JP2012524523A - 遺伝毒性試験 - Google Patents

遺伝毒性試験 Download PDF

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JP2012524523A
JP2012524523A JP2012501380A JP2012501380A JP2012524523A JP 2012524523 A JP2012524523 A JP 2012524523A JP 2012501380 A JP2012501380 A JP 2012501380A JP 2012501380 A JP2012501380 A JP 2012501380A JP 2012524523 A JP2012524523 A JP 2012524523A
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gluc
cell
assay
expression cassette
cells
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English (en)
Japanese (ja)
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JP2012524523A5 (enExample
Inventor
ラビノウィッツ,アダム
ウォームズリー,リチャード
テイト,マシュー
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ジェントロニクス・リミテッド
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Publication of JP2012524523A publication Critical patent/JP2012524523A/ja
Publication of JP2012524523A5 publication Critical patent/JP2012524523A5/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/60Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012501380A 2009-03-28 2010-03-26 遺伝毒性試験 Pending JP2012524523A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0905410.7 2009-03-28
GBGB0905410.7A GB0905410D0 (en) 2009-03-28 2009-03-28 Genotoxicity testing
PCT/GB2010/000581 WO2010112821A1 (en) 2009-03-28 2010-03-26 Genotoxicity testing

Publications (2)

Publication Number Publication Date
JP2012524523A true JP2012524523A (ja) 2012-10-18
JP2012524523A5 JP2012524523A5 (enExample) 2013-05-16

Family

ID=40671920

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012501380A Pending JP2012524523A (ja) 2009-03-28 2010-03-26 遺伝毒性試験

Country Status (8)

Country Link
US (2) US20120035079A1 (enExample)
EP (1) EP2411540A1 (enExample)
JP (1) JP2012524523A (enExample)
CN (1) CN102449168A (enExample)
AU (1) AU2010231209A1 (enExample)
CA (1) CA2755985A1 (enExample)
GB (1) GB0905410D0 (enExample)
WO (1) WO2010112821A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022512611A (ja) * 2018-10-03 2022-02-07 プロメガ コーポレイション セレンテラジンならびにその類似体及び誘導体を安定化させるための組成物及び方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9285358B2 (en) * 2011-04-08 2016-03-15 Anthem Biosciences Pvt Ltd Vitro method for high throughput screening of genotoxic agents in eukaryotic cells
CA2876402A1 (en) * 2012-06-13 2013-12-19 Merck Patent Gmbh Protein expression analyses for identifying genotoxic compounds
CN102851388B (zh) * 2012-09-29 2014-03-19 山东大学齐鲁医院 一种用于鉴别卵巢癌易感性的分子标记、试剂盒及其鉴别方法
CN102864234B (zh) * 2012-09-29 2014-03-19 山东大学齐鲁医院 一种用于鉴别卵巢癌易感性的分子标记
CN105200069A (zh) * 2015-10-16 2015-12-30 北京交通大学 基于rna聚合酶ⅰ的rsv微型复制基因组及其应用
US11307205B2 (en) 2016-09-19 2022-04-19 University Of Southern California Non-radioactive cytotoxicity assays
SG11202003885UA (en) 2017-11-08 2020-05-28 Twinstrand Biosciences Inc Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
AU2019221549C1 (en) * 2018-02-13 2025-11-27 Twinstrand Biosciences, Inc. Methods and reagents for detecting and assessing genotoxicity
SG11202100141SA (en) 2018-07-12 2021-02-25 Twinstrand Biosciences Inc Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
CN114606269B (zh) * 2022-03-17 2024-02-23 国家食品安全风险评估中心 一种用于食品接触材料迁移物的遗传毒性的高通量检测方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537745A (ja) * 2004-05-20 2007-12-27 ジェントロニックス リミテッド 遺伝子毒性試験

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5405111B2 (ja) * 2005-09-26 2014-02-05 ウルリヒ ルース Tsh受容体及び新規tsh受容体キメラに対する自己免疫抗体検出方法
CN101149327B (zh) * 2007-11-06 2010-06-30 浙江大学 基于细胞显微图像信息的抗肿瘤药物评价和筛选方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537745A (ja) * 2004-05-20 2007-12-27 ジェントロニックス リミテッド 遺伝子毒性試験

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6014034429; Molecular Therapy Vol.11, No.3, 2005, p.435-443 *
JPN6014034430; Internet Citation , 2005 *
JPN6014034432; DATABESE Geneseq, [online] , 20080807, accession no.ARW46012 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022512611A (ja) * 2018-10-03 2022-02-07 プロメガ コーポレイション セレンテラジンならびにその類似体及び誘導体を安定化させるための組成物及び方法
JP7447101B2 (ja) 2018-10-03 2024-03-11 プロメガ コーポレイション セレンテラジンならびにその類似体及び誘導体を安定化させるための組成物及び方法

Also Published As

Publication number Publication date
US20120035079A1 (en) 2012-02-09
EP2411540A1 (en) 2012-02-01
WO2010112821A1 (en) 2010-10-07
CN102449168A (zh) 2012-05-09
CA2755985A1 (en) 2010-10-07
AU2010231209A1 (en) 2011-10-06
GB0905410D0 (en) 2009-05-13
US20140302512A1 (en) 2014-10-09

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