CN102448962A - 杂环脲衍生物及其使用方法 - Google Patents
杂环脲衍生物及其使用方法 Download PDFInfo
- Publication number
- CN102448962A CN102448962A CN2010800246088A CN201080024608A CN102448962A CN 102448962 A CN102448962 A CN 102448962A CN 2010800246088 A CN2010800246088 A CN 2010800246088A CN 201080024608 A CN201080024608 A CN 201080024608A CN 102448962 A CN102448962 A CN 102448962A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- infection
- ethyl
- amino
- randomly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCNC(Nc(nc1)cc(-c2nc(-c3ccccc3)c[s]2)c1-c(cc12)ncc1N([C@]1CN(CC*)CCC1)C=C(C(O)=O)C2=O)=O Chemical compound CCNC(Nc(nc1)cc(-c2nc(-c3ccccc3)c[s]2)c1-c(cc12)ncc1N([C@]1CN(CC*)CCC1)C=C(C(O)=O)C2=O)=O 0.000 description 2
- UNRBEYYLYRXYCG-ZETCQYMHSA-N CCN1[C@H](CN)CCC1 Chemical compound CCN1[C@H](CN)CCC1 UNRBEYYLYRXYCG-ZETCQYMHSA-N 0.000 description 1
- RGAXMYJTDNBJNF-UHFFFAOYSA-N CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c(cc12)cnc1N(CCOP(OCc1ccccc1)(OCc1ccccc1)=O)C=C(C(OCC)=O)C2=O)=O Chemical compound CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c(cc12)cnc1N(CCOP(OCc1ccccc1)(OCc1ccccc1)=O)C=C(C(OCC)=O)C2=O)=O RGAXMYJTDNBJNF-UHFFFAOYSA-N 0.000 description 1
- FAJCYZOSUVJIJI-DEOSSOPVSA-N CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c1cc(C(C(C(OCC)=O)=CN2[C@@H](CC(C)C)COP(O)(OCc3ccccc3)=O)=O)c2nc1)=O Chemical compound CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c1cc(C(C(C(OCC)=O)=CN2[C@@H](CC(C)C)COP(O)(OCc3ccccc3)=O)=O)c2nc1)=O FAJCYZOSUVJIJI-DEOSSOPVSA-N 0.000 description 1
- UABDHLLEPNWGOD-UHFFFAOYSA-P CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c1cc(C(C(C(OCCO[P+](O)=O)=O)=CN2CC)=O)c2nc1)=O Chemical compound CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c1cc(C(C(C(OCCO[P+](O)=O)=O)=CN2CC)=O)c2nc1)=O UABDHLLEPNWGOD-UHFFFAOYSA-P 0.000 description 1
- FAPBRAUAOGDOKV-UHFFFAOYSA-N CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c1cc(C(C(CN2CC3CCN(C)CC3)C(O)=O)=O)c2nc1)=O Chemical compound CCNC(Nc(nc1)cc(-c2nc(C(F)(F)F)c[s]2)c1-c1cc(C(C(CN2CC3CCN(C)CC3)C(O)=O)=O)c2nc1)=O FAPBRAUAOGDOKV-UHFFFAOYSA-N 0.000 description 1
- MKHIOVUBMRCQNH-QENILXLESA-N CCOC(/C(/C(c(cc(cn1)Br)c1Cl)=O)=C\N[C@@H](CC(C)C)CO)=O Chemical compound CCOC(/C(/C(c(cc(cn1)Br)c1Cl)=O)=C\N[C@@H](CC(C)C)CO)=O MKHIOVUBMRCQNH-QENILXLESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18237309P | 2009-05-29 | 2009-05-29 | |
| US61/182373 | 2009-05-29 | ||
| US28501709P | 2009-12-09 | 2009-12-09 | |
| US61/285017 | 2009-12-09 | ||
| PCT/GB2010/050908 WO2010136817A1 (en) | 2009-05-29 | 2010-05-28 | Heterocyclic urea derivatives and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102448962A true CN102448962A (zh) | 2012-05-09 |
Family
ID=42635508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800246088A Pending CN102448962A (zh) | 2009-05-29 | 2010-05-28 | 杂环脲衍生物及其使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8569484B2 (enExample) |
| EP (1) | EP2435434A1 (enExample) |
| JP (1) | JP2012528137A (enExample) |
| CN (1) | CN102448962A (enExample) |
| AR (1) | AR076899A1 (enExample) |
| TW (1) | TW201102065A (enExample) |
| UY (1) | UY32674A (enExample) |
| WO (1) | WO2010136817A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107445981A (zh) * | 2017-08-25 | 2017-12-08 | 牡丹江医学院 | 一种用于防治宫颈炎的活性化合物 |
| CN110446699A (zh) * | 2017-03-24 | 2019-11-12 | 大正制药株式会社 | 2（1h）-喹啉酮衍生物 |
| CN110475777A (zh) * | 2017-03-30 | 2019-11-19 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2012146246A (ru) | 2010-03-31 | 2014-05-10 | Актелион Фармасьютиклз Лтд | Антибактериальные производные изохинолин-3-илмочевины |
| AR088729A1 (es) | 2011-03-29 | 2014-07-02 | Actelion Pharmaceuticals Ltd | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
| CA3070073A1 (en) * | 2017-07-18 | 2019-01-24 | Nuvation Bio Inc. | 1,8-naphthyridinone compounds and uses thereof |
| WO2020064661A1 (en) * | 2018-09-26 | 2020-04-02 | F. Hoffmann-La Roche Ag | Substituted pyridoindoles for the treatment and prophylaxis of bacterial infection |
| AU2020208644A1 (en) | 2019-01-18 | 2021-08-26 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
