JP2012528137A - 複素環式尿素誘導体およびそれらの使用方法 - Google Patents
複素環式尿素誘導体およびそれらの使用方法 Download PDFInfo
- Publication number
- JP2012528137A JP2012528137A JP2012512460A JP2012512460A JP2012528137A JP 2012528137 A JP2012528137 A JP 2012528137A JP 2012512460 A JP2012512460 A JP 2012512460A JP 2012512460 A JP2012512460 A JP 2012512460A JP 2012528137 A JP2012528137 A JP 2012528137A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- infection
- pharmaceutically acceptable
- substituted
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- OGBVTDGOOQARCJ-HNNXBMFYSA-N CCN1[C@H](CN(C=C(C(OCC)=O)C(c2c3)=O)c2nc(NCCN(C)C)c3I)CCC1 Chemical compound CCN1[C@H](CN(C=C(C(OCC)=O)C(c2c3)=O)c2nc(NCCN(C)C)c3I)CCC1 OGBVTDGOOQARCJ-HNNXBMFYSA-N 0.000 description 1
- KAWNQUVEXZRMHM-UHFFFAOYSA-N CCNC(Nc(cc1C(N)=O)ncc1Br)=O Chemical compound CCNC(Nc(cc1C(N)=O)ncc1Br)=O KAWNQUVEXZRMHM-UHFFFAOYSA-N 0.000 description 1
- MKNVKKOHPHSHLR-UHFFFAOYSA-N CCNC(Nc(nc1)cc(-c2nc(-c3c[n](C)nc3)c[s]2)c1Br)=O Chemical compound CCNC(Nc(nc1)cc(-c2nc(-c3c[n](C)nc3)c[s]2)c1Br)=O MKNVKKOHPHSHLR-UHFFFAOYSA-N 0.000 description 1
- IQIKUODALKKGDE-UHFFFAOYSA-N CCNC(Nc(nc1)cc(C(SC2)=NC2(C(F)(F)F)O)c1Br)=O Chemical compound CCNC(Nc(nc1)cc(C(SC2)=NC2(C(F)(F)F)O)c1Br)=O IQIKUODALKKGDE-UHFFFAOYSA-N 0.000 description 1
- UZDKLMMIUBPSEJ-UHFFFAOYSA-N CCNC(Nc1ncc(-c2cc(C(C(C(OCCCOP(OCc3ccccc3)(OCc3ccccc3)=O)=O)=CN3CC)=O)c3nc2)c(-c2nc(C(F)(F)F)c[s]2)c1)=O Chemical compound CCNC(Nc1ncc(-c2cc(C(C(C(OCCCOP(OCc3ccccc3)(OCc3ccccc3)=O)=O)=CN3CC)=O)c3nc2)c(-c2nc(C(F)(F)F)c[s]2)c1)=O UZDKLMMIUBPSEJ-UHFFFAOYSA-N 0.000 description 1
- MBQDJMUUJOVTQF-UHFFFAOYSA-N CCOC(C(C(c1c2)=O)=CN(CC3CCN(C)CC3)c1ncc2Br)=O Chemical compound CCOC(C(C(c1c2)=O)=CN(CC3CCN(C)CC3)c1ncc2Br)=O MBQDJMUUJOVTQF-UHFFFAOYSA-N 0.000 description 1
- 0 CCOC(C(C(c1c2)=O)=CN([C@@](*)CO)c1nc(F)c2I)=O Chemical compound CCOC(C(C(c1c2)=O)=CN([C@@](*)CO)c1nc(F)c2I)=O 0.000 description 1
- RDPZMDFZAWXNFZ-UHFFFAOYSA-N CCOC(C1=CN(C2CN(C)C2)c(cnc(Br)c2)c2C1=O)=O Chemical compound CCOC(C1=CN(C2CN(C)C2)c(cnc(Br)c2)c2C1=O)=O RDPZMDFZAWXNFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18237309P | 2009-05-29 | 2009-05-29 | |
| US61/182,373 | 2009-05-29 | ||
| US28501709P | 2009-12-09 | 2009-12-09 | |
| US61/285,017 | 2009-12-09 | ||
| PCT/GB2010/050908 WO2010136817A1 (en) | 2009-05-29 | 2010-05-28 | Heterocyclic urea derivatives and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012528137A true JP2012528137A (ja) | 2012-11-12 |
| JP2012528137A5 JP2012528137A5 (enExample) | 2013-06-20 |
Family
ID=42635508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512460A Withdrawn JP2012528137A (ja) | 2009-05-29 | 2010-05-28 | 複素環式尿素誘導体およびそれらの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8569484B2 (enExample) |
| EP (1) | EP2435434A1 (enExample) |
| JP (1) | JP2012528137A (enExample) |
| CN (1) | CN102448962A (enExample) |
| AR (1) | AR076899A1 (enExample) |
| TW (1) | TW201102065A (enExample) |
| UY (1) | UY32674A (enExample) |
| WO (1) | WO2010136817A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018174288A1 (ja) * | 2017-03-24 | 2018-09-27 | 大正製薬株式会社 | ２（１ｈ）－キノリノン誘導体 |
| JP2020512372A (ja) * | 2017-03-30 | 2020-04-23 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 細菌感染の治療及び予防のための新規ピリド［２，３−ｂ］インドール化合物 |
| JP2022501391A (ja) * | 2018-09-26 | 2022-01-06 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 細菌感染症の治療及び予防のための、置換ピリドインドール |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012010666A (es) | 2010-03-31 | 2012-10-05 | Actelion Pharmaceuticals Ltd | Derivados de isoquinolin-3-ilurea antibacterianos. |
| AR088729A1 (es) | 2011-03-29 | 2014-07-02 | Actelion Pharmaceuticals Ltd | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
| AU2018302178A1 (en) * | 2017-07-18 | 2020-02-13 | Nuvation Bio Inc. | 1,8-naphthyridinone compounds and uses thereof |
| CN107445981B (zh) * | 2017-08-25 | 2018-06-22 | 牡丹江医学院 | 一种用于防治宫颈炎的活性化合物 |
