JP2012530496A5 - - Google Patents
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- Publication number
- JP2012530496A5 JP2012530496A5 JP2012516307A JP2012516307A JP2012530496A5 JP 2012530496 A5 JP2012530496 A5 JP 2012530496A5 JP 2012516307 A JP2012516307 A JP 2012516307A JP 2012516307 A JP2012516307 A JP 2012516307A JP 2012530496 A5 JP2012530496 A5 JP 2012530496A5
- Authority
- JP
- Japan
- Prior art keywords
- cdr
- seq
- antibody
- binding fragment
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims 18
- 230000035772 mutation Effects 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000000611 antibody drug conjugate Substances 0.000 claims 5
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 5
- 102220250290 rs1554074673 Human genes 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 102220568015 Merlin_H97E_mutation Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229960000397 bevacizumab Drugs 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000001394 metastastic effect Effects 0.000 claims 3
- 206010061289 metastatic neoplasm Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229960003876 ranibizumab Drugs 0.000 claims 3
- 102220344151 rs1287146448 Human genes 0.000 claims 3
- 102220465452 Angiogenin_K64Q_mutation Human genes 0.000 claims 2
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000058223 human VEGFA Human genes 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 102220592281 7SK snRNA methylphosphate capping enzyme_K64S_mutation Human genes 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010055114 Colon cancer metastatic Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 102220359630 c.158A>T Human genes 0.000 claims 1
- 102220417854 c.293A>T Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21800509P | 2009-06-17 | 2009-06-17 | |
| US61/218,005 | 2009-06-17 | ||
| PCT/US2010/039029 WO2010148223A2 (en) | 2009-06-17 | 2010-06-17 | Anti-vegf antibodies and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530496A JP2012530496A (ja) | 2012-12-06 |
| JP2012530496A5 true JP2012530496A5 (https=) | 2013-08-01 |
| JP5785941B2 JP5785941B2 (ja) | 2015-09-30 |
Family
ID=42543312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516307A Expired - Fee Related JP5785941B2 (ja) | 2009-06-17 | 2010-06-17 | 抗ｖｅｇｆ抗体とその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9079953B2 (https=) |
| EP (2) | EP2894167B1 (https=) |
| JP (1) | JP5785941B2 (https=) |
| KR (1) | KR20120034739A (https=) |
| CN (1) | CN102482349B (https=) |
| AU (1) | AU2010262836B2 (https=) |
| BR (1) | BRPI1012321A8 (https=) |
| CA (1) | CA2765755C (https=) |
| CL (1) | CL2011003182A1 (https=) |
| CO (1) | CO6480962A2 (https=) |
| CR (1) | CR20110653A (https=) |
| EC (1) | ECSP12011584A (https=) |
| ES (2) | ES2656446T3 (https=) |
| GT (1) | GT201100326A (https=) |
| HK (1) | HK1211961A1 (https=) |
| IL (2) | IL216835A0 (https=) |
| MX (2) | MX2011013781A (https=) |
| NZ (1) | NZ596837A (https=) |
| PE (1) | PE20120622A1 (https=) |
| PH (1) | PH12011502602A1 (https=) |
| RU (1) | RU2567639C2 (https=) |
| SG (2) | SG177265A1 (https=) |
| TW (1) | TWI510248B (https=) |
| UA (1) | UA104626C2 (https=) |
| WO (1) | WO2010148223A2 (https=) |
| ZA (1) | ZA201109098B (https=) |
Families Citing this family (41)
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| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| US20130310281A1 (en) * | 2011-02-02 | 2013-11-21 | Glaxo Group Limited | Novel antigen binding proteins |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| JP6243325B2 (ja) * | 2011-04-12 | 2017-12-06 | ガンガゲン インコーポレーティッド | キメラ抗菌ポリペプチド |
| LT3495387T (lt) | 2012-07-13 | 2021-11-25 | Roche Glycart Ag | Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti |
| AU2013318047A1 (en) * | 2012-09-19 | 2015-03-12 | Genentech, Inc. | Methods and compositions for preventing norleucine misincorporation into proteins |