| WO2020150676A1 (en) | 2019-01-18 | 2020-07-23 | Nuvation Bio Inc. | 1,8-naphthyridinone compounds and uses thereof |
| AU2020372700A1 (en) | 2019-11-01 | 2022-05-12 | Syngenta Crop Protection Ag | Pesticidally active fused bicyclic heteroaromatic compounds |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0519449A1 (en) * | 1991-06-21 | 1992-12-23 | Boehringer Mannheim Italia S.P.A. | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract |
| CN1481368A (zh) * | 2000-12-15 | 2004-03-10 | ��̩��˹ҩ��ɷ�����˾ | 促旋酶抑制剂和其用途 |
| CN101171247A (zh) * | 2005-03-04 | 2008-04-30 | 阿斯利康(瑞典)有限公司 | 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物 |
| WO2008068470A1 (en) * | 2006-12-04 | 2008-06-12 | Astrazeneca Ab | Antibacterial polycyclic urea compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW538046B (en) | 1998-01-08 | 2003-06-21 | Hoechst Marion Roussel Inc | Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof |
| JP2003520233A (ja) | 2000-01-18 | 2003-07-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | ジャイレースインヒビターおよびそれらの使用 |
| TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| JP2008530193A (ja) | 2005-02-18 | 2008-08-07 | アストラゼネカ アクチボラグ | 化合物 |
| EP1856103A2 (en) | 2005-02-18 | 2007-11-21 | AstraZeneca AB | Pyrrole derivatives as dna gyrase and topoisomerase inhibitors |
| JP4058106B2 (ja) | 2005-02-18 | 2008-03-05 | アストラゼネカ アクチボラグ | 抗菌性のピペリジン誘導体 |
| WO2006092608A1 (en) | 2005-03-04 | 2006-09-08 | Astrazeneca Ab | Tricyclic derivatives of azetidine and pyrrole with antibacterial activity |
| BRPI0620196A2 (pt) | 2005-12-23 | 2013-01-15 | Astrazeneca Ab | composto, processo para a preparaÇço do mesmo, composiÇço farmacÊutica, uso de um composto, e, mÉtodos para a produÇço de um efeito antibacteriano em um animal de sangue quente, para a inibiÇço de dna girase e/ou topoisomerase iv bacteriana em um animal de sangue quente e para o tratamento de uma infecÇço bacteriana em um animal de sangue quente |
| EP2231665A4 (en) | 2008-01-07 | 2012-04-25 | Ardea Biosciences Inc | NEW COMPOSITIONS AND METHODS OF USE |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| EP2300463A1 (en) * | 2008-06-04 | 2011-03-30 | AstraZeneca AB | Heterocyclic urea derivatives for the treatment of bacterial infections |
-
2010
- 2010-05-27 TW TW099117083A patent/TW201102065A/zh unknown
- 2010-05-28 UY UY0001032674A patent/UY32674A/es not_active Application Discontinuation
- 2010-05-28 WO PCT/GB2010/050908 patent/WO2010136817A1/en not_active Ceased
- 2010-05-28 US US13/322,717 patent/US8569484B2/en not_active Expired - Fee Related
- 2010-05-28 AR ARP100101876A patent/AR076899A1/es unknown
- 2010-05-28 JP JP2012512460A patent/JP2012528137A/ja not_active Withdrawn
- 2010-05-28 EP EP10724561A patent/EP2435434A1/en not_active Withdrawn
- 2010-05-28 CN CN2010800246088A patent/CN102448962A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0519449A1 (en) * | 1991-06-21 | 1992-12-23 | Boehringer Mannheim Italia S.P.A. | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract |
| CN1481368A (zh) * | 2000-12-15 | 2004-03-10 | ��̩��˹ҩ��ɷ�����˾ | 促旋酶抑制剂和其用途 |
| CN101171247A (zh) * | 2005-03-04 | 2008-04-30 | 阿斯利康(瑞典)有限公司 | 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物 |
| WO2008068470A1 (en) * | 2006-12-04 | 2008-06-12 | Astrazeneca Ab | Antibacterial polycyclic urea compounds |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110446699A (zh) * | 2017-03-24 | 2019-11-12 | 大正制药株式会社 | 2（1h）-喹啉酮衍生物 |
| CN110475777A (zh) * | 2017-03-30 | 2019-11-19 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物 |
| CN110475777B (zh) * | 2017-03-30 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物 |
| CN107445981A (zh) * | 2017-08-25 | 2017-12-08 | 牡丹江医学院 | 一种用于防治宫颈炎的活性化合物 |
| CN107445981B (zh) * | 2017-08-25 | 2018-06-22 | 牡丹江医学院 | 一种用于防治宫颈炎的活性化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8569484B2 (en) | 2013-10-29 |
| US20120122817A1 (en) | 2012-05-17 |
| AR076899A1 (es) | 2011-07-13 |
| WO2010136817A1 (en) | 2010-12-02 |
| UY32674A (es) | 2010-12-31 |
| EP2435434A1 (en) | 2012-04-04 |
| TW201102065A (en) | 2011-01-16 |
| JP2012528137A (ja) | 2012-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120509 |