JP2012526531A5 - - Google Patents
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- JP2012526531A5 JP2012526531A5 JP2012510276A JP2012510276A JP2012526531A5 JP 2012526531 A5 JP2012526531 A5 JP 2012526531A5 JP 2012510276 A JP2012510276 A JP 2012510276A JP 2012510276 A JP2012510276 A JP 2012510276A JP 2012526531 A5 JP2012526531 A5 JP 2012526531A5
- Authority
- JP
- Japan
- Prior art keywords
- orthopoxvirus
- anion exchange
- cell
- exchange adsorbent
- packaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 30
- 241000700629 Orthopoxvirus Species 0.000 claims description 22
- 239000003463 adsorbent Substances 0.000 claims description 19
- 238000005349 anion exchange Methods 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 16
- 238000004806 packaging method and process Methods 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 101710163270 Nuclease Proteins 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims description 5
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 4
- YTAHJIFKAKIKAV-XNMGPUDCSA-N [(1R)-3-morpholin-4-yl-1-phenylpropyl] N-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]carbamate Chemical compound O=C1[C@H](N=C(C2=C(N1)C=CC=C2)C1=CC=CC=C1)NC(O[C@H](CCN1CCOCC1)C1=CC=CC=C1)=O YTAHJIFKAKIKAV-XNMGPUDCSA-N 0.000 claims description 3
- 230000002238 attenuated effect Effects 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 20
- 241000271566 Aves Species 0.000 claims 8
- 239000011148 porous material Substances 0.000 claims 5
- 108010017842 Telomerase Proteins 0.000 claims 4
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 claims 4
- 238000011026 diafiltration Methods 0.000 claims 4
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 2
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 210000000170 cell membrane Anatomy 0.000 claims 2
- 238000005352 clarification Methods 0.000 claims 2
- 238000011118 depth filtration Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108010034546 Serratia marcescens nuclease Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- -1 dimethylaminoethyl Chemical group 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000002523 gelfiltration Methods 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000001471 micro-filtration Methods 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000000527 sonication Methods 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 10
- 239000000872 buffer Substances 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 2
- 235000013923 monosodium glutamate Nutrition 0.000 description 2
- 229940073490 sodium glutamate Drugs 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305422.9 | 2009-05-12 | ||
| EP09305422 | 2009-05-12 | ||
| US21348409P | 2009-06-12 | 2009-06-12 | |
| US61/213,484 | 2009-06-12 | ||
| PCT/EP2010/056491 WO2010130753A1 (en) | 2009-05-12 | 2010-05-11 | Method for orthopoxvirus production and purification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526531A JP2012526531A (ja) | 2012-11-01 |
| JP2012526531A5 true JP2012526531A5 (https=) | 2015-11-19 |
| JP5855564B2 JP5855564B2 (ja) | 2016-02-09 |
Family
ID=43084645
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510276A Expired - Fee Related JP5855564B2 (ja) | 2009-05-12 | 2010-05-11 | オルソポックスウイルスの製造および精製方法 |
| JP2012510278A Ceased JP2012526532A (ja) | 2009-05-12 | 2010-05-11 | 不死化鳥類細胞系およびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510278A Ceased JP2012526532A (ja) | 2009-05-12 | 2010-05-11 | 不死化鳥類細胞系およびその用途 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8445270B2 (https=) |
| EP (2) | EP2429580A1 (https=) |