| WO2014052713A2 (en) | 2012-09-27 | 2014-04-03 | Massachusetts Institute Of Technology | Her2-and vegf-a-binding proteins with enhanced stability |
| KR101279895B1 (ko) * | 2012-10-24 | 2013-06-28 | 주식회사 진흥기공 | 유체 이송용 덕트에 결합 사용되는 댐퍼의 이중 브레이드 밀폐 장치 |
| US20140154255A1 (en) * | 2012-11-30 | 2014-06-05 | Abbvie Biotherapeutics Inc. | Anti-vegf antibodies and their uses |
| AU2013364043B2 (en) | 2012-12-21 | 2018-01-04 | Seagen Inc. | Anti-NTB-A antibodies and related compositions and methods |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| RU2646098C2 (ru) * | 2013-04-30 | 2018-03-01 | Интас Фармасьютикалс Лтд | Новый способ клонирования, экспрессии и очистки для получения ранибизумаба |
| AU2014286996A1 (en) * | 2013-07-12 | 2016-01-07 | Iveric Bio, Inc. | Methods for treating or preventing ophthalmological conditions |
| JP6463361B2 (ja) | 2013-09-08 | 2019-01-30 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | 第ｖｉｉｉ因子両性イオンポリマーコンジュゲート |
| WO2015164723A1 (en) * | 2014-04-25 | 2015-10-29 | The Trustees Of The University Of Pennsylvania | Methods and compositions for treating metastatic breast cancer and other cancers in the brain |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| EP3929302A1 (en) * | 2014-07-14 | 2021-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method for identifying epitope on protein |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| CN108148133B (zh) * | 2015-01-06 | 2020-04-24 | 珠海亿胜生物制药有限公司 | 抗vegf抗体 |
| KR102799807B1 (ko) * | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| JP7046828B2 (ja) * | 2016-04-15 | 2022-04-04 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 滲出型加齢性黄斑変性の治療のための組成物 |
| WO2017181021A1 (en) * | 2016-04-15 | 2017-10-19 | Regenxbio Inc. | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab |
| CN106039309B (zh) * | 2016-06-30 | 2024-04-19 | 中国人民解放军总医院第一附属医院 | 用于治疗恶性肿瘤造成的胸腔积液的药物组合物及其应用 |
| RU2656160C2 (ru) | 2016-08-17 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Антитело или его антигенсвязывающий фрагмент, способный связываться с рецептором интерлейкина-6 человека |
| SG11202002396TA (en) * | 2017-09-27 | 2020-04-29 | Regenxbio Inc | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab |
| MX2020006435A (es) | 2017-12-19 | 2021-02-09 | Akouos Inc | Administracion de anticuerpos terapeuticos mediada por vector de virus adenoasociado (aav) en el oido interno. |
| US12558434B2 (en) * | 2018-02-20 | 2026-02-24 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| CN109053895B (zh) | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| US20200115443A1 (en) * | 2018-10-12 | 2020-04-16 | Trican Biotechnology Co., Ltd | Bi-functional fusion proteins and uses thereof |
| CN111423512B (zh) * | 2019-01-10 | 2024-01-05 | 北京比洋生物技术有限公司 | 阻断血管内皮细胞生长且活化t细胞的多靶向融合蛋白和包含其的药物组合物 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN111363038A (zh) * | 2020-03-26 | 2020-07-03 | 北京纽安博生物技术有限公司 | 抗VEGF单域抗体及其人源化、单域抗体和IgG1-Fc构建的融合蛋白和应用 |
| CN111808191A (zh) * | 2020-05-11 | 2020-10-23 | 廊坊天光生物技术有限公司 | 一种用于检测血清中vegf含量的抗体对及其用途 |
| EP4206226A4 (en) * | 2020-08-31 | 2024-10-16 | Medytox Inc. | Anti-vegf hexameric antibody and composition comprising same |
| US20230372397A1 (en) | 2020-10-06 | 2023-11-23 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| IL303317A (en) | 2020-12-01 | 2023-07-01 | Akouos Inc | ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA |
| CN116897052A (zh) * | 2021-03-04 | 2023-10-17 | 百奥泰生物制药股份有限公司 | 抗vegf抗体制剂 |
| EP4473011A1 (en) | 2022-02-02 | 2024-12-11 | Akouos, Inc. | Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms |
| CN120248142B (zh) * | 2025-06-06 | 2025-09-12 | 上海兴瑞一达生物科技有限公司 | 一种共表达cd47和il-15的双靶点嵌合抗原受体、car-t细胞及其应用 |
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