JP2012523576A5 - - Google Patents
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- JP2012523576A5 JP2012523576A5 JP2012506135A JP2012506135A JP2012523576A5 JP 2012523576 A5 JP2012523576 A5 JP 2012523576A5 JP 2012506135 A JP2012506135 A JP 2012506135A JP 2012506135 A JP2012506135 A JP 2012506135A JP 2012523576 A5 JP2012523576 A5 JP 2012523576A5
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- 239000000523 sample Substances 0.000 claims description 51
- 239000012491 analyte Substances 0.000 claims description 33
- 230000005291 magnetic effect Effects 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 20
- 238000003556 assay Methods 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 10
- 230000009260 cross reactivity Effects 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 9
- 239000003446 ligand Substances 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims 8
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 5
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 description 4
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 description 4
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 3
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 3
- 230000005294 ferromagnetic effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 230000002494 anti-cea effect Effects 0.000 description 2
- 239000002885 antiferromagnetic material Substances 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000002331 protein detection Methods 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229910001316 Ag alloy Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 229910001252 Pd alloy Inorganic materials 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229910001260 Pt alloy Inorganic materials 0.000 description 1
- 229910000929 Ru alloy Inorganic materials 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910001128 Sn alloy Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 229910003445 palladium oxide Inorganic materials 0.000 description 1
- JQPTYAILLJKUCY-UHFFFAOYSA-N palladium(ii) oxide Chemical compound [O-2].[Pd+2] JQPTYAILLJKUCY-UHFFFAOYSA-N 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 229910001925 ruthenium oxide Inorganic materials 0.000 description 1
- WOCIAKWEIIZHES-UHFFFAOYSA-N ruthenium(iv) oxide Chemical compound O=[Ru]=O WOCIAKWEIIZHES-UHFFFAOYSA-N 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- -1 tin alloys Chemical class 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- QHGNHLZPVBIIPX-UHFFFAOYSA-N tin(ii) oxide Chemical class [Sn]=O QHGNHLZPVBIIPX-UHFFFAOYSA-N 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16892209P | 2009-04-13 | 2009-04-13 | |
| US61/168,922 | 2009-04-13 | ||
| PCT/US2010/030919 WO2011022093A2 (en) | 2009-04-13 | 2010-04-13 | Methods and devices for detecting the presence of an analyte in a sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012523576A JP2012523576A (ja) | 2012-10-04 |
| JP2012523576A5 true JP2012523576A5 (enExample) | 2013-04-11 |
Family
ID=43527414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012506135A Pending JP2012523576A (ja) | 2009-04-13 | 2010-04-13 | 試料中の分析物の存在を検出するための方法および装置 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9506919B2 (enExample) |
| EP (1) | EP2419733A4 (enExample) |
| JP (1) | JP2012523576A (enExample) |
| WO (1) | WO2011022093A2 (enExample) |
Families Citing this family (52)
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| US9267894B2 (en) | 2012-08-10 | 2016-02-23 | Hamamatsu Photonics K.K. | Method for making surface enhanced Raman scattering device |
| CN101868286A (zh) | 2007-09-20 | 2010-10-20 | 马格雷股份有限公司 | 采用磁性传感器进行的分析物检测 |
| US8790916B2 (en) | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
| WO2011112929A2 (en) * | 2010-03-12 | 2011-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Magnetic sensor based quantitative binding kinetics analysis |
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| WO2013006629A1 (en) * | 2011-07-06 | 2013-01-10 | Alere San Diego Inc. | Methods and compositions for assigning likelihood of acute kidney injury progression |
| EP2610609B1 (en) * | 2011-12-29 | 2018-10-10 | Honeywell Romania S.R.L. | Oxygen fluorescence quenching sensor, detector comprising the sensor, and method for producing the sensor |
| US9588113B2 (en) | 2012-02-22 | 2017-03-07 | Church & Dwight Co., Inc. | Methods for electronic analyte assaying |
| US10132755B2 (en) | 2012-08-10 | 2018-11-20 | Hamamatsu Photonics K.K. | Surface-enhanced Raman scattering element, and method for manufacturing surface-enhanced Raman scattering element |
| JP6023509B2 (ja) | 2012-08-10 | 2016-11-09 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
| CN108827928B (zh) * | 2012-08-10 | 2021-12-24 | 浜松光子学株式会社 | 表面增强拉曼散射单元及其使用方法 |
| JP6080648B2 (ja) * | 2013-03-29 | 2017-02-15 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
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| EP2884262B1 (en) * | 2012-08-10 | 2022-04-27 | Hamamatsu Photonics K.K. | Surface-enhanced raman scattering unit |
| JP6230250B2 (ja) * | 2013-03-29 | 2017-11-15 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット、及びラマン分光分析方法 |
| JP6058313B2 (ja) * | 2012-08-10 | 2017-01-11 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
| CN104508466B (zh) | 2012-08-10 | 2018-07-17 | 浜松光子学株式会社 | 表面增强拉曼散射元件 |
| JP5921380B2 (ja) | 2012-08-10 | 2016-05-24 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
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| JP5921381B2 (ja) | 2012-08-10 | 2016-05-24 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
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| EP2884264B1 (en) | 2012-08-10 | 2019-11-20 | Hamamatsu Photonics K.K. | Surface-enhanced raman scattering element, and method for producing same |
| JP5945192B2 (ja) | 2012-08-10 | 2016-07-05 | 浜松ホトニクス株式会社 | 表面増強ラマン散乱ユニット |
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| US10542918B2 (en) * | 2013-10-23 | 2020-01-28 | Verily Life Sciences Llc | Modulation of a response signal to distinguish between analyte and background signals |
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| US7977111B2 (en) * | 2008-01-18 | 2011-07-12 | Magic Technologies, Inc. | Devices using addressable magnetic tunnel junction array to detect magnetic particles |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| KR101088885B1 (ko) * | 2008-12-23 | 2011-12-07 | 연세대학교 산학협력단 | 바이오프로브, 그 제조방법, 상기를 사용한 분석 장치 및 분석 방법 |
| WO2011112929A2 (en) * | 2010-03-12 | 2011-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Magnetic sensor based quantitative binding kinetics analysis |
-
2010
- 2010-04-13 WO PCT/US2010/030919 patent/WO2011022093A2/en not_active Ceased
- 2010-04-13 EP EP10810304.5A patent/EP2419733A4/en not_active Withdrawn
- 2010-04-13 US US12/759,584 patent/US9506919B2/en not_active Expired - Fee Related
- 2010-04-13 JP JP2012506135A patent/JP2012523576A/ja active Pending
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