 2020-07-17 | 2022-01-20 | The University Of Western Australia | Compositions and methods for the treatment of cancer |
| CN111876400B (zh) * | 2020-08-06 | 2022-05-24 | 昆明理工大学 | 一种常温裂解酶Sly和编码此酶的多核苷酸 |
| SK289101B6 (sk) * | 2020-12-17 | 2023-08-09 | Ústav molekulárnej biológie Slovenskej akadémie vied, verejná výskumná inštitúcia | Antimikrobiálny proteín, antimikrobiálny rekombinantný proteín s lytickými vlastnosťami, expresný vektor, spôsob ich prípravy a použitie |
| US11548917B1 (en) * | 2021-11-24 | 2023-01-10 | Intron Biotechnology, Inc. | Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same |
| WO2024241070A1 (en) | 2023-05-22 | 2024-11-28 | L'oreal | Cosmetic composition comprising an endolysin and a polyvinyl alcohol |
| WO2024246325A1 (en) | 2023-06-02 | 2024-12-05 | L'oreal | Cosmetic composition comprising an endolysin derived from a staphylococcus aureus phage and an aromatic alcohol |
| FR3149208B1 (fr) | 2023-06-02 | 2026-03-20 | Oreal | Composition cosmétique, notamment aqueuse, comprenant une endolysine et un pullulane |
| FR3149204B1 (fr) | 2023-06-02 | 2026-02-13 | Oreal | Composition cosmétique comprenant une endolysine et un tensioactif non ionique comprenant un résidu carbohydrate |
| FR3149202B1 (fr) | 2023-06-02 | 2026-04-10 | Oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et une huile. |
| FR3149205B1 (fr) | 2023-06-02 | 2026-04-24 | Oreal | Composition cosmétique comprenant une endolysine et un agent de charge organique |
| FR3149206B1 (fr) | 2023-06-02 | 2026-03-13 | Oreal | Composition cosmétique aqueuse comprenant une endolysine et du tréhalose |
| FR3152395B1 (fr) | 2023-08-28 | 2026-06-26 | Oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et la 4-hydroxyacetophenone |
| FR3149209B1 (fr) | 2023-06-02 | 2026-04-03 | Oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique |
| FR3149207B1 (fr) | 2023-06-02 | 2026-03-13 | Oreal | Composition cosmétique comprenant une endolysine et un composé de formule (I) |
| FR3149203B1 (fr) | 2023-06-02 | 2026-03-13 | Oreal | Composition anhydre comprenant une endolysine et de l’hydroxypropylmethylcellulose et/ou du pullulane |
| FR3152394B1 (fr) | 2023-08-28 | 2026-04-24 | Oreal | Composition cosmétique comprenant une endolysine et des particules d’aérogel de silice hydrophobe |
| FR3152396B1 (fr) | 2023-08-28 | 2026-05-22 | Oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un polyhydroxyalcane |
| FR3152393B1 (fr) | 2023-08-28 | 2026-04-24 | Oreal | Composition cosmétique comprenant une endolysine dérivée d’un phage de Staphylococcus aureus et une charge minérale |
| WO2025093666A1 (en) | 2023-11-01 | 2025-05-08 | University Of Copenhagen | Treatment of lymphoma |
| CN117534733B (zh) * | 2024-01-10 | 2024-03-29 | 黑龙江八一农垦大学 | 抗菌肽cm24、重组基因、乳酸工程菌及其应用 |
| CN118895244B (zh) * | 2024-07-23 | 2025-06-20 | 浙江自贸区中航生物科技有限责任公司 | 一种提高nk细胞杀伤活性的多肽及其应用 |
| WO2026052743A1 (en) | 2024-09-04 | 2026-03-12 | Micreos Human Health B.V. | Reduction of trans-epidermal water loss by a polypeptide with antibacterial properties |
| CN120665848A (zh) * | 2025-06-17 | 2025-09-19 | 广州医科大学 | 革兰氏阴性菌裂解酶及其应用 |
| CN121108287A (zh) * | 2025-09-01 | 2025-12-12 | 重庆市畜牧科学院 | 一种含羟基磷酸化非天然氨基酸的蜂毒肽类似物及其制备方法与应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3854476T2 (de) | 1987-07-06 | 1996-04-04 | Univ Louisiana State | Inhibierung von eukaryotischen pathogenen und neoplasmen mit lytischen peptiden. |
| GB8816693D0 (en) | 1988-07-13 | 1988-08-17 | Agricultural & Food Res | Viral enzyme & gene |
| GB2255561B (en) | 1991-04-20 | 1995-06-21 | Agricultural & Food Res | Lysins from bacteriophages |
| WO1994004688A2 (en) | 1992-08-21 | 1994-03-03 | The University Of British Columbia | Cationic peptides and method for production |
| ES2154344T3 (es) * | 1994-09-01 | 2001-04-01 | Novozymes As | Composicion proteica basica para matar o inhibir celulas microbianas. |
| US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US20030113298A1 (en) * | 1997-10-31 | 2003-06-19 | Vincent Fischetti | Use of bacterial phage associated lysing proteins for the prophylactic and therapeutic treatment of various illnesses |
| US6428784B1 (en) | 1997-10-31 | 2002-08-06 | New Horizons Diagnostics Corp | Vaginal suppository for treating group B Streptococcus infection |
| US5997862A (en) | 1997-10-31 | 1999-12-07 | New Horizons Diagnostics Corporation | Therapeutic treatment of group A streptococcal infections |
| US6288212B1 (en) * | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| US5993809A (en) | 1998-11-18 | 1999-11-30 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| AU5553600A (en) | 1999-06-23 | 2001-01-31 | Ppl Therapeutics (Scotland) Ltd | Fusion proteins incorporating lysozyme |
