CA2755985A1 - Genotoxicity testing - Google Patents
Genotoxicity testing Download PDFInfo
- Publication number
- CA2755985A1 CA2755985A1 CA2755985A CA2755985A CA2755985A1 CA 2755985 A1 CA2755985 A1 CA 2755985A1 CA 2755985 A CA2755985 A CA 2755985A CA 2755985 A CA2755985 A CA 2755985A CA 2755985 A1 CA2755985 A1 CA 2755985A1
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- Prior art keywords
- gluc
- cell
- assay
- cells
- expression cassette
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- 229960004799 tryptophan Drugs 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0905410.7 | 2009-03-28 | ||
| GBGB0905410.7A GB0905410D0 (en) | 2009-03-28 | 2009-03-28 | Genotoxicity testing |
| PCT/GB2010/000581 WO2010112821A1 (en) | 2009-03-28 | 2010-03-26 | Genotoxicity testing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2755985A1 true CA2755985A1 (en) | 2010-10-07 |
Family
ID=40671920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2755985A Abandoned CA2755985A1 (en) | 2009-03-28 | 2010-03-26 | Genotoxicity testing |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120035079A1 (enExample) |
| EP (1) | EP2411540A1 (enExample) |
| JP (1) | JP2012524523A (enExample) |
| CN (1) | CN102449168A (enExample) |
| AU (1) | AU2010231209A1 (enExample) |
| CA (1) | CA2755985A1 (enExample) |
| GB (1) | GB0905410D0 (enExample) |
| WO (1) | WO2010112821A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9285358B2 (en) * | 2011-04-08 | 2016-03-15 | Anthem Biosciences Pvt Ltd | Vitro method for high throughput screening of genotoxic agents in eukaryotic cells |
| CA2876402A1 (en) * | 2012-06-13 | 2013-12-19 | Merck Patent Gmbh | Protein expression analyses for identifying genotoxic compounds |
| CN102851388B (zh) * | 2012-09-29 | 2014-03-19 | 山东大学齐鲁医院 | 一种用于鉴别卵巢癌易感性的分子标记、试剂盒及其鉴别方法 |
| CN102864234B (zh) * | 2012-09-29 | 2014-03-19 | 山东大学齐鲁医院 | 一种用于鉴别卵巢癌易感性的分子标记 |
| CN105200069A (zh) * | 2015-10-16 | 2015-12-30 | 北京交通大学 | 基于rna聚合酶ⅰ的rsv微型复制基因组及其应用 |
| US11307205B2 (en) | 2016-09-19 | 2022-04-19 | University Of Southern California | Non-radioactive cytotoxicity assays |
| SG11202003885UA (en) | 2017-11-08 | 2020-05-28 | Twinstrand Biosciences Inc | Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters |
| AU2019221549C1 (en) * | 2018-02-13 | 2025-11-27 | Twinstrand Biosciences, Inc. | Methods and reagents for detecting and assessing genotoxicity |
| SG11202100141SA (en) | 2018-07-12 | 2021-02-25 | Twinstrand Biosciences Inc | Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications |
| CN119955899A (zh) * | 2018-10-03 | 2025-05-09 | 普洛麦格公司 | 用于稳定腔肠素及其类似物和衍生物的组合物、方法和试剂盒 |
| CN114606269B (zh) * | 2022-03-17 | 2024-02-23 | 国家食品安全风险评估中心 | 一种用于食品接触材料迁移物的遗传毒性的高通量检测方法及应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411198D0 (en) * | 2004-05-20 | 2004-06-23 | Gentronix Ltd | Genotoxic testing |
| JP5405111B2 (ja) * | 2005-09-26 | 2014-02-05 | ウルリヒ ルース | Ｔｓｈ受容体及び新規ｔｓｈ受容体キメラに対する自己免疫抗体検出方法 |
| CN101149327B (zh) * | 2007-11-06 | 2010-06-30 | 浙江大学 | 基于细胞显微图像信息的抗肿瘤药物评价和筛选方法 |
-
2009
- 2009-03-28 GB GBGB0905410.7A patent/GB0905410D0/en not_active Ceased
-
2010
- 2010-03-26 CN CN2010800231330A patent/CN102449168A/zh active Pending
- 2010-03-26 EP EP10723255A patent/EP2411540A1/en not_active Withdrawn
- 2010-03-26 WO PCT/GB2010/000581 patent/WO2010112821A1/en not_active Ceased
- 2010-03-26 US US13/260,458 patent/US20120035079A1/en not_active Abandoned
- 2010-03-26 CA CA2755985A patent/CA2755985A1/en not_active Abandoned
- 2010-03-26 JP JP2012501380A patent/JP2012524523A/ja active Pending
- 2010-03-26 AU AU2010231209A patent/AU2010231209A1/en not_active Abandoned
-
2013
- 2013-10-14 US US14/053,070 patent/US20140302512A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120035079A1 (en) | 2012-02-09 |
| EP2411540A1 (en) | 2012-02-01 |
| WO2010112821A1 (en) | 2010-10-07 |
| CN102449168A (zh) | 2012-05-09 |
| JP2012524523A (ja) | 2012-10-18 |
| AU2010231209A1 (en) | 2011-10-06 |
| GB0905410D0 (en) | 2009-05-13 |
| US20140302512A1 (en) | 2014-10-09 |
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