| KR20210116550A (ko) | 2019-01-18 | 2021-09-27 | 누베이션 바이오 인크. | 아데노신 길항제로서의 헤테로시클릭 화합물 |
| US11254670B2 (en) | 2019-01-18 | 2022-02-22 | Nuvation Bio Inc. | 1,8-naphthyridinone compounds and uses thereof |
| US20230002359A1 (en) | 2019-11-01 | 2023-01-05 | Syngenta Crop Protection Ag | Pesticidally active fused bicyclic heteroaromatic compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0589985A1 (en) * | 1991-06-21 | 1994-04-06 | Boehringer Mannheim Italia S.P.A. | 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract |
| TW538046B (en) | 1998-01-08 | 2003-06-21 | Hoechst Marion Roussel Inc | Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof |
| NZ520628A (en) | 2000-01-18 | 2004-05-28 | Vertex Pharma | thiazole, oxazole, imdazole or pyrazole substituted pyrazole derivatives useful as treating bacterial infections |
| DE60139964D1 (de) * | 2000-12-15 | 2009-10-29 | Vertex Pharma | Bakterielle Gyrase-Hemmer sowie deren Verwendung |
| TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| EP1856103A2 (en) | 2005-02-18 | 2007-11-21 | AstraZeneca AB | Pyrrole derivatives as dna gyrase and topoisomerase inhibitors |
| WO2006087543A1 (en) | 2005-02-18 | 2006-08-24 | Astrazeneca Ab | Antibacterial piperidine derivatives |
| US20080161306A1 (en) | 2005-02-18 | 2008-07-03 | Brian Sherer | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors |
| US20090253671A1 (en) | 2005-03-04 | 2009-10-08 | Astrazeneca Ab | Tricyclic derivatives of azetidine and pyrrole with antibacterial activity |
| JP2008531671A (ja) | 2005-03-04 | 2008-08-14 | アストラゼネカ アクチボラグ | 化合物 |
| JP2009520785A (ja) | 2005-12-23 | 2009-05-28 | アストラゼネカ アクチボラグ | 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン |
| DE602007014256D1 (de) | 2006-12-04 | 2011-06-09 | Astrazeneca Ab | Antibakterielle polycyclische harnstoffverbindungen |
| WO2009089263A2 (en) | 2008-01-07 | 2009-07-16 | Ardea Biosciences Inc. | Novel compositions and methods of use |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| KR20110014710A (ko) * | 2008-06-04 | 2011-02-11 | 아스트라제네카 아베 | 박테리아 감염의 치료를 위한 헤테로시클릭 우레아 유도체 |
-
2010
- 2010-05-27 TW TW099117083A patent/TW201102065A/zh unknown
- 2010-05-28 US US13/322,717 patent/US8569484B2/en not_active Expired - Fee Related
- 2010-05-28 CN CN2010800246088A patent/CN102448962A/zh active Pending
- 2010-05-28 JP JP2012512460A patent/JP2012528137A/ja not_active Withdrawn
- 2010-05-28 UY UY0001032674A patent/UY32674A/es not_active Application Discontinuation
- 2010-05-28 AR ARP100101876A patent/AR076899A1/es unknown
- 2010-05-28 EP EP10724561A patent/EP2435434A1/en not_active Withdrawn
- 2010-05-28 WO PCT/GB2010/050908 patent/WO2010136817A1/en not_active Ceased
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018174288A1 (ja) * | 2017-03-24 | 2018-09-27 | 大正製薬株式会社 | ２（１ｈ）－キノリノン誘導体 |
| JP2020512372A (ja) * | 2017-03-30 | 2020-04-23 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 細菌感染の治療及び予防のための新規ピリド［２，３−ｂ］インドール化合物 |
| JP7344125B2 (ja) | 2017-03-30 | 2023-09-13 | エフ． ホフマン－ラ ロシュ アーゲー | 細菌感染の治療及び予防のための新規ピリド［２，３－ｂ］インドール化合物 |
| JP2022501391A (ja) * | 2018-09-26 | 2022-01-06 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 細菌感染症の治療及び予防のための、置換ピリドインドール |
| JP7443351B2 (ja) | 2018-09-26 | 2024-03-05 | エフ． ホフマン－ラ ロシュ アーゲー | 細菌感染症の治療及び予防のための、置換ピリドインドール |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201102065A (en) | 2011-01-16 |
| US20120122817A1 (en) | 2012-05-17 |
| WO2010136817A1 (en) | 2010-12-02 |
| UY32674A (es) | 2010-12-31 |
| CN102448962A (zh) | 2012-05-09 |
| AR076899A1 (es) | 2011-07-13 |
| US8569484B2 (en) | 2013-10-29 |
| EP2435434A1 (en) | 2012-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130501 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130501 |
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| A761 | Written withdrawal of application |
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| A977 | Report on retrieval |
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