| JP (2) | JP5855564B2 (https=) |
| KR (1) | KR20120026526A (https=) |
| CN (2) | CN102740881A (https=) |
| AU (2) | AU2010247371B2 (https=) |
| BR (2) | BRPI1007744A2 (https=) |
| CA (2) | CA2760465A1 (https=) |
| CR (1) | CR20110641A (https=) |
| IL (2) | IL216310A0 (https=) |
| NZ (1) | NZ596595A (https=) |
| RU (2) | RU2011148791A (https=) |
| SG (1) | SG176554A1 (https=) |
| WO (2) | WO2010130756A1 (https=) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009132195A1 (en) * | 2008-04-23 | 2009-10-29 | Michigan State University | Immortal avian cell line and methods of use |
| RU2011148791A (ru) * | 2009-05-12 | 2013-06-20 | Трансген Са | Иммортализованные линии клеток птиц и их применение |
| CN102807969B (zh) * | 2011-06-03 | 2013-09-25 | 中国科学院动物研究所 | 高产杆状病毒的转基因卵巢细胞系及其制备方法和应用 |
| TWI623618B (zh) | 2011-07-12 | 2018-05-11 | 傳斯堅公司 | Ｈｂｖ聚合酶突變體 |
| WO2013045668A2 (en) | 2011-09-29 | 2013-04-04 | Transgene Sa | Immunotherapy composition and regimen for treating hepatitis c virus infection |
| WO2013045658A1 (en) | 2011-09-29 | 2013-04-04 | Transgene Sa | Immunotherapy composition and regimen for treating hepatitis c virus infection |
| US20150141620A1 (en) * | 2012-06-01 | 2015-05-21 | Momenta Pharmaceuticals, Inc. | Methods related to rituximab |
| US9695244B2 (en) | 2012-06-01 | 2017-07-04 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
| WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| CN104640564B (zh) | 2012-07-10 | 2020-08-04 | 特兰斯吉恩股份有限公司 | 分枝杆菌抗原疫苗 |
| US20150210753A1 (en) | 2012-07-26 | 2015-07-30 | Momenta Pharmaceuticals, Inc. | Glycoproteins with anti-inflammatory properties |
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| FI2970398T3 (fi) | 2013-03-13 | 2024-08-06 | Us Health | Rsv f -prefuusioproteiineja ja niiden käyttö |
| US10450361B2 (en) | 2013-03-15 | 2019-10-22 | Momenta Pharmaceuticals, Inc. | Methods related to CTLA4-Fc fusion proteins |
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| GB201310031D0 (en) * | 2013-06-05 | 2013-07-17 | Pirbright Inst The | Cell |
| JP6864474B2 (ja) * | 2013-10-07 | 2021-04-28 | ノバルティス アーゲー | 処理済みフィルタ |
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| ES3011733T3 (en) | 2015-02-13 | 2025-04-08 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
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| US11084850B2 (en) | 2016-12-16 | 2021-08-10 | The Pirbright Institute | Recombinant prefusion RSV F proteins and uses thereof |
| KR20190097240A (ko) | 2016-12-28 | 2019-08-20 | 트랜스진 에스.에이. | 종양용해성 바이러스 및 치료 분자 |
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| KR102658198B1 (ko) * | 2017-05-15 | 2024-04-16 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정한 바이러스 함유 조성물 |
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| EP3847246A1 (en) | 2018-09-06 | 2021-07-14 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| JP2022514112A (ja) | 2018-10-15 | 2022-02-09 | リジェネクスバイオ インコーポレイテッド | 複製欠損型ウイルスベクター及びウイルスの感染性を測定するための方法 |
| JP7625521B2 (ja) | 2018-12-28 | 2025-02-03 | トランスジーン | ｍ２欠陥ポックスウイルス |
| CN111763661B (zh) * | 2019-04-02 | 2022-07-29 | 普莱柯生物工程股份有限公司 | 一种病毒纯化的方法、制备的疫苗组合物及其应用 |
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| CN112143693B (zh) * | 2019-06-28 | 2024-12-27 | 杭州康万达医药科技有限公司 | 一种生产病毒的方法及收获液组合物 |
| CN110468107A (zh) * | 2019-08-09 | 2019-11-19 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 一种对jev易感的猪扁桃体细胞系 |
| CN110396502A (zh) * | 2019-08-09 | 2019-11-01 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 对jev易感的猪扁桃体细胞系的构建方法 |