| US7338936B2 (en) * | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| CA2482995C (en) * | 2002-04-22 | 2013-01-29 | Dow Global Technologies Inc. | Low-cost production of peptides |
| US7566447B2 (en) * | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
| BRPI0413833A (pt) | 2003-09-11 | 2006-10-24 | Novozymes As | célula hospedeira microbiana recombinante, construção de ácido nucleico, método para produzir uma enzima e/ou um agente antimicrobiano, produto de fusão, aditivo e composição de ração animal, animal não humano transgênico ou produtos ou elementos deste, usos do produto de fusão, da co-expressão de um agente antimicrobiano e uma enzima, e de um peptìdeo de proteção, e, método para identificar um peptìdeo de proteção |
| WO2005108563A2 (en) | 2004-04-19 | 2005-11-17 | University Of Chicago | Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4 |
| US20070207209A1 (en) * | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| US7572602B1 (en) | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DE102005040347A1 (de) | 2005-08-25 | 2007-03-01 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von Listerien |
| WO2007113499A1 (en) | 2006-03-31 | 2007-10-11 | The University Court Of The University Of St Andrews | Anti-microbial compositions comprising a cationic peptide and a glycylglycine endopeptidase |
| DE102006061002A1 (de) | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
| CN107129524B (zh) * | 2007-09-25 | 2023-11-21 | 田园温室气体研究有限公司 | 用于抑制微生物细胞的疫苗和疫苗组分 |
| EP2225263A1 (en) | 2007-11-26 | 2010-09-08 | Plant Bioscience Limited | Novel polypeptides having endolysin activity and uses thereof |
| WO2010011960A2 (en) | 2008-07-24 | 2010-01-28 | The United State Of America, As Represented By The Secretary Of Agriculture | Triple acting antimicrobials that are refractory to resistance development |
| EP2157100A1 (en) | 2008-08-19 | 2010-02-24 | Profos AG | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| JP5654493B2 (ja) * | 2009-02-03 | 2015-01-14 | アプライド・バイオミメティック・エイ／エス | 重合プロテオリポソームを用いたナノ加工膜 |
| US8389679B2 (en) | 2009-02-05 | 2013-03-05 | The Regents Of The University Of California | Targeted antimicrobial moieties |
| US8383102B2 (en) | 2009-05-21 | 2013-02-26 | The United States Of America As Represented By The Secretary Of Agriculture | Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens |
| PL2445515T3 (pl) | 2009-06-26 | 2016-10-31 | Środki przeciwdrobnoustrojowe | |
| US20120195872A1 (en) | 2009-06-26 | 2012-08-02 | Lysando Ag | Antimicrobial agents |
| JP5847081B2 (ja) | 2009-08-24 | 2016-01-20 | カトリック ユニバーシテイト ルーベン ケイ．ユー． ルーベン アール アンド ディー | エンドリシンＯＢＰｇｐＬＹＳ |
| DK2563916T3 (en) | 2010-04-27 | 2015-10-05 | Lysando Ag | METHOD FOR REDUCING biofilms |
| WO2014001571A1 (en) | 2012-06-29 | 2014-01-03 | Lysando Ag | Composition for use in mycobacteria diagnosis |
-
2010
- 2010-06-28 PL PL10730139.2T patent/PL2445515T3/pl unknown
- 2010-06-28 CN CN201510751765.3A patent/CN105440139B/zh active Active
- 2010-06-28 AU AU2010264656A patent/AU2010264656B2/en active Active
- 2010-06-28 MX MX2015006025A patent/MX360300B/es unknown
- 2010-06-28 EA EA201270079A patent/EA037202B1/ru not_active IP Right Cessation
- 2010-06-28 CA CA2764131A patent/CA2764131C/en active Active
- 2010-06-28 US US13/380,312 patent/US8906365B2/en active Active
- 2010-06-28 BR BRPI1015192A patent/BRPI1015192A2/pt not_active IP Right Cessation
- 2010-06-28 KR KR1020127002107A patent/KR101711062B1/ko active Active
- 2010-06-28 EP EP16163433.2A patent/EP3058950B1/en active Active
- 2010-06-28 JP JP2012516776A patent/JP6034187B2/ja active Active
- 2010-06-28 EP EP20158514.8A patent/EP3714895A3/en not_active Withdrawn
- 2010-06-28 SI SI201031217A patent/SI2445515T1/sl unknown
- 2010-06-28 KR KR1020177004886A patent/KR20170024129A/ko not_active Ceased
- 2010-06-28 WO PCT/EP2010/059146 patent/WO2010149792A2/en not_active Ceased
- 2010-06-28 DK DK10730139.2T patent/DK2445515T3/en active
- 2010-06-28 SG SG2011096310A patent/SG177370A1/en unknown
- 2010-06-28 CN CN201080028371.0A patent/CN102458452B/zh active Active
- 2010-06-28 EP EP10730139.2A patent/EP2445515B1/en active Active
- 2010-06-28 ES ES10730139.2T patent/ES2579806T3/es active Active
- 2010-06-28 MX MX2011013288A patent/MX2011013288A/es active IP Right Grant
-
2011
- 2011-12-21 IL IL217124A patent/IL217124A/en active IP Right Grant
-
2014
- 2014-11-07 US US14/535,457 patent/US10137175B2/en active Active
-
2016
- 2016-04-13 AU AU2016202296A patent/AU2016202296B2/en active Active
- 2016-06-07 JP JP2016113291A patent/JP2017008033A/ja active Pending
-
2017
- 2017-03-05 IL IL250938A patent/IL250938B/en active IP Right Grant
-
2018
- 2018-03-16 AU AU2018201931A patent/AU2018201931B2/en active Active
- 2018-10-24 US US16/169,472 patent/US11052137B2/en active Active
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