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| AU2007204024B2 (en) * | 2006-01-05 | 2012-01-19 | Transgene S.A. | Avian telomerase reverse transcriptase |
| CN101365789A (zh) * | 2006-01-05 | 2009-02-11 | 特兰斯吉恩股份有限公司 | 鸟类端粒酶反转录酶 |
| AU2007241405A1 (en) | 2006-04-21 | 2007-11-01 | Transgene S.A. | HPV-18-based papillomavirus vaccine |
| HUE030533T2 (hu) * | 2006-06-20 | 2017-05-29 | Transgene Sa | Eljárás poxvírusok és poxvírus-készítmények elõállítására |
| EP1982727A1 (en) * | 2007-04-17 | 2008-10-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for purification of viral proteins |
| EP1985305A1 (en) * | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
| JP2010526546A (ja) | 2007-05-14 | 2010-08-05 | バヴァリアン・ノルディック・アクティーゼルスカブ | ワクシニアウイルス系及び組換えワクシニアウイルス系ワクチンの精製 |
| US8003363B2 (en) * | 2007-05-14 | 2011-08-23 | Bavarian Nordic A/S | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
| CA2691868C (en) * | 2007-07-03 | 2016-12-20 | Transgene S.A. | Immortalized avian cell lines |
| CA2705869C (en) | 2007-11-19 | 2012-10-30 | Philippe Erbs | Poxviral oncolytic vectors |
| KR101542275B1 (ko) | 2007-11-19 | 2015-08-06 | 트랜스진 에스.에이. | 폭스바이러스성 온콜리틱 벡터 |
| CN102257134B (zh) * | 2008-02-12 | 2014-03-05 | 赛诺菲巴斯德有限公司 | 使用离子交换和凝胶过滤色谱进行痘病毒纯化的方法 |
| AU2009244776B2 (en) * | 2008-02-25 | 2013-03-07 | Nanotherapeutics, Inc. | Method for producing continuous cell lines |
| EP2310494A1 (en) * | 2008-06-25 | 2011-04-20 | ProBioGen AG | Cell line for propagation of highly attenuated alphaviruses |
| RU2011148791A (ru) * | 2009-05-12 | 2013-06-20 | Трансген Са | Иммортализованные линии клеток птиц и их применение |
-
2010
- 2010-05-11 RU RU2011148791/02A patent/RU2011148791A/ru not_active Application Discontinuation
- 2010-05-11 EP EP10721439A patent/EP2429580A1/en not_active Withdrawn
- 2010-05-11 BR BRPI1007744A patent/BRPI1007744A2/pt not_active IP Right Cessation
- 2010-05-11 NZ NZ59659510A patent/NZ596595A/xx not_active IP Right Cessation
- 2010-05-11 RU RU2011148790/10A patent/RU2560976C2/ru not_active IP Right Cessation
- 2010-05-11 WO PCT/EP2010/056497 patent/WO2010130756A1/en not_active Ceased
- 2010-05-11 US US12/777,731 patent/US8445270B2/en not_active Expired - Fee Related
- 2010-05-11 US US13/319,874 patent/US8609392B2/en not_active Expired - Fee Related
- 2010-05-11 CN CN2010800316470A patent/CN102740881A/zh active Pending
- 2010-05-11 AU AU2010247371A patent/AU2010247371B2/en not_active Ceased
- 2010-05-11 KR KR20117029009A patent/KR20120026526A/ko not_active Withdrawn
- 2010-05-11 JP JP2012510276A patent/JP5855564B2/ja not_active Expired - Fee Related
- 2010-05-11 WO PCT/EP2010/056491 patent/WO2010130753A1/en not_active Ceased
- 2010-05-11 EP EP10718219A patent/EP2429579A1/en not_active Withdrawn
- 2010-05-11 SG SG2011082518A patent/SG176554A1/en unknown
- 2010-05-11 CA CA2760465A patent/CA2760465A1/en not_active Abandoned
- 2010-05-11 CA CA 2761457 patent/CA2761457A1/en not_active Abandoned
- 2010-05-11 CN CN201080021253.7A patent/CN103547285A/zh active Pending
- 2010-05-11 BR BRPI1007743A patent/BRPI1007743A2/pt not_active IP Right Cessation
- 2010-05-11 JP JP2012510278A patent/JP2012526532A/ja not_active Ceased
- 2010-05-11 AU AU2010247374A patent/AU2010247374A1/en not_active Abandoned
-
2011
- 2011-11-10 IL IL216310A patent/IL216310A0/en unknown
- 2011-11-10 IL IL216312A patent/IL216312A0/en unknown
- 2011-11-29 CR CR20110641A patent/CR20110641A/es unknown
-
2013
- 2013-02-25 US US13/775,314 patent/US8778675B2/en not_active Expired - Fee Related
- 2013-11-12 US US14/077,621 patent/US9012198B2/en not_active Expired - Fee Related
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